CN116916919A - 抗体-药物缀合物与抗SIRPα抗体的组合 - Google Patents

抗体-药物缀合物与抗SIRPα抗体的组合 Download PDF

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Publication number
CN116916919A
CN116916919A CN202180075998.XA CN202180075998A CN116916919A CN 116916919 A CN116916919 A CN 116916919A CN 202180075998 A CN202180075998 A CN 202180075998A CN 116916919 A CN116916919 A CN 116916919A
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antibody
amino acid
seq
heavy chain
drug conjugate
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CN202180075998.XA
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Chinese (zh)
Inventor
须江真由美
椿卓也
石本容子
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202180075998.XA 2020-11-11 2021-11-10 抗体-药物缀合物与抗SIRPα抗体的组合 Pending CN116916919A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-188084 2020-11-11
JP2020188084 2020-11-11
PCT/JP2021/041255 WO2022102634A1 (ja) 2020-11-11 2021-11-10 抗体－薬物コンジュゲートと抗ＳＩＲＰα抗体の組み合わせ

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CN116916919A true CN116916919A (zh) 2023-10-20

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US (1) US20230414778A1 (https=)
EP (1) EP4245321A4 (https=)
JP (1) JPWO2022102634A1 (https=)
KR (1) KR20230106645A (https=)
CN (1) CN116916919A (https=)
AU (1) AU2021378152A1 (https=)
BR (1) BR112023008845A2 (https=)
CA (1) CA3198330A1 (https=)
IL (1) IL302812A (https=)
TW (1) TW202227140A (https=)
WO (1) WO2022102634A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2025103377A1 (zh) * 2023-11-13 2025-05-22 苏州宜联生物医药有限公司 抗b7h3抗体-药物偶联物治疗癌症的方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250282865A1 (en) * 2022-05-10 2025-09-11 Daiichi Sankyo Company, Limited COMBINATION OF ANTIBODY-DRUG CONJUGATE AND ANTI-SIRPa ANTIBODY
CN119255825A (zh) * 2022-05-24 2025-01-03 第一三共株式会社 抗-cdh6抗体-药物缀合物的剂量方案
WO2025002310A1 (zh) * 2023-06-29 2025-01-02 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途

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