CN116870112B - 一种治疗变应性鼻炎的中药制剂 - Google Patents
一种治疗变应性鼻炎的中药制剂 Download PDFInfo
- Publication number
- CN116870112B CN116870112B CN202311089119.6A CN202311089119A CN116870112B CN 116870112 B CN116870112 B CN 116870112B CN 202311089119 A CN202311089119 A CN 202311089119A CN 116870112 B CN116870112 B CN 116870112B
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- chinese medicine
- root
- allergic rhinitis
- treating allergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 47
- 206010039085 Rhinitis allergic Diseases 0.000 title claims abstract description 18
- 201000010105 allergic rhinitis Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 241000132012 Atractylodes Species 0.000 claims abstract description 14
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 14
- 244000126002 Ziziphus vulgaris Species 0.000 claims abstract description 14
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 12
- 235000006545 Ziziphus mauritiana Nutrition 0.000 claims abstract description 12
- 235000008529 Ziziphus vulgaris Nutrition 0.000 claims abstract description 12
- 235000011477 liquorice Nutrition 0.000 claims abstract description 12
- 244000077995 Coix lacryma jobi Species 0.000 claims abstract description 11
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 11
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 11
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 11
- 235000006533 astragalus Nutrition 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 241001061264 Astragalus Species 0.000 claims abstract description 10
- 210000004233 talus Anatomy 0.000 claims abstract description 10
- 244000170916 Paeonia officinalis Species 0.000 claims abstract 2
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract 2
- 235000006751 Platycodon Nutrition 0.000 claims description 10
- 229930189914 platycodon Natural products 0.000 claims description 10
- 229940126680 traditional chinese medicines Drugs 0.000 claims description 9
- 241001180876 Saposhnikovia Species 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 3
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 241000045403 Astragalus propinquus Species 0.000 claims 1
- 241001124537 Bovinae Species 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 12
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 235000010726 Vigna sinensis Nutrition 0.000 abstract 1
- 244000042314 Vigna unguiculata Species 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 10
- 241001106477 Paeoniaceae Species 0.000 description 9
- 230000003266 anti-allergic effect Effects 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 238000005728 strengthening Methods 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 3
- 229940107666 astragalus root Drugs 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000002633 protecting effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000229179 Ledebouriella Species 0.000 description 2
- 229930194248 Licoflavone Natural products 0.000 description 2
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical class C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 241000131458 Elsholtzia Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 240000000950 Hippophae rhamnoides Species 0.000 description 1
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DRDRYGIIYOPBBZ-XBXARRHUSA-N Licochalcone B Natural products COC1=C(O)C(O)=CC=C1\C=C\C(=O)C1=CC=C(O)C=C1 DRDRYGIIYOPBBZ-XBXARRHUSA-N 0.000 description 1
- WBDNTJSRHDSPSR-UHFFFAOYSA-N Licochalcone C Natural products C1=CC(O)=C(CC=C(C)C)C(OC)=C1C=CC(=O)C1=CC=C(O)C=C1 WBDNTJSRHDSPSR-UHFFFAOYSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- FURUXTVZLHCCNA-UHFFFAOYSA-N Liquiritigenin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-UHFFFAOYSA-N 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 206010052437 Nasal discomfort Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 201000009961 allergic asthma Diseases 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- LBQIJVLKGVZRIW-ZDUSSCGKSA-N glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 description 1
- 229940093767 glabridin Drugs 0.000 description 1
- PMPYOYXFIHXBJI-ZDUSSCGKSA-N glabridin Natural products C1([C@H]2CC=3C=CC4=C(C=3OC2)CCC(O4)(C)C)=CC=C(O)C=C1O PMPYOYXFIHXBJI-ZDUSSCGKSA-N 0.000 description 1
- LBQIJVLKGVZRIW-UHFFFAOYSA-N glabridine Natural products C1OC2=C3C=CC(C)(C)OC3=CC=C2CC1C1=CC=C(O)C=C1O LBQIJVLKGVZRIW-UHFFFAOYSA-N 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000005182 global health Effects 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- DXDRHHKMWQZJHT-FPYGCLRLSA-N isoliquiritigenin Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)C1=CC=C(O)C=C1O DXDRHHKMWQZJHT-FPYGCLRLSA-N 0.000 description 1
- 235000008718 isoliquiritigenin Nutrition 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 229930187586 licochalcone Natural products 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供一种治疗变应性鼻炎的中药制剂，其特征在于包括黄芪、防风、白术、葛根、白芍、牛子、薏苡仁、桔梗、甘草、大枣；本发明的中药组合物均采用天然的中药原料，其配制方法简单、原料药来源广泛、成本低，无激素刺激类毒副作用，复发率低。
Description
技术领域
本发明涉及中药技术领域，尤其涉及一种治疗变应性鼻炎的中药制剂。
背景技术
变应性鼻炎又称过敏性鼻炎(Allergic rhinitis，AR)，是耳鼻喉头颈外科常见病之一。据报道，全球有6亿人左右患有AR且逐渐增加，我国AR患病率范围为4％-38％。AR虽然不危及生命，但会因季节、温度、空气等各种外在因素以及过敏原的影响而反复发作，其典型症状是鼻痒、鼻塞、清涕、打喷嚏，如治疗不及时或不合理可能将导致患者出现过敏性结膜炎、哮喘等并发症，症状发作时严重影响患者生活、工作和学习，现已是全球性的健康问题。
变应性鼻炎从中医角度来探讨，大部分医家认为主因为脏腑功能失调、外感风寒以及异气之邪侵袭鼻窍。其中以肺、脾、肾之虚损为主，可透过温补肺脏或是肾阳，健脾益气，滋肾阴等方法来调理病患体质，加强患者抗病能力。
变应性鼻炎发病机制是经过变应原所引起之变态反应，现今西医治疗法，大多采用糖皮质激素与抗组胺药物，但仍有其限制，不仅副作用比较多而且无法预防复发，过敏性鼻炎选择中医药来治疗，能取得较好的临床疗效，并且有一定的优势。
发明内容
根据以上技术问题，本发明提供一种疗效显著且不易复发的一种治疗变应性鼻炎的中药制剂。
本发明提供一种治疗变应性鼻炎的中药制剂，其特征在于，该中药组合物由以下中药制备而成：黄芪、防风、白术、葛根、白芍、牛子、薏苡仁、桔梗、甘草以及大枣。
优选的，该中药组合物包括下列重量配比的中药原料组成：黄芪12-15g、防风5-7g、白术9-11g、葛根8-10g、白芍9-10g、牛子8-10g、薏苡仁10-13g、桔梗5-7g、甘草6-8g、大枣12-15g。
优选的，该中药组合物各原料的重量配比选：黄芪12g、防风6g、白术9g、葛根9g、白芍9g、牛子9g、薏苡仁12g、桔梗6g、甘草6g、大枣12g。
本发明中药组合物的制备方法，其特征在于该方法包括下列步骤：
步骤一：将各个中药原料组分在300ml水中浸泡20分钟；
步骤二：然后文火煎制，煮沸后维持20分钟；
步骤三：将煎制后的药液过滤后服用，其中，服用时间为一天服用两次，七天一疗程，服用2-3疗程为佳。
本发明选用的中药原料在本领域的常见药理功效如下：
黄芪：发散风寒之解表药。黄芪具有类激素样和免疫促进作用，提高机体免疫力，减少疾病的复发。
防风：发散风寒之解表药防风。防风能增强单核巨噬细胞活性，提高非特异性免疫能力，抑制细胞免疫功能。研究证实有较强的抗过敏作用。
白术：健脾益气。白术的主要化学成分包括多糖、挥发油、内酯类等，具有抗炎、调节消化系统、抗肿瘤等药理作用，临床上多与其他中药配伍使用，可治疗胃肠道肝脏及免疫系统等疾病。
葛根：葛根辛甘性凉，具有退热解肌，升阳透珍，生津止渴，止污的功效。葛根中主要含有异黄酮类、香豆素类、生物碱、三萜类、淀粉、氨基酸等成分。葛根具有增强免疫力、保护心肌、降血脂、降血糖、解酒保肝、预防骨质疏松等作用。
白芍：白芍具有补肺健脾、祛风散邪、调和营卫的功效，白芍总苷可抑制特异性细胞免疫反应等。
牛子：疏风散热、解毒消肿，用于风热感冒、咳嗽、咽喉肿痛、便秘、风火上扰之头晕、耳鸣耳聋、目昏，外用治头面风毒赤肿、热毒牙痛、齿龈肿痛、痈疸恶疮。
薏苡仁：性凉，味甘淡，利水消肿、健脾去湿、舒筋除痹等功效。薏苡仁在《本草纲目》记载，能健脾益胃，补肺清热以及去风胜湿。
桔梗：化痰止咳平喘。具有祛痰、镇咳、抗炎、抗肿瘤、提高人体免疫力等广泛的药理活性，含有的化学成分为三姑皂苷类、黄酮类、酚酸类等多种成分。总皂苷在体外肥大细胞抗过敏实验、皮试中具有明显抑制一己糖胺酶和组胺的释放。
甘草：健脾益气，补气之补虚。具抗炎、抗过敏、抗氧化、抗病毒、抑制肿瘤生长、抗溃疡等多种活。甘草黄酮类化合物，如异甘草素、异甘草者、甘草素、甘草查耳酮、光甘草定、甘草醇等、甘草多糖和甘草酸是甘草抗炎和免疫调节的活性成分。甘草黄酮类化合物可提高吞噬细胞的吞噬功能，调节淋巴细胞数量和功能，抑制IgE抗体形成，具有抗炎症介质、前炎性细胞因子作用，可产生抗炎、抗变态反应。
大枣：大枣为民间常用之益气养血滋补品，食疗用途为补益脾胃。处方中常用来治疗脾胃虚弱、气血不足，失眠等。现代功效研究有：健胃养脾、补益气血(含丰富钙及铁)、安神定志、和药性(减少烈性药物副作用)、抗过敏(含有大量具抗过敏的物质：环磷酸腺有CAMP，能减少过敏物质释放)、护肝。
本发明的有益效果为：本发明为一种治疗变应性鼻炎的中药制剂，本发明的中药组合物均采用天然的中药原料，其配制方法简单、原料药来源广泛、成本低，无激素刺激类毒副作用，复发率低。本发明各味中药及其之间的配比均是经过试验筛选，效果显著。本发明可根据患者需要制成临床上可接受的药物制剂，便于患者服用，此外，中黄芪、防风为君药，白术、葛根、牛子为臣药，薏苡仁、桔梗、白芍为佐药，甘草、大枣为使药，本方中各药物“君臣佐使”，相辅相成，可有效治疗变应性鼻炎。
具体实施方式
实施例1
本发明提供一种治疗变应性鼻炎的中药制剂，其特征在于，该中药组合物由以下中药制备而成：黄芪、防风、白术、葛根、白芍、牛子、薏苡仁、桔梗、甘草以及大枣。
优选的，该中药组合物包括下列重量配比的中药原料组成：黄芪12-15g、防风5-7g、白术9-11g、葛根8-10g、白芍9-10g、牛子8-10g、薏苡仁10-13g、桔梗5-7g、甘草6-8g、大枣12-15g。
优选的，该中药组合物各原料的重量配比选：黄芪12g、防风6g、白术9g、葛根9g、白芍9g、牛子9g、薏苡仁12g、桔梗6g、甘草6g、大枣12g。
本发明中药组合物的制备方法，其特征在于该方法包括下列步骤：
步骤一：将各个中药原料组分在300ml水中浸泡20分钟；
步骤二：然后文火煎制，煮沸后维持20分钟；
步骤三：将煎制后的药液过滤后服用，其中，服用时间为一天服用两次，七天一疗程，服用2-3疗程为佳。
另外，还可以用以下药食同源物质：甘草，桑叶，桃仁，人参，枸杞子，菊花，香薷，金银花，黄芪，沙棘。
实施例2
患者王某，女，天津人，43岁，2021年5月5日来诊，患有鼻炎，给予本实施例1中各原料的重量配比选：黄芪12g、防风6g、白术9g、葛根9g、白芍9g、牛子9g、薏苡仁12g、桔梗6g、甘草6g、大枣12g，10天症状缓解，一个疗程治愈，回访至今无复发。
实施例3
患者薛某，女，山西人，10岁，2022年5月10日来诊，患有过敏性鼻炎，给予本实施例1中各原料的重量配比选：黄芪12g、防风5g、白术9g、葛根8g、白芍9g、牛子9g、薏苡仁10g、桔梗6g、甘草6g、大枣12g。12天症状缓解，三个疗程治愈，回访至今无复发。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本发明提到的各个部件为现有领域常见技术，本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (3)
1.一种治疗变应性鼻炎的中药制剂，其特征在于，该中药组合物由以下中药组成：黄芪9-10g、防风5-7g、白术9-11g、葛根6-8g、白芍9-10g、牛子12-14g、薏苡仁10-13g、桔梗5-7g、甘草6-8g、大枣12-15g。
2.根据权利要求1所述的一种治疗变应性鼻炎的中药制剂，其特征在于：该中药组合物由以下中药组成：黄芪10g、防风6g、白术9g、葛根8g、白芍9g、牛子12g、薏苡仁12g、桔梗6g、甘草6g、大枣12g。
3.根据权利要求1所述的一种治疗变应性鼻炎的中药制剂的制备方法，其特征在于该方法包括下列步骤：
步骤一：将各个中药原料组分在300毫升水中浸泡20分钟；
步骤二：然后文火煎制，煮沸后维持20分钟；
步骤三：将煎制后的药液过滤后服用，其中，服用时间为一天服用两次，七天一疗程，服用2-3疗程。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311089119.6A CN116870112B (zh) | 2023-08-28 | 2023-08-28 | 一种治疗变应性鼻炎的中药制剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311089119.6A CN116870112B (zh) | 2023-08-28 | 2023-08-28 | 一种治疗变应性鼻炎的中药制剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116870112A CN116870112A (zh) | 2023-10-13 |
| CN116870112B true CN116870112B (zh) | 2024-04-19 |
Family
ID=88260779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311089119.6A Active CN116870112B (zh) | 2023-08-28 | 2023-08-28 | 一种治疗变应性鼻炎的中药制剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116870112B (zh) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317324A (zh) * | 2000-04-10 | 2001-10-17 | 陈江辉 | 一种温肺散寒饮液及其制备方法 |
| KR20030007243A (ko) * | 2002-10-02 | 2003-01-23 | 김경렬 | 의이인, 상백피, 어성초, 길경, 생지황, 금은화, 삼백초, 생강, 진피, 적작을 주성분으로 함유하는 의약 조성물 |
| US6524627B1 (en) * | 2002-03-20 | 2003-02-25 | Daehan Biolink Co., Ltd. | Pharmaceutical composition for preventing and treating allergic diseases and a method for preparation thereof |
| CN1511564A (zh) * | 2002-12-30 | 2004-07-14 | 董俊明 | 鼻渊清口服液的制作方法 |
| KR20050101942A (ko) * | 2004-04-20 | 2005-10-25 | (주)바이오솔루션 | 알레르기성 비염과 감기의 예방 및 치료용 건강식품조성물 및 그 제조 방법 |
| CN102100388A (zh) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | 一种玉屏风功能性饮料制备技术 |
| CN103341147A (zh) * | 2013-07-21 | 2013-10-09 | 谢银芳 | 一种治疗寒湿夹热型变应性鼻炎、慢性鼻炎的中药制剂 |
| CN103386044A (zh) * | 2013-07-24 | 2013-11-13 | 马丽 | 一种治疗变应性鼻炎的中药制剂 |
| CN103432475A (zh) * | 2013-09-06 | 2013-12-11 | 梁怡芃 | 一种治疗过敏性鼻炎的中药组合物及其制备方法 |
| CN103638140A (zh) * | 2013-12-17 | 2014-03-19 | 黄书芳 | 一种治疗鼻炎的药物 |
| CN105148244A (zh) * | 2015-10-13 | 2015-12-16 | 仲学龙 | 治疗荨麻疹的中药制剂 |
| CN107184736A (zh) * | 2017-05-12 | 2017-09-22 | 大连大学 | 一种金花茶抗过敏颗粒剂及其制备方法 |
| CN111150823A (zh) * | 2019-12-25 | 2020-05-15 | 北京中医药大学东直门医院 | 一种治疗变应性鼻炎的药物组合物 |
-
2023
- 2023-08-28 CN CN202311089119.6A patent/CN116870112B/zh active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317324A (zh) * | 2000-04-10 | 2001-10-17 | 陈江辉 | 一种温肺散寒饮液及其制备方法 |
| US6524627B1 (en) * | 2002-03-20 | 2003-02-25 | Daehan Biolink Co., Ltd. | Pharmaceutical composition for preventing and treating allergic diseases and a method for preparation thereof |
| KR20030007243A (ko) * | 2002-10-02 | 2003-01-23 | 김경렬 | 의이인, 상백피, 어성초, 길경, 생지황, 금은화, 삼백초, 생강, 진피, 적작을 주성분으로 함유하는 의약 조성물 |
| CN1511564A (zh) * | 2002-12-30 | 2004-07-14 | 董俊明 | 鼻渊清口服液的制作方法 |
| KR20050101942A (ko) * | 2004-04-20 | 2005-10-25 | (주)바이오솔루션 | 알레르기성 비염과 감기의 예방 및 치료용 건강식품조성물 및 그 제조 방법 |
| CN102100388A (zh) * | 2009-12-17 | 2011-06-22 | 苏州知微堂生物科技有限公司 | 一种玉屏风功能性饮料制备技术 |
| CN103341147A (zh) * | 2013-07-21 | 2013-10-09 | 谢银芳 | 一种治疗寒湿夹热型变应性鼻炎、慢性鼻炎的中药制剂 |
| CN103386044A (zh) * | 2013-07-24 | 2013-11-13 | 马丽 | 一种治疗变应性鼻炎的中药制剂 |
| CN103432475A (zh) * | 2013-09-06 | 2013-12-11 | 梁怡芃 | 一种治疗过敏性鼻炎的中药组合物及其制备方法 |
| CN103638140A (zh) * | 2013-12-17 | 2014-03-19 | 黄书芳 | 一种治疗鼻炎的药物 |
| CN105148244A (zh) * | 2015-10-13 | 2015-12-16 | 仲学龙 | 治疗荨麻疹的中药制剂 |
| CN107184736A (zh) * | 2017-05-12 | 2017-09-22 | 大连大学 | 一种金花茶抗过敏颗粒剂及其制备方法 |
| CN111150823A (zh) * | 2019-12-25 | 2020-05-15 | 北京中医药大学东直门医院 | 一种治疗变应性鼻炎的药物组合物 |
Non-Patent Citations (6)
| Title |
|---|
| 外感表证治法与方药;陈滨砫;;新中医;-;20060415;第-卷(第04期);第83-84页 * |
| 桂枝汤治验三则;张朝银, 牟方友;现代医药卫生;-;20060815;第-卷(第20期);第2819页 * |
| 牛阳教授运用石葛汤联合玉屏风散治疗过敏性鼻炎经验;师小茜;牛阳;;光明中医;20160229(第04期);第43-44页 * |
| 玉屏风散加味治疗变应性鼻炎的临床研究进展;陈伊芮;赵庚雷;彭秀;张若蒙;包艳;樊力;严韵;彭顺林;;湖南中医杂志;20170928(第09期);第209-211页 * |
| 玉屏风散新用;黄祥标;新中医;-;19950415;第-卷(第04期);第52页 * |
| 过敏性鼻炎;黄丽辉;;广西中医药;-;19000101;第-卷(第02期);第39-40页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116870112A (zh) | 2023-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107114781B (zh) | 一种用于保肝的保健食品及其制备方法 | |
| KR101456937B1 (ko) | 천연물 추출물로 구성된 비만의 억제 및 치료용 조성물 | |
| CN109820943B (zh) | 一种治疗痛风的壮药制剂及其制备方法 | |
| CN106109521A (zh) | 一种三七口服液 | |
| CN116870112B (zh) | 一种治疗变应性鼻炎的中药制剂 | |
| CN112717113B (zh) | 一种治疗过敏性鼻炎中药组合物及其膏方和应用 | |
| WO2019104931A1 (zh) | 一种治疗白血病的中药组合物及其制备方法 | |
| CN111407808B (zh) | 一种中药组合物及其制备方法与制药应用 | |
| CN103860773A (zh) | 用于治疗心肌缺血的中药组合物及其制备方法 | |
| CN110960632B (zh) | 一种改善睡眠产品的配方及其制备方法 | |
| CN103041112B (zh) | 一种治疗单纯肥胖性脂肪肝的中药 | |
| CN102626471B (zh) | 一种具有防敏脱敏、修复再生作用的中药组合物 | |
| CN112402569A (zh) | 一种抗疲劳保健品及其制备方法 | |
| CN105106634A (zh) | 一种治疗急性阑尾炎的中药制剂及其应用 | |
| CN105106499A (zh) | 一种用于狭窄性胆管炎外科分流术后使用的中药组合物 | |
| CN110946950A (zh) | 一种治疗老年期血管性痴呆的中药组合物及其制备方法 | |
| CN104606570A (zh) | 一种适宜糖尿病患者服用的消渴代茶饮及制备方法 | |
| CN116712523B (zh) | 一种治疗中虚气逆型反流性食管炎组合物及其制备方法 | |
| CN114712470B (zh) | 一种治疗男士肾亏的药物及其制备方法 | |
| CN105833228A (zh) | 一种逆转胃癌耐药性的药物制剂及其用途 | |
| CN110585268A (zh) | 一种提高男性耐力和精力活力的组合物及其制备方法和用途 | |
| CN110960620A (zh) | 一种预防和治疗糖尿病的纯天然中药方剂 | |
| CN114404517A (zh) | 一种用于痛风和降低尿酸的组合物及其用途与制备方法 | |
| CN117599124A (zh) | 一种治疗荨麻疹的中药组合物 | |
| CN113876881A (zh) | 一种改善睡眠的中药组合物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |