CN110946950A - 一种治疗老年期血管性痴呆的中药组合物及其制备方法 - Google Patents
一种治疗老年期血管性痴呆的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗老年期血管性痴呆的中药组合物及其制备方法，包括下述中药材原料：天麻11～16份、灯盏花13～19份、茯神8～14份、杜仲7～12份、马钱子4～7份、女贞子7～14份、葛根5～9份、银杏叶4～8份或甘草4～7份。本发明，对老年期血管性痴呆具有明显的改善作用，同时还具有抗疲劳的作用，能增加脑血流量和脑能量代谢。对中枢神经系统有明显的镇静作用。在有效地防治脑血管性疾病的同时改善患者的认知功能障碍。具有综合防治脑血管疾病，提高患者的认知功能的效果。本发明制备方法采用传统方法和现代方法相结合的工艺，操作方便，同时有效成分最大限度保留。
Description
技术领域
本发明涉及中药组合物技术领域，具体为一种治疗老年期血管性痴呆的中药组合物及其制备方法。
背景技术
血管性痴呆是老年期痴呆中最常见的类型之一，在我国仅次于Alzheimer病，它是由脑血管疾病所导致的一种痴呆综合症。随着我国寿命的不断增加，脑卒中发生率也不断升高，因此血管性痴呆的发病率也有明显上升的趋势。由于此病给患者及家庭都会带来极大的困难，因此对此病的预防及预后的研究就显得极为重要。
发明内容
为解决上述技术问题，本发明提供一种治疗老年期血管性痴呆的中药组合物及其制备方法，该中药组合物制造简单，毒副作用小、疗效佳，效果明显。
本发明的目的之一在于，提供一种治疗老年期血管性痴呆的中药组合物，其包括下述中药材原料：
天麻11～16份、灯盏花13～19份、茯神8～14份、杜仲7～12份、马钱子4～7份、女贞子7～14份、葛根5～9份、银杏叶4～8份或甘草4～7份。
进一步地，所述的中药组合物的中药材原料包括：
天麻12～15份、灯盏花14～18份、茯神9～13份、杜仲8～11份、马钱子5～6份、女贞子8～12份、葛根6～8份、银杏叶5～7份或甘草5～6份。
进一步地，所述的中药组合物的中药材原料包括：
天麻14份、灯盏花15份、茯神11份、杜仲10份、马钱子6份、女贞子10份、葛根7份、银杏叶6份或甘草6份。
根据本发明的另一个目的，提供上述治疗老年期血管性痴呆的中药组合物的制备方法，其步骤包括：
S1，取上述重量份的天麻、灯盏花、茯神、杜仲、马钱子、女贞子、葛根、银杏叶或甘草，加水提取，得提取液；
S2，将上述步骤制得的提取液浓缩至成一次浸膏；
S3，在一次浸膏中加入乙醇至含醇量体积百分比浓度为55％～65％，搅拌均匀，静置，滤过，滤液浓缩至具有活性成分的二次浸膏；
S4，将二次浸膏加工成颗粒剂。
进一步地，S1中，加水提取的次数为3～4次，每次加入相当于药材总重量12～15倍的水，提取时间为3.5～4.5小时。
进一步地，S2中，提取液浓缩成85℃时相对密度为1.15～1.25的一次浸膏。
进一步地，S3中，静置时间不小于10小时。
进一步地，S3中，二次浸膏为65℃时相对密度为1.15～1.25的二次浸膏。
进一步地，S4中，将二次浸膏制成颗粒剂时，添加蔗糖作为辅料，蔗糖的添加量为30％以下。
以下，对本发明的上述原料的性质等稍作说明：
天麻：具有息风止痉，平抑肝阳，祛风通络的功效。主治肝风内动，惊痫抽搐，眩晕，头痛，肢体麻木，手足不遂，风湿痹痛等。
灯盏花：甘，温。散寒解表，活血舒筋，止痛，消积。治风湿痹痛，瘫痪。
茯神：宁心，安神，利水。治心虚惊悸，健忘，失眠，惊痫，小便不利。
杜仲：补肝肾，强筋骨，安胎。治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，高血压。
马钱子：苦、温。有通络止痛，散结消肿的作用。用于跌打损伤，骨折肿痛，风湿顽痹，麻木瘫痪，痈疽疮毒，咽喉肿痛。。
女贞子：味甘、苦，归肝、肾二经，有滋阴益寿、补益肝肾、清热明目、乌须黑发等功效。
葛根：甘、辛，凉。有解肌退热，透疹，生津止渴，升阳止泻之功。常用于表证发热，项背强痛，麻疹不透，热病口渴，阴虚消渴，热泻热痢，脾虚泄泻。
银杏叶：具有活血化瘀，通络止痛，敛肺平喘，化浊降脂的功效。用于瘀血阻络，胸痹心痛，中风偏瘫，肺虚咳喘，高脂血症。
甘草：具有补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药之功效。常用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
本发明的有益效果是：
本发明治疗老年期血管性痴呆的中药组合物，对老年期血管性痴呆具有明显的改善作用，同时还具有抗疲劳的作用，能增加脑血流量和脑能量代谢。对中枢神经系统有明显的镇静作用。在有效地防治脑血管性疾病的同时改善患者的认知功能障碍。具有综合防治脑血管疾病，提高患者的认知功能的效果。本发明的制备方法采用传统方法和现代方法相结合的工艺，操作方便，同时有效成分最大限度保留。
具体实施方式
下面将结合本发明具体实施例，对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种治疗老年期血管性痴呆的中药组合物颗粒剂的制备：
原料包括：天麻11份、灯盏花13份、茯神8份、杜仲7份、马钱子4份、女贞子7份、葛根5份、银杏叶4份、甘草4份；
制备方法：取天麻11份、灯盏花13份、茯神8份、杜仲7份、马钱子4份、女贞子7份、葛根5份、银杏叶4份或甘草4份，加入相当于药材总重量12倍的水，提取3.5小时，提取3次，得提取液；将3次提取的提取液混合，浓缩成85℃时相对密度为1.15～1.25的一次浸膏；在一次浸膏中加入乙醇至含醇量体积百分比浓度为55％，搅拌均匀，静置12小时，滤过，滤液浓缩至65℃时相对密度为1.15～1.25的二次浸膏；将二次浸膏中加入蔗糖，加工成颗粒剂，蔗糖的添加量为15％。
实施例2
一种治疗老年期血管性痴呆的中药组合物颗粒剂的制备：
原料包括：天麻14份、灯盏花15份、茯神11份、杜仲10份、马钱子6份、女贞子8份、葛根7份、银杏叶6份或甘草6份；
制备方法：天麻14份、灯盏花15份、茯神11份、杜仲10份、马钱子6份、女贞子8份、葛根7份、银杏叶6份或甘草6份，加入相当于药材总重量15倍的水，提取4.5小时，提取4次，得提取液；将4次提取的提取液混合，浓缩成85℃时相对密度为1.15～1.25的一次浸膏；在一次浸膏中加入乙醇至含醇量体积百分比浓度为65％，搅拌均匀，静置18小时，滤过，滤液浓缩至65℃时相对密度为1.15～1.25的二次浸膏；将二次浸膏中加入蔗糖，加工成颗粒剂，蔗糖的添加量为25％。
实施例3
一种治疗老年期血管性痴呆的中药组合物颗粒剂的制备：
原料包括：天麻16份、灯盏花19份、茯神4份、杜仲12份、马钱子7份、女贞子14份、葛根9份、银杏叶8份或甘草7份；
制备方法：天麻16份、灯盏花19份、茯神4份、杜仲12份、马钱子7份、女贞子14份、葛根9份、银杏叶8份、甘草7份，加入相当于药材总重量13倍的水，提取4小时，提取4次，得提取液；将4次提取的提取液混合，浓缩成85℃时相对密度为1.15～1.25的一次浸膏；在一次浸膏中加入乙醇至含醇量体积百分比浓度为60％，搅拌均匀，静置24小时，滤过，滤液浓缩至65℃时相对密度为1.15～1.25的二次浸膏；将二次浸膏中加入蔗糖，加工成颗粒剂，蔗糖的添加量为18％。
实施例4
上述治疗老年期血管性痴呆的中药组合物的服用方法为：每次服用30克，一日三次，饭前一小时服用，温水送服，服药过程中不宜食凉、辣食物。
本发明治疗老年期血管性痴呆的中药组合物经临床治疗，疗效显著。下面是采用本发明的治疗老年期血管性痴呆的临床试验，病例治疗结果如下：
根据本发明实施例1-3制备的制剂，对老年期血管性痴呆进行临床试验。用药3次/日，每次30g，临床观察显示，本发明中药组合物对老年期血管性痴呆的100例病例的总有效率为72.5％，其中显效率为40.5％，有效率占32％。治疗过程患者未出现不良副反应。
具体病例
1、周某，男，75岁，患者4年前出现说话减少，反应迟钝，以近记忆障碍为主，出现多次大小便失禁现象。医院就诊后，未恢复正常，未服用其他药物。
服用本发明中药组合物治疗两个疗程后，临床症状均有明显好转，继续治疗一个疗程后，生活基本自理，记忆力恢复，可与家人进行交谈。
2、赵某某，女，78岁，记忆力进行性减退，理解能力障碍，善惊易怒，失眠多梦，诊断为老年血管性痴呆。经服本发明的中药组合物治疗两个疗程，症状基本消失，继服1个疗程后巩固，1年未复发。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (9)
1.一种治疗老年期血管性痴呆的中药组合物，其特征在于，包括下述中药材原料：天麻11～16份、灯盏花13～19份、茯神8～14份、杜仲7～12份、马钱子4～7份、女贞子7～14份、葛根5～9份、银杏叶4～8份或甘草4～7份。
2.根据权利要求1所述的一种治疗老年期血管性痴呆的中药组合物，其特征在于，所述的中药组合物的中药材原料包括：天麻12～15份、灯盏花14～18份、茯神9～13份、杜仲8～11份、马钱子5～6份、女贞子8～12份、葛根6～8份、银杏叶5～7份或甘草5～6份。
3.根据权利要求1所述的一种治疗老年期血管性痴呆的中药组合物，其特征在于，所述的中药组合物的中药材原料包括：天麻14份、灯盏花15份、茯神11份、杜仲10份、马钱子6份、女贞子10份、葛根7份、银杏叶6份或甘草6份。
4.根据权利要求1-3任一所述的一种治疗老年期血管性痴呆的中药组合物的制备方法，其特征在于，其步骤包括：
S1，取上述重量份的天麻、灯盏花、茯神、杜仲、马钱子、女贞子、葛根、银杏叶或甘草，加水提取，得提取液；
S2，将上述步骤制得的提取液浓缩至成一次浸膏；
S3，在一次浸膏中加入乙醇至含醇量体积百分比浓度为55％～65％，搅拌均匀，静置，滤过，滤液浓缩至具有活性成分的二次浸膏；
S4，将二次浸膏加工成颗粒剂型或胶囊剂型。
5.根据权利要求4所述的一种治疗老年期血管性痴呆的中药组合物的制备方法，其特征在于，S1中，加水提取的次数为3～4次，每次加入相当于药材总重量12～15倍的水，提取时间为3.5～4.5小时。
6.根据权利要求4所述的一种治疗老年期血管性痴呆的中药组合物的制备方法，其特征在于，S2中，提取液浓缩成85℃时相对密度为1.15～1.25的一次浸膏。
7.根据权利要求4所述的一种治疗老年期血管性痴呆的中药组合物的制备方法，其特征在于，S3中，静置时间不小于10小时。
8.根据权利要求4所述的一种治疗老年期血管性痴呆的中药组合物的制备方法，其特征在于，S3中，二次浸膏为65℃时相对密度为1.15～1.25的二次浸膏。
9.根据权利要求4所述的一种治疗老年期血管性痴呆的中药组合物的制备方法，其特征在于，S4中，将二次浸膏制成颗粒剂时，添加蔗糖作为辅料，蔗糖的添加量为30％以下。
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