CN1203179C - 一种禾本科植物过敏原的dna序列和重组生产的方法 - Google Patents

一种禾本科植物过敏原的dna序列和重组生产的方法 Download PDF

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Publication number
CN1203179C
CN1203179C CNB008066566A CN00806656A CN1203179C CN 1203179 C CN1203179 C CN 1203179C CN B008066566 A CNB008066566 A CN B008066566A CN 00806656 A CN00806656 A CN 00806656A CN 1203179 C CN1203179 C CN 1203179C
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CN
China
Prior art keywords
dna molecule
lys
polypeptide
gly
allergen
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Expired - Fee Related
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CNB008066566A
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English (en)
Chinese (zh)
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CN1351664A (zh
Inventor
阿恩德·彼得森
R·苏克
H·菲比格
O·克罗姆维尔
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Merck Patent GmbH
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Merck Patent GmbH
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Publication date
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Publication of CN1351664A publication Critical patent/CN1351664A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB008066566A 1999-04-23 2000-04-12 一种禾本科植物过敏原的dna序列和重组生产的方法 Expired - Fee Related CN1203179C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19918682.0 1999-04-23
DE19918682A DE19918682A1 (de) 1999-04-23 1999-04-23 DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens

Publications (2)

Publication Number Publication Date
CN1351664A CN1351664A (zh) 2002-05-29
CN1203179C true CN1203179C (zh) 2005-05-25

Family

ID=7905749

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008066566A Expired - Fee Related CN1203179C (zh) 1999-04-23 2000-04-12 一种禾本科植物过敏原的dna序列和重组生产的方法

Country Status (15)

Country Link
US (1) US7241450B1 (https=)
EP (1) EP1171604B1 (https=)
JP (1) JP4588888B2 (https=)
CN (1) CN1203179C (https=)
AT (1) ATE338126T1 (https=)
AU (1) AU781275B2 (https=)
CA (1) CA2370393C (https=)
CZ (1) CZ20013796A3 (https=)
DE (2) DE19918682A1 (https=)
ES (1) ES2270828T3 (https=)
HU (1) HUP0200883A2 (https=)
PL (1) PL201818B1 (https=)
PT (1) PT1171604E (https=)
RU (1) RU2238321C2 (https=)
WO (1) WO2000065060A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19939982A1 (de) 1999-08-24 2001-03-01 Merck Patent Gmbh Verfahren zur Isolierung und Aufreinigung von Gräserpollenallergenen
AUPR779201A0 (en) * 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
SE0200946D0 (sv) * 2002-03-27 2002-03-27 Pharmacia Diagnostics Ab Novel Allergen
WO2004022588A1 (de) * 2002-08-19 2004-03-18 Merck Patent Gmbh Varianten des majorallergens phl p 1 aus lieschgras
ATE513848T1 (de) * 2003-06-04 2011-07-15 Merck Patent Gmbh Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität
DE10359351A1 (de) * 2003-12-16 2005-07-21 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden
DE102004035337A1 (de) * 2004-07-21 2006-03-16 Merck Patent Gmbh Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität
WO2011085782A1 (de) * 2010-01-14 2011-07-21 Merck Patent Gmbh Varianten der gruppe 6-allergene der süssgräser mit reduzierter allergenität durch mutagenese von prolinresten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736362A (en) * 1990-10-26 1998-04-07 The University Of Melbourne Ryegrass pollen allergen

Also Published As

Publication number Publication date
CZ20013796A3 (cs) 2002-01-16
ES2270828T3 (es) 2007-04-16
CN1351664A (zh) 2002-05-29
JP2002542783A (ja) 2002-12-17
US7241450B1 (en) 2007-07-10
CA2370393C (en) 2010-09-14
JP4588888B2 (ja) 2010-12-01
RU2238321C2 (ru) 2004-10-20
DE19918682A1 (de) 2000-10-26
EP1171604A2 (de) 2002-01-16
EP1171604B1 (de) 2006-08-30
WO2000065060A2 (de) 2000-11-02
ATE338126T1 (de) 2006-09-15
HUP0200883A2 (hu) 2003-07-28
AU4547700A (en) 2000-11-10
WO2000065060A3 (de) 2001-03-01
PL356055A1 (en) 2004-06-14
DE50013400D1 (de) 2006-10-12
PL201818B1 (pl) 2009-05-29
AU781275B2 (en) 2005-05-12
PT1171604E (pt) 2007-01-31
CA2370393A1 (en) 2000-11-02

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CF01 Termination of patent right due to non-payment of annual fee