CN116555264A - 转录调节元件及其在增强异源蛋白表达中的应用 - Google Patents

转录调节元件及其在增强异源蛋白表达中的应用 Download PDF

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CN116555264A
CN116555264A CN202310511931.7A CN202310511931A CN116555264A CN 116555264 A CN116555264 A CN 116555264A CN 202310511931 A CN202310511931 A CN 202310511931A CN 116555264 A CN116555264 A CN 116555264A
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sequence
proteins
vector
seq
protein
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Chinese (zh)
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张峥
李晓璐
张玉琛
李雅蓉
董慧芳
蔡洁行
周伟昌
陈智胜
牟丽丽
汤传龙
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Wuxi Biologics Shanghai Co Ltd
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Wuxi Biologics Shanghai Co Ltd
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN202310511931.7A 2018-08-14 2019-08-14 转录调节元件及其在增强异源蛋白表达中的应用 Pending CN116555264A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/CN2018/100467 WO2020034097A1 (en) 2018-08-14 2018-08-14 Transcriptional regulatory element and its use in enhancing the expression of exogenous protein
CNPCT/CN2018/100467 2018-08-14
PCT/CN2019/100549 WO2020034986A1 (en) 2018-08-14 2019-08-14 Transcriptional regulatory element and its use in enhancing the expression of heterologous protein
CN201980052283.5A CN113039272B (zh) 2018-08-14 2019-08-14 转录调节元件及其在增强异源蛋白表达中的应用

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CN201980052283.5A Active CN113039272B (zh) 2018-08-14 2019-08-14 转录调节元件及其在增强异源蛋白表达中的应用

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US (2) US11254952B2 (ko)
EP (1) EP3837368B1 (ko)
JP (1) JP7018163B2 (ko)
KR (1) KR102370150B1 (ko)
CN (2) CN116555264A (ko)
SG (1) SG11202101396SA (ko)
WO (2) WO2020034097A1 (ko)

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WO2021164704A2 (en) 2020-02-19 2021-08-26 Wuxi Biologics (Shanghai) Co., Ltd. Enhanced expression system and methods of use thereof
US20230323391A1 (en) * 2020-06-30 2023-10-12 The University Court Of The University Of Edinburgh Transgene expression system
CN115584394A (zh) * 2022-10-17 2023-01-10 昆明理工大学 一种从废旧锂离子电池中浸出锂镍钴锰的方法

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JP4917886B2 (ja) 2003-06-24 2012-04-18 ジェンザイム・コーポレーション 新規β−アクチンおよびRPS21プロモーター、ならびにこれらの使用方法
WO2005008888A1 (ja) 2003-07-22 2005-01-27 Daishinku Corporation 音叉型振動片、音叉型振動子、および音叉型振動片の製造方法
US7790446B2 (en) 2005-02-11 2010-09-07 Kosagen Cell Factory Oü Vectors, cell lines and their use in obtaining extended episomal maintenance replication of hybrid plasmids and expression of gene products
US8377653B2 (en) 2005-02-11 2013-02-19 Icosagen Cell Factory Oü Viral expression plasmids for production of proteins, antibodies, enzymes, virus-like particles and for use in cell-based assays
US20080124760A1 (en) * 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
JP4525863B1 (ja) * 2009-06-05 2010-08-18 東洋紡績株式会社 高生産性細胞の樹立のための発現ベクター及び高生産性細胞
WO2011033375A2 (en) * 2009-09-18 2011-03-24 Selexis S.A. Products and methods for enhanced transgene expression and processing
WO2012076715A1 (en) * 2010-12-09 2012-06-14 Institut Pasteur Mgmt-based method for obtaining high yield of recombinant protein expression
ES2540753T3 (es) * 2012-09-24 2015-07-13 Lonza Biologics Plc. Vectores de expresión que comprenden secuencias quiméricas de promotor y amplificador de citomegalovirus
CN103834686B (zh) * 2012-11-23 2016-05-25 上海药明生物技术有限公司 高效克隆筛选表达载体、其制备方法及用途
KR101599138B1 (ko) 2014-06-17 2016-03-03 한국생명공학연구원 재조합 단백질 발현 증진을 위한 유전자 절편을 포함하는 벡터 및 이의 용도
WO2015195049A1 (en) * 2014-06-18 2015-12-23 Agency For Science, Technology And Research Novel promoters for high level expression
KR20160068558A (ko) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
CN106432501B (zh) * 2015-08-06 2021-07-30 基石药业 新型抗pd-l1抗体
CN105255895B (zh) * 2015-11-06 2018-01-02 爱博环球生物技术有限公司 用于真核细胞系的提高蛋白表达水平的mar转录调控元件及其表达系统
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IL265331B2 (en) 2016-09-19 2024-01-01 I Mab Anti-GM-CSF antibodies and uses thereof
CN106987559A (zh) * 2017-03-22 2017-07-28 上海药明生物技术有限公司 一种重组chok1细胞株的构建方法及其应用

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US20210254100A1 (en) 2021-08-19
EP3837368B1 (en) 2023-01-11
KR102370150B1 (ko) 2022-03-03
US11254952B2 (en) 2022-02-22
CN113039272B (zh) 2023-05-30
WO2020034097A1 (en) 2020-02-20
CN113039272A (zh) 2021-06-25
SG11202101396SA (en) 2021-03-30
WO2020034986A1 (en) 2020-02-20
KR20210046706A (ko) 2021-04-28
JP2021525548A (ja) 2021-09-27
US20220127637A1 (en) 2022-04-28
EP3837368A1 (en) 2021-06-23
EP3837368A4 (en) 2021-12-01
JP7018163B2 (ja) 2022-02-09

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