KR100705726B1 - 가르도스 통로 길항제 - Google Patents

가르도스 통로 길항제 Download PDF

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Publication number
KR100705726B1
KR100705726B1 KR1020017010707A KR20017010707A KR100705726B1 KR 100705726 B1 KR100705726 B1 KR 100705726B1 KR 1020017010707 A KR1020017010707 A KR 1020017010707A KR 20017010707 A KR20017010707 A KR 20017010707A KR 100705726 B1 KR100705726 B1 KR 100705726B1
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KR
South Korea
Prior art keywords
compound
compounds
substituent
ring
acetamide
Prior art date
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Expired - Fee Related
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KR1020017010707A
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English (en)
Korean (ko)
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KR20020002393A (ko
Inventor
맥넛톤-스미스그랜트앤드류
릭돈그레고리쿡세이
스톡커조나단월터
Original Assignee
이카겐, 인코포레이티드
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Application filed by 이카겐, 인코포레이티드 filed Critical 이카겐, 인코포레이티드
Publication of KR20020002393A publication Critical patent/KR20020002393A/ko
Application granted granted Critical
Publication of KR100705726B1 publication Critical patent/KR100705726B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020017010707A 1999-02-23 2000-02-10 가르도스 통로 길항제 Expired - Fee Related KR100705726B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13551199P 1999-02-23 1999-02-23
US60/135,511 1999-02-23
US09/386,601 US6288122B1 (en) 1999-02-23 1999-08-31 Gardos channel antagonists
US09/386,601 1999-08-31

Publications (2)

Publication Number Publication Date
KR20020002393A KR20020002393A (ko) 2002-01-09
KR100705726B1 true KR100705726B1 (ko) 2007-04-11

Family

ID=26833406

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017010707A Expired - Fee Related KR100705726B1 (ko) 1999-02-23 2000-02-10 가르도스 통로 길항제

Country Status (16)

Country Link
US (1) US6288122B1 (https=)
EP (1) EP1158971B1 (https=)
JP (2) JP4038337B2 (https=)
KR (1) KR100705726B1 (https=)
CN (1) CN1193748C (https=)
AP (1) AP1465A (https=)
AT (1) ATE370728T1 (https=)
AU (1) AU762039B2 (https=)
BR (1) BR0008416A (https=)
CA (1) CA2371857C (https=)
DE (1) DE60036093T2 (https=)
ES (1) ES2291191T3 (https=)
HK (1) HK1045262B (https=)
IL (2) IL145012A0 (https=)
OA (1) OA11838A (https=)
WO (1) WO2000050026A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004010A1 (en) * 2001-07-06 2003-01-16 Poseidon Pharmaceuticals A/S Carbonylamino derivatives useful for obtaining immune regulation
JP4394451B2 (ja) * 2002-01-04 2010-01-06 ニューロサーチ、アクティーゼルスカブ カリウムチャネルモジュレーター
US20040029771A1 (en) * 2002-02-28 2004-02-12 Icagen, Inc. Methods for treating diseases related to intraocular pressure
WO2005003143A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Novel potassium channel modulators
WO2005003094A1 (en) * 2003-07-03 2005-01-13 Poseidon Pharmaceuticals A/S Diarylmethyl derivatives as potassium channel modulators
US7709533B2 (en) * 2005-02-01 2010-05-04 Icagen, Inc. Imines as ion channel modulators
KR20080086511A (ko) * 2005-12-20 2008-09-25 이카겐, 인코포레이티드 트리아릴 메탄 화합물을 이용한 치료 방법
US20100056637A1 (en) * 2005-12-20 2010-03-04 Icagen, Inc. Treatment methods using triaryl methane compounds
ES2358564T3 (es) 2007-08-24 2011-05-11 Neurosearch A/S Derivados de carbonilamino útiles para el tratamiento de una enfermedad inflamatoria intestinal.
US20090076157A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched senicapoc
CA2720824C (en) 2008-04-09 2021-09-14 Cerus Corporation Improved quenching methods for red blood cell pathogen inactivation
CN102272152B (zh) 2008-11-10 2014-05-28 贝林格尔.英格海姆国际有限公司 通过中电导钙激活钾通道调控细胞-细胞融合的组合物及方法
WO2016134353A1 (en) * 2015-02-20 2016-08-25 Children's Medical Center Corporation Methods for treating malaria using potassium channel inhibitors
EP3106155A1 (en) * 2015-06-15 2016-12-21 Universite d'Aix Marseille Treatment and diagnosis of hereditary xerocytosis
WO2018081018A1 (en) * 2016-10-25 2018-05-03 Paracelsus Neuroscience Llc Use of senicapoc for treatment of neuropathic pain
WO2018162426A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment and diagnosis of hereditary xerocytosis
CN112020353A (zh) * 2019-03-29 2020-12-01 深圳仁泰医药科技有限公司 2,2-双(4-氟苯基)-2-苯乙酰胺的晶型a及其制备方法和应用
US12186286B2 (en) * 2019-07-29 2025-01-07 Paracelsus Neuroscience Llc Use of senicapoc for treatment of stroke
WO2022015893A2 (en) * 2020-07-14 2022-01-20 Adimabio Llc Compositions comprising gardos channel antagonists and their uses
EP4259130B1 (en) * 2020-12-11 2026-03-04 Sanquin IP B.V. Gardos channel inhibitor or other agents for use in the treatment and prevention of anaemia of inflammation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034589A1 (en) * 1996-03-20 1997-09-25 President And Fellows Of Harvard College Triaryl methane compounds for sickle cell disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273992A (en) 1992-11-02 1993-12-28 Beth Israel Hospital Assoc. Inc. Method for reducing sickle erythrocyte dehydration and delaying the occurrence of erythrocyte sickling in-situ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034589A1 (en) * 1996-03-20 1997-09-25 President And Fellows Of Harvard College Triaryl methane compounds for sickle cell disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1020017010707 - 544238

Also Published As

Publication number Publication date
AU2880700A (en) 2000-09-14
JP2007262075A (ja) 2007-10-11
ATE370728T1 (de) 2007-09-15
CN1193748C (zh) 2005-03-23
HK1045262A1 (en) 2002-11-22
JP2002537331A (ja) 2002-11-05
WO2000050026A1 (en) 2000-08-31
CA2371857A1 (en) 2000-08-31
CN1344158A (zh) 2002-04-10
JP4038337B2 (ja) 2008-01-23
EP1158971A1 (en) 2001-12-05
EP1158971A4 (en) 2003-04-16
OA11838A (en) 2005-08-22
ES2291191T3 (es) 2008-03-01
DE60036093D1 (de) 2007-10-04
US6288122B1 (en) 2001-09-11
HK1045262B (zh) 2005-07-29
IL145012A (en) 2006-12-10
CA2371857C (en) 2008-07-29
AP1465A (en) 2005-09-22
IL145012A0 (en) 2002-06-30
AU762039B2 (en) 2003-06-19
AP2001002268A0 (en) 2001-09-30
BR0008416A (pt) 2002-01-29
DE60036093T2 (de) 2008-05-15
KR20020002393A (ko) 2002-01-09
EP1158971B1 (en) 2007-08-22

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