CN103041112B - 一种治疗单纯肥胖性脂肪肝的中药 - Google Patents
一种治疗单纯肥胖性脂肪肝的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗单纯肥胖性脂肪肝的中药，由以下重量配比的药材制备而成：白术12份、冬瓜藤9份、菩提香9啤酒花6份、远志5份、茵陈6份、肉桂1份、黄芪9份、莱菔子10份、芦荟3份。临床实验证明，本发明能够安全有效治疗单纯肥胖性脂肪肝。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗单纯肥胖性脂肪肝的中药。
背景技术
脂肪肝是一种多病因引起的脂肪在肝细胞内异常积累的病理状态。正常人的肝内总脂肪量，约占肝重的5%，内含磷脂、甘油三酯、脂酸、胆固醇及胆固醇脂。脂肪量超过5%为轻度脂肪肝，超过10%为中度脂肪肝，超过25% 为重度脂肪肝。当肝内总脂肪量超过30%时，用B超才能检查出来，被确诊为“脂肪肝”。而平时所说的脂肪肝患者，总脂量可达40%～50%，有些达60%以上。脂肪肝久治不愈则会发展成脂肪性肝炎、脂肪性肝硬化。
脂肪肝按病因可分为： 1、肥胖性脂肪肝2、酒精性脂肪肝3、快速减肥性脂肪肝4、营养不良性脂肪肝5、糖尿病脂肪肝6、药物性脂肪肝7、妊娠脂肪肝8、其他疾病引起的脂肪肝。
到目前为止，西药尚无防治脂肪肝的有效药物，以中药长期调理性的治疗最好。
本发明中药所涉及药材的研究现状如下：
白术【来源】本品为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。冬季下部叶枯黄、上部叶变脆时采挖，除去泥沙，烘干或晒干，再除去须根。【性味】苦、甘，温。【归经】归脾、胃经。【功能主治】健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。【用法用量】 6～12g。
冬瓜藤【性味】味苦；性寒。【归经】归肺；肝经。【功能主治】清肺化痰；通经活络。主肺热咳痰；关节不利；脱肛；疮疥。【用法用量】内服：煎汤或捣汁，9-15g，鲜品加倍。外用：适量，煎水或烧灰洗。
菩提香【来源】蔷薇科菩提香Geum urbanum L.，以全草入药。【生境分布】西藏。【性味】辛、甘，平。【功能主治】滋阴补肾，平肝明目，消肿止痛。治感冒，头晕头痛，高血压，贫血，慢性肠胃炎，月经不调，乳腺炎，疮毒等症。【用法用量】 10-15克。
啤酒花【来源】桑科葎草属植物啤酒花Humulus lupulus L.，以未成熟的绿色果穗入药。8～9月间，果穗呈绿色而略带黄色时摘下，晒干，或烘干。（烘烤温度开始为28℃，6小时后升至45℃为止。一般16～24小时即可干燥。【性味】苦，平。【功能主治】健胃消食，抗痨，安神利尿。用于食欲不振，腹胀，肺结核，胸膜炎，失眠，癔病，浮肿，膀胱炎。【用法用量】 0.5～1.5钱，水煎服，或水煎当茶饮。
远志【来源】本品为远志科植物远志Polygala tenuifolia Willd.或卵叶远志Polygala sibirica L. 的干燥根。春、秋二季采挖，除去须根及泥沙，晒干。【性味】苦、辛、温。【归经】归心、肾、肺经。【功能主治】安神益智，祛痰，消肿。用于心肾不交引起的失眠多梦，健忘惊悸，神志恍惚，咳痰不爽，疮疡肿毒，乳房肿痛。【用法用量】 3～9g。
茵陈【来源】本品为菊科植物滨蒿Artemisia scoparia Waldst. et Kit. 或茵陈蒿Artemisia capillaris Thunb.的干燥地上部分。春季幼苗高 6～10cm时采收或秋季花蕾长成时采割，除去杂质及老茎，晒干。春季采收的习称“绵茵陈”，秋季采割的称“茵陈蒿”。 【炮制】除去残根及杂质，搓碎或切碎。绵茵陈筛去灰屑。【性味】苦、辛，微寒。【归经】归脾、胃、肝、胆经。【功能主治】清湿热，退黄疸。用于黄疸尿少，湿疮瘙痒；传染性黄疸型肝炎。【用法用量】 6～15g。外用适量，煎汤熏洗。
肉桂【来源】本品为樟科植物肉桂Cinnamomum cassia Presl 的干燥树皮。多于秋季剥取，阴干。炮制】除去杂质及粗皮。用时捣碎。【性味】辛、甘，大热。【归经】归肾、脾、心、肝经。【功能主治】补火助阳，引火归源，散寒止痛，活血通经。用于阳痿，宫冷，腰膝冷痛，肾虚作喘，阳虚眩晕，目赤咽痛，心腹冷痛，虚寒吐泻，寒疝，奔豚，经闭，痛经。【用法用量】 1～4.5g。
黄芪【来源】本品为豆科植物蒙古黄芪 Astragalus membranaceus （Fisch.） Bge. var. mongholicus （Bge.）Hsiao 或膜荚黄芪 Astragalus membranaceus （Fisch.） Bge.的干燥根。春、秋二季采挖，除去须根及根头，晒干。【性味】甘，温。【归经】归肺、脾经。【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。【用法用量】 9～30g。
莱菔子【来源】本品为十字花科植物萝卜Raphanus sativus L.的干燥成熟种子。夏季果实成熟时采割植株，晒干，搓出种子，除去杂质，再晒干。【性味】辛、甘，平。【归经】归肺、脾、胃经。【功能主治】消食除胀，降气化痰。用于饮食停滞，脘腹胀痛，大便秘结，积滞泻痢，痰壅喘咳。【用法用量】 4.5～9g。
芦荟【来源】本品为百合科植物库拉索芦荟Aloe barbadensis Miller、好望角芦荟Aloe ferox Miller或其他同属近缘植物叶的汁液浓缩干燥物。库拉索芦荟习称“老芦荟”，好望角芦荟习称“新芦荟”。 【性味】苦，寒。【归经】归肝、胃、大肠经。【功能主治】清肝热，通便。用于便秘，小儿疳积，惊风；外治湿癣。【用法用量】 2～5g。外用适量，研末敷患处。
发明内容
本发明旨在提供一种治疗单纯肥胖性脂肪肝的中药，通过选择合适的药材及其配比，达到安全有效治愈单纯肥胖性脂肪肝的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗单纯肥胖性脂肪肝的中药，其特征在于，由以下重量配比的药材制备而成：白术12份、冬瓜藤9份、菩提香9啤酒花6份、远志5份、茵陈6份、肉桂1份、黄芪9份、莱菔子10份、芦荟3份。
下面结合中医理论来说明本发明的有益效果：
发明人认为，单纯肥胖性脂肪肝，多是由于过食甘肥，脾失健运，导致肝失疏泄，湿浊结聚阻于肝络。因而治疗应在疏肝健脾的同时，抑制食欲，并通过泻下的方式排出过多的痰湿。本发明运用：
白术健脾益气燥湿利水，茵陈清湿热，菩提香平肝阳，芦荟清肝热、通便，黄芪补气托毒利尿，莱菔子降气化痰，冬瓜藤化痰通络，啤酒花安神利尿，远志安神益智，肉桂温阳散寒，诸药合用，从而疏肝健脾，排毒利湿，同时温补阳气、安神清心，降脂减肥，从根本上调理肥胖性脂肪肝。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年6月-2011年10月间共收集67例诊断为单纯肥胖性脂肪肝的门诊患者，年龄32-67岁，病程0.5-6年。随机分为：治疗组45例，空白组22例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 45 | 5（11.1%） | 34（75.6%) | 6(13.3%) | 0 | 86.7% |
| 空白组 | 22 | 0（0%） | 3（13.6%） | 19（86.4%） | 0 | 13.6% |
可见，本发明制得的药物能够安全有效治疗单纯肥胖性脂肪肝。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：白术12克、冬瓜藤9克、菩提香9啤酒花6克、远志5克、茵陈6克、肉桂1克、黄芪9克、莱菔子10克、芦荟3克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗单纯肥胖性脂肪肝。口服，每日分早晚两次服用。
具体实施例2
称取：白术12克、冬瓜藤9克、菩提香9啤酒花6克、远志5克、茵陈6克、肉桂1克、黄芪9克、莱菔子10克、芦荟3克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗单纯肥胖性脂肪肝。口服，每日分早晚两次服用。
具体实施例3
称取：白术12克、冬瓜藤9克、菩提香9啤酒花6克、远志5克、茵陈6克、肉桂1克、黄芪9克、莱菔子10克、芦荟3克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗单纯肥胖性脂肪肝。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗单纯肥胖性脂肪肝的中药，其特征在于，由以下重量配比的药材制备而成：白术12份、冬瓜藤9份、菩提香9份、啤酒花6份、远志5份、茵陈6份、肉桂1份、黄芪9份、莱菔子10份、芦荟3份。
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