IL153560A0 - Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer - Google Patents

Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer

Info

Publication number
IL153560A0
IL153560A0 IL15356001A IL15356001A IL153560A0 IL 153560 A0 IL153560 A0 IL 153560A0 IL 15356001 A IL15356001 A IL 15356001A IL 15356001 A IL15356001 A IL 15356001A IL 153560 A0 IL153560 A0 IL 153560A0
Authority
IL
Israel
Prior art keywords
farnesyl transferase
transferase inhibiting
quinoline enantiomer
annelated quinoline
annelated
Prior art date
Application number
IL15356001A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL153560A0 publication Critical patent/IL153560A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15356001A 2000-06-22 2001-06-13 Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer IL153560A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202181 2000-06-22
PCT/EP2001/006747 WO2001098302A1 (en) 2000-06-22 2001-06-13 Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer

Publications (1)

Publication Number Publication Date
IL153560A0 true IL153560A0 (en) 2003-07-06

Family

ID=8171675

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15356001A IL153560A0 (en) 2000-06-22 2001-06-13 Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer
IL153560A IL153560A (en) 2000-06-22 2002-12-19 (-) - 5– (3 – chlorophenyl) - a– (4– chlorophenyl) - a– (1– methyl– H1 – imidazol – 5 – il) –tetrazolo [5,1– a] quinazoline – 7 – methanol as a drug Anti-arthropic and anti-inflammatory

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL153560A IL153560A (en) 2000-06-22 2002-12-19 (-) - 5– (3 – chlorophenyl) - a– (4– chlorophenyl) - a– (1– methyl– H1 – imidazol – 5 – il) –tetrazolo [5,1– a] quinazoline – 7 – methanol as a drug Anti-arthropic and anti-inflammatory

Country Status (33)

Country Link
US (3) US20030114471A1 (OSRAM)
EP (1) EP1296984B1 (OSRAM)
JP (1) JP4919575B2 (OSRAM)
KR (2) KR100846370B1 (OSRAM)
CN (1) CN1207296C (OSRAM)
AR (1) AR030704A1 (OSRAM)
AT (1) ATE294804T1 (OSRAM)
AU (3) AU6396201A (OSRAM)
BG (1) BG65894B1 (OSRAM)
BR (1) BRPI0111743B8 (OSRAM)
CA (1) CA2410232C (OSRAM)
CZ (1) CZ295278B6 (OSRAM)
DE (1) DE60110592T2 (OSRAM)
EA (1) EA005065B1 (OSRAM)
EE (1) EE04966B1 (OSRAM)
EG (1) EG24180A (OSRAM)
ES (1) ES2241830T3 (OSRAM)
HR (1) HRP20020989B1 (OSRAM)
HU (1) HU229095B1 (OSRAM)
IL (2) IL153560A0 (OSRAM)
IS (1) IS2596B (OSRAM)
JO (1) JO2361B1 (OSRAM)
MX (1) MXPA02012845A (OSRAM)
MY (1) MY127734A (OSRAM)
NO (1) NO324494B1 (OSRAM)
NZ (1) NZ522481A (OSRAM)
PA (1) PA8519501A1 (OSRAM)
PL (1) PL209521B1 (OSRAM)
SA (1) SA01220349B1 (OSRAM)
SK (1) SK285699B6 (OSRAM)
UA (1) UA73572C2 (OSRAM)
WO (1) WO2001098302A1 (OSRAM)
ZA (1) ZA200210305B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018135A1 (en) 2001-08-24 2003-03-06 Wyeth Holdings Corporation Method of using 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
AU2003229688B2 (en) 2002-04-15 2009-07-30 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
US10076512B2 (en) 2014-05-01 2018-09-18 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
JP2017536403A (ja) * 2014-12-04 2017-12-07 アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． デルタ肝炎ウイルス感染の治療
WO2016172342A1 (en) 2015-04-21 2016-10-27 Eiger Biopharmaceuticals, Inc. Pharmaceutical compositions comprising lonafarnib and ritonavir
WO2017031101A1 (en) 2015-08-17 2017-02-23 Kura Oncology, Inc. Methods of treating cancer patients with farnesyl transferase inhibitors
AU2017353838A1 (en) 2016-11-03 2019-05-23 Kura Oncology, Inc. Farnesyltransferase inhibitors for use in methods of treating cancer

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1519765A (en) * 1974-09-05 1978-08-02 Ici Ltd Pesticidal dihydrotetrazolo(1,5a) quinazolines compositions and processes
US4141979A (en) * 1976-12-23 1979-02-27 Pfizer Inc. Tetrazolo[a]quinazol-5-ones antiallergy and antiulcer agents
GB9513577D0 (en) * 1995-07-04 1995-09-06 Brotherwood Rodney J Improvements in passenger carrying vehicles
TW349948B (en) * 1995-10-31 1999-01-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 2-quinolone derivatives
IL123568A (en) * 1995-12-08 2001-08-08 Janssen Pharmaceutica Nv History (Imidazole - 5Il) Methyl-2-quinolinone inhibitors of Prenzyl transferase, their preparation, pharmaceutical preparations containing them and their preparation and drugs containing them
AU715658B2 (en) 1996-04-03 2000-02-10 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
KR100520401B1 (ko) * 1997-04-25 2005-10-12 얀센 파마슈티카 엔.브이. 파네실 트랜스퍼라제 억제작용을 갖는 퀴나졸리논
CN1231215C (zh) 1997-06-02 2005-12-14 詹森药业有限公司 (咪唑－5－基)甲基－2－喹啉酮衍生物用作平滑肌细胞增殖抑制剂
HRP20000904A2 (en) 1998-07-06 2001-12-31 Janssen Pharmaceutica Nv Farnesyl protein transferase inhibitors for treating arthropathies
ATE238811T1 (de) * 1998-07-06 2003-05-15 Janssen Pharmaceutica Nv Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften
GEP20033001B (en) * 1998-08-27 2003-06-25 Pfizer Prod Inc Alkynyl-Substituted Quinolin-2-One Derivatives Useful As Anticancer Agents
JP3494409B2 (ja) * 1998-08-27 2004-02-09 ファイザー・プロダクツ・インク 抗がん剤として有用なアルキニル置換キノリン−２−オン誘導体
JP4725940B2 (ja) * 1998-12-23 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １，２−環付加キノリン誘導体
US6462201B1 (en) * 1998-12-29 2002-10-08 Isp Investments Inc. Process for the production of N-vinyl-2-pyrrolidone by vinylation
JP4090200B2 (ja) * 1999-02-11 2008-05-28 ファイザー・プロダクツ・インク 抗癌薬として有用なヘテロアリール置換キノリン−２−オン誘導体
HN2000000266A (es) 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
EP1267848B1 (en) * 2000-02-24 2007-10-17 Janssen Pharmaceutica N.V. Dosing regimen comprising a farnesyl protein transferase inhibitor for the treatment of cancer
US7067531B2 (en) 2000-09-25 2006-06-27 Angibaud Patrick Rene Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
US7196094B2 (en) 2000-09-25 2007-03-27 Janssen Pharmaceutica, N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives

Also Published As

Publication number Publication date
BG107310A (bg) 2003-07-31
AU6396201A (en) 2002-01-02
IL153560A (en) 2011-06-30
MXPA02012845A (es) 2003-05-15
KR20070121847A (ko) 2007-12-27
PL209521B1 (pl) 2011-09-30
CN1437601A (zh) 2003-08-20
US20030114471A1 (en) 2003-06-19
HUP0300872A2 (hu) 2003-07-28
CA2410232C (en) 2008-10-07
AU2001263962B2 (en) 2006-07-20
JO2361B1 (en) 2006-12-12
KR100846370B1 (ko) 2008-07-15
ATE294804T1 (de) 2005-05-15
CA2410232A1 (en) 2001-12-27
DE60110592T2 (de) 2006-01-19
US8318753B2 (en) 2012-11-27
AU2006220405A1 (en) 2006-10-12
HRP20020989B1 (hr) 2011-05-31
BG65894B1 (bg) 2010-04-30
US8329714B2 (en) 2012-12-11
CN1207296C (zh) 2005-06-22
HU229095B1 (en) 2013-07-29
EG24180A (en) 2008-09-28
AU2006220405B2 (en) 2009-05-21
KR20030009463A (ko) 2003-01-29
HK1058363A1 (en) 2004-05-14
EA005065B1 (ru) 2004-10-28
CZ295278B6 (cs) 2005-06-15
HUP0300872A3 (en) 2004-11-29
CZ2003114A3 (cs) 2003-05-14
EE200200695A (et) 2004-06-15
EP1296984B1 (en) 2005-05-04
SA01220349B1 (ar) 2007-01-23
IS2596B (is) 2010-03-15
NO20026032L (no) 2002-12-16
ES2241830T3 (es) 2005-11-01
DE60110592D1 (de) 2005-06-09
JP2004501153A (ja) 2004-01-15
JP4919575B2 (ja) 2012-04-18
US20070259902A1 (en) 2007-11-08
MY127734A (en) 2006-12-29
EE04966B1 (et) 2008-02-15
PL358918A1 (en) 2004-08-23
NO20026032D0 (no) 2002-12-16
EA200300048A1 (ru) 2003-04-24
BR0111743A (pt) 2003-07-08
AR030704A1 (es) 2003-09-03
HRP20020989A2 (en) 2005-02-28
WO2001098302A1 (en) 2001-12-27
NZ522481A (en) 2004-09-24
ZA200210305B (en) 2004-03-19
BRPI0111743B1 (pt) 2019-03-26
IS6590A (is) 2002-10-25
NO324494B1 (no) 2007-10-29
UA73572C2 (en) 2005-08-15
PA8519501A1 (es) 2002-08-29
SK502003A3 (en) 2003-05-02
KR100831940B1 (ko) 2008-05-23
BRPI0111743B8 (pt) 2021-05-25
US20080114009A1 (en) 2008-05-15
EP1296984A1 (en) 2003-04-02
SK285699B6 (sk) 2007-06-07

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