CN1195063C - 蛋白酶抑制剂融合蛋白 - Google Patents

蛋白酶抑制剂融合蛋白 Download PDF

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Publication number
CN1195063C
CN1195063C CNB988117886A CN98811788A CN1195063C CN 1195063 C CN1195063 C CN 1195063C CN B988117886 A CNB988117886 A CN B988117886A CN 98811788 A CN98811788 A CN 98811788A CN 1195063 C CN1195063 C CN 1195063C
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CN
China
Prior art keywords
plant
protein
plants
seq
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988117886A
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English (en)
Chinese (zh)
Other versions
CN1280627A (zh
Inventor
H·J·阿特金森
M·J·麦克菲森
P·E·尤威
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Novartis AG
Syngenta Participations AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Syngenta Participations AG filed Critical Novartis AG
Publication of CN1280627A publication Critical patent/CN1280627A/zh
Application granted granted Critical
Publication of CN1195063C publication Critical patent/CN1195063C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CNB988117886A 1997-12-03 1998-12-01 蛋白酶抑制剂融合蛋白 Expired - Fee Related CN1195063C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9725556.6A GB9725556D0 (en) 1997-12-03 1997-12-03 Organic compounds
GB9725556.6 1997-12-03

Publications (2)

Publication Number Publication Date
CN1280627A CN1280627A (zh) 2001-01-17
CN1195063C true CN1195063C (zh) 2005-03-30

Family

ID=10823024

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988117886A Expired - Fee Related CN1195063C (zh) 1997-12-03 1998-12-01 蛋白酶抑制剂融合蛋白

Country Status (19)

Country Link
US (1) US6784337B1 (enExample)
EP (1) EP1036185B1 (enExample)
JP (1) JP2001525343A (enExample)
CN (1) CN1195063C (enExample)
AR (1) AR017190A1 (enExample)
AT (1) ATE264396T1 (enExample)
AU (1) AU1672499A (enExample)
BR (1) BR9814707A (enExample)
CA (1) CA2312050A1 (enExample)
DE (1) DE69823225T2 (enExample)
DK (1) DK1036185T3 (enExample)
ES (1) ES2215333T3 (enExample)
GB (1) GB9725556D0 (enExample)
HU (1) HUP0004509A3 (enExample)
PL (1) PL340924A1 (enExample)
RU (1) RU2230787C2 (enExample)
TR (1) TR200001572T2 (enExample)
UA (1) UA71901C2 (enExample)
WO (1) WO1999028484A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7622301B2 (en) * 2004-02-24 2009-11-24 Basf Plant Science Gmbh Compositions and methods using RNA interference for control of nematodes
EP1778848A2 (en) * 2004-08-13 2007-05-02 BASF Plant Science GmbH Compositions and methods using rna interference for control of nematodes
AU2007266307C1 (en) * 2006-05-25 2012-10-25 Hexima Limited Multi-gene expression vehicle
SG192063A1 (en) 2011-02-07 2013-08-30 Hexima Ltd Modified plant defensins useful as anti-pathogenic agents
US11692016B2 (en) 2012-03-09 2023-07-04 Vestaron Corporation High gene expression yeast strain
CA3181424A1 (en) 2012-03-09 2013-09-12 Vestaron Corporation Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides
SG11201500682WA (en) * 2012-09-07 2015-02-27 Sanofi Sa Fusion proteins for treating a metabolic syndrome
WO2015167809A1 (en) * 2014-04-28 2015-11-05 Syngenta Participations Ag Method for controlling nematode pests
JP2020500009A (ja) 2016-10-21 2020-01-09 ベスタロン コーポレイション 切断可能ペプチドならびにそれを含む殺虫性タンパク質及び殺線虫性タンパク質
WO2022155619A2 (en) * 2021-01-03 2022-07-21 Impetus Agriculture, Inc. Novel affinity constructs and methods for their use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US5436392A (en) 1990-01-12 1995-07-25 Arizona Technology Development Corporation Transgenic plants expressing M. sexta protease inhibitor
AU648140B2 (en) 1991-02-01 1994-04-14 Virtual Drug Development, Inc. Reverse antimicrobial peptides and antimicrobial compositions
US5461032A (en) 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
GB9104617D0 (en) * 1991-03-05 1991-04-17 Nickerson Int Seed Pest control
ATE291624T1 (de) * 1992-12-16 2005-04-15 Hexima Ltd Ein proteinase inhibitor, vorläufer davon und genetische sequenzen dafür kodierend
US5849870A (en) 1993-03-25 1998-12-15 Novartis Finance Corporation Pesticidal proteins and strains
US6680424B2 (en) * 1994-11-21 2004-01-20 University Of Leeds Modified proteinase inhibitors
US5837876A (en) * 1995-07-28 1998-11-17 North Carolina State University Root cortex specific gene promoter
GB9524395D0 (en) * 1995-11-29 1996-01-31 Nickerson Biocem Ltd Promoters

Also Published As

Publication number Publication date
HUP0004509A2 (hu) 2001-04-28
EP1036185B1 (en) 2004-04-14
GB9725556D0 (en) 1998-02-04
AR017190A1 (es) 2001-08-22
AU1672499A (en) 1999-06-16
JP2001525343A (ja) 2001-12-11
CN1280627A (zh) 2001-01-17
TR200001572T2 (tr) 2000-11-21
BR9814707A (pt) 2000-10-03
ATE264396T1 (de) 2004-04-15
DE69823225T2 (de) 2004-09-02
WO1999028484A1 (en) 1999-06-10
DK1036185T3 (da) 2004-08-02
ES2215333T3 (es) 2004-10-01
CA2312050A1 (en) 1999-06-10
EP1036185A1 (en) 2000-09-20
DE69823225D1 (de) 2004-05-19
US6784337B1 (en) 2004-08-31
RU2230787C2 (ru) 2004-06-20
PL340924A1 (en) 2001-03-12
HUP0004509A3 (en) 2002-11-28
HK1032073A1 (en) 2001-07-06
UA71901C2 (en) 2005-01-17

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SE01 Entry into force of request for substantive examination
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Owner name: SINGENTA PARTICIPATION AG

Free format text: FORMER OWNER: NOVANNIS COMPANY

Effective date: 20021017

C41 Transfer of patent application or patent right or utility model
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Address after: Basel

Applicant after: Xingenta Shara Co., Ltd.

Address before: Basel

Applicant before: Novartis AG

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee