CN106389965A - 一种治疗糖尿病的中药组合物及其制备方法 - Google Patents
一种治疗糖尿病的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明提供一种治疗糖尿病的中药组合物及其制备方法,该中药组合物包括如下重量份的原料:绞股蓝27‑32份、山查27‑32份、翻白草27‑32份、黄连4‑6份、黄芪27‑32份、黄精19‑21份、隔山撬19‑21份、麦芽19‑21份、葛根19‑21份、川谷根29‑32份。本发明经过大量实例验证,对糖尿病疗效显著,无毒副作用。
Description
技术领域
本发明涉及中医药领域,特别是涉及一种治疗糖尿病的中药组合物及其制备方法。
背景技术
糖尿病是一组以高血糖为特征的代谢性疾病。高血糖则是由于胰岛素分泌缺陷或其生物作用受损,或两者兼有而引起。糖尿病患者长期存在高血糖,导致各种组织,特别是眼、肾、心脏、血管、神经的慢性损害、功能障碍。
糖尿病是人类第二杀手,以高血糖为特征的代谢性疾病,它对各器官的损害等同于高烧患者肾火上升,难以平抑所致。现有的药物副作用大,疗效欠佳。
发明内容
鉴于以上所述现有技术的缺点,本发明的目的在于提供一种治疗糖尿病的中药组合物及其制备方法,用于解决现有技术中糖尿病药物疗效欠佳、副作用大等问题。
为实现上述目的及其他相关目的,本发明第一方面提供一种治疗糖尿病的中药组合物,包括如下重量份的原料:绞股蓝27-32份、山查27-32份、翻白草27-32份、黄连4-6份、黄芪27-32份、黄精19-21份、隔山撬19-21份、麦芽19-21份、葛根19-21份、川谷根29-32份。
进一步地,包括如下重量份的原料:绞股蓝30份、山查30份、翻白草30份、黄连5份、黄芪30份、黄精20份、隔山撬20份、麦芽20份、葛根20份、川谷根30份。
本发明第二方面提供利用上述组合物制得的提取物。
本发明第三方面提供上述提取物的制备方法,按配方量将各原料制成粉末,加水熬制,静置,制得的上清液即为所述提取物。
优选地,将各原料制成70-90目的粉末。
优选地,将各原料制成80目的粉末。
进一步地,加入水的重量为原料药总重量的7-9倍。
更进一步地,加入水的重量为原料药总重量的8倍。
进一步地,加水熬制的时间为15-20分钟,即水开后15-20分钟。
本发明第四方面提供上述组合物或提取物在制备治疗糖尿病药物中的应用。
如上所述,本发明的一种治疗糖尿病的中药组合物及其制备方法,具有以下有益效果:中医认为糖尿病根源在肾上,本发明经过大量实例验证,对糖尿病疗效显著,无毒副作用。
各原料药的来源及主要功效如下:
绞股蓝:又称天堂草、福音草、超人参、公罗锅底、遍地生根、七叶胆、五叶参和七叶参等,拉丁文名Gynostemma pentaphyllum(Thunb.)Makino,葫芦科、绞股蓝属草质攀援植物。有消炎解毒、止咳祛痰的功效。
山查:为蔷薇科植物山里红Crataegus pinnatifida Bge.var.major N.E.Br.或山楂Crataegus pinnatifida Bge.的干燥成熟果实。秋季果实成熟时采收,切片,干燥。消食化滞,散瘀止痛。果实主治肉食积滞、消化不良、小儿疳积、细菌性痢疾、肠炎、产后腹痛、高血压病、绦虫病、冻疮等。
翻白草:学名Potentilla discolor Bge.,蔷薇科、委陵菜属多年生草本,味甘、微苦,性平,无毒。药理作用包括清热、解毒、止血、消肿。治痢疾、疟疾、肺痈、咳血、吐血、下血、崩漏、痈肿、疮癣、瘰疬结核等。
黄连:毛茛科植物黄连Coptis chinensis Franch.、三角叶黄连Coptisdeltoidea C.Y.Cheng et Hsiao或云连Coptis teeta Wall.的干燥根茎。味苦,性寒。归心、脾、胃、肝、胆、大肠经。清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴,痈肿疔疮;外治湿疹,湿疮,耳道流脓。
黄芪:又名绵芪。多年生草本,拉丁学名Astragalus membranaceus(Fisch.)Bunge.,味甘,性微温,归肺、脾、肝、肾经。主治表虚自汗、阴虚盗汗、急性肾炎水肿、慢性肾炎水肿、阳气虚弱、疮疡溃破、肺气虚证、气虚衰弱等。
黄精:百合科植物滇黄精Polygonatum kingianum Coll.et Hemsl.、黄精Polygonatum sibiricum Red.或多花黄精Polygonatum cyrtonema Hua的干燥根茎。味甘,性平。归脾、肺、肾经。补气养阴,健脾,润肺,益肾。用于脾胃虚弱,体倦乏力,口干食少,肺虚燥咳,精血不足,内热消渴。
隔山撬:别名为白首乌[吉林]、白奶奶、豆角蛤蜊、过山飘、无粱藤等,萝藦科牛皮消属植物隔山消Cynanchum wilfordii(Maxim.)Hemsl.,以块根入药。秋季采,晒干,润透,切片。补益肝肾,强筋壮骨。用于神经衰弱,阳痿,遗精,腰腿疼痛。
麦芽:禾本科植物大麦Hordeum vulgare L.的成熟果实经发芽干燥而得。将麦粒用水浸泡后,保持适宜温、湿度,待幼芽长至约0.5cm时,晒干或低温干燥。味甘,性平。归脾、胃经。行气消食,健脾开胃,退乳消胀。用于食积不消,脘腹胀痛,脾虚食少,乳汁郁积,乳房胀痛,妇女断乳。
葛根:豆科植物野葛Pueraria lobata(Willd.)Ohwi或甘葛藤Puerariathomsonii Benth.的干燥根。味甘、辛,性凉。归脾、胃经。解肌退热,生津,透疹,升阳止泻。用于外感发热头痛、项背强痛、消渴、麻疹不透、热痢、泄泻、高血压颈项强痛。
川谷根:又名五谷子根。拉丁学名Coix lacryma-jobi L.var.monilifer Watt,归脾、膀胱经,清热利湿,通淋止血,消积杀虫。
本发明对于人体内脏有协调作用,直指患者病灶,对任何类型糖尿病都适用。
具体实施方式
以下通过特定的具体实例说明本发明的实施方式,本领域技术人员可由本说明书所揭露的内容轻易地了解本发明的其他优点与功效。本发明还可以通过另外不同的具体实施方式加以实施或应用,本说明书中的各项细节也可以基于不同观点与应用,在没有背离本发明的精神下进行各种修饰或改变。
实施例1
一种治疗糖尿病的中药组合物,包括如下重量的原料:绞股蓝30g、山查30g、翻白草30g、黄连5g、黄芪30g、黄精20g、隔山撬20g、麦芽20g、葛根20g、川谷根30g。
将上述配方中的各原料研成细粉,加水煎开后,继续熬制15分钟,静置至上清液澄清,上清液即为药液,分早、中、晚三次空腹喝上清液。第二天又将药渣加水再煎。在实际案例中发现,原料药经研细后制得的上清液药效比未研细原料药制得的上清液药效提高约40%,长期治疗证明本发明无任何毒副作用。
临床实验
1、诊断标准
按照ADA糖尿病诊断标准:
(1)糖化血红蛋白Alc≥6.5%;
(2)空腹血糖FPG≥7.0mmol/L;空腹定义为至少8h内无热量摄入。
(3)口服糖耐量试验时2h血糖≥11.1mmol/L。
(4)在伴有典型的高血糖或高血糖危象症状的患者,随机血糖≥11.1mmol/L。
(5)在无明确高血糖时,应通过重复检测来证实标准1-3.
2、一般资料
采用本发明共医治符合上述诊断标准的病例198例,其中男125例,女73例,年龄35~60岁,平均45岁;病程最短半年,最长18年。
3、疗效标准
痊愈:治疗后症状全部消失,空腹血糖<7.2mmol/L,(130mg/dL),餐后2小时血糖<8.3mmol/L(150mg/dL),24小时尿糖总量<10.0g,或血糖较治疗前下降30%以上。
有效:治疗后症状明显改善,空腹血糖<8.3mmol/L,(150mg/dL),餐后2小时血糖<10.0mmol/L(180mg/dL),24小时尿糖总量<25.0g,或血糖较治疗前下降10%以上。
无效:治疗后症状无明显改善,血糖下降未达到上述标准。
表1 治疗结果统计表
痊愈时间 | 例数 |
治疗后1周 | 5 |
治疗后2周 | 18 |
治疗后3周 | 30 |
治疗后4周 | 55 |
治疗后5周 | 63 |
治疗后6周 | 20 |
治疗后7周 | 7 |
从上表1可以看出,采用本发明医治的198人中,无一例未痊愈,痊愈率高达100%。
典型病例:
1、朱某,男,52岁,家住荣昌区恒荣半岛,患糖尿病17年,糖尿病并发症均现。服药9副,血糖降至6mmol/L以下,各种病症消失,痊愈。
2、张某,女,52岁,家住荣昌区花园街,患糖尿病7年,血糖长期在10mmol/L左右,浑身无力,消瘦,连续服药10副,一切症状消失,痊愈。
3、李某,男,42岁,江苏南通人,患糖尿病3年,头胀神志不清,四肢发热,上海各大医院治疗无效,且危及生命,在我处连续服药12副,痊愈。
4、朱某,男,55岁,家住荣昌区东门桥,患糖尿病9年,小便失禁,气喘出粗气,心慌意乱,行走300米就停下来休息,性功能全无,连续服药12副,逐渐康复。
5、王某,男,43岁,家住荣昌区路孔镇街道办事处,患者头脑发昏,体重下降40多斤,眼睛雾,分不清人和物。连续服药15副,一切病症消失,体重增重12斤,且康复。
病人康复后,每隔10天还应服药1副,6个月停药,不复发。每副药可重复用三天。
综上所述,本发明经过大量的实际案例验证,对糖尿病疗效显著,并且无毒副作用,展现中药的独到之处,弘扬了中医药文化。
上述实施例仅例示性说明本发明的原理及其功效,而非用于限制本发明。任何熟悉此技术的人士皆可在不违背本发明的精神及范畴下,对上述实施例进行修饰或改变。因此,举凡所属技术领域中具有通常知识者在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变,仍应由本发明的权利要求所涵盖。
Claims (10)
1.一种治疗糖尿病的中药组合物,其特征在于,包括如下重量份的原料:绞股蓝27-32份、山查27-32份、翻白草27-32份、黄连4-6份、黄芪27-32份、黄精19-21份、隔山撬19-21份、麦芽19-21份、葛根19-21份、川谷根29-32份。
2.根据权利要求1所述的治疗糖尿病的中药组合物,其特征在于,包括如下重量份的原料:绞股蓝30份、山查30份、翻白草30份、黄连5份、黄芪30份、黄精20份、隔山撬20份、麦芽20份、葛根20份、川谷根30份。
3.一种利用如权利要求1或2所述的中药组合物制得的中药提取物。
4.一种根据权利要求3所述的中药提取物的制备方法,其特征在于:按配方量将各原料制成粉末,加水熬制,静置,制得的上清液即为所述提取物。
5.根据权利要求4所述的制备方法,其特征在于:将各原料制成70-90目的粉末。
6.根据权利要求5所述的制备方法,其特征在于:将各原料制成80目的粉末。
7.根据权利要求4所述的制备方法,其特征在于:加入水的重量为原料药总重量的7-9倍。
8.根据权利要求7所述的制备方法,其特征在于:加入水的重量为原料药总重量的8倍。
9.根据权利要求4所述的制备方法,其特征在于:加水熬制的时间为15-20分钟。
10.根据权利要求1或2所述的中药组合物、根据权利要求3所述的中药提取物在制备治疗糖尿病药物中的应用。
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