AR033554A1 - Un compuesto derivado de quinolina, su uso, procedimientos para su preparacion, y un medicamento que lo comprende - Google Patents
Un compuesto derivado de quinolina, su uso, procedimientos para su preparacion, y un medicamento que lo comprendeInfo
- Publication number
- AR033554A1 AR033554A1 ARP010103784A ARP010103784A AR033554A1 AR 033554 A1 AR033554 A1 AR 033554A1 AR P010103784 A ARP010103784 A AR P010103784A AR P010103784 A ARP010103784 A AR P010103784A AR 033554 A1 AR033554 A1 AR 033554A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- cycloalkyl
- haloalkyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos derivados de quinolina de formula (1), donde: A es un ûCH2-, -CH(OH)-, -C(O)-, >C=NOR4, -NR5-, -O-, -S-, -S(O)2- donde: R4 es hidrogeno o alquilo y R5 es hidrogeno, alquilo o acilo; Ar es fenilo opcionalmente sustituido; R1 es hidrogeno, alquilo, alquenilo, alquinilo, haloalquilo, heteroalquilo, cicloalquilo, cicloalquilalquilo, alcoxi, alqueniloxi, cicloalquiloxi, cicloalquilalquiloxi, haloalquiloxi, hidroxialquiloxi, alcoxialquiloxi, alquil-sulfanilo, alquilsulfinilo, alquilsulfonilo, cicloalquil-sulfanilo, cicloalquilalquilsulfanilo, hidroxi, halogeno, ciano, -NR9R10, -OCONR9R10, u ûOSO2R11 donde R9 y R10 son independientemente hidrogeno, alquilo, o acilo; y R11 es alquilo, cicloalquilo o haloalquilo; R2 es hidrogeno, alquilo, alquenilo, alcoxi, hidroxi, halogeno, haloalquilo, heteroalquilo, alquilsulfanilo, alquilsulfinilo, alquilsulfonilo, nitro, ciano, o ûNR9R10 donde R9 y R10 son de la forma descripta con anterioridad; R3 es ûSR12, -SOR12, -SO2R12, o ûSO2NR13R14 donde: R12 es alquilo, hidroxialquilo, alcoxialquilo, aminoalquilo, mono- o di-alquilaminoalquilo, carboxialquilo, o alcoxicarbonilalquilo; R13 es hidrogeno o alquilo, y R14 es hidrogeno, alquilo, cicloalquilo, cicloalquilalquilo, hidroxialquilo, alcoxialquilo, alcoxicarbonil-alquilo, aminoalquilo, arilo, o aralquilo; o R13 y R14 junto con el átomo de nitrogeno al que están unidos, forman un grupo heterocicloamino; y profármacos, isomeros individuales, mezclas de isomeros, y sales farmacéuticamente aceptables de los mismos. Los compuestos son utiles como inhibidores de COX-II y, por lo tanto, pueden ser utilizados para el tratamiento de una enfermedad tratable a través de la administracion de un inhibidor de COX-II selectivo, como ser una enfermedad inflamatoria, una enfermedad autoinmune. Procedimientos para prepara los compuestos de formula (1), y medicamentos que los comprenden.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22419600P | 2000-08-09 | 2000-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033554A1 true AR033554A1 (es) | 2003-12-26 |
Family
ID=22839655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103784A AR033554A1 (es) | 2000-08-09 | 2001-08-08 | Un compuesto derivado de quinolina, su uso, procedimientos para su preparacion, y un medicamento que lo comprende |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7049325B2 (es) |
| EP (1) | EP1313707B1 (es) |
| JP (1) | JP3930428B2 (es) |
| KR (1) | KR20030027016A (es) |
| CN (1) | CN1199950C (es) |
| AR (1) | AR033554A1 (es) |
| AT (1) | ATE367379T1 (es) |
| AU (1) | AU2001277560A1 (es) |
| BR (1) | BR0113175A (es) |
| CA (1) | CA2418832A1 (es) |
| DE (1) | DE60129445T2 (es) |
| ES (1) | ES2290161T3 (es) |
| MX (1) | MXPA03001178A (es) |
| WO (1) | WO2002012192A1 (es) |
| ZA (1) | ZA200300847B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW591089B (en) * | 2001-08-09 | 2004-06-11 | Cheil Ind Inc | Slurry composition for use in chemical mechanical polishing of metal wiring |
| GB0220953D0 (en) * | 2002-09-10 | 2002-10-23 | Novartis Ag | Organic compounds |
| US7132432B2 (en) * | 2003-06-05 | 2006-11-07 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) |
| NZ562167A (en) * | 2005-03-08 | 2011-01-28 | Boehringer Ingelheim Int | Process for preparing macrocyclic compounds |
| EP2337583A1 (en) * | 2008-09-17 | 2011-06-29 | Boehringer Ingelheim International GmbH | Combination of hcv ns3 protease inhibitor with interferon and ribavirin |
| BR112012010110A2 (pt) | 2009-10-30 | 2019-09-24 | Boehringer Ingelheim Int | regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina |
| US9383448B2 (en) | 2012-07-05 | 2016-07-05 | Deca System Co., Ltd. | Golf GPS device with automatic hole recognition and playing hole selection |
| CN117924243B (zh) * | 2024-01-16 | 2025-09-12 | 沈阳药科大学 | 一种喹啉衍生物及其药用组合物和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9018134D0 (en) * | 1989-09-29 | 1990-10-03 | Ici Plc | Heterocyclic derivatives |
| JP3531944B2 (ja) | 1991-02-07 | 2004-05-31 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のベンジル基で置換された窒素系二環式誘導体及びその製造方法 |
| MX9200299A (es) | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
| GB9311790D0 (en) * | 1993-06-08 | 1993-07-28 | Minnesota Mining & Mfg | Photothermographic materials |
| DK122693D0 (da) | 1993-10-29 | 1993-10-29 | Hempels Skibsfarve Fab J C | Marin struktur |
| WO1996033717A1 (en) * | 1995-04-28 | 1996-10-31 | Takeda Chemical Industries, Ltd. | Therapeutic composition for arthritis |
| DE19638484A1 (de) * | 1996-09-20 | 1998-03-26 | Basf Ag | Hetaroylderivate |
| DE19638486A1 (de) * | 1996-09-20 | 1998-03-26 | Basf Ag | Hetaroylderivate |
| US6069151A (en) | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
| PA8444901A1 (es) * | 1997-01-28 | 2000-05-24 | Hoffmann La Roche | Derivados de 5-aroilnaftaleno como agentes anti-inflamatorios |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| US6034256A (en) * | 1997-04-21 | 2000-03-07 | G.D. Searle & Co. | Substituted benzopyran derivatives for the treatment of inflammation |
| US6479438B2 (en) * | 2001-01-04 | 2002-11-12 | Isp Investments Inc. | Gel inhibited liquid carrier for a biocide containing a carbodiimide and an emulsifier mixture |
-
2001
- 2001-08-01 BR BR0113175-3A patent/BR0113175A/pt not_active IP Right Cessation
- 2001-08-01 EP EP01955382A patent/EP1313707B1/en not_active Expired - Lifetime
- 2001-08-01 ES ES01955382T patent/ES2290161T3/es not_active Expired - Lifetime
- 2001-08-01 JP JP2002518170A patent/JP3930428B2/ja not_active Expired - Fee Related
- 2001-08-01 AU AU2001277560A patent/AU2001277560A1/en not_active Abandoned
- 2001-08-01 CA CA002418832A patent/CA2418832A1/en not_active Abandoned
- 2001-08-01 KR KR10-2003-7001942A patent/KR20030027016A/ko not_active Ceased
- 2001-08-01 CN CNB018163513A patent/CN1199950C/zh not_active Expired - Fee Related
- 2001-08-01 DE DE60129445T patent/DE60129445T2/de not_active Expired - Fee Related
- 2001-08-01 WO PCT/EP2001/008880 patent/WO2002012192A1/en not_active Ceased
- 2001-08-01 AT AT01955382T patent/ATE367379T1/de not_active IP Right Cessation
- 2001-08-01 MX MXPA03001178A patent/MXPA03001178A/es unknown
- 2001-08-07 US US09/925,883 patent/US7049325B2/en not_active Expired - Fee Related
- 2001-08-08 AR ARP010103784A patent/AR033554A1/es not_active Application Discontinuation
-
2003
- 2003-01-30 ZA ZA200300847A patent/ZA200300847B/en unknown
-
2005
- 2005-11-30 US US11/291,867 patent/US7186840B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60129445T2 (de) | 2008-04-24 |
| AU2001277560A1 (en) | 2002-02-18 |
| KR20030027016A (ko) | 2003-04-03 |
| CN1199950C (zh) | 2005-05-04 |
| US7186840B2 (en) | 2007-03-06 |
| BR0113175A (pt) | 2004-02-17 |
| CA2418832A1 (en) | 2002-02-14 |
| JP3930428B2 (ja) | 2007-06-13 |
| EP1313707A1 (en) | 2003-05-28 |
| US7049325B2 (en) | 2006-05-23 |
| JP2004505951A (ja) | 2004-02-26 |
| ATE367379T1 (de) | 2007-08-15 |
| ES2290161T3 (es) | 2008-02-16 |
| EP1313707B1 (en) | 2007-07-18 |
| WO2002012192A1 (en) | 2002-02-14 |
| MXPA03001178A (es) | 2003-06-30 |
| US20020082276A1 (en) | 2002-06-27 |
| DE60129445D1 (de) | 2007-08-30 |
| CN1466575A (zh) | 2004-01-07 |
| ZA200300847B (en) | 2004-04-30 |
| US20060084677A1 (en) | 2006-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |