CA3207191A1 - Voltage-gated potassium channel opener for use in treating anhedonia - Google Patents

Voltage-gated potassium channel opener for use in treating anhedonia Download PDF

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Publication number
CA3207191A1
CA3207191A1 CA3207191A CA3207191A CA3207191A1 CA 3207191 A1 CA3207191 A1 CA 3207191A1 CA 3207191 A CA3207191 A CA 3207191A CA 3207191 A CA3207191 A CA 3207191A CA 3207191 A1 CA3207191 A1 CA 3207191A1
Authority
CA
Canada
Prior art keywords
compound
disorder
human
anhedonia
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3207191A
Other languages
English (en)
French (fr)
Inventor
Simon Neil PIMSTONE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of CA3207191A1 publication Critical patent/CA3207191A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Shovels (AREA)
  • Ignition Installations For Internal Combustion Engines (AREA)
CA3207191A 2021-02-09 2022-02-09 Voltage-gated potassium channel opener for use in treating anhedonia Pending CA3207191A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163147742P 2021-02-09 2021-02-09
US63/147,742 2021-02-09
PCT/US2022/015854 WO2022173855A1 (en) 2021-02-09 2022-02-09 Voltage-gated potassium channel opener for use in treating anhedonia

Publications (1)

Publication Number Publication Date
CA3207191A1 true CA3207191A1 (en) 2022-08-18

Family

ID=80445983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3207191A Pending CA3207191A1 (en) 2021-02-09 2022-02-09 Voltage-gated potassium channel opener for use in treating anhedonia

Country Status (15)

Country Link
US (3) US11957675B2 (https=)
EP (1) EP4291189A1 (https=)
JP (1) JP2024508660A (https=)
KR (1) KR20240004241A (https=)
CN (1) CN116847843A (https=)
AU (1) AU2022220675A1 (https=)
CA (1) CA3207191A1 (https=)
CL (1) CL2023002321A1 (https=)
GE (1) GEAP202416348A (https=)
IL (1) IL304920A (https=)
MA (1) MA61732A1 (https=)
MX (1) MX2023009314A (https=)
PE (1) PE20231815A1 (https=)
TW (1) TW202245744A (https=)
WO (1) WO2022173855A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022005490A (es) 2019-11-08 2022-08-10 Xenon Pharmaceuticals Inc Metodos para el tratamiento de trastornos depresivos.
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia
US20220288057A1 (en) * 2021-02-09 2022-09-15 Xenon Pharmaceuticals Inc. Conjoint therapy for treating seizure disorders
WO2025034745A1 (en) * 2023-08-07 2025-02-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 4-aminopiperidines as selective modulators of potassium channels
TW202541796A (zh) * 2023-12-28 2025-11-01 美商查斯治療公司 用於治療失樂症的組成物及方法

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Also Published As

Publication number Publication date
KR20240004241A (ko) 2024-01-11
MX2023009314A (es) 2023-08-16
PE20231815A1 (es) 2023-11-16
GEAP202416348A (en) 2024-01-10
US11957675B2 (en) 2024-04-16
CL2023002321A1 (es) 2024-03-08
MA61732A1 (fr) 2024-01-31
JP2024508660A (ja) 2024-02-28
IL304920A (en) 2023-10-01
WO2022173855A1 (en) 2022-08-18
AU2022220675A1 (en) 2023-09-21
TW202245744A (zh) 2022-12-01
US20240408076A1 (en) 2024-12-12
CN116847843A (zh) 2023-10-03
EP4291189A1 (en) 2023-12-20
US12171759B1 (en) 2024-12-24
US20250186426A1 (en) 2025-06-12
US20220265634A1 (en) 2022-08-25

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