CN116997325B - 稳定的吲哚菁绿制剂 - Google Patents

稳定的吲哚菁绿制剂

Info

Publication number
CN116997325B
CN116997325B CN202280021996.7A CN202280021996A CN116997325B CN 116997325 B CN116997325 B CN 116997325B CN 202280021996 A CN202280021996 A CN 202280021996A CN 116997325 B CN116997325 B CN 116997325B
Authority
CN
China
Prior art keywords
indocyanine green
composition
weight
icg
edta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202280021996.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN116997325A (zh
Inventor
玛丽娜·劳伦
巴巴克·萨耶
尼古拉斯·洛佩斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Provepharm Life Solutions SA
Original Assignee
Provepharm Life Solutions SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provepharm Life Solutions SA filed Critical Provepharm Life Solutions SA
Publication of CN116997325A publication Critical patent/CN116997325A/zh
Application granted granted Critical
Publication of CN116997325B publication Critical patent/CN116997325B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202280021996.7A 2021-03-17 2022-03-14 稳定的吲哚菁绿制剂 Active CN116997325B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21305323.4 2021-03-17
EP21305323 2021-03-17
PCT/EP2022/056445 WO2022194733A2 (en) 2021-03-17 2022-03-14 Stable formulations of indocyanine green

Publications (2)

Publication Number Publication Date
CN116997325A CN116997325A (zh) 2023-11-03
CN116997325B true CN116997325B (zh) 2025-12-05

Family

ID=75302475

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280021996.7A Active CN116997325B (zh) 2021-03-17 2022-03-14 稳定的吲哚菁绿制剂

Country Status (6)

Country Link
US (1) US20240165275A1 (enExample)
EP (1) EP4308081A2 (enExample)
JP (1) JP7842776B2 (enExample)
CN (1) CN116997325B (enExample)
BR (1) BR112023018942A2 (enExample)
WO (1) WO2022194733A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119215199B (zh) * 2024-10-12 2025-12-09 石家庄四药有限公司 一种注射用吲哚菁绿的冻干工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111514125A (zh) * 2020-05-26 2020-08-11 中山万汉制药有限公司 含有喹诺酮类化合物与依地酸类化合物的组合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08509260A (ja) * 1993-04-20 1996-10-01 マリンクロット・メディカル・インコーポレイテッド 電圧感受性染料の安定化
FR2710060B1 (fr) 1993-09-17 1995-11-17 Rech Biolog Et Procédé de préparation de benz[e]indoles substitués de pureté élevée et leurs sels alcalins.
GB9712524D0 (en) 1997-06-16 1997-08-20 Nycomed Imaging As Method
US6944493B2 (en) 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
US8337809B2 (en) * 2006-09-11 2012-12-25 William Marsh Rice University Charge-assembled capsules for phototherapy
DE102007030403A1 (de) 2007-06-29 2009-01-08 Universität Bielefeld Verfahren zur Verbesserung der Photostabilität von Fluoreszenzfarbstoffen
JP5257971B2 (ja) 2007-10-25 2013-08-07 国立大学法人 千葉大学 胚性幹細胞から肝芽細胞を得る方法
CN103301482B (zh) 2013-06-27 2014-12-17 深圳先进技术研究院 两亲性三嵌段聚多肽载icg胶束及其制备方法
JP2015040185A (ja) 2013-08-21 2015-03-02 キヤノン株式会社 造影用組成物
JP6623479B2 (ja) 2015-02-08 2019-12-25 トンリ・バイオメディカル・カンパニー・リミテッド 脂質ナノ粒子及びその使用
CA3021809A1 (en) 2015-05-11 2016-11-17 Dicronis Sagl Compositions for circulatory system visualization
DK3383436T3 (da) 2015-12-01 2023-11-20 Dishman Carbogen Amcis Ltd Forbedret fremgangsmåde til fremstilling af indocyaningrønt
US20190337896A1 (en) 2018-05-02 2019-11-07 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN)
WO2020240514A1 (en) * 2019-05-30 2020-12-03 Leiutis Pharmaceuticals Pvt, Ltd. Stable formulations of indocyanine green

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111514125A (zh) * 2020-05-26 2020-08-11 中山万汉制药有限公司 含有喹诺酮类化合物与依地酸类化合物的组合物

Also Published As

Publication number Publication date
CN116997325A (zh) 2023-11-03
EP4308081A2 (en) 2024-01-24
US20240165275A1 (en) 2024-05-23
JP7842776B2 (ja) 2026-04-08
WO2022194733A2 (en) 2022-09-22
BR112023018942A2 (pt) 2023-10-10
WO2022194733A3 (en) 2022-11-10
JP2024510302A (ja) 2024-03-06

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