CN118891269A - 核酸寡聚物的制造方法 - Google Patents

核酸寡聚物的制造方法 Download PDF

Info

Publication number
CN118891269A
CN118891269A CN202380028404.9A CN202380028404A CN118891269A CN 118891269 A CN118891269 A CN 118891269A CN 202380028404 A CN202380028404 A CN 202380028404A CN 118891269 A CN118891269 A CN 118891269A
Authority
CN
China
Prior art keywords
group
formula
mol
production method
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380028404.9A
Other languages
English (en)
Chinese (zh)
Inventor
宫川卓也
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of CN118891269A publication Critical patent/CN118891269A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202380028404.9A 2022-03-23 2023-03-20 核酸寡聚物的制造方法 Pending CN118891269A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022047341 2022-03-23
JP2022-047341 2022-03-23
PCT/JP2023/010891 WO2023182274A1 (ja) 2022-03-23 2023-03-20 核酸オリゴマーの製造方法

Publications (1)

Publication Number Publication Date
CN118891269A true CN118891269A (zh) 2024-11-01

Family

ID=88100953

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380028404.9A Pending CN118891269A (zh) 2022-03-23 2023-03-20 核酸寡聚物的制造方法

Country Status (6)

Country Link
US (1) US12509485B2 (https=)
EP (1) EP4488282A4 (https=)
JP (1) JPWO2023182274A1 (https=)
KR (1) KR20240162536A (https=)
CN (1) CN118891269A (https=)
WO (1) WO2023182274A1 (https=)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
US8158775B2 (en) * 2006-02-27 2012-04-17 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
EP2639307B1 (en) 2010-08-03 2015-03-04 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
MX370398B (es) * 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
CN104039961A (zh) 2012-01-07 2014-09-10 株式会社博纳克 具有氨基酸骨架的单链核酸分子
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
EP3450439B8 (en) 2016-04-26 2021-06-30 Sumitomo Chemical Company, Limited Method for producing monomer for single-stranded nucleic acid molecule
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
CN115397831B (zh) * 2020-04-14 2026-02-24 住友化学株式会社 包含核酸寡聚物的组合物
CN115867559A (zh) * 2020-07-09 2023-03-28 住友化学株式会社 核酸寡聚物的制造方法
JP7570858B2 (ja) 2020-09-11 2024-10-22 日鉄ステンレス株式会社 マルテンサイト系ステンレス鋼板およびマルテンサイト系ステンレス鋼板の製造方法
KR20230074205A (ko) * 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법

Also Published As

Publication number Publication date
US20250145655A1 (en) 2025-05-08
WO2023182274A1 (ja) 2023-09-28
JPWO2023182274A1 (https=) 2023-09-28
EP4488282A1 (en) 2025-01-08
US12509485B2 (en) 2025-12-30
EP4488282A4 (en) 2025-11-19
KR20240162536A (ko) 2024-11-15

Similar Documents

Publication Publication Date Title
DK2857412T3 (en) Method for Oligonucleotide Synthesis Using High-Resolution Liquid Phase Carrier
JP7640461B2 (ja) 核酸オリゴマーの製造方法
JP6730932B2 (ja) リン保護基ならびにそれらの調製方法および使用
WO1998039352A1 (en) Novel bicyclonucleoside and oligonucleotide analogues
BR122020014853B1 (pt) Éter, e, método de produção de um éter
EP1995253B1 (en) Method for detaching protecting group on nucleic acid
EA003091B1 (ru) Синтез олигонуклеотидов в жидкой фазе
JP7719788B2 (ja) 核酸オリゴマーの製造方法
AU2013234303A1 (en) Tricyclic nucleosides and oligomeric compounds prepared therefrom
CZ20022930A3 (cs) Způsob výroby fosfonothioátových triesterů
WO2021153047A1 (ja) 核酸オリゴマーの製造方法
CN118891269A (zh) 核酸寡聚物的制造方法
WO2022009959A1 (ja) 核酸オリゴマーの製造方法
EP4563559A1 (en) Thionizing solution
CA2659703C (en) Method for introducing a nucleic-acid-protecting group
CN117980285A (zh) 纯化二氯乙酸的制造方法
WO2024019137A1 (ja) オリゴヌクレオチドの製造方法
JP7825064B2 (ja) オリゴヌクレオチドの製造方法
WO2021080021A1 (ja) オリゴヌクレオチドを製造する方法
JP7776154B2 (ja) ホスホロチオエート及びボラノホスフェートを含むキメラ型核酸オリゴマー、及びその製造方法
CN120418262A (zh) 寡核苷酸的制造方法
CN121464145A (zh) 寡核苷酸合成用的高脂溶性核苷酸砌块及使用其的寡核苷酸的合成
CN115315430A (zh) 使用了链段型亚磷酰胺化合物的核酸合成法
AU2005315631A1 (en) Synthesis of phosphitylated compounds using a quaternary heterocyclic activator

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination