CN116600815A - 自噬激活剂 - Google Patents

自噬激活剂 Download PDF

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Publication number
CN116600815A
CN116600815A CN202180073319.5A CN202180073319A CN116600815A CN 116600815 A CN116600815 A CN 116600815A CN 202180073319 A CN202180073319 A CN 202180073319A CN 116600815 A CN116600815 A CN 116600815A
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CN
China
Prior art keywords
autophagy
inositol
gene
salt
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180073319.5A
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English (en)
Chinese (zh)
Inventor
中上夕子
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Resonac Corp
Original Assignee
Resonac Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resonac Corp filed Critical Resonac Corp
Publication of CN116600815A publication Critical patent/CN116600815A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180073319.5A 2020-09-17 2021-09-17 自噬激活剂 Pending CN116600815A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020156460 2020-09-17
JP2020-156460 2020-09-17
PCT/JP2021/034305 WO2022059776A1 (ja) 2020-09-17 2021-09-17 オートファジー活性化剤

Publications (1)

Publication Number Publication Date
CN116600815A true CN116600815A (zh) 2023-08-15

Family

ID=80776143

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180073319.5A Pending CN116600815A (zh) 2020-09-17 2021-09-17 自噬激活剂

Country Status (6)

Country Link
US (1) US20230364119A1 (https=)
EP (1) EP4215200A4 (https=)
JP (1) JPWO2022059776A1 (https=)
KR (1) KR20230051237A (https=)
CN (1) CN116600815A (https=)
WO (1) WO2022059776A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000039141A1 (en) * 1998-12-23 2000-07-06 Rademacher Group Limited Inositol-containing hexasaccharides, their synthesis and their uses
CN101385722A (zh) * 2003-02-27 2009-03-18 乔安妮·麦克劳林 预防、治疗和诊断蛋白聚集疾病的方法
CN102046638A (zh) * 2008-03-21 2011-05-04 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
US20110224423A1 (en) * 2008-07-22 2011-09-15 Chung Sung-Kee Inositol and trehalose derivatives and pharmaceutical compositions for treating neurodegenerative diseases comprising the same
WO2019045113A1 (ja) * 2017-09-04 2019-03-07 昭和電工株式会社 イノシトール誘導体の混合物

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
JPS5944375A (ja) 1982-09-06 1984-03-12 Senjiyu Seiyaku Kk α−トコフエロ−ルリン酸エステルの安定な水溶液
US4654869A (en) 1985-09-11 1987-03-31 Itt Corporation Information collecting and forwarding apparatus
JPH0649715B2 (ja) 1987-02-10 1994-06-29 栗田工業株式会社 末端にイノシト−ル残基を結合したグルコオリゴ糖およびその製造方法
JPH0730066B2 (ja) 1988-03-09 1995-04-05 株式会社日本ハイポックス アスコルビン酸誘導体及びアスコルビン酸誘導体からなる抗酸化剤
JP2747001B2 (ja) 1989-04-18 1998-05-06 昭和電工株式会社 Ｌ―アスコルビン酸―２―リン酸エステル類の製造法
JP2926412B2 (ja) 1989-05-19 1999-07-28 株式会社林原生物化学研究所 α―グリコシル―Ｌ―アスコルビン酸とその製造方法並びに用途
JPH05213763A (ja) * 1992-02-10 1993-08-24 Sanwa Kagaku Kenkyusho Co Ltd 易吸収活性化カルシウム製剤
JPH06298783A (ja) 1993-03-31 1994-10-25 Mitsui Toatsu Chem Inc 新規なグリコシドの製造法
JP2705512B2 (ja) 1993-06-04 1998-01-28 昭和電工株式会社 Ｌ−アスコルビン酸−２−リン酸エステルの製造方法
JPH08134055A (ja) 1994-11-08 1996-05-28 Nippon High Potsukusu:Kk ３−ｏ−置換アスコルビン酸の製造方法
JPH0914705A (ja) 1995-06-29 1997-01-17 Hitachi Ltd 流体移送装置
RU2309733C2 (ru) * 1999-08-20 2007-11-10 Ферросан А/С Фармацевтическая система доставки витамина с и витамина е и применение комбинации витаминов с и е для профилактики или лечения состояний, связанных с окислительной нагрузкой
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
JP4624831B2 (ja) * 2004-03-25 2011-02-02 昭和電工株式会社 イノシトール誘導体を含有する皮膚外用剤及び化粧料
US20060258626A1 (en) * 2004-07-06 2006-11-16 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
WO2013018779A1 (ja) * 2011-08-01 2013-02-07 株式会社林原 α－グルコシルヘスペリジンの結晶とその用途
JP6312333B2 (ja) 2013-05-10 2018-04-18 昭和電工株式会社 糖化反応抑制剤
WO2016076310A1 (ja) 2014-11-10 2016-05-19 昭和電工株式会社 保湿剤
KR20170141705A (ko) 2015-04-08 2017-12-26 바이오멘딕스, 엘엘씨 상처 치유를 조절하기 위한 제형 및 방법
JP6740354B2 (ja) 2015-10-05 2020-08-12 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
JP7136765B2 (ja) * 2017-03-24 2022-09-13 株式会社林原 オートファジー誘導剤とその用途
JP2019112354A (ja) * 2017-12-25 2019-07-11 昭和電工株式会社 抗炎症剤及び抗炎症用組成物
JP2020156460A (ja) 2019-03-20 2020-10-01 株式会社リコー 液滴吐出装置用の液セット

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000039141A1 (en) * 1998-12-23 2000-07-06 Rademacher Group Limited Inositol-containing hexasaccharides, their synthesis and their uses
CN101385722A (zh) * 2003-02-27 2009-03-18 乔安妮·麦克劳林 预防、治疗和诊断蛋白聚集疾病的方法
CN102046638A (zh) * 2008-03-21 2011-05-04 综合医院公司 检测和治疗阿尔茨海默病和相关疾病的化合物和组合物
US20110224423A1 (en) * 2008-07-22 2011-09-15 Chung Sung-Kee Inositol and trehalose derivatives and pharmaceutical compositions for treating neurodegenerative diseases comprising the same
WO2019045113A1 (ja) * 2017-09-04 2019-03-07 昭和電工株式会社 イノシトール誘導体の混合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARIANO BIZZARRI 等: "Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease", 《EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY》, vol. 12, no. 10, 28 June 2016 (2016-06-28), pages 1181 - 1196 *

Also Published As

Publication number Publication date
US20230364119A1 (en) 2023-11-16
KR20230051237A (ko) 2023-04-17
JPWO2022059776A1 (https=) 2022-03-24
WO2022059776A1 (ja) 2022-03-24
EP4215200A4 (en) 2024-10-09
EP4215200A1 (en) 2023-07-26

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