CN1199950C - 作为抗炎剂的喹啉衍生物 - Google Patents

作为抗炎剂的喹啉衍生物 Download PDF

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Publication number
CN1199950C
CN1199950C CNB018163513A CN01816351A CN1199950C CN 1199950 C CN1199950 C CN 1199950C CN B018163513 A CNB018163513 A CN B018163513A CN 01816351 A CN01816351 A CN 01816351A CN 1199950 C CN1199950 C CN 1199950C
Authority
CN
China
Prior art keywords
alkyl
compound
methoxy
phenyl
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018163513A
Other languages
English (en)
Chinese (zh)
Other versions
CN1466575A (zh
Inventor
克里斯·艾伦·布罗卡
伍恩基·金
凯文·李·麦克拉伦
戴维·伯纳德·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1466575A publication Critical patent/CN1466575A/zh
Application granted granted Critical
Publication of CN1199950C publication Critical patent/CN1199950C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB018163513A 2000-08-09 2001-08-01 作为抗炎剂的喹啉衍生物 Expired - Fee Related CN1199950C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22419600P 2000-08-09 2000-08-09
US60/224,196 2000-08-09

Publications (2)

Publication Number Publication Date
CN1466575A CN1466575A (zh) 2004-01-07
CN1199950C true CN1199950C (zh) 2005-05-04

Family

ID=22839655

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018163513A Expired - Fee Related CN1199950C (zh) 2000-08-09 2001-08-01 作为抗炎剂的喹啉衍生物

Country Status (15)

Country Link
US (2) US7049325B2 (https=)
EP (1) EP1313707B1 (https=)
JP (1) JP3930428B2 (https=)
KR (1) KR20030027016A (https=)
CN (1) CN1199950C (https=)
AR (1) AR033554A1 (https=)
AT (1) ATE367379T1 (https=)
AU (1) AU2001277560A1 (https=)
BR (1) BR0113175A (https=)
CA (1) CA2418832A1 (https=)
DE (1) DE60129445T2 (https=)
ES (1) ES2290161T3 (https=)
MX (1) MXPA03001178A (https=)
WO (1) WO2002012192A1 (https=)
ZA (1) ZA200300847B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW591089B (en) * 2001-08-09 2004-06-11 Cheil Ind Inc Slurry composition for use in chemical mechanical polishing of metal wiring
GB0220953D0 (en) * 2002-09-10 2002-10-23 Novartis Ag Organic compounds
US7132432B2 (en) * 2003-06-05 2006-11-07 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
AU2006220708B9 (en) * 2005-03-08 2013-01-17 Boehringer Ingelheim International Gmbh Process for preparing macrocyclic compounds
PE20110343A1 (es) * 2008-09-17 2011-06-25 Boehringer Ingelheim Int Combinacion de inhibidor de la proteasa ns3 de hcv con interferon y ribavirina
EA201200650A1 (ru) 2009-10-30 2012-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин
US9383448B2 (en) 2012-07-05 2016-07-05 Deca System Co., Ltd. Golf GPS device with automatic hole recognition and playing hole selection
CN117924243B (zh) * 2024-01-16 2025-09-12 沈阳药科大学 一种喹啉衍生物及其药用组合物和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9018134D0 (en) 1989-09-29 1990-10-03 Ici Plc Heterocyclic derivatives
MX9200299A (es) 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
EP0498722B1 (fr) 1991-02-07 1997-07-30 Roussel Uclaf Dérivés bicycliques azotés, leur procédé de préparation, les intermédiaires obtenus, leur application comme médicaments et les compositions pharmaceutiques les renfermant
GB9311790D0 (en) * 1993-06-08 1993-07-28 Minnesota Mining & Mfg Photothermographic materials
DK122693D0 (da) 1993-10-29 1993-10-29 Hempels Skibsfarve Fab J C Marin struktur
AU715358B2 (en) * 1995-04-28 2000-01-20 Takeda Chemical Industries Ltd. Therapeutic composition for arthritis
DE19638484A1 (de) * 1996-09-20 1998-03-26 Basf Ag Hetaroylderivate
DE19638486A1 (de) * 1996-09-20 1998-03-26 Basf Ag Hetaroylderivate
US6069151A (en) 1996-11-06 2000-05-30 Darwin Discovery, Ltd. Quinolines and their therapeutic use
PA8444901A1 (es) 1997-01-28 2000-05-24 Hoffmann La Roche Derivados de 5-aroilnaftaleno como agentes anti-inflamatorios
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6479438B2 (en) * 2001-01-04 2002-11-12 Isp Investments Inc. Gel inhibited liquid carrier for a biocide containing a carbodiimide and an emulsifier mixture

Also Published As

Publication number Publication date
ZA200300847B (en) 2004-04-30
DE60129445T2 (de) 2008-04-24
EP1313707A1 (en) 2003-05-28
EP1313707B1 (en) 2007-07-18
US7049325B2 (en) 2006-05-23
US20060084677A1 (en) 2006-04-20
JP3930428B2 (ja) 2007-06-13
US7186840B2 (en) 2007-03-06
MXPA03001178A (es) 2003-06-30
US20020082276A1 (en) 2002-06-27
ATE367379T1 (de) 2007-08-15
AR033554A1 (es) 2003-12-26
JP2004505951A (ja) 2004-02-26
KR20030027016A (ko) 2003-04-03
WO2002012192A1 (en) 2002-02-14
AU2001277560A1 (en) 2002-02-18
ES2290161T3 (es) 2008-02-16
BR0113175A (pt) 2004-02-17
CA2418832A1 (en) 2002-02-14
CN1466575A (zh) 2004-01-07
DE60129445D1 (de) 2007-08-30

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050504

Termination date: 20090801