CN116637047A

CN116637047A - Tear-free shampoo and preparation method thereof

Info

Publication number: CN116637047A
Application number: CN202310623408.3A
Authority: CN
Inventors: 刘伟
Original assignee: Guangzhou Meisi Biotechnology Co ltd
Current assignee: Guangzhou Meisi Biotechnology Co ltd
Priority date: 2023-05-30
Filing date: 2023-05-30
Publication date: 2023-08-25

Abstract

The application particularly discloses a lacrimation-free shampoo and a preparation method thereof. The tear-free shampoo comprises 15-20 parts of amino acid surfactant, 10-15 parts of APG surfactant, 0.5-1 part of conditioner, 1-2 parts of thickener, 0.5-1 part of preservative, 0.5-2 parts of pH regulator, 1-2 parts of lentinus edodes extract, 0.5-1.5 parts of grifola frondosa extract and 100-150 parts of water; the Lentinus Edodes extract comprises lentinan, adenosine, and phenols, and the Maitake Mushroom extract comprises Maitake Mushroom polysaccharide, amino acids, and vitamin E. The application has the advantages of reducing the irritation of the shampoo and further improving the hair care effect on the scalp and the hair.

Description

Tear-free shampoo and preparation method thereof

Technical Field

The application relates to the technical field of daily chemical products, in particular to a lacrimation-free shampoo and a preparation method thereof.

Background

The life rhythm of people in the modern society is faster and faster, and a plurality of problems such as irregular work and rest, high mental stress, frequent insomnia and the like are brought, and negative effects are generated on the health of hair. With the increase of the incomes available to people, people attach more importance to the health problem of hair, and the demands for better shampoo products and shampoos are higher.

Shampoo generally comprises surfactant, conditioner, essence, thickener and antiseptic, and can remove dirt on scalp and hair to keep scalp and hair clean and healthy. At present, shampoo with various functions sold in the market can achieve a part of effects after long-term use and can also generate certain side effects on scalp and hair, because some chemical synthetic substances in the shampoo are easy to remain on the scalp or/and the hair and have certain irritation on the scalp; and part of chemical synthetic substances are allergic substances, and the scalp of part of people can be stimulated by improper use, so that allergic reaction is caused, the scalp becomes more greasy and the hair is dry, and phenomena such as alopecia and the like can occur seriously.

Thus, there is a need to provide a tear free shampoo that is non-irritating and has a positive promoting effect on scalp and hair health growth.

Disclosure of Invention

In order to solve the problem that the irritation of the existing shampoo products is unfavorable for the growth of scalp and hair, the application provides a lacrimation-free shampoo and a preparation method thereof.

In a first aspect, the application provides a tear-free shampoo, which adopts the following technical scheme:

the tear-free shampoo comprises 15-20 parts of amino acid surfactant, 10-15 parts of APG surfactant, 0.5-1 part of conditioner, 1-2 parts of thickener, 0.5-1 part of preservative, 0.5-2 parts of pH regulator, 1-2 parts of lentinus edodes extract, 0.5-1.5 parts of grifola frondosa extract and 100-150 parts of water;

the Lentinus Edodes extract comprises lentinan, adenosine, and phenols, and the Maitake Mushroom extract comprises Maitake Mushroom polysaccharide, amino acids, and vitamin E.

Firstly, phenolic substances in the lentinus edodes extract, the grifola frondosa polysaccharide and the APG surfactant act together to obviously improve the antibacterial performance of the shampoo, and the shampoo has high safety coefficient and small irritation, does not generate irritation to scalp when being used together with the surfactant used in the application, is beneficial to maintaining the healthy stability of scalp, provides stable and healthy environment for the growth and development of hair follicles, and is very friendly to sensitive scalp groups and infants; secondly, lentinan in the lentinus edodes extract can induce cells to secrete NO, TNF-alpha and IL-6, NO can inhibit 5 alpha-reductase, and increase cell activity and blood activating performance, so that hair growth is promoted, and grifola frondosa polysaccharide can promote IL-1β production, and acts together with TNF-alpha and IL-6, so that activation of shampoo on endothelial cells, nerve peripheral cells and dermal sheath cells is improved, proliferation and differentiation of hair follicle stem cells are improved, and hair follicle growth and development are promoted; finally, the adenosine in the lentinus edodes extract, the amino acid and vitamin E in the grifola frondosa extract can further promote the regeneration of epithelial cells at the scalp, and moisten hair while providing nutrition for the scalp; in addition, the combined action of the lentinus edodes extract and the grifola frondosa extract can also enhance the immunity and the resistance of the scalp, thereby reducing the influence of the stimulation component on the scalp and improving the maintenance effect of the shampoo on the scalp and the hair.

Preferably, the lacrimation-free shampoo further comprises plant components based on the lacrimation-free shampoo, wherein the plant components comprise phyllanthus emblica extract and hydrolyzed wheat protein; the phyllanthus emblica extract comprises tannins, phenolic acid compounds and beta-glucoretannin.

Hydrolyzed wheat proteins are low molecular weight proteins extracted from soft wheat.

The tannins and phenolic acid compounds contained in the phyllanthus emblica extract have antibacterial effect, and can act together with an antibacterial system formed by the lentinus edodes extract, the grifola frondosa extract and the APG surfactant to further maintain scalp health and healthy growth of hair follicles; the beta-glucosinolate is beneficial to improving the activity of hair follicle cells, promoting the proliferation of human hair follicle dermal papilla cells, enhancing the hair induction capability of human hair follicle dermal papilla cells and promoting the growth of hair follicles, and can promote healthy hair growth of hair follicles by combining with mushroom extract and grifola frondosa extract; the grifola frondosa extract, the phyllanthus emblica extract and the hydrolyzed wheat protein act together to improve the hair fiber structure, form a layer of glossy protective film on the surface of hair, and realize the toughening effect on hair.

Preferably, the mass of the plant component accounts for 30% -50% of the total mass of the grifola frondosa extract and the lentinus edodes extract.

By controlling the quality of the plant components, the plant components can be optimally matched with the shiitake mushroom extract and the grifola frondosa extract, so that the performance of the shampoo, which has no irritation and excellent scalp and hair care effects, is improved.

Preferably, the molecular weight of the hydrolyzed wheat protein is 1000Da to 3000Da.

By adjusting the molecular weight of the hydrolyzed wheat protein, the hydrolyzed wheat protein can better play a role in cooperation with the phyllanthus emblica extract and is easy to be absorbed by human bodies, so that plant components show excellent scalp care and hair care effects.

Preferably, the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein is 1: (2-5).

Preferably, the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein is 1: (3-4).

The quality of the phyllanthus emblica extract and the quality of the hydrolyzed wheat protein are adjusted, so that plant components can be better matched with the lentinus edodes extract and the grifola frondosa extract, and the shampoo which is free of irritation and good in scalp and hair care effect is prepared.

Preferably, the APG surfactant is selected from at least one of APG1214, APG0816, APG 1216.

Preferably, the amino acid surfactant is at least one selected from sodium cocoyl methyl taurate, sodium lauroyl glutamate and sodium cocoyl glycinate.

The surfactant with small skin irritation is selected, so that the irritation of the lacrimation-free shampoo to the scalp can be remarkably reduced after long-time use, and the healthy growth of hair follicles is facilitated.

Preferably, the conditioning agent is silicone oil, the thickening agent is at least one of glycerol and sorbitol, the preservative is phenoxyethanol, and the pH regulator is citric acid.

In a second aspect, the application provides a preparation method of a lacrimation-free shampoo, which adopts the following technical scheme:

a preparation method of a lacrimation-free shampoo comprises the following steps:

step one: weighing the raw materials according to parts by weight, mixing the amino acid surfactant, the APG surfactant, the thickener, the preservative and the water at the temperature, stirring, and cooling to obtain a mixed system;

step two: and adding the conditioner, the pH regulator, the lentinus edodes extract, the grifola frondosa extract and the plant components into the mixed system, and stirring to obtain the lacrimation-free shampoo.

Preferably, the temperature of the water in the first step is 70-80 ℃, the stirring speed is 200-400rpm, and the stirring time is 20-30min; in the second step, the stirring speed is 60-100rpm, and the stirring time is 30-50min.

Detailed Description

For a better understanding and implementation, the technical solutions of the present application will be clearly and completely described below in connection with examples.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

Unless otherwise indicated, all numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth herein are approximations that may vary depending upon the desired properties to be obtained.

As used herein, "and/or" means one or all of the elements mentioned.

The use of "including" and "comprising" herein encompasses both the situation in which only the elements are mentioned and the situation in which other elements not mentioned are present in addition to the elements mentioned.

All percentages in the present application are by weight unless otherwise indicated.

As used in this specification, the terms "a," "an," "the," and "the" are intended to include "at least one" or "one or more," unless otherwise specified. For example, "a component" refers to one or more components, and thus more than one component may be considered and possibly employed or used in the practice of the embodiments.

Examples

Example 1

The tear-free shampoo comprises the following raw materials in parts by weight:

18g of sodium cocoyl methyl taurate, 12g of APG1214, 0.5g of silicone oil, 1g of glycerol, 0.7g of phenoxyethanol, 1g of citric acid, 1.5g of lentinus edodes extract, 1.5g of grifola frondosa extract and 120g of water.

A tear-free shampoo is prepared by the following steps:

step one: weighing the raw materials according to the weight, mixing cocoyl methyl taurine sodium, APG1214, silicone oil and phenoxyethanol with 75 ℃ water, stirring for 25min at 300rpm, and cooling to 45 ℃ to obtain a mixed system;

step two: adding glycerol, citric acid, lentinus Edodes extract, and Maitake Mushroom extract into the mixed system, and stirring at 80rpm for 40min to obtain lacrimation-free shampoo.

Example 2

The tear-free shampoo comprises the following raw materials in parts by weight:

15g of sodium lauroyl glutamate, 15g of APG0816, 0.7g of silicone oil, 1.5g of sorbitol, 0.5g of phenoxyethanol, 2g of citric acid, 1g of lentinus edodes extract, 1g of grifola frondosa extract and 100g of water.

A tear-free shampoo is prepared by the following steps:

step one: weighing the raw materials according to the weight, mixing sodium lauroyl glutamate, APG0816, silicone oil and phenoxyethanol with water at 80 ℃, stirring for 30min at 200rpm, and cooling to 50 ℃ to obtain a mixed system;

step two: adding sorbitol, citric acid, lentinus Edodes extract, and Maitake Mushroom extract into the mixed system, and stirring at 100rpm for 30min to obtain lacrimation-free shampoo.

Example 3

The tear-free shampoo comprises the following raw materials in parts by weight:

20g of sodium cocoyl glycinate, 10g of APG1213, 1g of silicone oil, 2g of glycerol, 1g of phenoxyethanol, 0.5g of citric acid, 2g of lentinus edodes extract, 0.5g of grifola frondosa extract and 150g of water.

A tear-free shampoo is prepared by the following steps:

step one: weighing the raw materials according to the weight, mixing sodium cocoyl glycinate, APG1216, silicone oil and phenoxyethanol with water at 70 ℃, stirring for 20min at 400rpm, and cooling to 40 ℃ to obtain a mixed system;

step two: adding glycerol, citric acid, lentinus Edodes extract, and Maitake Mushroom extract into the mixed system, and stirring at 60rpm for 50min to obtain lacrimation-free shampoo.

Example 4

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 30% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:3.5.

the tear-free shampoo in this example was prepared by the following steps:

step two: adding glycerol, citric acid, lentinus Edodes extract, maitake Mushroom extract, fructus Phyllanthi extract and hydrolyzed wheat protein into the mixed system, and stirring at 80rpm for 40min to obtain lacrimation-free shampoo.

The remainder remained the same as in example 1.

Example 5

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 50% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:3.5.

the tear-free shampoo in this example was prepared by the following steps:

The remainder remained the same as in example 1.

Example 6

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 40% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:3.5.

the tear-free shampoo in this example was prepared by the following steps:

The remainder remained the same as in example 1.

Example 7

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 40% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:2.

the tear-free shampoo in this example was prepared by the following steps:

The remainder remained the same as in example 1.

Example 8

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 40% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:5.

example 9

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 40% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:3.

the tear-free shampoo in this example was prepared by the following steps:

The remainder remained the same as in example 1.

Example 10

This embodiment differs from embodiment 1 in that:

the lacrimation-free shampoo also comprises plant additive components, wherein the mass of the plant additive components accounts for 40% of the total mass of the grifola frondosa extract and the lentinus edodes extract; the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein in the plant additive component is 1:4.

the tear-free shampoo in this example was prepared by the following steps:

The remainder remained the same as in example 1.

Example 11

This example differs from example 6 in that the hydrolyzed wheat protein has a molecular weight of 5000-10000Da; the remainder remained the same as in example 6.

Example 12

This example differs from example 6 in that an equivalent weight of the extract of phyllanthus emblica fruit was used instead of hydrolyzed wheat protein; the remainder remained the same as in example 6.

Comparative example 1

This comparative example differs from example 1 in that the shiitake mushroom extract and the grifola frondosa extract are not used.

Comparative example 2

This comparative example differs from example 1 in that a commercially available tear free shampoo was used.

Detection method

1. Stimulation test of rabbit

The shampoos prepared in examples 1 to 12 and comparative example 2 were scored and rated for irritation, and specific test methods were referred to the "cosmetic safety Specification" (2015 edition) acute eye irritation/corrosiveness test, and the specific procedures were as follows:

1. experimental animals: 39 healthy adult white rabbits, female, 1.8-2.2kg, were divided into 13 groups of 3.

2. The experimental steps are as follows:

adapting the environment of a healthy adult white rabbit in an experimental animal house for 12 hours; both eyes of the test animals were examined (including examination with sodium fluorescein) within 24 hours before the start of the test. Animals with symptoms of eye irritation, corneal defects, and conjunctival lesions cannot be used for the test.

The lower eyelid of the eyes of the rabbit was gently pulled open, and 0.1mL of the test substance was instilled into the conjunctival sac, and the upper and lower eyelids were passively closed for 1s, so as to prevent the test substance from being lost. The other eye was not treated as a self-control. The test subjects were instilled into the eyes of rabbits for 3 minutes, and then rinsed with a sufficient amount of water at a relatively rapid flow rate without causing damage to the eyes of animals for at least 30 seconds, and then examined and scored as shown in Table 1, and the eye irritation response grade of the products was judged as shown in Table 2.

TABLE 1 eye damage scoring criteria table

TABLE 2 hierarchical table of eye irritation response

Table 3 Graded Table of the products response to eye irritation in rabbits

Furthermore, the tear-free shampoos of examples 1-12 and comparative example 2 were scored for skin response according to the cosmetic safety Specification (2015 edition) skin irritation/corrosiveness test, which shows that the tear-free shampoos of examples 1-12 of the present application have a highest integrated mean value of < 0.5 at each observation time point in the test, and the tear-free shampoo of comparative example 2 has a highest integrated mean value of 1.6 at each observation time point in the test, and are slightly irritating. Therefore, the lacrimation-free shampoo provided by the application is milder to eyes and scalp, has no irritation, and is very friendly to scalp of sensitive people and scalp of infants.

2. Antibacterial property test

The shampoos of examples 1-12 and comparative examples 1-2 were tested for their bacteriostatic effect as follows: preparing bacterial suspension of each test strain (Staphylococcus aureus, escherichia coli, malassezia furfur) subjected to subculture with physiological saline with a bacterial content of 1.0X10 ⁷ CFU/mL, diluting the products (shampoo in application examples 1-12 and comparative examples 1-2) to different concentrations by using oxford cup bacteriostasis, uniformly coating a certain amount of test bacterial liquid on a culture medium plate, slightly placing the sterile oxford cup into a culture dish by using tweezers, adding sample liquid with different concentrations into the oxford cup, and culturing in a constant temperature incubator at 37 ℃ for 24 hours, wherein the result is shown in Table 4.

Table 4 minimum inhibitory concentration table (unit: mg/mL) of product against different microorganisms

Examples and comparative examples	Staphylococcus aureus	Large intestineBacillus species	Malassezia furfur
				Example 1	1.66	2.65	1.14
Example 2	1.68	2.68	1.16
				Example 3	1.72	2.69	1.18
Example 4	1.59	2.61	1.09
				Example 5	1.58	2.59	1.11
Example 6	1.57	2.58	1.07
				Example 7	1.62	2.61	1.1
Example 8	1.63	2.62	1.11
				Example 9	1.61	2.58	1.08
Example 10	1.59	2.59	1.07
				Example 11	1.64	2.63	1.12
Example 12	1.67	2.65	1.15
				Comparative example 1	3.02	3.86	1.85
Comparative example 2	2.55	3.42	1.76

3. Hair combing effect test

Combing effect test on hair after shampoo of examples 1-12 and comparative examples 1-2: test methods wet combing performance and dry combing performance were tested and combing work was calculated from the combing curve and recorded in table 5, with reference to the method in section 3.3.2 of the master paper modification of hydroxyethyl cellulose and application study in shampoo, lv Miao.

TABLE 5 carding performance table of hair after application of product (unit: mJ)

By combining examples 1-3, comparative examples 1-2 and tables 3-5, it can be seen that the shampoo prepared by the application has mild and non-irritating effects; in addition, by adding the lentinus edodes extract and the grifola frondosa extract, the antibacterial performance and the carding performance of the shampoo can be improved; this is probably because the components in the shiitake mushroom extract and the grifola frondosa extract can co-act with the APG surfactant having broad-spectrum antibacterial performance, so that excellent antibacterial effect can be achieved without adding a bacteriostatic agent; the components of the lentinus edodes extract and the grifola frondosa extract are safe, so that the irritation is small, and the irritation of the shampoo can be obviously reduced; finally, the combined action of the lentinus edodes extract and the grifola frondosa extract can further improve the healthy growth of hair follicles, is beneficial to the growth of healthy hairlines, and grows hair with excellent combing performance.

By combining example 1, examples 4 to 6 and tables 3 to 5, it can be seen that healthy growth of hair follicle can be further promoted and a strong effect is exerted on hair, thereby improving combing performance of hair, by adding a plant component comprising an extract of phyllanthus emblica and hydrolyzed wheat protein to a tear-free shampoo; in addition, the components in the plant components can act together with the lentinus edodes extract, the grifola frondosa extract and the APG surfactant in the shampoo, so that the antibacterial performance of the shampoo is further improved, and a healthy scalp environment is provided for hair follicle growth.

By combining example 1, examples 7-10 and tables 3-5, it can be seen that the plant ingredients can be better matched with the extracts of lentinus edodes and grifola frondosa in the shampoo by adjusting the dosage of the phyllanthus emblica extract and the hydrolyzed wheat protein in the plant ingredients, and the tear-free shampoo with no irritation, excellent antibacterial performance and excellent combing performance can be prepared.

By combining the embodiment 1, the embodiment 11-12 and the table 3-5, it can be seen that the antibacterial performance and the combing performance of the shampoo can be further improved on the basis of the embodiment 1 by matching the hydrolyzed wheat protein with the phyllanthus emblica extract, so that the smooth and tough hairline can be grown; in addition, when the molecular weight of the hydrolyzed wheat protein is small, the hydrolyzed wheat protein can be better combined with the phyllanthus emblica extract and absorbed by skin, and an excellent synergistic effect can be exerted.

The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.

Claims

1. The tear-free shampoo is characterized in that: comprises 15-20 parts of amino acid surfactant, 10-15 parts of APG surfactant, 0.5-1 part of conditioner, 1-2 parts of thickener, 0.5-1 part of preservative, 0.5-2 parts of pH regulator, 1-2 parts of lentinus edodes extract, 0.5-1.5 parts of grifola frondosa extract and 100-150 parts of water;

2. The tear-free shampoo of claim 1, wherein: the lacrimation-free shampoo is used as a reference, and the lacrimation-free shampoo also comprises plant components, wherein the plant components comprise phyllanthus emblica extract and hydrolyzed wheat protein; the phyllanthus emblica extract comprises tannins, phenolic acid compounds and beta-glucoretannin.

3. A tear-free shampoo according to claim 2, characterized in that: the mass of the plant components accounts for 30% -50% of the total mass of the grifola frondosa extract and the lentinus edodes extract.

4. A tear-free shampoo according to claim 2, characterized in that: the molecular weight of the hydrolyzed wheat protein is 1000Da-3000Da.

5. A tear-free shampoo according to claim 2, characterized in that: the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein is 1: (2-5).

6. The tear-free shampoo of claim 5, wherein: the mass ratio of the phyllanthus emblica extract to the hydrolyzed wheat protein is 1: (3-4).

7. The tear-free shampoo of claim 1, wherein: the APG surfactant is at least one selected from APG1214, APG0816 and APG 1216.

8. The tear-free shampoo of claim 1, wherein: the amino acid surfactant is at least one selected from sodium cocoyl methyl taurate, sodium lauroyl glutamate and sodium cocoyl glycinate.

9. The tear-free shampoo of claim 1, wherein: the conditioning agent is silicone oil, the thickening agent is at least one of glycerol and sorbitol, the preservative is phenoxyethanol, and the pH regulator is citric acid.

10. The method for preparing the lacrimal-free shampoo according to any of claims 1-9, wherein: the method comprises the following steps:

step one: weighing the raw materials according to parts by weight, mixing the amino acid surfactant, the APG surfactant, the thickener and the preservative with the water, stirring, and cooling to obtain a mixed system;