CN103041037B - 一种治疗营养不良性脂肪肝的中药 - Google Patents
一种治疗营养不良性脂肪肝的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗营养不良性脂肪肝的中药，由以下重量配比的药材制备而成：白术8份、莱菔子5份、牡丹皮9份、木香6份、枸杞子10份、桂枝6份、夏天无12份。临床实验证明，本发明能够安全有效治疗营养不良性脂肪肝。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗营养不良性脂肪肝的中药。
背景技术
脂肪肝是一种多病因引起的脂肪在肝细胞内异常积累的病理状态。正常人的肝内总脂肪量，约占肝重的5%，内含磷脂、甘油三酯、脂酸、胆固醇及胆固醇脂。脂肪量超过5%为轻度脂肪肝，超过10%为中度脂肪肝，超过25% 为重度脂肪肝。当肝内总脂肪量超过30%时，用B超才能检查出来，被确诊为“脂肪肝”。而平时所说的脂肪肝患者，总脂量可达40%～50%，有些达60%以上。脂肪肝久治不愈则会发展成脂肪性肝炎、脂肪性肝硬化。
脂肪肝按病因可分为： 1、肥胖性脂肪肝2、酒精性脂肪肝3、快速减肥性脂肪肝4、营养不良性脂肪肝5、糖尿病脂肪肝6、药物性脂肪肝7、妊娠脂肪肝8、其他疾病引起的脂肪肝。
到目前为止，西药尚无防治脂肪肝的有效药物，以中药长期调理性的治疗最好。
本发明中药所涉及药材的研究现状如下：
白术【来源】本品为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。冬季下部叶枯黄、上部叶变脆时采挖，除去泥沙，烘干或晒干，再除去须根。【性味】苦、甘，温。【归经】归脾、胃经。【功能主治】健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。【用法用量】 6～12g。
莱菔子【来源】本品为十字花科植物萝卜Raphanus sativus L.的干燥成熟种子。夏季果实成熟时采割植株，晒干，搓出种子，除去杂质，再晒干。【性味】辛、甘，平。【归经】归肺、脾、胃经。【功能主治】消食除胀，降气化痰。用于饮食停滞，脘腹胀痛，大便秘结，积滞泻痢，痰壅喘咳。【用法用量】 4.5～9g。
牡丹皮【来源】本品为毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮。秋季采挖根部，除去细根，剥取根皮，晒干。【炮制】迅速洗净，润后切薄片，晒干。【性味】苦、辛，微寒。【归经】归心、肝、肾经。【功能主治】清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。【用法用量】 6～12g。
木香【来源】本品为菊科植物木香Aucklandia lappa Decne. 的干燥根。秋、冬二季采挖，除去泥沙及须根，切段，大的再纵剖成瓣，干燥后撞去粗皮。【性味】辛、苦，温。【归经】归脾、胃、大肠、三焦、胆经。【功能主治】行气止痛，健脾消食。用于胸脘胀痛，泻痢后重，食积不消，不思饮食。煨木香实肠止泻。用于泄泻腹痛。【用法用量】 1.5～6g。
枸杞子【来源】本品为茄科植物宁夏枸杞Lycium barbarum L. 的干燥成熟果实。夏、秋二季果实呈红色时采收，热风烘干，除去果梗。或晾至皮皱后，晒干，除去果梗。【性味】甘，平。【归经】归肝、肾经。【功能主治】滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。【用法用量】 6～12g。
桂枝【来源】本品为樟科植物肉桂 Cinnamomum cassia Presl的干燥嫩枝。春、夏二季采收，除去叶，晒干，或切片晒干。【性味】辛、甘，温。【归经】归心、肺、膀胱经。【功能主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【用法用量】 3～9g。
夏天无【来源】本品为罂粟科植物伏生紫堇Corydalis decumbens （Thunb.）Pers. 的干燥块茎。春季或初夏出苗后采挖，除去茎、叶及须根，洗净，干燥。【性味】苦、微辛，温。【归经】归肝经。【功能主治】活血通络，行气止痛。用于中风偏瘫，跌扑损伤，风湿性关节炎，坐骨神经痛。【用法用量】 6～12g，研末分3次服。
发明内容
本发明旨在提供一种治疗营养不良性脂肪肝的中药，通过选择合适的药材及其配比，达到安全有效治愈营养不良性脂肪肝的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗营养不良性脂肪肝的中药，其特征在于，由以下重量配比的药材制备而成：白术8份、莱菔子5份、牡丹皮9份、木香6份、枸杞子10份、桂枝6份、夏天无12份。
下面结合中医理论来说明本发明的有益效果：
发明人认为，营养不良性脂肪肝是由于长期肝胃不和而使得肝失疏泄、脾失健运，从而痰湿瘀滞。治疗应在健脾利湿的同时养血柔肝、益气活血的同时补肾养血。
本发明运用：白术健脾燥湿，夏天无活血行气，同时选用牡丹皮凉血活血利于养肝，又采用莱菔子、木香健脾消食，桂枝温阳化气，枸杞子滋补肝肾。诸药合用，才使得营养不良导致的脂肪肝患者在健脾活血的同时又得以清肝养血，在健脾胃的同时又辅以温阳化气，使补得以生化，同时加用枸杞子滋补肝肾，调节虚弱的体质，利于病情痊愈。缺一则不能达到如此良效。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年6月-2011年10月间共收集80例诊断为营养不良性脂肪肝的门诊患者，年龄14-67岁，病程0.5-6年。随机分为：治疗组50例，空白组30例。。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程15天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程15天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 不良反应例 | 总有效率(%) |
| 治疗组 | 50 | 10（20%） | 34（68%) | 6（12%) | 0 | 88% |
| 空白组 | 30 | 0 | 5（16.7%） | 25（83.3%） | 0 | 16.7% |
可见，本发明制得的药物能够安全有效治疗营养不良性脂肪肝。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：白术8克、莱菔子5克、牡丹皮9克、木香6克、枸杞子10克、桂枝6克、夏天无12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗营养不良性脂肪肝。口服，每日分早晚两次服用。
具体实施例2
称取：白术8克、莱菔子5克、牡丹皮9克、木香6克、枸杞子10克、桂枝6克、夏天无12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗营养不良性脂肪肝。口服，每日分早晚两次服用。
具体实施例3
称取：白术8克、莱菔子5克、牡丹皮9克、木香6克、枸杞子10克、桂枝6克、夏天无12克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗营养不良性脂肪肝。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗营养不良性脂肪肝的中药，其特征在于，由以下重量配比的药材制备而成：白术8份、莱菔子5份、牡丹皮9份、木香6份、枸杞子10份、桂枝6份、夏天无12份。
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| 夏天无药理作用研究进展;马宏达等;《中国药房》;20081231;第19卷(第36期);2867-2869 * |
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