CN1207296C - 抑制法尼基转移酶的1,2－增环喹啉对映体 - Google Patents

抑制法尼基转移酶的1,2－增环喹啉对映体 Download PDF

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Publication number
CN1207296C
CN1207296C CNB018113788A CN01811378A CN1207296C CN 1207296 C CN1207296 C CN 1207296C CN B018113788 A CNB018113788 A CN B018113788A CN 01811378 A CN01811378 A CN 01811378A CN 1207296 C CN1207296 C CN 1207296C
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CN
China
Prior art keywords
acid
chlorophenyl
pharmaceutically acceptable
compound
pharmaceutical composition
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Expired - Lifetime
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CNB018113788A
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English (en)
Chinese (zh)
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CN1437601A (zh
Inventor
M·G·韦内
P·R·安日博
D·W·恩德
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN1437601A publication Critical patent/CN1437601A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB018113788A 2000-06-22 2001-06-13 抑制法尼基转移酶的1,2－增环喹啉对映体 Expired - Lifetime CN1207296C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202181 2000-06-22
EP00202181.4 2000-06-22

Publications (2)

Publication Number Publication Date
CN1437601A CN1437601A (zh) 2003-08-20
CN1207296C true CN1207296C (zh) 2005-06-22

Family

ID=8171675

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018113788A Expired - Lifetime CN1207296C (zh) 2000-06-22 2001-06-13 抑制法尼基转移酶的1,2－增环喹啉对映体

Country Status (33)

Country Link
US (3) US20030114471A1 (OSRAM)
EP (1) EP1296984B1 (OSRAM)
JP (1) JP4919575B2 (OSRAM)
KR (2) KR100846370B1 (OSRAM)
CN (1) CN1207296C (OSRAM)
AR (1) AR030704A1 (OSRAM)
AT (1) ATE294804T1 (OSRAM)
AU (3) AU6396201A (OSRAM)
BG (1) BG65894B1 (OSRAM)
BR (1) BRPI0111743B8 (OSRAM)
CA (1) CA2410232C (OSRAM)
CZ (1) CZ295278B6 (OSRAM)
DE (1) DE60110592T2 (OSRAM)
EA (1) EA005065B1 (OSRAM)
EE (1) EE04966B1 (OSRAM)
EG (1) EG24180A (OSRAM)
ES (1) ES2241830T3 (OSRAM)
HR (1) HRP20020989B1 (OSRAM)
HU (1) HU229095B1 (OSRAM)
IL (2) IL153560A0 (OSRAM)
IS (1) IS2596B (OSRAM)
JO (1) JO2361B1 (OSRAM)
MX (1) MXPA02012845A (OSRAM)
MY (1) MY127734A (OSRAM)
NO (1) NO324494B1 (OSRAM)
NZ (1) NZ522481A (OSRAM)
PA (1) PA8519501A1 (OSRAM)
PL (1) PL209521B1 (OSRAM)
SA (1) SA01220349B1 (OSRAM)
SK (1) SK285699B6 (OSRAM)
UA (1) UA73572C2 (OSRAM)
WO (1) WO2001098302A1 (OSRAM)
ZA (1) ZA200210305B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018135A1 (en) 2001-08-24 2003-03-06 Wyeth Holdings Corporation Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
AU2003229688B2 (en) 2002-04-15 2009-07-30 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
JP2017536403A (ja) * 2014-12-04 2017-12-07 アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． デルタ肝炎ウイルス感染の治療
WO2016172342A1 (en) 2015-04-21 2016-10-27 Eiger Biopharmaceuticals, Inc. Pharmaceutical compositions comprising lonafarnib and ritonavir
WO2017031101A1 (en) 2015-08-17 2017-02-23 Kura Oncology, Inc. Methods of treating cancer patients with farnesyl transferase inhibitors
AU2017353838A1 (en) 2016-11-03 2019-05-23 Kura Oncology, Inc. Farnesyltransferase inhibitors for use in methods of treating cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1519765A (en) * 1974-09-05 1978-08-02 Ici Ltd Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes
US4141979A (en) * 1976-12-23 1979-02-27 Pfizer Inc. Tetrazolo[a]quinazol-5-ones antiallergy and antiulcer agents
GB9513577D0 (en) * 1995-07-04 1995-09-06 Brotherwood Rodney J Improvements in passenger carrying vehicles
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
IL123568A (en) * 1995-12-08 2001-08-08 Janssen Pharmaceutica Nv History (Imidazole - 5Il) Methyl-2-quinolinone inhibitors of Prenzyl transferase, their preparation, pharmaceutical preparations containing them and their preparation and drugs containing them
AU715658B2 (en) 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
KR100520401B1 (ko) * 1997-04-25 2005-10-12 얀센 파마슈티카 엔.브이. 파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논
CN1231215C (zh) 1997-06-02 2005-12-14 詹森药业有限公司 (咪唑－5－基)甲基－2－喹啉酮衍生物用作平滑肌细胞增殖抑制剂
HRP20000904A2 (en) 1998-07-06 2001-12-31 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for treating arthropathies
ATE238811T1 (de) * 1998-07-06 2003-05-15 Janssen Pharmaceutica Nv Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften
GEP20033001B (en) * 1998-08-27 2003-06-25 Pfizer Prod Inc Alkynyl-Substituted Quinolin-2-One Derivatives Useful As Anticancer Agents
JP3494409B2 (ja) * 1998-08-27 2004-02-09 ファイザー・プロダクツ・インク 抗がん剤として有用なアルキニル置換キノリン−２−オン誘導体
JP4725940B2 (ja) * 1998-12-23 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １，２−環付加キノリン誘導体
US6462201B1 (en) * 1998-12-29 2002-10-08 Isp Investments Inc. Process for the production of N-vinyl-2-pyrrolidone by vinylation
JP4090200B2 (ja) * 1999-02-11 2008-05-28 ファイザー・プロダクツ・インク 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体
HN2000000266A (es) 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
EP1267848B1 (en) * 2000-02-24 2007-10-17 Janssen Pharmaceutica N.V. Dosing regimen comprising a farnesyl protein transferase inhibitor for the treatment of cancer
US7067531B2 (en) 2000-09-25 2006-06-27 Angibaud Patrick Rene Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
US7196094B2 (en) 2000-09-25 2007-03-27 Janssen Pharmaceutica, N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives

Also Published As

Publication number Publication date
BG107310A (bg) 2003-07-31
AU6396201A (en) 2002-01-02
IL153560A (en) 2011-06-30
MXPA02012845A (es) 2003-05-15
KR20070121847A (ko) 2007-12-27
PL209521B1 (pl) 2011-09-30
CN1437601A (zh) 2003-08-20
US20030114471A1 (en) 2003-06-19
HUP0300872A2 (hu) 2003-07-28
CA2410232C (en) 2008-10-07
AU2001263962B2 (en) 2006-07-20
JO2361B1 (en) 2006-12-12
KR100846370B1 (ko) 2008-07-15
ATE294804T1 (de) 2005-05-15
CA2410232A1 (en) 2001-12-27
DE60110592T2 (de) 2006-01-19
US8318753B2 (en) 2012-11-27
AU2006220405A1 (en) 2006-10-12
HRP20020989B1 (hr) 2011-05-31
BG65894B1 (bg) 2010-04-30
US8329714B2 (en) 2012-12-11
HU229095B1 (en) 2013-07-29
EG24180A (en) 2008-09-28
AU2006220405B2 (en) 2009-05-21
KR20030009463A (ko) 2003-01-29
HK1058363A1 (en) 2004-05-14
EA005065B1 (ru) 2004-10-28
CZ295278B6 (cs) 2005-06-15
HUP0300872A3 (en) 2004-11-29
CZ2003114A3 (cs) 2003-05-14
EE200200695A (et) 2004-06-15
EP1296984B1 (en) 2005-05-04
SA01220349B1 (ar) 2007-01-23
IS2596B (is) 2010-03-15
NO20026032L (no) 2002-12-16
IL153560A0 (en) 2003-07-06
ES2241830T3 (es) 2005-11-01
DE60110592D1 (de) 2005-06-09
JP2004501153A (ja) 2004-01-15
JP4919575B2 (ja) 2012-04-18
US20070259902A1 (en) 2007-11-08
MY127734A (en) 2006-12-29
EE04966B1 (et) 2008-02-15
PL358918A1 (en) 2004-08-23
NO20026032D0 (no) 2002-12-16
EA200300048A1 (ru) 2003-04-24
BR0111743A (pt) 2003-07-08
AR030704A1 (es) 2003-09-03
HRP20020989A2 (en) 2005-02-28
WO2001098302A1 (en) 2001-12-27
NZ522481A (en) 2004-09-24
ZA200210305B (en) 2004-03-19
BRPI0111743B1 (pt) 2019-03-26
IS6590A (is) 2002-10-25
NO324494B1 (no) 2007-10-29
UA73572C2 (en) 2005-08-15
PA8519501A1 (es) 2002-08-29
SK502003A3 (en) 2003-05-02
KR100831940B1 (ko) 2008-05-23
BRPI0111743B8 (pt) 2021-05-25
US20080114009A1 (en) 2008-05-15
EP1296984A1 (en) 2003-04-02
SK285699B6 (sk) 2007-06-07

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Granted publication date: 20050622