CN102935214B - 一种治疗尿毒症的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗尿毒症的中药组合物，属于中药技术领域。它是由下述重量的原料药制成：淫羊藿30g、枸杞子20g、肉苁蓉15g、党参15g、当归10g、熟地黄10g、蒲公英10g、牡丹皮12g、茯苓20g、桂枝15g、泽泻15g、丹参10g、川芎10g、生姜10g、车前草10g。该中药组合物价格低廉、服用方便，治疗效果好。
Description
技术领域
本发明涉及一种治疗尿毒症的中药组合物，属于中药技术领域。
背景技术
慢性肾衰竭是指各种肾脏病导致肾脏功能渐进性不可逆性减退，直至功能丧失所出现的一系列症状和代谢紊乱所组成的临床综合症，简称慢性肾衰。慢性肾衰的终末期即为人们常说的尿毒症。尿毒症不是一个独立的疾病，而是各种晚期的肾脏病共有的临床综合症，是慢性肾功能衰竭进入终末阶段时出现的一系列临床表现所组成的综合症。
目前，透析（人工肾）疗法和肾移植为治疗尿毒症的有效方法，但是由于手术费昂贵且肾源紧缺，一般患者只得望而却步。目前治疗尿毒症的药物，其治疗效果不理想，治愈率不高。
发明内容
本发明克服了现有技术的不足，提供了一种治疗尿毒症的中药组合物，该中药组合物服用方便，治疗效果好。
本发明的技术方案是：一种治疗尿毒症的中药组合物，其特征是，它是由下述重量的原料药制成：淫羊藿30g、枸杞子20g、肉苁蓉15g、党参15g、当归10g、熟地黄10g、蒲公英10g、牡丹皮12g、茯苓20g、桂枝15g、泽泻15g、丹参10g、川芎10g、生姜10g、车前草10g。
制备方法：水煎煮，每日1剂，分两次早晚服用。
各中药药理作用
淫羊藿：补肾阳，强筋骨，祛风湿。用于阳痿遗精，筋骨痿软，风湿痹痛，麻木拘挛；更年期高血压。
枸杞子：补肾益精，养肝明目，补血安神，生津止渴，润肺止咳。治肝肾阴亏，腰膝酸软，头晕，目眩，虚劳咳嗽，消渴，遗精。
肉苁蓉：甘酸咸，温。归经：归肾，大肠经。功效：补肾益精，润燥滑肠。主治：用于男子阳痿，女子不孕，带下，血崩，腰膝冷痛，血枯便秘。
党参：甘，平。归经：归脾，肺经。功效：补中益气，健脾益肺。主治：用于脾肺虚弱，气短心悸，食少便溏，虚喘咳嗽，内热消渴。
当归：甘辛，温。归经：归心，肝，脾经。功效：补血活血，调经止血，润燥滑肠。主治：用于月经不调，经闭腹痛，积聚，崩漏，血虚头痛，眩晕，痿痹，肠燥便难，赤痢后重，痈疽疮疡，跌打损伤。
熟地黄：甘，微温。归经：归肝，肾经。功效：滋阴补血。主治：用于阴虚血少，腰膝酸弱，劳嗽骨蒸，遗精，崩漏，月经不调，消渴，溲数，耳聋，目昏。
蒲公英：清热解毒 可用于热毒证，尤善清肝热，治疗肝热目赤肿痛，以及多种感染、化脓性疾病。
牡丹皮：苦、辛，微寒。归心、肝、肾经。清热凉血，活血散瘀。主治温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，跌扑伤痛，痈肿疮毒。
茯苓：甘淡，平。归经：归心，脾，肺经。功效：渗湿利水，益脾和胃，宁心安神。主治：用于小便不利，水肿胀满，痰饮咳逆，呕哕泄泻，遗精淋浊，惊悸健忘。
桂枝：辛甘，温。归经：归膀胱，心，肺经。功效：发汗解肌，温经通脉。主治：用于风寒表证，肩背肢节酸痛，胸痹痰饮，经闭症瘕。
泽泻：甘，寒。归经：归肾，膀胱经，功效：利水，渗湿，泻热。主治：用于小便不利，水肿胀满，呕吐，泻痢，痰饮，脚气，淋病，尿血。
丹参：苦，微寒。归心、肝经。活血调经，祛瘀止痛，凉血消痈，清心除烦，养血安神。主治：月经不调，经闭痛经， 症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
川芎：味辛，性温。归肝、胆、心包经。能活血行气，祛风止痛。用于安抚神经，正头风头痛，症瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
生姜：辛、微温，归肺脾胃经。发汗解表，温中止呕，温肺止咳，解鱼蟹毒，解药毒。
车前草：车前草是利水渗湿中药，主治：主小便不利、淋浊带下、水肿胀满、暑湿泻痢、目赤障翳、痰热咳喘。
在本组方中，淫羊藿、枸杞子、肉苁蓉补肾阳，益精血，强筋骨；党参补气，当归配以熟地黄、川芎补血能力加强，使攻邪而不伤正。扶正攻邪，正切中尿毒症久病虚寒的病变本质；泽泻、茯苓、桂枝和车前草通利小便；蒲公英和生姜清热解毒，牡丹皮和丹参活血散瘀。各原料药共同作用，从而达到治愈尿毒症的作用。
本发明的有益效果是：该中药组合物价格低廉、服用方便，治疗效果好。
以下结合临床资料和典型病例来进一步说明其有益效果。
一、临床资料
1.临床资料：选自2010.1-2011.1的门诊病人100例，其中男性64例，女性36例；年龄13～70岁，病程0.5-24年。
2.诊断标准：（1）内生肌酐清除率（CCr）＜25%；（2）血肌酐(Cr) ＞451 umol/L；（3）血尿素氮（BUN）＞17.9 mmol/L；（4）明显贫血，消化道症状；（5）代谢性酸中毒。
3.治疗方法：本发明中药组合物每日1剂，分早晚服用。
4.疗效评定标准：（1）临床痊愈：症状完全消失，观察项目大部分在正常范围，随访半年无复发；（2）显效：BUN下降≥30%，Cr下降≥30%，症状减轻或消失；（3）有效：BUN、Cr均下降≥20%，症状改善；（4）稳定BUN，Cr无恶化或略有下降，症状有改善；（5）治疗前后症状或体征不减轻或加重，BUN、Cr无明显改善或较治疗前升高。
5、治疗结果：临床痊愈：92例，显效5例，有效3例，总有效率为100%。
二、典型病例
病例1 王某，男，30岁。慢性肾炎2年。1月前尿少甚至无尿，恶心呕吐不食，嗜睡。医院检查BUN25mmol/L，西医诊为尿毒症。2010年3月接受本发明中药药物治疗。2个月后，化验正常，停药观察，至今未有复发。
病例2 王某，女，46岁。患者两年前曾患肾小球肾炎，经治疗恢复正常后，2010.5月感觉头晕目眩，周身无力，恶心呕吐。医院检查BUN28mmol/L，西医诊为尿毒症。2010年7月接受本发明中药药物治疗。3个月后，化验正常，停药观察，至今未有复发。
病例3 张某，男，57岁。膀胱结石，肾积水病史6个月。医院检查BUN30mmol/L，西医诊为尿毒症。2010年5月接受本发明中药药物治疗。3个月后，化验正常，诸症消失，停药观察，至今未有复发。
病例4 刘某，男，67岁，2型糖尿病3年。2个月前发现尿少，肢肿，精神恍惚，烦躁。查BUN27mmol/L，诊为尿毒症，于2010年5月接受本发明中药药物治疗，2个月后痊愈，停药观察，至今未有复发。
具体实施方式
实施例1
配比：淫羊藿30g、枸杞子20g、肉苁蓉15g、党参15g、当归10g、熟地黄10g、蒲公英10g、牡丹皮12g、茯苓20g、桂枝15g、泽泻15g、丹参10g、川芎10g、生姜10g、车前草10g。
制备方法：水煎煮，每日1剂，分两次早晚服用。
Claims (1)
1.一种治疗尿毒症的中药组合物，其特征是，它是由下述重量的原料药制成：淫羊藿30g、枸杞子20g、肉苁蓉15g、党参15g、当归10g、熟地黄10g、蒲公英10g、牡丹皮12g、茯苓20g、桂枝15g、泽泻15g、丹参10g、川芎10g、生姜10g、车前草10g。
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