CN116710053A - 口腔用组合物 - Google Patents
口腔用组合物 Download PDFInfo
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- CN116710053A CN116710053A CN202180087616.5A CN202180087616A CN116710053A CN 116710053 A CN116710053 A CN 116710053A CN 202180087616 A CN202180087616 A CN 202180087616A CN 116710053 A CN116710053 A CN 116710053A
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- 239000000203 mixture Substances 0.000 title claims abstract description 82
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 10
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- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 6
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- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 4
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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Abstract
本发明的课题在于提供一种口腔用组合物,其含有无机粉体和水溶性高分子,在该口腔用组合物中,除了保形性和刷扫性,而且来自粉体的粘稠感得到改善也兼具良好的使用感。本发明提供一种口腔用组合物,其含有(A)无机粉体、(B)水溶性高分子、以及(C)N‑(2‑羟基‑2‑苯基乙基)‑2‑异丙基‑5,5‑二甲基环己烷‑1‑甲酰胺,(B)成分的含量为0.5质量%~1.5质量%。
Description
技术领域
本发明涉及一种口腔用组合物。
背景技术
在洁齿剂等口腔用组合物中,为了赋予清扫附着于牙齿表面等口腔内表面的污渍的基本功能,配合有磷酸钙、碳酸钙、研磨性二氧化硅等研磨剂。研磨剂的配合量通常根据作为研磨剂配合的各个成分的清洁力设定。例如,由于研磨性二氧化硅的清洁力较高,因此对洁齿剂组合物的一般配合量为10质量%~25质量%,与此相对,由于磷酸钙和碳酸钙的清洁力较小,因此大多为30质量%~60质量%。在一般市售的洁齿剂中,在使用任何一种研磨剂的情况下,清洁力都会被调整到一定的范围内,没有大的差异。另一方面,由于清洁力没有差异,因此研磨剂的配合量因洁齿剂而产生2倍~3倍的差异,导致刷牙时针对牙齿表面、口腔内、或舌尖的使用感的不同。
另外,在洁齿剂等口腔用组合物中,出于维持用于容易采取至牙刷的保形性等目的,有时配合水溶性高分子作为粘结剂。水溶性高分子与口腔用组合物的流变特性相关,并且还影响使用洁齿剂刷牙时的使用感。
专利文献1中公开了:含有碳酸钙、二氧化硅颗粒和粘度不同的两种羧甲基纤维素钠的洁齿剂组合物,能够确保高清洁力,刷扫实感也优异,且没有异物感等,使用感良好,成型性和制剂外观也优异。专利文献2中公开了:含有重质碳酸钙、水不溶性无机颗粒和两种水溶性高分子物质的洁齿组合物,具有适当的研磨力,且具有基于颗粒的刷扫实感和优异的洁齿分散性的协同效果的优异的使用感。专利文献3中公开了:配合规定比率的交联型聚丙烯酸或其盐与羧甲基纤维素盐的粘结剂的组合、以及、碳酸钙等研磨剂而成的、含有特定量的水分的牙膏组合物,在牙刷上的保形性和口腔内的分散性优异。
[现有技术文献]
[专利文献]
专利文献1:国际公开第2012/090571号
专利文献2:国际公开第2006/003989号
专利文献3:日本专利第3959639号公报
发明内容
[发明所要解决的课题]
但是,在口腔用组合物中使用无机粉体即研磨剂和水溶性高分子的情况下,存在以下问题:它们的配合量导致无机粉体在口腔内的分散性降低,在口腔粘膜和舌尖会感觉到来自粉体的粘稠感(feeling of heavy bubbles),导致使用感降低。
本发明是鉴于上述情况而完成的,其课题在于提供一种口腔用组合物,其含有无机粉体和水溶性高分子,在口腔用组合物中,不仅具有保形性和刷扫性,而且来自粉体的粘稠感得到改善,还兼具良好的使用感。
[用于解决课题的手段]
即,本发明提供以下〔1〕~〔7〕。
〔1〕一种口腔用组合物,其特征在于,
上述口腔用组合物含有:(A)无机粉体、(B)水溶性高分子、以及(C)N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺,
(B)成分的含量为0.5质量%~1.5质量%。
〔2〕根据〔1〕记载的口腔用组合物,其中,无机粉体为无机钙盐。
〔3〕根据〔1〕或〔2〕记载的口腔用组合物,其中,水溶性高分子为选自由卡拉胶、海藻酸钠、黄原胶、羧甲基纤维素钠、甲基纤维素、羟乙基纤维素、聚丙烯酸钠、羧基乙烯基聚合物、丙烯酸-马来酸酐共聚物、聚乙烯醇和聚乙烯吡咯烷酮组成的组中的1种以上。
〔4〕根据〔1〕~〔3〕中任一项记载的口腔用组合物,其中,
水溶性高分子为选自以下的由(B1)组成的组中的1种以上和选自以下的由(B2)组成的组中的1种以上,
(B1)卡拉胶、海藻酸钠、黄原胶和羧甲基纤维素钠,
(B2)聚丙烯酸钠、羧基乙烯基聚合物和丙烯酸-马来酸酐共聚物。
〔5〕根据〔1〕~〔4〕中任一项记载的口腔用组合物,其中,(A)成分的含量为10质量%~60质量%。
〔6〕根据〔1〕~〔5〕中任一项记载的口腔用组合物,其中,(C)成分的含量为0.00001质量%~0.01质量%。
〔7〕根据〔1〕~〔6〕中任一项记载的口腔用组合物,其中,上述口腔用组合物为洁齿剂组合物。
[发明效果]
根据本发明,能够提供一种口腔用组合物,其能够抑制来自粉体的粘稠感,还兼具良好的使用感,能够发挥良好的清扫实感、保形性。
具体实施方式
以下,对本发明详细进行说明。
本发明的口腔用组合物含有以下(A)成分、(B)成分和(C)成分。应予说明,在本说明书中,各成分的含量以制造组合物时的各成分的投入量为基准。
[(A)成分]
(A)成分是作为研磨剂的无机粉体。通过使口腔用组合物含有(A)成分,能够提高刷扫实感。
作为(A)成分中所含的无机粉体,例如可举出:无机钙盐(例如,磷酸氢钙·2水合盐或非水合物、磷酸二氢钙、焦磷酸钙、不溶性偏磷酸钙、磷酸三钙、磷酸四钙、磷酸八钙等磷酸钙、碳酸钙(轻质、重质)、氢氧化钙、硫酸钙、氧化钙);二氧化硅系粉体(无水硅酸(日文原文:無水ケイ酸)、沸石、沉淀二氧化硅、硅酸铝、硅酸锆、钛结合性二氧化硅、硅胶等);氢氧化铝、氧化铝(alumina)等无机铝盐;碳酸镁、磷酸三镁等无机镁盐;羟基磷灰石、氟磷灰石、钙缺损磷灰石等磷灰石系粉体;膨润土;二氧化钛等。无机粉体优选为无机钙盐,更优选为碳酸钙、磷酸钙。(A)成分可以单独为1种无机粉体,也可以组合2种以上。
(A)成分中包含的无机粉体的含量的下限相对口腔用组合物整体(100质量%)通常为5质量%以上,优选为10质量%以上,更优选为20质量%以上,进一步优选为30质量%以上。由此,能够赋予良好的刷扫感。上限相对口腔用组合物整体(100质量%)通常为65质量%以下,优选为60质量%以下。由此,能够抑制使用时的粘稠感。即,(A)成分中包含的无机粉体的含量相对口腔用组合物整体(100质量%)通常为5-65质量%,优选为10-60质量%。应予说明的是,本说明书中“粘稠感”是指:包含粉体的泡与口腔粘膜及舌尖密合的不适感(所谓的重感)。在口腔用组合物含有无机钙盐等钙系研磨剂的情况下,其含量一般比其他研磨剂等的含量多的情况多,由此粘稠感容易成为问题,但在本发明中,即使(A)成分的含量多(例如,即使为30质量%以上),也能够抑制粘稠感。
[(B)成分]
(B)成分为水溶性高分子。通过使口腔用组合物含有(B)成分,能够提高保形性。
作为(B)成分中包含的水溶性高分子,例如可举出纤维素系粘结剂(例如,羧甲基纤维素钠、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基纤维素、阳离子化纤维素)、卡拉胶、黄原胶、瓜尔豆胶、黄蓍胶、刺梧桐胶、阿拉伯胶、刺槐豆胶、海藻酸钠、蒙脱石、聚丙烯酸钠、聚乙烯吡咯烷酮、聚乙烯醇、羧基乙烯基聚合物、丙烯酸-马来酸酐共聚物、海藻酸丙二醇酯等有机粘结剂。其中,优选为选自卡拉胶、海藻酸钠、黄原胶、羧甲基纤维素钠、甲基纤维素、羟乙基纤维素、聚丙烯酸钠、羧基乙烯基聚合物、丙烯酸-马来酸酐共聚物、聚乙烯醇和聚乙烯吡咯烷酮中的1种以上,更优选卡拉胶、羧甲基纤维素钠、聚丙烯酸钠、羧基乙烯基聚合物。
(B)成分可以为单独1种水溶性高分子,也可以组合2种以上。在组合2种以上的情况下,(B)成分中包含的水溶性高分子优选包含来自(B1)多糖类和(B2)(甲基)丙烯酸单体的单元的水溶性高分子的组合。作为(B1)(B2)成分,例如可举出下述成分。
(B1)选自卡拉胶、海藻酸钠、黄原胶和羧甲基纤维素钠中的1种以上。
(B2)选自聚丙烯酸钠、羧基乙烯基聚合物和丙烯酸-马来酸酐共聚物中的1种以上。
相对于口腔用组合物整体(100质量%),(B)成分的含量的下限通常为0.5质量%以上,优选为1质量%以上。由此,能够维持口腔用组合物的保形性。相对于口腔用组合物整体(100质量%),上限通常为1.5质量%以下,优选为1.3质量%以下。由此,能够抑制并改善使用时的粘稠感。即,相对于口腔用组合物整体(100质量%),(B)成分的含量通常为0.5质量%~1.5质量%,优选为1质量%~1.3质量%。
在(B1)成分和(B2)成分的组合的情况下,(B1)成分的含量优选为0.1质量%~1.4质量%,更优选为0.2质量%~1.3质量%。(B2)成分的含量优选为0.1质量%~1.4质量%,更优选为0.2质量%~1.3质量%(其中,(B)成分的量为0.5质量%~1.5质量%)。另外,(B1)/(B2)(含量比)优选为0.5~10,更优选为1~9.5,进一步优选为1.5~9。由此,能够在维持口腔用组合物的保形性的同时,抑制并改善使用时的粘稠感。
[(C)成分]
(C)成分为N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺。
通过使口腔用组合物含有(C)成分,能够抑制并改善使用时的粘稠感。
相对于口腔用组合物整体(100质量%),(C)成分的含量的下限通常为0.00001质量%以上,优选为0.00005质量%以上。由此,能够抑制并改善使用时的粘稠感。相对于口腔用组合物整体(100质量%),上限通常为0.01质量%以下,优选为0.005质量%以下。由此,在口腔内不会强烈地表现出刺激感,能够抑制使用感的降低。即,相对于口腔用组合物整体(100质量%),(C)成分的含量通常为0.00001质量%~0.01质量%,优选为0.00005质量%~0.005质量%。
[任意成分]
本实施方式的口腔用组合物在不损害本发明的效果的范围内,除了已经说明的(A)~(C)成分以外,还可以含有任意成分。
作为任意成分,例如可举出(A)成分以外的研磨剂、(C)成分以外的香料、增稠剂、表面活性剂、保湿剂、以及根据需要的甜味剂、溶剂、油性成分、着色剂、防腐剂、保存稳定剂、pH调节剂、有效成分。以下,具体地进行说明。
-(A)成分以外研磨剂-
作为(A)成分以外的研磨剂,例如可举出聚甲基丙烯酸甲酯、合成树脂系研磨剂等有机研磨剂。
相对于口腔用组合物整体(100质量%),(A)成分以外的研磨剂的含量优选调整为(A)成分中包含的无机粉体和(A)成分以外的研磨剂的总量为10质量%~60质量%。
-(C)成分以外的香料-
作为(C)成分以外的香料,例如可以举出:薄荷油(peppermint oil)、留兰香油、茴香油、桉树油、冬青(winter green)油、肉桂油、丁香油、百里香油、鼠尾草油、柠檬油、橙油、薄荷油、小豆蔻油、芫荽(Coriander)油、柑橘(Mandarin)油、酸橙油、薰衣草油、迷迭香油、月桂油、洋甘菊油、葛缕子(Caraway)油、马郁兰(marjoram)油、月桂叶油、柠檬草油、牛至(Origanum)油、松针油(pine needle oil)、橙花油(neroli oil)、玫瑰油、茉莉油、鸢尾油、薄荷纯油、玫瑰纯油、橙花(orange flower)油等天然香料以及将这些天然香料加工处理(预蒸馏部切割、后蒸馏部切割、分馏、液液萃取、精馏化、香料粉末化等)而得到的香料;薄荷醇、香芹酮(carvone)、茴香脑、桉树脑、水杨酸甲酯、肉桂醛、丁香酚、3-1-薄荷氧基丙烷-1,2-二醇、百里酚、芳樟醇、芳樟醇乙酸酯、柠檬烯、薄荷酮、乙酸薄荷酯、N-取代-对薄荷烷-3-甲酰胺、蒎烯、辛醛、柠檬醛、长叶薄荷酮(pulegone)、乙酸卡比醇酯、茴香醛、乙酸乙酯、丁酸乙酯、烯丙基环己烷丙酸酯、氨茴酸甲酯(methyl anthranilate)、甲基苯基缩水甘油酸乙酯(ethyl methylphenylglycidate)、香草醛、十一内酯、己醛、乙醇、丙醇、丁醇、异戊醇、己烯醇、二甲基硫醚、环甘素(Cyclotene)、糠醛、三甲基吡嗪、乳酸乙酯、乳酸甲酯、硫代乙酸乙酯等单品香料;草莓风味香精、苹果风味香精、香蕉风味香精、菠萝风味香精、葡萄风味香精、芒果风味香精、黄油风味香精、牛奶风味香精、混合水果风味香精、热带水果风味香精等调合香料。另外,(C)成分以外的冷感剂,例如也可例示出N-乙基-对薄荷烷-3-甲酰胺、乳酸薄荷酯、琥珀酸单薄荷酯、异胡薄荷醇(Isopulegol)、薄荷酮甘油酮缩醇(MenthoneGlycerol Ketal)、N-(4-氰基甲基苯基)-对薄荷烷甲酰胺、3-l-薄荷氧基丙烷-1,2-二醇、5-甲基-2-丙烷-2-基-N-(2-吡啶-2-基-乙基)环己烷-1-甲酰胺、3-(对薄荷烷-3甲酰胺)乙酸乙酯、2-异丙基-N-2,3-三甲基丁基酰胺。此外,也可以使用口腔用组合物中使用的公知的香料原材料。
相对于口腔用组合物整体(100质量%),(C)成分以外的香料的含量优选为0.000001质量%~1质量%。另外,在使用这些香料的赋香用香料的情况下,相对于口腔用组合物整体(100质量%),优选为0.1质量%~2.0质量%。
作为粘稠剂,例如可举出甘油、山梨醇、乙二醇、丙二醇、聚乙二醇、聚丙二醇、木糖醇、麦芽糖醇、乳糖醇等多元醇。
相对于口腔用组合物整体(100质量%),增稠剂的含量通常为1质量%~45质量%,优选为2质量%~40质量%。
-表面活性剂-
作为表面活性剂,例如可举出阴离子性表面活性剂、非离子性表面活性剂和两性表面活性剂。
作为阴离子表面活性剂,例如可举出烷基硫酸盐、酰基氨基酸盐、酰基牛磺酸盐、α-烯烃磺酸盐、氢化椰油脂肪酸单甘油酯单硫酸盐、月桂基磺基乙酸盐。在具有酰基的情况下,酰基可以是直链和支链中的任一种,可以是饱和和不饱和中的任一种,其碳原子数通常为10~20。盐能够从药理学上允许的盐中选择。作为药理学上允许的盐,例如可举出碱加成盐和氨基酸盐。具体而言,例如可举出钠盐、钾盐、钙盐、镁盐、铵盐等无机碱盐;三乙基铵盐、三乙醇铵盐、吡啶鎓盐、二异丙基铵盐等有机碱盐;精氨酸盐等碱性氨基酸盐。其中,优选无机碱盐,更优选碱金属盐(例如,钠盐、钾盐)或铵盐,进一步优选钠盐。
作为烷基硫酸盐,例如可举出月桂基硫酸盐、肉豆蔻酰基硫酸盐。作为酰基氨基酸盐,例如可举出月桂酰基肌氨酸盐、肉豆蔻酰基肌氨酸盐等酰基肌氨酸盐;月桂酰基谷氨酸盐、肉豆蔻酰基谷氨酸盐、棕榈酰基谷氨酸盐等酰基谷氨酸盐;N-月桂酰基-N-甲基甘氨酸盐、椰油酰基甘氨酸盐等酰基甘氨酸盐;N-月桂酰基-β-丙氨酸盐、N-肉豆蔻酰基-β-丙氨酸盐、N-椰油酰基-β-丙氨酸盐、N-月桂酰基-N-甲基-β-丙氨酸盐、N-肉豆蔻酰基-N-甲基-β-丙氨酸盐、N-甲基-N-酰基丙氨酸盐等酰基丙氨酸盐;月桂酰基天冬氨酸盐等酰基天冬氨酸盐。作为酰基牛磺酸盐,例如可举出月桂酰基甲基牛磺酸盐、N-甲基-N-酰基牛磺酸盐、N-椰油酰基甲基牛磺酸盐。作为α-烯烃磺酸盐,可举出十四烯磺酸盐等碳原子数为12~14的α-烯烃磺酸盐。作为阴离子表面活性剂的其它例子,可举出氢化椰油脂肪酸单甘油酯单硫酸钠、月桂醇磺基乙酸酯钠。
作为非离子性表面活性剂,例如可举出聚氧乙烯烷基醚、聚氧乙烯氢化蓖麻油、山梨糖醇酐脂肪酸酯、聚氧乙烯山梨糖醇酐脂肪酸酯(例如,聚氧乙烯山梨糖醇酐单硬脂酸酯)、烷醇酰胺、聚氧乙烯脂肪酸酯、聚氧乙烯烯基醚、甘油脂肪酸酯、蔗糖脂肪酸酯(例如,麦芽糖脂肪酸酯)、糖醇脂肪酸酯(例如,麦芽糖醇脂肪酸酯、乳糖醇脂肪酸酯)、脂肪酸二乙醇酰胺(例如,月桂酸单或二乙醇酰胺)、聚氧乙烯聚氧丙烯共聚物、聚氧乙烯聚氧丙烯脂肪酸酯。聚氧乙烯烷基醚的烷基链的碳原子数通常为14~18,环氧乙烷平均加成摩尔数通常为15摩尔~30摩尔。聚氧乙烯氢化蓖麻油的环氧乙烷平均加成摩尔数通常为20摩尔~100摩尔,优选为60摩尔~100摩尔。山梨糖醇酐脂肪酸酯的脂肪酸的碳原子数通常为12~18。聚氧乙烯山梨糖醇酐脂肪酸酯的脂肪酸的碳原子数通常为16~18,环氧乙烷平均加成摩尔数通常为10摩尔~40摩尔。烷醇酰胺的烷基链的碳原子数通常为12~14。
作为两性表面活性剂,例如可举出烷基二甲基氨基乙酸甜菜碱(例如,月桂基二甲基氨基乙酸甜菜碱)、脂肪酸酰胺丙基二甲基氨基乙酸甜菜碱(例如,椰油酰胺丙基甜菜碱)等甜菜碱型两性表面活性剂;N-脂肪酸酰基-N-羧甲基-N-羟基乙基乙二胺盐(例如,N-椰油脂肪酸酰基-N-羧甲基-N-羟乙基咪唑啉甜菜碱)、椰油脂肪酸咪唑啉甜菜碱、2-烷基-N-羧甲基-N-羟乙基咪唑啉甜菜碱等咪唑啉型两性表面活性剂;月桂基二甲基氨基乙酸甜菜碱等烷基甜菜碱。
相对于口腔用组合物整体(100质量%),表面活性剂的含量优选为0.1质量%~4质量%。
-甜味剂-
作为甜味剂,例如可举出木糖醇、赤藓糖醇、麦芽糖醇、糖精、糖精钠、阿斯巴甜、甜菊糖、甜叶菊提取物、对甲氧基肉桂醛、新橙皮苷二氢查耳酮、紫苏葶、甜味蛋白(Thaumatin)、天冬氨酰苯基丙氨酸甲酯(aspartyl-phenylalanine methyl ester)等。作为甜味剂,可以单独使用1种上述例示的甜味剂,也可以组合使用2种以上。
-溶剂-
作为溶剂,例如可举出水(精制水)。相对于组合物总量,溶剂的配合量通常为1质量%~90质量%,优选为15质量%~80质量%,更优选为20质量%~60质量%。
-油性成分-
作为油性成分,例如可举出角鲨烷、液体石蜡、凡士林、微晶蜡等烃类;高级醇(例如,月桂醇、鲸蜡醇、鲸蜡硬脂醇(Cetostearyl alcohol)、油醇、异硬脂醇等碳原子数为8~22的醇);高级脂肪酸(例如,月桂酸、肉豆蔻酸、油酸、异硬脂酸等碳原子数为8~22的脂肪酸)、橄榄油、蓖麻油、椰子油等植物油;肉豆蔻酸异丙酯等脂肪酸酯。
-着色剂-
作为着色剂,例如可举出:红色2号、红色3号、红色225号、红色226号、黄色4号、黄色5号、黄色205号、蓝色1号、蓝色2号、蓝色201号、蓝色204号、绿色3号、云母钛、氧化钛。
-防腐剂-
作为防腐剂,例如可举出对羟基苯甲酸酯(例如,对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丁酯)、苯甲酸钠等。
-pH调节剂-
作为pH调节剂,例如可举出邻苯二甲酸、柠檬酸、琥珀酸、乙酸、富马酸、苹果酸、及乳酸等有机酸或它们的盐、磷酸(正磷酸)等无机酸或它们的盐(例如,钾盐、钠盐及铵盐)、氢氧化钠、氢氧化钾等氢氧化物。作为无机酸盐,例如可举出磷酸氢二钠、磷酸二氢钠。
pH调节剂的含量通常能够设为使添加后的口腔用组合物的pH值为6~10,优选为7~9的量。
在本说明书中,pH值通常是指从测定开始起在25℃下3分钟后的值。pH值,例如,能够使用东亚电波工业株式会社制造的pH计(型号Hm-30S)进行测定。
-有效成分-
作为有效成分,例如可举出氯化十六烷基吡啶鎓、苯扎氯铵、苄索氯铵、异丙基甲基苯酚、葡萄糖酸锌、柠檬酸锌、三氯生(triclosan)、百里酚(thymol)、扁柏酚、氯化溶菌酶等杀菌或抗菌剂;葡聚糖酶、变聚糖酶、淀粉酶、蛋白酶、LeTech酶(日文原文:リテックエンザイム)等酶;氟化钠、单氟磷酸钠、氟化锡等氟化物;ε-氨基己酸、尿囊素、氨甲环酸、尿囊素氯羟基铝、甘草酸盐(例如,甘草酸二钾盐)、甘草次酸、甘草次酸衍生物(例如,甘草次酸硬脂酯)、薁、二氢胆固醇等抗炎剂;锌盐、铜盐、锡盐等金属盐;缩聚磷酸盐、乙烷羟基二膦酸酯等牙结石预防剂;维生素E(例如,乙酸生育酚)等血流促进剂;硝酸钾、乳酸铝、氯化锶等知觉过敏抑制剂;羟乙基纤维素二甲基二烯丙基氯化铵等涂布剂;维生素C(例如,抗坏血酸或其盐)、氯化溶菌酶、氯化钠等收敛剂;叶绿素铜、葡萄糖酸铜等水溶性铜化合物;牙结石预防剂、丙氨酸、甘氨酸、脯氨酸等氨基酸类;百里香、黄芩、丁香、北美金缕梅等植物提取物;海狗肽、聚乙烯吡吡咯烷酮。药效成分可以单独使用1种,也可以组合使用2种以上。上述药效成分的含量能够根据常规方法适当设定有效量。
-其他任意成分-
作为上述以外的任意成分的例子,可举出聚异丁烯、聚丁二烯、氨基甲酸酯、硅、天然橡胶。这些其他任意成分的含量能够在不妨碍本发明的效果的范围内适当设定。
[口腔用组合物的剂型和用途]
本发明的口腔用组合物能够通过按照常规方法的任意适当的方法制成任意合适的剂型。作为剂型,例如可列举出液体(溶液、乳液、悬浮液、糖浆等)、半固体(凝胶、乳膏剂(cream)、糊剂(paste)等)、固体(片剂、颗粒状剂、胶囊剂、膜剂、混炼物、熔融固体、蜡状固体、弹性固体、软胶囊剂等)。口腔用组合物的剂型优选为液体、半固体。
本发明的口腔用组合物能够在口腔用途中广泛利用。作为固体剂型的用途,例如可举出口含片(troche)、软糖(gummy)、口香糖(gum)、粉状或片剂的洁齿剂。作为半固体剂型的用途,例如可举出牙膏、凝胶状洁齿剂。作为液体剂型的用途,例如可举出漱口剂、液体洁齿剂、口中清新剂(喷雾等)。本发明的口腔用组合物能够实现良好的保湿实感,抑制浮粉感(日文原文:粉きしみ感),进而能够使保形性、拉丝性等物性良好,因此优选为洁齿剂(牙膏、凝胶状洁齿剂)或涂布剂(口腔用保湿凝胶、口腔用保湿乳膏剂)。
[组合物的制造方法]
口腔用组合物的制造方法没有特别限定,能够根据剂型通过各种通常的方法制造得到。例如,作为牙膏使用时,可举出在制备溶解于溶剂中的成分后,混合除此以外的不溶性成分,根据需要进行脱泡(例如,减压等)的方法。得到的牙膏可以容纳于容器中而制成产品。容器的形状、材质没有特别限制,能够使用通常洁齿剂组合物中使用的容器,例如可举出聚乙烯、聚丙烯、聚对苯二甲酸乙二醇酯、尼龙等塑料制层压管等容器等。
实施例
以下,示出实施例和比较例对本发明进行详细阐述。本发明不限于下述实施例。应予说明,下述表中的数值只要没有特别说明则表示质量%。
实施例1~25和比较例1~9
[实施例及比较例中使用的成分]
-(A)成分-
碳酸钙(Calfine株式会社制造,重质碳酸钙)
无水硅酸(Evonik制造,商品名:Carplex(注册商标)#67Q)
-(B)成分-
聚丙烯酸钠(东亚合成株式会社制造,商品名:RHEOGIC(注册商标)250H)
羧基乙烯基聚合物(Lubrizol制造,商品名:Carbopol(注册商标)980)
卡拉胶(CP Kelco Japan株式会社制造)
羧甲基纤维素钠(Daicel FineChem制造,商品名:CMC1260)
-(C)成分-
N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺:(高砂香料工业株式会社制造,商品名:Coolact(注册商标)370)
-比较例中代替(C)成分使用的香料成分-
N-乙基-对薄荷烷-3-甲酰胺:(德之馨(Symrise)日本公司制造,商品名:WS-3)
通过常规方法含有上述成分,制备具有下述表所示的组成的牙膏组合物,并将其收纳于层压管中。
[评价方法]
通过10名试验者,针对牙膏组合物中包含的来自无机粉体的粘稠感、刷扫性和保形性,分别求出下述所示的基于判定基准的10名试验者的平均分,并进行评价。应予说明,在本实施例中,对于任何一个评价项目,均将平均分3.0以上作为合格分数。
<粘稠感>
将1g牙膏组合物放置于牙刷(Clinica Advantage牙刷,4排紧凑普通型,狮王株式会社制造)上,并按照常规方法进行刷洗时,对口腔内感觉到的来自无机粉体的粘稠感进行评价。
判定基准
5分:口腔内完全没有感觉到粘稠感
4分:口腔内几乎感觉不到粘稠感
3分:在口腔内稍微感觉到粘稠感,但为不在意的水平
2分:口腔内感觉到粘稠感
1分:口腔内强烈感觉到粘稠感
评价基准
+++:平均分为4.5分以上
++:平均分为4.0分以上且小于4.5分
+:平均分为3.0分以上且小于4.0分
±:平均分为2.0分以上且小于3.0分
-:平均分为1.0分以上且小于2.0分
<刷扫性>
将牙膏组合物1g放置在该牙刷上,按照常规方法进行刷洗时,对口腔内感觉到的刷扫性进行评价。
判定基准
4分:非常地感觉到刷扫性
3分:感觉到刷扫性
2分:几乎感觉不到刷扫性
1分:未感觉到刷扫性
评价基准
++:平均分为3.5分以上且4.0分以下
+:平均分为3.0分以上且小于3.5分
±:平均分为2.0分以上且小于3.0分
-:平均分为1.0分以上且小于2.0分
<保形性>
在该牙刷上挤出牙膏组合物(长度10mm),目视观察3分钟后的牙膏组合物的形状,关于保形性进行评价。
判定基准
4分:形状没有变化,没有从牙刷滴落
3分:虽然形状稍有变化,但没有从牙刷滴落
2分:形状稍有变化,稍微从牙刷滴落
1分:形状有变化,从牙刷滴落
评价基准
++:平均分为3.5分以上且4.0分以下
+:平均分为3.0分以上且小于3.5分
±:平均分为2.0分以上且小于3.0分
-:平均分为1.0分以上且小于2.0分
[表1]
[表2]
[表3]
[表4]
在不含有(A)成分的比较例1中,刷扫实感低,在不含有(B)成分的比较例2中,保形性低。进而,在(B)成分的量超过1.5质量%的比较例3~7和不包含(C)成分的比较例8~9中,粘稠感没有被消除,在比较例9中,尽管含有N-乙基-对薄荷烷-3-甲酰胺来代替(C)成分,但没有实现粘稠感的消除。与此相对,含有(A)~(C)成分且(B)成分的含量为0.5~1.5质量%的实施例均在粘稠感、刷扫性和保形性的全部评价中,能够得到平均分为3.0以上的令人满意的结果。这些结果表明,本发明涉及的口腔用组合物,除了保形性和刷扫性,还兼具良好的使用感。
Claims (7)
1.一种口腔用组合物,其特征在于,
所述口腔用组合物含有:
(A)无机粉体、
(B)水溶性高分子、以及
(C)N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺,
(B)成分的含量为0.5质量%~1.5质量%。
2.根据权利要求1所述的口腔用组合物,其中,
无机粉体为无机钙盐。
3.根据权利要求1或2所述的口腔用组合物,其中,
水溶性高分子为选自由卡拉胶、海藻酸钠、黄原胶、羧甲基纤维素钠、甲基纤维素、羟乙基纤维素、聚丙烯酸钠、羧基乙烯基聚合物、丙烯酸-马来酸酐共聚物、聚乙烯醇和聚乙烯吡咯烷酮组成的组中的1种以上。
4.根据权利要求1~3中任一项所述的口腔用组合物,其中,
水溶性高分子为选自以下的由(B1)组成的组中的1种以上和选自以下的由(B2)组成的组中的1种以上,
(B1)卡拉胶、海藻酸钠、黄原胶和羧甲基纤维素钠,
(B2)聚丙烯酸钠、羧基乙烯基聚合物和丙烯酸-马来酸酐共聚物。
5.根据权利要求1~4中任一项所述的口腔用组合物,其中,
(A)成分的含量为10质量%~60质量%。
6.根据权利要求1~5中任一项所述的口腔用组合物,其中,
(C)成分的含量为0.00001质量%~0.01质量%。
7.根据权利要求1~6中任一项所述的口腔用组合物,其中,
所述口腔用组合物为洁齿剂组合物。
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