CN117177987A - 对突变型ras(g12d)显示选择结合性的结合分子 - Google Patents

对突变型ras(g12d)显示选择结合性的结合分子 Download PDF

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Publication number
CN117177987A
CN117177987A CN202280027920.5A CN202280027920A CN117177987A CN 117177987 A CN117177987 A CN 117177987A CN 202280027920 A CN202280027920 A CN 202280027920A CN 117177987 A CN117177987 A CN 117177987A
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China
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methyl
group
butan
carbonyl
methylpropyl
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Pending
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CN202280027920.5A
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English (en)
Chinese (zh)
Inventor
林龙儿
桥本哲
南沙纪
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Publication of CN117177987A publication Critical patent/CN117177987A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280027920.5A 2021-05-07 2022-05-06 对突变型ras(g12d)显示选择结合性的结合分子 Pending CN117177987A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2021/017466 WO2022234639A1 (ja) 2021-05-07 2021-05-07 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子
JPPCT/JP2021/017466 2021-05-07
PCT/JP2022/019541 WO2022234851A1 (ja) 2021-05-07 2022-05-06 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子

Publications (1)

Publication Number Publication Date
CN117177987A true CN117177987A (zh) 2023-12-05

Family

ID=83932681

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280027920.5A Pending CN117177987A (zh) 2021-05-07 2022-05-06 对突变型ras(g12d)显示选择结合性的结合分子

Country Status (5)

Country Link
US (1) US20240239842A1 (https=)
EP (1) EP4339204A4 (https=)
JP (1) JPWO2022234851A1 (https=)
CN (1) CN117177987A (https=)
WO (2) WO2022234639A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117603094A (zh) * 2023-11-30 2024-02-27 苏州爱玛特生物科技有限公司 一种氨基保护的2-氨基甲基烯酸衍生物的合成方法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI787670B (zh) 2011-12-28 2022-12-21 日商中外製藥股份有限公司 具有環狀部之胜肽化合物及其醫藥組成物
WO2018225851A1 (ja) 2017-06-09 2018-12-13 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
PE20221323A1 (es) 2019-11-07 2022-09-09 Chugai Pharmaceutical Co Ltd Compuesto de peptidos ciclicos que tiene accion inhibidora de kras
TW202309065A (zh) 2021-05-07 2023-03-01 日商中外製藥股份有限公司 包含n-取代胺基酸殘基之環狀化合物的製造方法
CA3256645A1 (en) 2022-05-06 2025-04-23 Chugai Seiyaku Kabushiki Kaisha CYCLIC COMPOUND HAVING A SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS
EP4585605A1 (en) * 2022-10-20 2025-07-16 Chugai Seiyaku Kabushiki Kaisha Method for producing cyclic peptide crystals
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
US20250114339A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor
AU2024357850A1 (en) 2023-10-09 2026-04-23 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI787670B (zh) 2011-12-28 2022-12-21 日商中外製藥股份有限公司 具有環狀部之胜肽化合物及其醫藥組成物
US10017540B2 (en) * 2015-03-11 2018-07-10 California Institute Of Technology Cyclic peptide binder against oncogenic K-Ras
WO2017150732A1 (ja) * 2016-03-03 2017-09-08 中外製薬株式会社 チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法
US10954287B2 (en) * 2016-04-15 2021-03-23 Ra Pharmaceuticals, Inc. Ras binding peptides and methods of use
JP7232758B2 (ja) * 2017-06-09 2023-03-06 中外製薬株式会社 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ
WO2020230780A1 (ja) * 2019-05-14 2020-11-19 一丸ファルコス株式会社 Ｒａｓ阻害ペプチド
US11414460B2 (en) * 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
PE20221323A1 (es) * 2019-11-07 2022-09-09 Chugai Pharmaceutical Co Ltd Compuesto de peptidos ciclicos que tiene accion inhibidora de kras

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117603094A (zh) * 2023-11-30 2024-02-27 苏州爱玛特生物科技有限公司 一种氨基保护的2-氨基甲基烯酸衍生物的合成方法

Also Published As

Publication number Publication date
JPWO2022234851A1 (https=) 2022-11-10
EP4339204A4 (en) 2025-07-30
WO2022234851A1 (ja) 2022-11-10
US20240239842A1 (en) 2024-07-18
WO2022234639A1 (ja) 2022-11-10
EP4339204A1 (en) 2024-03-20

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