CN117567624A - 仅有重链的抗bcma抗体 - Google Patents

仅有重链的抗bcma抗体 Download PDF

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Publication number
CN117567624A
CN117567624A CN202311558572.7A CN202311558572A CN117567624A CN 117567624 A CN117567624 A CN 117567624A CN 202311558572 A CN202311558572 A CN 202311558572A CN 117567624 A CN117567624 A CN 117567624A
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CN
China
Prior art keywords
antibody
heavy chain
bcma
antibodies
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202311558572.7A
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English (en)
Chinese (zh)
Inventor
N·特林克林
S·F·奥尔德雷
S·克拉克
W·范斯科顿
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Turner O'neill Co ltd
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Turner O'neill Co ltd
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Publication date
Application filed by Turner O'neill Co ltd filed Critical Turner O'neill Co ltd
Publication of CN117567624A publication Critical patent/CN117567624A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202311558572.7A 2017-06-20 2018-06-20 仅有重链的抗bcma抗体 Pending CN117567624A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762522295P 2017-06-20 2017-06-20
US62/522,295 2017-06-20
CN201880038588.6A CN110945026B (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体
PCT/US2018/038506 WO2018237006A1 (en) 2017-06-20 2018-06-20 Anti-bcma heavy chain-only antibodies

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880038588.6A Division CN110945026B (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体

Publications (1)

Publication Number Publication Date
CN117567624A true CN117567624A (zh) 2024-02-20

Family

ID=62875335

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202311558572.7A Pending CN117567624A (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体
CN201880038588.6A Active CN110945026B (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体
CN202410219072.9A Pending CN118146370A (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201880038588.6A Active CN110945026B (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体
CN202410219072.9A Pending CN118146370A (zh) 2017-06-20 2018-06-20 仅有重链的抗bcma抗体

Country Status (9)

Country Link
US (2) US11427642B2 (https=)
EP (1) EP3642236A1 (https=)
JP (3) JP7240335B2 (https=)
CN (3) CN117567624A (https=)
AU (2) AU2018288803B2 (https=)
BR (1) BR112019026803A2 (https=)
CA (1) CA3065951A1 (https=)
MX (2) MX2019015563A (https=)
WO (1) WO2018237006A1 (https=)

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JP7776987B2 (ja) 2019-04-05 2025-11-27 テネオバイオ， インコーポレイテッド Ｐｓｍａに結合する重鎖抗体
PE20220568A1 (es) 2019-05-21 2022-04-20 Novartis Ag Moleculas de union a cd19 y usos de las mismas
CN114206927B (zh) 2019-06-14 2025-03-21 特尼奥生物股份有限公司 与cd22和cd3结合的多特异性重链抗体
CN112574308A (zh) * 2019-09-30 2021-03-30 和铂医药(苏州)有限公司 靶向bcma的抗体、双特异性抗体及其用途
EP4077398A4 (en) * 2019-12-16 2024-04-10 Legend Biotech Ireland Limited SINGLE DOMAIN ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS TARGETTING BCMA AND METHODS OF USE THEREOF
TWI838621B (zh) 2020-04-29 2024-04-11 美商泰尼歐萬公司 具有經修飾重鏈恆定區之多特異性重鏈抗體
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KR20240099161A (ko) * 2021-10-20 2024-06-28 다케다 야쿠힌 고교 가부시키가이샤 Bcma를 표적화하는 조성물 및 이의 사용 방법

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CN110945026A (zh) 2020-03-31
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CN118146370A (zh) 2024-06-07
BR112019026803A2 (pt) 2020-06-30
AU2018288803B2 (en) 2025-02-27
EP3642236A1 (en) 2020-04-29
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