JPWO2022234851A1 - - Google Patents
Info
- Publication number
- JPWO2022234851A1 JPWO2022234851A1 JP2023518699A JP2023518699A JPWO2022234851A1 JP WO2022234851 A1 JPWO2022234851 A1 JP WO2022234851A1 JP 2023518699 A JP2023518699 A JP 2023518699A JP 2023518699 A JP2023518699 A JP 2023518699A JP WO2022234851 A1 JPWO2022234851 A1 JP WO2022234851A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2021/017466 WO2022234639A1 (ja) | 2021-05-07 | 2021-05-07 | 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子 |
| PCT/JP2022/019541 WO2022234851A1 (ja) | 2021-05-07 | 2022-05-06 | 変異型ｒａｓ（ｇ１２ｄ）に対する選択的結合性を示す結合分子 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPWO2022234851A1 true JPWO2022234851A1 (https=) | 2022-11-10 |
Family
ID=83932681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023518699A Pending JPWO2022234851A1 (https=) | 2021-05-07 | 2022-05-06 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240239842A1 (https=) |
| EP (1) | EP4339204A4 (https=) |
| JP (1) | JPWO2022234851A1 (https=) |
| CN (1) | CN117177987A (https=) |
| WO (2) | WO2022234639A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI787670B (zh) | 2011-12-28 | 2022-12-21 | 日商中外製藥股份有限公司 | 具有環狀部之胜肽化合物及其醫藥組成物 |
| WO2018225851A1 (ja) | 2017-06-09 | 2018-12-13 | 中外製薬株式会社 | Ｎ－置換アミノ酸を含むペプチドの合成方法 |
| PE20221323A1 (es) | 2019-11-07 | 2022-09-09 | Chugai Pharmaceutical Co Ltd | Compuesto de peptidos ciclicos que tiene accion inhibidora de kras |
| TW202309065A (zh) | 2021-05-07 | 2023-03-01 | 日商中外製藥股份有限公司 | 包含n-取代胺基酸殘基之環狀化合物的製造方法 |
| CA3256645A1 (en) | 2022-05-06 | 2025-04-23 | Chugai Seiyaku Kabushiki Kaisha | CYCLIC COMPOUND HAVING A SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS |
| EP4585605A1 (en) * | 2022-10-20 | 2025-07-16 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic peptide crystals |
| IL326136A (en) | 2023-08-07 | 2026-03-01 | Revolution Medicines Inc | RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein |
| US20250114339A1 (en) | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor |
| AU2024357850A1 (en) | 2023-10-09 | 2026-04-23 | Incyte Corporation | Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| CN117603094A (zh) * | 2023-11-30 | 2024-02-27 | 苏州爱玛特生物科技有限公司 | 一种氨基保护的2-氨基甲基烯酸衍生物的合成方法 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020230780A1 (ja) * | 2019-05-14 | 2020-11-19 | 一丸ファルコス株式会社 | Ｒａｓ阻害ペプチド |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI787670B (zh) | 2011-12-28 | 2022-12-21 | 日商中外製藥股份有限公司 | 具有環狀部之胜肽化合物及其醫藥組成物 |
| US10017540B2 (en) * | 2015-03-11 | 2018-07-10 | California Institute Of Technology | Cyclic peptide binder against oncogenic K-Ras |
| WO2017150732A1 (ja) * | 2016-03-03 | 2017-09-08 | 中外製薬株式会社 | チオール基をアミノ基近傍に有するアミノ酸をｎ末端に持つ非環状ペプチド－核酸複合体、そのライブラリー、およびそれから誘導される環状ペプチド－核酸複合体ライブラリーの製造方法 |
| US10954287B2 (en) * | 2016-04-15 | 2021-03-23 | Ra Pharmaceuticals, Inc. | Ras binding peptides and methods of use |
| JP7232758B2 (ja) * | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| US11414460B2 (en) * | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
| PE20221323A1 (es) * | 2019-11-07 | 2022-09-09 | Chugai Pharmaceutical Co Ltd | Compuesto de peptidos ciclicos que tiene accion inhibidora de kras |
-
2021
- 2021-05-07 WO PCT/JP2021/017466 patent/WO2022234639A1/ja not_active Ceased
-
2022
- 2022-05-06 CN CN202280027920.5A patent/CN117177987A/zh active Pending
- 2022-05-06 US US18/289,071 patent/US20240239842A1/en active Pending
- 2022-05-06 JP JP2023518699A patent/JPWO2022234851A1/ja active Pending
- 2022-05-06 WO PCT/JP2022/019541 patent/WO2022234851A1/ja not_active Ceased
- 2022-05-06 EP EP22798955.5A patent/EP4339204A4/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020230780A1 (ja) * | 2019-05-14 | 2020-11-19 | 一丸ファルコス株式会社 | Ｒａｓ阻害ペプチド |
Non-Patent Citations (2)
| Title |
|---|
| SOGABE, S. ET AL.: "Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, JPN6021028742, 2017, pages 732 - 736, ISSN: 0005796940 * |
| ZHANG, Z. ET AL.: "GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf", ACS CENTRAL SCIENCE, vol. 6, JPN6021028745, 2020, pages 1753 - 1761, ISSN: 0005796941 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117177987A (zh) | 2023-12-05 |
| EP4339204A4 (en) | 2025-07-30 |
| WO2022234851A1 (ja) | 2022-11-10 |
| US20240239842A1 (en) | 2024-07-18 |
| WO2022234639A1 (ja) | 2022-11-10 |
| EP4339204A1 (en) | 2024-03-20 |
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