PT1171604E - Sequência de dna e preparação recombinente de um alergénio de gramíneas - Google Patents
Sequência de dna e preparação recombinente de um alergénio de gramíneas Download PDFInfo
- Publication number
- PT1171604E PT1171604E PT00926876T PT00926876T PT1171604E PT 1171604 E PT1171604 E PT 1171604E PT 00926876 T PT00926876 T PT 00926876T PT 00926876 T PT00926876 T PT 00926876T PT 1171604 E PT1171604 E PT 1171604E
- Authority
- PT
- Portugal
- Prior art keywords
- allergen
- phleum
- phleum pratense
- polypeptide
- lys
- Prior art date
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- IQPWNQRRAJHOKV-KATARQTJSA-N Thr-Ser-Lys Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCCCN IQPWNQRRAJHOKV-KATARQTJSA-N 0.000 description 1
- DSGIVWSDDRDJIO-ZXXMMSQZSA-N Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O DSGIVWSDDRDJIO-ZXXMMSQZSA-N 0.000 description 1
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- 208000006673 asthma Diseases 0.000 description 1
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- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 108010016616 cysteinylglycine Proteins 0.000 description 1
- 108010060199 cysteinylproline Proteins 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 238000001962 electrophoresis Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 108010055341 glutamyl-glutamic acid Proteins 0.000 description 1
- VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 1
- XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 description 1
- 108010089804 glycyl-threonine Proteins 0.000 description 1
- 108010050848 glycylleucine Proteins 0.000 description 1
- 108010015792 glycyllysine Proteins 0.000 description 1
- 108010077515 glycylproline Proteins 0.000 description 1
- 108010087823 glycyltyrosine Proteins 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
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- 108010034529 leucyl-lysine Proteins 0.000 description 1
- 108010003700 lysyl aspartic acid Proteins 0.000 description 1
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- 108010038320 lysylphenylalanine Proteins 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
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- CJWXCNXHAIFFMH-AVZHFPDBSA-N n-[(2s,3r,4s,5s,6r)-2-[(2r,3r,4s,5r)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxy-3,5-dihydroxy-6-methyloxan-4-yl]acetamide Chemical compound C[C@H]1O[C@@H](O[C@@H]([C@@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O)[C@H](O)[C@@H](NC(C)=O)[C@@H]1O CJWXCNXHAIFFMH-AVZHFPDBSA-N 0.000 description 1
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- 230000008313 sensitization Effects 0.000 description 1
- 108010048397 seryl-lysyl-leucine Proteins 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19918682A DE19918682A1 (de) | 1999-04-23 | 1999-04-23 | DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1171604E true PT1171604E (pt) | 2007-01-31 |
Family
ID=7905749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00926876T PT1171604E (pt) | 1999-04-23 | 2000-04-12 | Sequência de dna e preparação recombinente de um alergénio de gramíneas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7241450B1 (https=) |
| EP (1) | EP1171604B1 (https=) |
| JP (1) | JP4588888B2 (https=) |
| CN (1) | CN1203179C (https=) |
| AT (1) | ATE338126T1 (https=) |
| AU (1) | AU781275B2 (https=) |
| CA (1) | CA2370393C (https=) |
| CZ (1) | CZ20013796A3 (https=) |
| DE (2) | DE19918682A1 (https=) |
| ES (1) | ES2270828T3 (https=) |
| HU (1) | HUP0200883A2 (https=) |
| PL (1) | PL201818B1 (https=) |
| PT (1) | PT1171604E (https=) |
| RU (1) | RU2238321C2 (https=) |
| WO (1) | WO2000065060A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19939982A1 (de) | 1999-08-24 | 2001-03-01 | Merck Patent Gmbh | Verfahren zur Isolierung und Aufreinigung von Gräserpollenallergenen |
| AUPR779201A0 (en) * | 2001-09-20 | 2001-10-11 | University Of Melbourne, The | Immunotherapeutic and immunoprophylactic reagents |
| SE0200946D0 (sv) * | 2002-03-27 | 2002-03-27 | Pharmacia Diagnostics Ab | Novel Allergen |
| WO2004022588A1 (de) * | 2002-08-19 | 2004-03-18 | Merck Patent Gmbh | Varianten des majorallergens phl p 1 aus lieschgras |
| ATE513848T1 (de) * | 2003-06-04 | 2011-07-15 | Merck Patent Gmbh | Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität |
| DE10359351A1 (de) * | 2003-12-16 | 2005-07-21 | Merck Patent Gmbh | DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden |
| DE102004035337A1 (de) * | 2004-07-21 | 2006-03-16 | Merck Patent Gmbh | Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität |
| WO2011085782A1 (de) * | 2010-01-14 | 2011-07-21 | Merck Patent Gmbh | Varianten der gruppe 6-allergene der süssgräser mit reduzierter allergenität durch mutagenese von prolinresten |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736362A (en) * | 1990-10-26 | 1998-04-07 | The University Of Melbourne | Ryegrass pollen allergen |
-
1999
- 1999-04-23 DE DE19918682A patent/DE19918682A1/de not_active Withdrawn
-
2000
- 2000-04-12 CA CA2370393A patent/CA2370393C/en not_active Expired - Fee Related
- 2000-04-12 JP JP2000614395A patent/JP4588888B2/ja not_active Expired - Fee Related
- 2000-04-12 AT AT00926876T patent/ATE338126T1/de active
- 2000-04-12 WO PCT/EP2000/003259 patent/WO2000065060A2/de not_active Ceased
- 2000-04-12 EP EP00926876A patent/EP1171604B1/de not_active Expired - Lifetime
- 2000-04-12 DE DE50013400T patent/DE50013400D1/de not_active Expired - Lifetime
- 2000-04-12 HU HU0200883A patent/HUP0200883A2/hu unknown
- 2000-04-12 PL PL356055A patent/PL201818B1/pl unknown
- 2000-04-12 RU RU2001130165A patent/RU2238321C2/ru not_active IP Right Cessation
- 2000-04-12 PT PT00926876T patent/PT1171604E/pt unknown
- 2000-04-12 CN CNB008066566A patent/CN1203179C/zh not_active Expired - Fee Related
- 2000-04-12 US US09/959,340 patent/US7241450B1/en not_active Expired - Fee Related
- 2000-04-12 AU AU45477/00A patent/AU781275B2/en not_active Ceased
- 2000-04-12 CZ CZ20013796A patent/CZ20013796A3/cs unknown
- 2000-04-12 ES ES00926876T patent/ES2270828T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20013796A3 (cs) | 2002-01-16 |
| ES2270828T3 (es) | 2007-04-16 |
| CN1351664A (zh) | 2002-05-29 |
| JP2002542783A (ja) | 2002-12-17 |
| US7241450B1 (en) | 2007-07-10 |
| CA2370393C (en) | 2010-09-14 |
| JP4588888B2 (ja) | 2010-12-01 |
| RU2238321C2 (ru) | 2004-10-20 |
| DE19918682A1 (de) | 2000-10-26 |
| EP1171604A2 (de) | 2002-01-16 |
| EP1171604B1 (de) | 2006-08-30 |
| WO2000065060A2 (de) | 2000-11-02 |
| ATE338126T1 (de) | 2006-09-15 |
| HUP0200883A2 (hu) | 2003-07-28 |
| AU4547700A (en) | 2000-11-10 |
| WO2000065060A3 (de) | 2001-03-01 |
| PL356055A1 (en) | 2004-06-14 |
| DE50013400D1 (de) | 2006-10-12 |
| CN1203179C (zh) | 2005-05-25 |
| PL201818B1 (pl) | 2009-05-29 |
| AU781275B2 (en) | 2005-05-12 |
| CA2370393A1 (en) | 2000-11-02 |
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