CN1194702C - 治疗前列腺肥大的淫羊藿提取物及其在制备药物中的应用 - Google Patents
治疗前列腺肥大的淫羊藿提取物及其在制备药物中的应用 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Engineering & Computer Science (AREA)
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- Alternative & Traditional Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
种名 | 产地 | 含量(%) | |||
淫羊藿甙 | 淫羊藿甙I | 总黄酮 | 总多糖 | ||
淫羊藿 | 陕西 | 1.193 | 0.445 | 12.3 | 20.7 |
四川 | 1.088 | 0.794 | 11.6 | 19.0 | |
箭叶淫羊藿 | 湖南 | 0.961 | 0.190 | 7.2 | 15.9 |
湖北 | 0.735 | 0.110 | 6.4 | 13.4 |
贵州 | 3.098 | 0.084 | 18.3 | 26.1 | |
乌山淫羊藿 | 四川 | 3.343 | 0.094 | 20.1 | 25.6 |
贵州 | 2.882 | 0.030 | 8.9 | 20.1 | |
柔毛淫羊藿 | 四川 | 1.140 | 0.067 | 10.2 | 18.6 |
朝鲜淫羊藿 | 辽宁 | 0.890 | 0.104 | 16.9 | 22.5 |
种名 | 产地 | A部分得率 | B部分得率 |
淫羊藿 | 陕西 | 20g,4% | 37g,7.4% |
四川 | 10g,3% | 29g,5.8% | |
箭叶淫羊藿 | 湖南 | 12g,2.4% | 20g,4.0% |
湖北 | 8g,1.6% | 30g,6.0% | |
贵州 | 27g,5.8% | 39g.7.8% | |
乌山淫羊藿 | 四川 | 23g,4.6% | 42g,8.4% |
贵州 | 16g,3.2% | 32g,6.4% | |
柔毛淫羊藿 | 四川 | 9g,1.8% | 25g,5.0% |
朝鲜淫羊藿 | 辽宁 | 18g,3.6% | 28g,5.6% |
组别 | 例数 | 年龄(岁) | 病程(年) | 合并性功能障碍例数 |
良性前列腺肥大* | 32 | 64.90±7.8 | 11.5+8.7 | |
前列腺肥大伴慢性前列腺炎** | 24 | 42.42±12.1 | 3.5±3.3 | 24 |
分组 | 治前积分 | 治后积分 | P值 |
良性前列腺肥大 | 12.16±2.42 | 6.26±1.98 | P<0.01 |
良性前列腺肥大伴炎症 | 10.42±2.54 | 4.88±2.82 | P<0.01 |
分组 | 治前 | 治后积分 | P值 |
良性前列腺肥大 | 65.93±60.19 | 37.19±43.05 | P<0.05 |
良性前列腺肥大伴炎症 | 45.83±53.48 | 25.41±34.38 | P<0.05 |
分组 | 治前 | 治后积分 | P值 |
良性前列腺肥大 | 4.41±1.44 | 7.74±3.33 | P<0.01 |
良性前列腺肥大伴炎症 | 7.02±3.29 | 10.91±5.46 | P<0.01 |
分组 | 治前 | 治后积分 | P值 |
良性前列腺肥大 | 3.31±3.68 | 3.03±3.84 | P>0.05 |
良性前列腺肥大伴炎症 | 4.41±5.28 | 1.84±1.07 | P<0.01 |
分组 | 例数 | 控制 | 显效 | 有效 | 无效 | 总有效 | 总有效率 |
肥大组 | 32 | 2 | 12 | 16 | 2 | 30 | 93.8% |
肥大兼炎症组 | 24 | 1 | 6 | 11 | 6 | 18 | 75.0% |
Claims (6)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021485712A CN1194702C (zh) | 2002-12-18 | 2002-12-18 | 治疗前列腺肥大的淫羊藿提取物及其在制备药物中的应用 |
DE60333586T DE60333586D1 (de) | 2002-12-18 | 2003-11-24 | Medikament mit epimedium-extrakt zur behandlung vo |
EP03779644A EP1574218B1 (en) | 2002-12-18 | 2003-11-24 | A medicament containing epimedium extract for treatment of prostatic hyperplasia and prostatitis |
US10/539,497 US7205005B2 (en) | 2002-12-18 | 2003-11-24 | Medicament containing epidemium extract for treatment of prostatic hyperplasia and prostatitis |
JP2004559564A JP4448034B2 (ja) | 2002-12-18 | 2003-11-24 | 淫羊霍抽出物の薬物調製上における応用 |
AT03779644T ATE475455T1 (de) | 2002-12-18 | 2003-11-24 | Medikament mit epimedium-extrakt zur behandlung von prostatahyperplasie und prostatitis |
KR1020057011420A KR100713088B1 (ko) | 2002-12-18 | 2003-11-24 | 전립선 비대증 및 전립선염 치료용 음양곽 추출물을포함하는 약학적 조성물 |
PCT/CN2003/000994 WO2004054596A1 (fr) | 2002-12-18 | 2003-11-24 | Medicament contenant un extrait d'epimedium et destine au traitement de l'hyperplasie prostatique et de la prostatite |
AU2003289644A AU2003289644A1 (en) | 2002-12-18 | 2003-11-24 | A medicament containing epidemium extract for treatment of prostatic hyperplasia and prostatitis |
US11/476,458 US7250182B2 (en) | 2002-12-18 | 2006-06-28 | Medicament containing Epimedium extract for treatment of prostatic hyperplasia and prostatitis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021485712A CN1194702C (zh) | 2002-12-18 | 2002-12-18 | 治疗前列腺肥大的淫羊藿提取物及其在制备药物中的应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200410034456 Division CN1254260C (zh) | 2002-12-18 | 2002-12-18 | 含淫羊藿提取物的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1422622A CN1422622A (zh) | 2003-06-11 |
CN1194702C true CN1194702C (zh) | 2005-03-30 |
Family
ID=4751485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021485712A Expired - Lifetime CN1194702C (zh) | 2002-12-18 | 2002-12-18 | 治疗前列腺肥大的淫羊藿提取物及其在制备药物中的应用 |
Country Status (9)
Country | Link |
---|---|
US (2) | US7205005B2 (zh) |
EP (1) | EP1574218B1 (zh) |
JP (1) | JP4448034B2 (zh) |
KR (1) | KR100713088B1 (zh) |
CN (1) | CN1194702C (zh) |
AT (1) | ATE475455T1 (zh) |
AU (1) | AU2003289644A1 (zh) |
DE (1) | DE60333586D1 (zh) |
WO (1) | WO2004054596A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1295224C (zh) * | 2004-11-11 | 2007-01-17 | 中国药科大学 | 注射用淫羊藿总黄酮苷的制备方法 |
KR100803577B1 (ko) * | 2005-11-30 | 2008-02-15 | (주)아모레퍼시픽 | 이카린의 가수분해물을 함유하는 화장료용 조성물 |
EP1952816A1 (en) * | 2007-01-26 | 2008-08-06 | The Jordanian Pharmaceutical Manufacturing Co. | Multi-component herbal composition for the treatment of male erectile dysfunction |
KR101040477B1 (ko) | 2008-06-03 | 2011-06-09 | 고려대학교 산학협력단 | 항안드로겐 조성물 |
KR101144991B1 (ko) * | 2009-12-29 | 2012-06-27 | 대한민국 | 인삼 추출물을 포함하는 전립선비대증을 예방 또는 치료하기 위한 약학적 조성물 및 건강 기능성식품 조성물 |
CN103613675B (zh) * | 2010-11-05 | 2016-08-17 | 北京中安佐际生物科技有限公司 | 淫羊藿多糖及其组分和它们用于疫苗佐剂的用途 |
JP6034293B2 (ja) * | 2010-11-05 | 2016-11-30 | ベイジン チョンアン アジュバント バイオテクノロジー カンパニー,リミティド | イカリソウの多糖、その画分、及びワクチンアジュバントとしてのその使用 |
TWI533877B (zh) | 2012-06-27 | 2016-05-21 | 景鑫生物科技有限公司 | 台灣山蘇萃取物 |
CA2912438A1 (en) * | 2013-04-10 | 2014-10-16 | Glycobiosciences, Inc. | Topical nutraceutical composition |
CN103565993B (zh) * | 2013-11-11 | 2014-12-10 | 王纯治 | 一种治疗前列腺炎的中药方剂 |
KR20210054481A (ko) | 2019-11-05 | 2021-05-13 | 경희대학교 산학협력단 | 금은화 추출물을 포함하는 전립선비대증 예방 또는 치료용 조성물 |
CN111920858B (zh) * | 2020-09-02 | 2021-10-15 | 毛蕴衡 | 一种组合物及其在制备辅助治疗前列腺炎药物中的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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NL8102073A (nl) * | 1980-04-30 | 1981-11-16 | Zenyaku Kogyo Kk | Nieuw extract uit een plant van het geslacht epimedium sp., werkwijze voor het bereiden van het extract, de immuniteit stimulerend middel, dat het extract als effectieve component omvat en immunotherapie onder toepassing van het extract. |
CN1093600A (zh) * | 1993-04-10 | 1994-10-19 | 河南省三门峡市九九三神力保健品厂 | 前列腺保健品及其制造方法 |
US5587167A (en) * | 1993-09-14 | 1996-12-24 | Choi; Hyung K. | Pharmaceutical composition for prophylaxis and treatment of premature ejaculation |
CN1113802A (zh) * | 1994-05-27 | 1995-12-27 | 四川省遂宁市医药研究所 | 前列宁冲剂 |
CA2137219C (en) * | 1994-12-02 | 1997-10-21 | Salva Gideon | Extract for improving male sperm count and use as anti-microbial or anti-inflammatory agent |
CN1219408A (zh) * | 1997-12-07 | 1999-06-16 | 孙树春 | 安神通神胶囊 |
CN1058902C (zh) * | 1998-02-25 | 2000-11-29 | 荆延有 | 壮肾助阳液 |
US6123944A (en) * | 1998-03-19 | 2000-09-26 | Phytoceutica, Inc. | Icariin preparations |
CN1245194C (zh) * | 2000-04-28 | 2006-03-15 | 韩富生 | 治疗老年性前列腺肥大的口服液 |
US6750248B2 (en) * | 2001-11-09 | 2004-06-15 | National University Of Singapore | Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof |
US6476203B1 (en) * | 2002-03-14 | 2002-11-05 | Xinxian Zhao | Safe pharmaceutical composition for treating and preventing infertility and increasing immune function |
-
2002
- 2002-12-18 CN CNB021485712A patent/CN1194702C/zh not_active Expired - Lifetime
-
2003
- 2003-11-24 AT AT03779644T patent/ATE475455T1/de not_active IP Right Cessation
- 2003-11-24 AU AU2003289644A patent/AU2003289644A1/en not_active Abandoned
- 2003-11-24 WO PCT/CN2003/000994 patent/WO2004054596A1/zh active Application Filing
- 2003-11-24 US US10/539,497 patent/US7205005B2/en not_active Expired - Lifetime
- 2003-11-24 JP JP2004559564A patent/JP4448034B2/ja not_active Expired - Lifetime
- 2003-11-24 KR KR1020057011420A patent/KR100713088B1/ko active IP Right Grant
- 2003-11-24 DE DE60333586T patent/DE60333586D1/de not_active Expired - Lifetime
- 2003-11-24 EP EP03779644A patent/EP1574218B1/en not_active Expired - Lifetime
-
2006
- 2006-06-28 US US11/476,458 patent/US7250182B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60333586D1 (de) | 2010-09-09 |
EP1574218A1 (en) | 2005-09-14 |
EP1574218B1 (en) | 2010-07-28 |
KR100713088B1 (ko) | 2007-05-02 |
US7250182B2 (en) | 2007-07-31 |
JP2006510678A (ja) | 2006-03-30 |
WO2004054596A1 (fr) | 2004-07-01 |
CN1422622A (zh) | 2003-06-11 |
US20060105067A1 (en) | 2006-05-18 |
ATE475455T1 (de) | 2010-08-15 |
US20060246164A1 (en) | 2006-11-02 |
JP4448034B2 (ja) | 2010-04-07 |
AU2003289644A1 (en) | 2004-07-09 |
EP1574218A4 (en) | 2007-06-06 |
US7205005B2 (en) | 2007-04-17 |
KR20050084420A (ko) | 2005-08-26 |
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