CN1193748C - Gardos通道拮抗剂 - Google Patents

Gardos通道拮抗剂 Download PDF

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Publication number
CN1193748C
CN1193748C CNB008054525A CN00805452A CN1193748C CN 1193748 C CN1193748 C CN 1193748C CN B008054525 A CNB008054525 A CN B008054525A CN 00805452 A CN00805452 A CN 00805452A CN 1193748 C CN1193748 C CN 1193748C
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CN
China
Prior art keywords
substituent
compound
ring
compounds
acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008054525A
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English (en)
Chinese (zh)
Other versions
CN1344158A (zh
Inventor
G·A·麦克诺顿－史密斯
G·C·里格登
J·W·施特克尔
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Icagen Inc
Original Assignee
Icagen Inc
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Publication date
Application filed by Icagen Inc filed Critical Icagen Inc
Publication of CN1344158A publication Critical patent/CN1344158A/zh
Application granted granted Critical
Publication of CN1193748C publication Critical patent/CN1193748C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB008054525A 1999-02-23 2000-02-10 Gardos通道拮抗剂 Expired - Fee Related CN1193748C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13551199P 1999-02-23 1999-02-23
US60/135,511 1999-02-23
US09/386,601 US6288122B1 (en) 1999-02-23 1999-08-31 Gardos channel antagonists
US09/386,601 1999-08-31

Publications (2)

Publication Number Publication Date
CN1344158A CN1344158A (zh) 2002-04-10
CN1193748C true CN1193748C (zh) 2005-03-23

Family

ID=26833406

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008054525A Expired - Fee Related CN1193748C (zh) 1999-02-23 2000-02-10 Gardos通道拮抗剂

Country Status (16)

Country Link
US (1) US6288122B1 (https=)
EP (1) EP1158971B1 (https=)
JP (2) JP4038337B2 (https=)
KR (1) KR100705726B1 (https=)
CN (1) CN1193748C (https=)
AP (1) AP1465A (https=)
AT (1) ATE370728T1 (https=)
AU (1) AU762039B2 (https=)
BR (1) BR0008416A (https=)
CA (1) CA2371857C (https=)
DE (1) DE60036093T2 (https=)
ES (1) ES2291191T3 (https=)
HK (1) HK1045262B (https=)
IL (2) IL145012A0 (https=)
OA (1) OA11838A (https=)
WO (1) WO2000050026A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004010A1 (en) * 2001-07-06 2003-01-16 Poseidon Pharmaceuticals A/S Carbonylamino derivatives useful for obtaining immune regulation
JP4394451B2 (ja) * 2002-01-04 2010-01-06 ニューロサーチ、アクティーゼルスカブ カリウムチャネルモジュレーター
US20040029771A1 (en) * 2002-02-28 2004-02-12 Icagen, Inc. Methods for treating diseases related to intraocular pressure
WO2005003143A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Novel potassium channel modulators
WO2005003094A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Diarylmethyl derivatives as potassium channel modulators
US7709533B2 (en) * 2005-02-01 2010-05-04 Icagen, Inc. Imines as ion channel modulators
KR20080086511A (ko) * 2005-12-20 2008-09-25 이카겐, 인코포레이티드 트리아릴 메탄 화합물을 이용한 치료 방법
US20100056637A1 (en) * 2005-12-20 2010-03-04 Icagen, Inc. Treatment methods using triaryl methane compounds
ES2358564T3 (es) 2007-08-24 2011-05-11 Neurosearch A/S Derivados de carbonilamino útiles para el tratamiento de una enfermedad inflamatoria intestinal.
US20090076157A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched senicapoc
CA2720824C (en) 2008-04-09 2021-09-14 Cerus Corporation Improved quenching methods for red blood cell pathogen inactivation
CN102272152B (zh) 2008-11-10 2014-05-28 贝林格尔.英格海姆国际有限公司 通过中电导钙激活钾通道调控细胞-细胞融合的组合物及方法
WO2016134353A1 (en) * 2015-02-20 2016-08-25 Children's Medical Center Corporation Methods for treating malaria using potassium channel inhibitors
EP3106155A1 (en) * 2015-06-15 2016-12-21 Universite d'Aix Marseille Treatment and diagnosis of hereditary xerocytosis
WO2018081018A1 (en) * 2016-10-25 2018-05-03 Paracelsus Neuroscience Llc Use of senicapoc for treatment of neuropathic pain
WO2018162426A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment and diagnosis of hereditary xerocytosis
CN112020353A (zh) * 2019-03-29 2020-12-01 深圳仁泰医药科技有限公司 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用
US12186286B2 (en) * 2019-07-29 2025-01-07 Paracelsus Neuroscience Llc Use of senicapoc for treatment of stroke
WO2022015893A2 (en) * 2020-07-14 2022-01-20 Adimabio Llc Compositions comprising gardos channel antagonists and their uses
EP4259130B1 (en) * 2020-12-11 2026-03-04 Sanquin IP B.V. Gardos channel inhibitor or other agents for use in the treatment and prevention of anaemia of inflammation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273992A (en) 1992-11-02 1993-12-28 Beth Israel Hospital Assoc. Inc. Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ
AU732881C (en) 1994-09-16 2002-11-07 Children's Medical Center Corporation Triaryl and diaryl compounds, their analogues and uses thereof

Also Published As

Publication number Publication date
AU2880700A (en) 2000-09-14
JP2007262075A (ja) 2007-10-11
ATE370728T1 (de) 2007-09-15
HK1045262A1 (en) 2002-11-22
JP2002537331A (ja) 2002-11-05
WO2000050026A1 (en) 2000-08-31
CA2371857A1 (en) 2000-08-31
CN1344158A (zh) 2002-04-10
JP4038337B2 (ja) 2008-01-23
KR100705726B1 (ko) 2007-04-11
EP1158971A1 (en) 2001-12-05
EP1158971A4 (en) 2003-04-16
OA11838A (en) 2005-08-22
ES2291191T3 (es) 2008-03-01
DE60036093D1 (de) 2007-10-04
US6288122B1 (en) 2001-09-11
HK1045262B (zh) 2005-07-29
IL145012A (en) 2006-12-10
CA2371857C (en) 2008-07-29
AP1465A (en) 2005-09-22
IL145012A0 (en) 2002-06-30
AU762039B2 (en) 2003-06-19
AP2001002268A0 (en) 2001-09-30
BR0008416A (pt) 2002-01-29
DE60036093T2 (de) 2008-05-15
KR20020002393A (ko) 2002-01-09
EP1158971B1 (en) 2007-08-22

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Granted publication date: 20050323

Termination date: 20140210