CN118027246A - 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体 - Google Patents

透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体 Download PDF

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Publication number
CN118027246A
CN118027246A CN202410233747.5A CN202410233747A CN118027246A CN 118027246 A CN118027246 A CN 118027246A CN 202410233747 A CN202410233747 A CN 202410233747A CN 118027246 A CN118027246 A CN 118027246A
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China
Prior art keywords
hyaluronic acid
acid derivative
group
less
molecular weight
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CN202410233747.5A
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English (en)
Chinese (zh)
Inventor
薮内昂平
宫本佳季
福本圭介
胜又彻
中川庆之
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Asahi Kasei Corp
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Asahi Kasei Corp
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Publication of CN118027246A publication Critical patent/CN118027246A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202410233747.5A 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体 Pending CN118027246A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2020019963 2020-02-07
JP2020-019963 2020-02-07
JP2020111674 2020-06-29
JP2020-111674 2020-06-29
PCT/JP2021/004158 WO2021157665A1 (ja) 2020-02-07 2021-02-04 ヒアルロン酸誘導体、医薬組成物及びヒアルロン酸誘導体－薬物結合体
CN202180009356.XA CN114945600A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体

Related Parent Applications (1)

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CN202180009356.XA Division CN114945600A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体

Publications (1)

Publication Number Publication Date
CN118027246A true CN118027246A (zh) 2024-05-14

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Family Applications (3)

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CN202410233747.5A Pending CN118027246A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体
CN202410237023.8A Pending CN118108876A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体
CN202180009356.XA Pending CN114945600A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体

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CN202410237023.8A Pending CN118108876A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体
CN202180009356.XA Pending CN114945600A (zh) 2020-02-07 2021-02-04 透明质酸衍生物、药物组合物和透明质酸衍生物-药物结合体

Country Status (6)

Country Link
US (1) US20230066990A1 (https=)
EP (1) EP4101860A4 (https=)
JP (2) JPWO2021157665A1 (https=)
CN (3) CN118027246A (https=)
TW (2) TW202525342A (https=)
WO (1) WO2021157665A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026077409A1 (zh) * 2024-10-12 2026-04-16 华熙生物科技股份有限公司 植醇-透明质酸接枝物及其用途

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TWI834948B (zh) * 2020-02-05 2024-03-11 日商旭化成股份有限公司 玻尿酸衍生物組合物、醫藥組合物及玻尿酸衍生物－藥物結合體組合物
CN116410346A (zh) * 2021-12-31 2023-07-11 华熙生物科技股份有限公司 一种还原性透明质酸酯及其制备方法
CN115403681A (zh) * 2022-05-13 2022-11-29 宁波格鲁康生物科技有限公司 生物安全注射用改性透明质酸、制备方法及其在美容整形注射材料上的应用
KR20240164786A (ko) * 2022-05-31 2024-11-20 아사히 가세이 가부시키가이샤 히알루론산 유도체, 의약 조성물 및 의약 조성물의 제조 방법
CA3262434A1 (en) * 2022-07-20 2025-06-12 Asahi Kasei Kabushiki Kaisha Hyaluronic acid derivative drug composition and drug composition
JP2024041256A (ja) * 2022-09-14 2024-03-27 旭化成株式会社 化粧料
CN117607297A (zh) * 2023-11-24 2024-02-27 天津键凯科技有限公司 一种基于sec-mals法检测peg修饰的透明质酸的方法

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JP3051215B2 (ja) * 1991-08-27 2000-06-12 株式会社資生堂 ヒアルロン酸ゲル及びその製造方法
JP2005139409A (ja) * 2003-11-10 2005-06-02 Medicaraise Corp デルマタン硫酸の製法
CN101020724A (zh) * 2006-02-14 2007-08-22 镇江东方生物工程设备技术有限责任公司 一种低分子量透明质酸钠的制备方法
JP5043364B2 (ja) 2006-05-01 2012-10-10 生化学工業株式会社 多糖誘導体の製造方法
US8759322B2 (en) * 2008-11-05 2014-06-24 National University Corporation Tokyo Medical And Dental University Hyaluronic acid derivative and pharmaceutical composition thereof
WO2014038641A1 (ja) * 2012-09-05 2014-03-13 中外製薬株式会社 アミノ酸およびステリル基が導入されたヒアルロン酸誘導体
CZ2012842A3 (cs) * 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CN103435718B (zh) * 2013-08-21 2016-12-28 中国药科大学 Peg修饰的透明质酸胆固醇酯
US11104813B2 (en) 2015-06-02 2021-08-31 Asahi Kasei Kabushiki Kaisha Dispersion
EP3456745B1 (en) * 2016-05-11 2021-08-25 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid derivatives into which cationic groups and hydrophobic groups are introduced
US11512147B2 (en) * 2017-11-15 2022-11-29 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid derivative modified with polyethylene glycol
JP2020111674A (ja) 2019-01-11 2020-07-27 住友ゴム工業株式会社 タイヤ
WO2020158771A1 (ja) * 2019-01-29 2020-08-06 国立大学法人三重大学 がんワクチン製剤
TWI834948B (zh) * 2020-02-05 2024-03-11 日商旭化成股份有限公司 玻尿酸衍生物組合物、醫藥組合物及玻尿酸衍生物－藥物結合體組合物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026077409A1 (zh) * 2024-10-12 2026-04-16 华熙生物科技股份有限公司 植醇-透明质酸接枝物及其用途

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TW202140073A (zh) 2021-11-01
CN118108876A (zh) 2024-05-31
WO2021157665A1 (ja) 2021-08-12
EP4101860A1 (en) 2022-12-14
JP2024054248A (ja) 2024-04-16
JPWO2021157665A1 (https=) 2021-08-12
EP4101860A4 (en) 2023-07-19
CN114945600A (zh) 2022-08-26
US20230066990A1 (en) 2023-03-02
TW202525342A (zh) 2025-07-01
TWI888483B (zh) 2025-07-01

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