CN118891269A - 核酸寡聚物的制造方法 - Google Patents
核酸寡聚物的制造方法 Download PDFInfo
- Publication number
- CN118891269A CN118891269A CN202380028404.9A CN202380028404A CN118891269A CN 118891269 A CN118891269 A CN 118891269A CN 202380028404 A CN202380028404 A CN 202380028404A CN 118891269 A CN118891269 A CN 118891269A
- Authority
- CN
- China
- Prior art keywords
- group
- formula
- mol
- production method
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022-047341 | 2022-03-23 | ||
| JP2022047341 | 2022-03-23 | ||
| PCT/JP2023/010891 WO2023182274A1 (ja) | 2022-03-23 | 2023-03-20 | 核酸オリゴマーの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118891269A true CN118891269A (zh) | 2024-11-01 |
Family
ID=88100953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202380028404.9A Pending CN118891269A (zh) | 2022-03-23 | 2023-03-20 | 核酸寡聚物的制造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12509485B2 (https=) |
| EP (1) | EP4488282A4 (https=) |
| JP (1) | JPWO2023182274A1 (https=) |
| KR (1) | KR20240162536A (https=) |
| CN (1) | CN118891269A (https=) |
| WO (1) | WO2023182274A1 (https=) |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077709A (en) | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| DK1149109T3 (da) | 1999-02-05 | 2010-01-11 | Ge Healthcare Bio Sciences | Fremgangsmåde til afbeskyttelse af oligonukleotider |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| ES2386709T3 (es) | 2004-08-26 | 2012-08-27 | Nippon Shinyaku Co., Ltd. | Compuesto de fosforamidita y método para producir un oligo-ARN |
| US8158775B2 (en) * | 2006-02-27 | 2012-04-17 | Nippon Shinyaku Co., Ltd. | Method for detaching protecting group on nucleic acid |
| WO2008049085A1 (en) | 2006-10-18 | 2008-04-24 | Isis Pharmaceuticals, Inc. | Antisense compounds |
| HUE037500T2 (hu) | 2010-07-08 | 2018-08-28 | Bonac Corp | Egyszálú nukleinsav molekula a génexpresszió szabályozására |
| ES2527660T3 (es) | 2010-08-03 | 2015-01-28 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| WO2013027843A1 (ja) | 2011-08-25 | 2013-02-28 | 株式会社ボナック | 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法 |
| US9528111B2 (en) | 2012-01-07 | 2016-12-27 | Bonac Corporation | Single-stranded nucleic acid molecule having amino acid backbone |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| JP6787398B2 (ja) | 2016-04-26 | 2020-11-18 | 住友化学株式会社 | 一本鎖核酸分子用モノマーの製造方法 |
| EP3604528A4 (en) | 2017-03-31 | 2021-01-13 | Bonac Corporation | CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION |
| KR20250046363A (ko) | 2017-09-19 | 2025-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법 |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| US20230192755A1 (en) * | 2020-04-14 | 2023-06-22 | Sumitomo Chemical Company, Limited | Composition containing nucleic acid oligomer |
| US20230242570A1 (en) * | 2020-07-09 | 2023-08-03 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| JP7570858B2 (ja) | 2020-09-11 | 2024-10-22 | 日鉄ステンレス株式会社 | マルテンサイト系ステンレス鋼板およびマルテンサイト系ステンレス鋼板の製造方法 |
| JP7719788B2 (ja) * | 2020-09-24 | 2025-08-06 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
-
2023
- 2023-03-20 KR KR1020247034021A patent/KR20240162536A/ko active Pending
- 2023-03-20 CN CN202380028404.9A patent/CN118891269A/zh active Pending
- 2023-03-20 EP EP23774869.4A patent/EP4488282A4/en active Pending
- 2023-03-20 WO PCT/JP2023/010891 patent/WO2023182274A1/ja not_active Ceased
- 2023-03-20 US US18/848,797 patent/US12509485B2/en active Active
- 2023-03-20 JP JP2024510168A patent/JPWO2023182274A1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023182274A1 (ja) | 2023-09-28 |
| US20250145655A1 (en) | 2025-05-08 |
| KR20240162536A (ko) | 2024-11-15 |
| EP4488282A4 (en) | 2025-11-19 |
| US12509485B2 (en) | 2025-12-30 |
| JPWO2023182274A1 (https=) | 2023-09-28 |
| EP4488282A1 (en) | 2025-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |