CN116847843A - 用于治疗快感缺乏的电压门控的钾通道开放剂 - Google Patents

用于治疗快感缺乏的电压门控的钾通道开放剂 Download PDF

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Publication number
CN116847843A
CN116847843A CN202280014279.1A CN202280014279A CN116847843A CN 116847843 A CN116847843 A CN 116847843A CN 202280014279 A CN202280014279 A CN 202280014279A CN 116847843 A CN116847843 A CN 116847843A
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S·N·皮姆斯顿
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Xenon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Shovels (AREA)
  • Ignition Installations For Internal Combustion Engines (AREA)
CN202280014279.1A 2021-02-09 2022-02-09 用于治疗快感缺乏的电压门控的钾通道开放剂 Pending CN116847843A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163147742P 2021-02-09 2021-02-09
US63/147,742 2021-02-09
PCT/US2022/015854 WO2022173855A1 (en) 2021-02-09 2022-02-09 Voltage-gated potassium channel opener for use in treating anhedonia

Publications (1)

Publication Number Publication Date
CN116847843A true CN116847843A (zh) 2023-10-03

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CN202280014279.1A Pending CN116847843A (zh) 2021-02-09 2022-02-09 用于治疗快感缺乏的电压门控的钾通道开放剂

Country Status (15)

Country Link
US (3) US11957675B2 (https=)
EP (1) EP4291189A1 (https=)
JP (1) JP2024508660A (https=)
KR (1) KR20240004241A (https=)
CN (1) CN116847843A (https=)
AU (1) AU2022220675A1 (https=)
CA (1) CA3207191A1 (https=)
CL (1) CL2023002321A1 (https=)
GE (1) GEAP202416348A (https=)
IL (1) IL304920A (https=)
MA (1) MA61732A1 (https=)
MX (1) MX2023009314A (https=)
PE (1) PE20231815A1 (https=)
TW (1) TW202245744A (https=)
WO (1) WO2022173855A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022005490A (es) 2019-11-08 2022-08-10 Xenon Pharmaceuticals Inc Metodos para el tratamiento de trastornos depresivos.
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia
US20220288057A1 (en) * 2021-02-09 2022-09-15 Xenon Pharmaceuticals Inc. Conjoint therapy for treating seizure disorders
WO2025034745A1 (en) * 2023-08-07 2025-02-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 4-aminopiperidines as selective modulators of potassium channels
TW202541796A (zh) * 2023-12-28 2025-11-01 美商查斯治療公司 用於治療失樂症的組成物及方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101563085A (zh) * 2006-08-23 2009-10-21 威朗国际制药公司 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺的衍生物
CN109689055A (zh) * 2016-05-25 2019-04-26 田边三菱制药株式会社 用于治疗非精神分裂症患者中的阴性症状的组合物和方法
US20190343823A1 (en) * 2018-05-11 2019-11-14 Xenon Pharmaceuticals Inc. Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener

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KR20240004241A (ko) 2024-01-11
MX2023009314A (es) 2023-08-16
PE20231815A1 (es) 2023-11-16
GEAP202416348A (en) 2024-01-10
US11957675B2 (en) 2024-04-16
CL2023002321A1 (es) 2024-03-08
MA61732A1 (fr) 2024-01-31
JP2024508660A (ja) 2024-02-28
IL304920A (en) 2023-10-01
CA3207191A1 (en) 2022-08-18
WO2022173855A1 (en) 2022-08-18
AU2022220675A1 (en) 2023-09-21
TW202245744A (zh) 2022-12-01
US20240408076A1 (en) 2024-12-12
EP4291189A1 (en) 2023-12-20
US12171759B1 (en) 2024-12-24
US20250186426A1 (en) 2025-06-12
US20220265634A1 (en) 2022-08-25

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