CN116473901B - Moisturizing and repairing freeze-dried mask and preparation method thereof - Google Patents
Moisturizing and repairing freeze-dried mask and preparation method thereof Download PDFInfo
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- CN116473901B CN116473901B CN202310690467.2A CN202310690467A CN116473901B CN 116473901 B CN116473901 B CN 116473901B CN 202310690467 A CN202310690467 A CN 202310690467A CN 116473901 B CN116473901 B CN 116473901B
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- extract
- skin conditioner
- skin
- mask
- freeze
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Abstract
The invention provides a moisturizing and repairing freeze-dried mask and a preparation method thereof, wherein the preparation raw materials of the freeze-dried mask comprise a skin conditioner a and a skin conditioner b; the skin conditioner a comprises reed extract, corn silk extract, rice extract, aloe vera leaf extract and mallow flower leaf and stem extract; the skin conditioning agent b comprises a sphingomonas fermentation product extract. The freeze-dried mask provided by the invention adopts most of natural plant extracts or extracts of beneficial bacteria as raw materials, has good relieving effect, can nourish and regenerate skin, reduce skin sensitivity, radically resist water loss, lead the skin to get rid of dryness and repair skin injury.
Description
Technical Field
The invention belongs to the technical field of masks, and particularly relates to a moisturizing and repairing freeze-dried mask and a preparation method thereof.
Background
With the improvement of the living standard of people, the facial mask has become a popular beautifying and maintenance mode, and the facial mask comprises a plurality of facial masks, such as gel facial masks, water aqua facial masks, printing facial masks, local facial masks and the like. The most widely used is a water-based mask of essence with non-woven fabric as a carrier and impregnated with an effective component. The prior facial mask can be carried about after being packaged, and when in use, the facial mask is unpacked and directly taken out to be applied to the face, thereby achieving the effects of beautifying and maintaining.
The conventional facial mask is usually manufactured in a wet mode, each tablet contains 20-30mL of water and is compounded with other various components, the preservative can ensure that the mask does not deteriorate for a long time, the activity of some components can be greatly reduced in a liquid environment, and some components can even bring sensitization reaction to skin, so that the wet facial mask has the following defects: (1) The skin absorbs the nutrient components and also absorbs the preservative; (2) The product itself can also affect the health of the skin due to the production process and microorganisms in the raw materials; (3) Perfumes and solubilising surfactants also affect skin health; (4) The mask cloth and the mask bag are soaked in the mask liquid for a long time, and the leaching of some harmful substances can also influence skin health; (5) Some unstable raw materials with high biological activity can be attenuated in the mask, so that the mask is not beneficial to preservation and play of biological effects; (6) After the use, the face should be cleaned, mainly reducing the damage to the skin caused by the above reasons; (7) Because more of the active ingredients are washed away and not absorbed by the skin.
CN109394552a relates to a freeze-dried face mask of glow Yan Qingchun and a preparation method thereof, the freeze-dried face mask of glow Yan Qingchun comprises the following raw material components in parts by weight: 72 to 85 parts of water, 5 to 10 parts of saccharide composition, 0.05 to 0.15 part of glycerin, 0.1 to 0.5 part of glycine, 0.05 to 0.15 part of sodium hyaluronate, 1 to 4 parts of silanediol salicylate, 0.01 to 0.06 part of collagen, 1 to 4 parts of first auxiliary agent, 0.5 to 2.5 parts of second auxiliary agent and 1 to 6 parts of third auxiliary agent; the first auxiliary agent is formed by mixing 1, 2-hexanediol and ethylhexyl glycerol; the second auxiliary agent is formed by mixing oligopeptide 1, oligopeptide 3, monopotassium phosphate and sodium chloride; the third auxiliary agent is prepared by mixing dipeptide diamino Ding Xianbian-base amide diacetate, palmitoyl pentapeptide 4 and acetyl hexapeptide 8.
CN110960456a discloses a Shu Minbao wet freeze-dried mask, wherein the Shu Minbao wet freeze-dried mask is prepared by attaching functional components to mask cloth and freeze-drying; the functional components comprise 100 parts by weight of the total: 1.0 to 2.0 parts of paeonia lactiflora root extract, 2.0 to 5.0 parts of purslane extract, 4.0 to 8.0 parts of golden chamomile extract, 0.05 to 3.0 parts of baical skullcap root extract, 0.5 to 3.0 parts of sodium hyaluronate, 0.2 to 1.0 parts of tremella polysaccharide, 0.5 to 2.0 parts of allantoin, 0.2 to 2.0 parts of sodium polyglutamate, 2.3 to 5.1 parts of fibronectin, 1.5 to 5.6 parts of collagen, 2.0 to 4.0 parts of rhamnose and the balance of deionized water.
CN111743836a discloses a soothing and repairing mask liquid, a preparation method thereof and a freeze-dried mask containing the same. The preparation raw materials of the soothing and repairing mask liquid comprise: oligopeptide-1, glucan, tetrahydropyrimidine, a Inonotus umbellatus extract, type III collagen, a composite humectant and water.
Because the freeze-dried mask does not contain moisture, no preservative is required to be added, and skin injury or allergy caused by the preservative can be reduced; the mask is flexible to use, the wetting time is quick, and the mask can be used after being wetted by clear water or other nutrient water, so that the mask becomes a popular mask for the public. Therefore, development of a freeze-dried mask which is mild and does not irritate skin, repairs skin inflammation and can efficiently preserve moisture at the same time is a research focus in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the freeze-dried mask for moisturizing and repairing and the preparation method thereof.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
in a first aspect, the invention provides a moisturizing and repairing freeze-dried mask, wherein the preparation raw materials of the freeze-dried mask comprise a skin conditioner a and a skin conditioner b;
the skin conditioner a comprises reed extract, corn silk extract, rice extract, aloe vera leaf extract and mallow flower leaf and stem extract;
the skin conditioning agent b comprises a sphingomonas fermentation product extract.
The freeze-dried mask provided by the invention adopts most of natural plant extracts or extracts of beneficial bacteria as raw materials, has good nutrition and soothing effects, can nourish and regenerate skin, reduce skin sensibility, radically resist water loss, enable the skin to get rid of dryness and other effects, repair damaged collagen fibers and elastic fibers in dermis of the skin, repair skin injury and restore skin elasticity. Wherein the skin conditioner a comprises reed (PHRAGMITES COMMUNIS) extract, corn (ZEA MAYS) silk extract, rice (Oryza SATIVA) extract, ALOE vera (Aloe BARBADENSIS) leaf extract and flower/leaf/stem extract of Malva sylvestris (MALVA SYLVESTRIS) which are mutually matched and cooperated to exert moisturizing and repairing effects. The Sphingomonas (Sphingomonas) fermentation product extract is obtained by fermentation of Sphingomonas, and can inhibit the expression of two proteins p21Waf1 and p16INK4a related to skin aging, rebuild extracellular matrix, increase collagen and fibrin synthesis, and resist oxidative stress.
Preferably, the mass ratio of the skin conditioning agent a to the skin conditioning agent b is (0.5-1): 1, for example, may be 0.6:1, 0.8:1, 0.9:1, etc.
Preferably, the mass ratio of reed extract, corn silk extract, rice extract, aloe vera leaf extract and mallow leaf and stem extract in the skin conditioner a is (8-10): (8-10): 5-7): (5-7): 1, for example, may be 8:8:5:5:1, 9:8:5:5:1, 10:8:5:5:1, 9:8:6:5:1, 9:9:6:5:1, 9:10:6:5:1, 9:9:5:5:1, 9:9:7:5:1, 9:9:6:6:1, and the like, preferably 9.5:9.5:5:6:6:1.
Preferably, the mass percentage of the Sphingomonas fermentation product extract in the skin conditioner b is 4-6%, for example, 4.5%, 5%, 5.5%, etc., preferably 5%.
Preferably, the preparation raw materials of the freeze-dried facial mask further comprise a skin conditioner c.
Preferably, the skin conditioning agent c comprises hydroxypropyl tetrahydropyran triol.
Preferably, the content of the hydroxypropyl tetrahydropyran triol in the skin conditioning agent c is 20-40% by mass, for example, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38% and the like, preferably 30%.
The hydroxypropyl tetrahydropyran triol is also called as vitrine, is an anti-aging effective substance, delays the generation of fine wrinkles, moisturizes and moistens skin, has the effect of promoting collagen synthesis, promotes the repair of the fine wrinkles of the skin, and ensures that the skin is full, compact and elastic.
Preferably, the preparation raw material of the freeze-dried facial mask further comprises a skin conditioner d.
Preferably, the skin conditioner d comprises oligopeptide-1, tremella fruit body extract and glyceroglycosides.
Preferably, the mass ratio of oligopeptide-1, tremella fruit body extract and glyceroglycosides in the skin conditioner d is 1 (0.5-1.5): (10-15), for example, may be 1:0.5:10, 1:1:10, 1:1.5:10, 1:1:12, 1:1:15, and the like, preferably 1:1:12.
Other specific point values in the above numerical ranges are selectable, and will not be described in detail here.
The oligopeptide-1 is mainly used for repairing and nourishing skin, and the oligopeptide-1 can promote the growth, division and metabolism of cells in the deep layer of the skin, promote the growth of micro blood vessels and improve the microenvironment for cell growth. The tremella (TREMELLA FUCIFORMIS) fruiting body extract is a substance-derived hyaluronic acid, and the water-soluble polymer polysaccharide extracted from tremella has moisture retention performance exceeding that of hyaluronic acid, and can also enhance cellular immunity, remove free radicals, resist oxidation and aging, supplement nutrition, increase skin elasticity and reduce skin texture. The glyceroglycosides have the characteristics of low water absorbability and high moisture retention, have the effects of antioxidation, anti-aging, cell repair and the like, can effectively activate cells, promote cell regeneration, enhance the activity of the cells, accelerate the process of cell metabolism, and stimulate skin cells to regrow. Oligopeptide-1, tremella (TREMELLA FUCIFORMIS) fruiting body extract and glyceroglycosides cooperate to play a role in moisturizing and repairing.
Preferably, the preparation raw materials of the freeze-dried facial mask further comprise a skin conditioner e.
Preferably, the skin conditioner e comprises stephania tetrandra extract and gentian extract.
Preferably, the mass ratio of the stephania tetrandra extract to the gentian extract in the skin conditioner e is (1.5-2): 1, for example, 1.5:1, 1.8:1, 2:1, etc., preferably (1.7-1.8): 1.
The radix stephaniae tetrandrae (STEPHANIA TETRANDRA) extract has broad-spectrum anti-inflammatory effect and has inhibiting effect on various links of inflammatory reaction to different degrees; the GENTIANA SCABRA extract mainly contains gentiopicroside, has anti-inflammatory effect, can inhibit the increase of capillary permeability, has an activating effect on luciferase, has the functions of whitening and lightening spots, can inhibit the activity of enzyme, thereby destroying the growth condition of melanin, achieving the aim of delaying aging, and is beneficial to skin when being used in proper amount. The radix stephaniae tetrandrae (STEPHANIA TETRANDRA) extract and the radix gentianae (GENTIANA SCABRA) extract have synergistic effect, and further exert anti-inflammatory and repairing effects.
Preferably, when the preparation raw materials of the freeze-dried mask include the skin conditioner a, the skin conditioner b, the skin conditioner c, the skin conditioner d and the skin conditioner e, the mass ratio is (3.5-4.5): (3.5-4.5): 1.5-2.5): (2-2.5): 1, for example, may be 3.5:4:2:2:1, 4:4:2:2:1, 4.5:4:2:2:1, 4:3.5:2:1, 4:4:1.5:2:1, 4:4:2.5:2:1, 4:4:2.5:2.5:1, and the like, preferably, 4:4:2:2.2:1.
Preferably, the preparation raw materials of the freeze-dried facial mask further comprise a humectant.
Preferably, the humectant comprises trehalose, glycerol, sodium hyaluronate, sodium polyglutamate, beta-glucan, hydrolyzed sodium hyaluronate, tetrahydropyrimidine carboxylic acid, 1, 2-hexanediol, butylene glycol, 1, 2-pentanediol, and propylene glycol.
Other specific point values in the above numerical ranges are selectable, and will not be described in detail here.
In a second aspect, the present invention provides a method for preparing a lyophilized mask according to the first aspect, the method comprising:
(1) Adding humectant and water into a batching pot, stirring, homogenizing, cooling, adding skin conditioner a and skin conditioner b, and optionally skin conditioner c, skin conditioner d and skin conditioner e, continuously stirring, homogenizing, and filtering to obtain facial mask liquid;
(2) Soaking the mask cloth in the mask liquid, and freeze-drying the completely soaked mask cloth to obtain the freeze-dried mask.
Preferably, the rotational speeds of the stirring are each independently 30-40rpm, for example, 32rpm, 34rpm, 36rpm, 38rpm, etc.; the time is 10-15min, such as 12min, 13min, 14min, etc.
Preferably, the rotational speeds of the homogenizations are each independently 2500-3500rpm, for example 2600rpm, 2800rpm, 3000rpm, 3200rpm, 3400rpm, etc.; the time is 3-5min, such as 3.5min, 4min, 4.5min, etc.
Preferably, the temperature is raised to 85-90 ℃ after the humectant and water are put into the batching pot, and for example, 86 ℃, 87 ℃, 88 ℃, 89 ℃ and the like can be adopted.
Preferably, the temperature is reduced to 35-40deg.C, such as 36deg.C, 37deg.C, 38deg.C, 39deg.C, etc.
Preferably, the filtering screen is 550-650 mesh, for example, 560 mesh, 580 mesh, 600 mesh, 620 mesh, 640 mesh, etc.
Preferably, the time for soaking the mask cloth in the mask liquid is more than or equal to 12 hours, for example, 13 hours, 14 hours, 15 hours, 16 hours and the like.
Preferably, the freeze drying process is to cool to-45 ℃, keep the temperature for 2 hours, cool to-60 ℃, vacuumize to 50-60Pa, such as 52Pa, 54Pa, 56Pa, 58Pa, etc., then heat up to-20 ℃, keep the temperature for 120min, heat up to 10 ℃, keep the temperature for 460min, heat up to 42 ℃ and keep the temperature for 180min.
Other specific point values in the above numerical ranges are selectable, and will not be described in detail here.
Compared with the prior art, the invention has the following beneficial effects:
the freeze-dried mask provided by the invention adopts most of natural plant extracts or extracts of beneficial bacteria as raw materials, has good relieving effect, can nourish and regenerate skin, reduce skin sensitivity, radically resist water loss, lead the skin to get rid of dryness and repair skin injury.
The skin conditioner a, the skin conditioner b, the optional skin conditioner c, the optional skin conditioner d and the optional skin conditioner e are matched in the raw materials to play roles in efficiently moisturizing, relieving and repairing skin, and when the five skin conditioners are combined, the five skin conditioners cooperate with each other to play more excellent effects of moisturizing, relieving and repairing skin.
The five substances of reed extract, corn silk extract, rice extract, aloe vera leaf extract and mallow flower leaf and stem extract in the skin conditioner a are matched and synergistic to play the anti-inflammatory and repairing roles; the skin conditioner d further plays a role in moisturizing and repairing by the synergistic effect of oligopeptide-1, tremella fruit body extract and glyceroglycosides; the skin conditioner e comprises radix stephaniae tetrandrae extract and radix gentianae extract which are matched, so that the moisturizing and repairing effects of the mask are further improved.
Drawings
FIG. 1 is a graph of the inflammatory condition of the face of a subject before using a freeze-dried mask;
FIG. 2 is a graph of facial inflammation conditions of subjects using a freeze-dried mask for 4 weeks;
fig. 3 is a graph of facial inflammation conditions of subjects using a lyophilized mask for 8 weeks.
Detailed Description
The technical scheme of the invention is further described by the following specific embodiments. It will be apparent to those skilled in the art that the examples are merely to aid in understanding the invention and are not to be construed as a specific limitation thereof.
The terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, step, method, article, or apparatus.
"optional" or "any" means that the subsequently described event or event may or may not occur, and that the description includes both cases where the event occurs and cases where the event does not.
The indefinite articles "a" and "an" preceding an element or component of the invention are not limited to the requirement (i.e. the number of occurrences) of the element or component. Thus, the use of "a" or "an" should be interpreted as including one or at least one, and the singular reference of an element or component includes the plural reference unless the amount clearly dictates otherwise.
The description of the terms "one embodiment," "some embodiments," "exemplarily," "specific examples," or "some examples," etc., herein described means that a specific feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this document, the schematic representations of the above terms are not necessarily for the same embodiment or example.
The reagents or instrument sources in the following examples are as follows:
reed (PHRAGMITES COMMUNIS) extract, corn (ZEA MAYS) silk extract, rice (ORYZA SATIVA) extract, ALOE vera (ALOE barbadens) leaf extract, malva (MALVA SYLVESTRIS) flower/leaf/stem extract: purchased from guangzhou , biotechnology limited;
sphingomonas (SPHINGOMONAS) fermentation product extract: purchased from degares biotechnology limited, guangzhou city;
tremella (TREMELLA FUCIFORMIS) fruiting body extract: purchased from cantai biotechnology limited, guangzhou;
radix stephaniae tetrandrae (STEPHANIA TETRANDRA) extract, radix gentianae (GENTIANA SCABRA) extract: purchased from guangzhou gamma energy biotechnology limited.
Example 1
The embodiment provides a freeze-dried mask, and the raw materials and the dosage of the freeze-dried mask are shown in the table:
the preparation method of the freeze-dried mask comprises the following steps:
(1) Adding the solvent and the humectant a into a batching pot, heating to 90 ℃, stirring for 15 minutes at 35r/min, homogenizing for 5 minutes at 3000r/min, and cooling to 35 ℃.
(2) Adding humectant b, skin conditioner a, skin conditioner b, skin conditioner c, skin conditioner d and skin conditioner e, stirring for 35r/min, stirring for 15min, homogenizing for 3000r/min, cooling to room temperature for 5min, and sieving with 600 mesh sieve.
(3) Soaking the mask cloth for 12 hours, and feeding the mask cloth into a freeze dryer after the mask cloth is completely soaked. The refrigerating process comprises the following steps: and (3) after 90 minutes, the temperature reaches-45 ℃, the temperature is kept for 2 hours, then the temperature is slowly reduced to-60 ℃, the vacuum pumping process is carried out, the vacuum value reaches 60Pa, and the vacuum pumping process is completed. Entering a temperature technological curve process: heating to-20deg.C, and maintaining for 120min; heating to 10 ℃ after heat preservation, and preserving heat for 460min; heating to 42 ℃, preserving heat for 180min, pressing, returning to vacuum, and deflating to obtain the freeze-dried mask.
Examples 2 to 3
The embodiment provides a freeze-dried mask, and the raw materials and the dosage of the freeze-dried mask are shown in the table:
example 4
This example provides a freeze-dried mask which differs from example 1 only in that no reed (PHRAGMITES COMMUNIS) extract was added to the skin conditioner a, the missing fraction was complemented by corn (ZEA MAYS) silk extract, rice (ORYZA SATIVA) extract, ALOE vera (ALOE barbadenosis) and malva (MALVA SYLVESTRIS) flower/leaf/stem extracts in the proportions of example 1, keeping the total amount of skin conditioner a unchanged, and the other raw materials, amounts and preparation methods were the same as example 1.
Example 5
This example provides a freeze-dried mask which differs from example 1 only in that no corn (ZEA MAYS) silk extract was added to the skin conditioner a, the missing fraction was complemented by reed (PHRAGMITES COMMUNIS) extract, rice (ORYZA SATIVA) extract, ALOE vera (ALOE barbadenosis) and okra (MALVA SYLVESTRIS) flower/leaf/stem extracts in the proportions of example 1, keeping the total amount of skin conditioner a unchanged, and the other raw materials, amounts and preparation methods were the same as example 1.
Example 6
This example provides a freeze-dried mask which differs from example 1 only in that no rice (ORYZA SATIVA) extract was added to the skin conditioner a, the missing fraction was made up of reed (PHRAGMITES COMMUNIS) extract, corn (ZEA MAYS) silk extract, ALOE vera (ALOE barbadenosis) and okra (MALVA SYLVESTRIS) flower/leaf/stem extracts in the proportions of example 1, keeping the total amount of skin conditioner a unchanged, and the other raw materials, amounts and preparation methods were the same as example 1.
Example 7
This example provides a freeze-dried mask which differs from example 1 only in that ALOE vera (ALOE barbadenosis) is not added to the skin conditioner a, the missing parts are complemented by reed (PHRAGMITES COMMUNIS) extract, corn (ZEA MAYS) silk extract, rice (ORYZA SATIVA) extract and malva (MALVA SYLVESTRIS) flower/leaf/stem extract in the proportions of example 1, keeping the total amount of skin conditioner a unchanged, and other raw materials, amounts and preparation methods are the same as example 1.
Example 8
This example provides a freeze-dried mask which differs from example 1 only in that no flower/leaf/stem extract of malva (MALVA SYLVESTRIS) was added to the skin conditioner a, the missing part was complemented by reed (PHRAGMITES COMMUNIS) extract, corn (ZEA MAYS) silk extract, rice (ORYZA SATIVA) extract and ALOE vera (ALOE barbadenosis) in the proportions of example 1, keeping the total amount of skin conditioner a unchanged, and the other raw materials, amounts and preparation methods were the same as example 1.
Example 9
This example provides a lyophilized mask which differs from example 1 only in that the SPHINGOMONAS (SPHINGOMONAS) fermentation product extract in skin conditioner b was replaced with an equivalent amount of wild soybean (GLYCINE SOJA) seed extract, and the other materials, amounts and preparation methods were the same as in example 1.
Example 10
This example provides a freeze-dried mask which differs from example 1 only in that the hydroxypropyl tetrahydropyran triol in the skin conditioner c is replaced by an equivalent amount of ergothioneine, and the other materials, amounts and preparation methods are the same as in example 1.
Example 11
This example provides a lyophilized mask which differs from example 1 only in that oligopeptide-1 is not added to the skin conditioner d, the missing part is complemented by tremella (TREMELLA FUCIFORMIS) fruiting body extract and glyceroglycosides according to the proportion in example 1, the total amount of the skin conditioner d is kept unchanged, and other raw materials, amounts and preparation methods are the same as those in example 1.
Example 12
This example provides a lyophilized mask which differs from example 1 only in that no tremella (TREMELLA FUCIFORMIS) fruiting body extract is added to the skin conditioner d, the missing part is complemented by oligopeptide-1 and glyceroglycosides according to the ratio in example 1, the total amount of the skin conditioner d is kept unchanged, and other raw materials, amounts and preparation methods are the same as those in example 1.
Example 13
This example provides a freeze-dried mask which differs from example 1 only in that no glucosides are added to the skin conditioner d, the missing parts are complemented by oligopeptide-1 and tremella (TREMELLA FUCIFORMIS) fruiting body extracts according to the proportion in example 1, the total amount of the skin conditioner d is kept unchanged, and other raw materials, amounts and preparation methods are the same as example 1.
Example 14
This example provides a freeze-dried mask which differs from example 1 only in that the extract of stephania tetrandra (STEPHANIA TETRANDRA) was not added to the skin conditioner e, the missing part was complemented by the extract of GENTIANA scanra (GENTIANA scanra), the total amount of the skin conditioner e was kept unchanged, and other raw materials, amounts and preparation methods were the same as in example 1.
Example 15
This example provides a freeze-dried mask which differs from example 1 only in that no GENTIANA scanra extract was added to the skin conditioner e, the missing part was complemented by stephania tetrandra (STEPHANIA TETRANDRA) extract, the total amount of the skin conditioner e was kept unchanged, and other raw materials, amounts and preparation methods were the same as example 1.
Comparative example 1
This comparative example provides a freeze-dried mask which differs from example 1 only in that no skin conditioner a is added, the missing parts are complemented by skin conditioner b, skin conditioner c, skin conditioner d and skin conditioner e in the proportions in example 1, the total amount of skin conditioner is kept unchanged, and other raw materials, amounts and preparation methods are the same as in example 1.
Comparative example 2
This comparative example provides a freeze-dried mask which differs from example 1 only in that no skin conditioner b is added, the missing parts are complemented by skin conditioner a, skin conditioner c, skin conditioner d and skin conditioner e in the proportions in example 1, the total amount of skin conditioner is kept unchanged, and other raw materials, amounts and preparation methods are the same as in example 1.
Comparative example 3
This comparative example provides a freeze-dried mask which differs from example 1 only in that no skin conditioner c is added, the missing parts are complemented by skin conditioner a, skin conditioner b, skin conditioner d and skin conditioner e in the proportions of example 1, the total amount of skin conditioner is kept unchanged, and other raw materials, amounts and preparation methods are the same as in example 1.
Comparative example 4
This comparative example provides a freeze-dried mask which differs from example 1 only in that no skin conditioner d is added, the missing parts are complemented by skin conditioner a, skin conditioner b, skin conditioner c and skin conditioner e in the proportions in example 1, the total amount of skin conditioner is kept unchanged, and other raw materials, amounts and preparation methods are the same as in example 1.
Comparative example 5
This comparative example provides a freeze-dried mask which differs from example 1 only in that no skin conditioner e was added, the missing parts were complemented by skin conditioner a, skin conditioner b, skin conditioner c and skin conditioner d in the proportions in example 1, keeping the total amount of skin conditioner unchanged, and the other raw materials, amounts and preparation methods were the same as in example 1.
Test example 1
Inflammatory factor inhibition assay
Test sample: the freeze-dried masks prepared in examples 1 to 15 and comparative examples 1 to 5.
The experimental method comprises the following steps: RAW264.7 macrophages were used as subjects to establish a model of cellular inflammation by stimulating cells with lipopolysaccharide LPS (bacterial endotoxin). Macrophage cells were inoculated into 12-well plates at 37℃in an incubator with 5% CO 2 Incubating for 24h under aeration, and adding 1% dilution of the sampleAfter 2 hours, LPS (1. Mu.g/mL) was added, and a group to which no diluent was added and a group to which no LPS was added were added, and the mixture was stimulated for 24 hours, and the supernatant was collected, centrifuged, and detected. The level of proinflammatory inflammatory factor TNF-alpha release from RAW264.7 was analyzed using ELISA kit.
TNF- α inhibition was calculated from the following formula:
TNF-alpha inhibition ratio (%) = [ (LPS stimulated inflammatory factor concentration-test agent active inflammatory factor concentration)/(LPS stimulated inflammatory factor concentration-non-stimulated inflammatory factor concentration) ]. Times.100%.
The higher the TNF- α inhibition, the better the anti-inflammatory effect. The TNF- α inhibition test results are shown in Table 1.
Test example 2
Hyaluronidase activity inhibition assay
Test sample: the freeze-dried masks prepared in examples 1 to 15 and comparative examples 1 to 5.
The testing process comprises the following steps: (1) solution preparation: hyaluronidase solution: accurately weighing 0.01g of hyaluronidase, adding 4mL of acetic acid buffer solution, and obtaining the final concentration of 1250 mug.mL -1 。
0.5mg·mL -1 Sodium hyaluronate solution: accurately weighing 0.005g of sodium hyaluronate, adding into 10mL of acetic acid buffer solution, and fully dissolving for later use.
Acetic acid buffer (ph=5.6): diluting 1155 mu L of glacial acetic acid to 100mL in a volumetric flask, uniformly mixing, and taking 4.8mL as A solution; 2.72g of sodium acetate crystal is taken, dissolved and fixed to 100mL, and 45.2mL is taken as solution B after uniform mixing; and mixing A, B solution, and uniformly mixing deionized water to 100 mL. The pH was precisely determined and adjusted to 5.6 with solutions A or B.
Ellich reagent: accurately weighing 0.8g of p-dimethylaminobenzaldehyde, and dissolving in 15mL of concentrated hydrochloric acid and 15mL of absolute ethyl alcohol for later use.
Acetylacetone solution: accurately taking 3.5mL of acetylacetone dissolved in 50mL of l.0 mol.L -1 Sodium carbonate solution of (a). The acetylacetone solution needs to be prepared in situ.
The sample was dissolved in deionized water to prepare a 3% solution for use.
(2) The experimental process comprises the following steps:
add 0.1mL of 0.25 mmol.L to the tube -1 CaCl 2 The solution and 0.5mL hyaluronidase solution are incubated for 20min at 37 ℃; adding 0.5mL of sample solution to be tested, and culturing at 37 ℃ for 20min; adding 0.5mL sodium hyaluronate solution, and maintaining the temperature at 37 ℃ for 30min; then standing at normal temperature for 5min, adding 0.4mol.L -1 NaOH solution 0.1mL and acetylacetone solution 0.5mL, and immediately carrying out ice bath for 5min after heating reaction in boiling water bath for 15 min; then, 1.0mL of an Escherichia reagent was added, and the mixture was diluted with 3.0mL of absolute ethanol, left for 20 minutes, and then developed, the absorbance was measured, and the inhibition ratio was calculated by substituting the following formula.
Hyaluronidase inhibition (%): { [ (A-B) - (C-D) ]/(A-B) }. Times.100%, wherein: a is the absorbance value of the control solution (acetic acid buffer solution is used instead of sample solution); b is the absorbance value of the blank control solution (acetic acid buffer solution is used for replacing the sample solution and enzyme solution); c is the absorbance value of the tested sample solution; d is the absorbance value of the blank solution of the sample (acetic acid buffer solution is used for replacing enzyme solution). The higher the inhibition of hyaluronidase showed better effects of alleviating inflammation and skin repair, and the test results are shown in table 1.
TABLE 1
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From the table data, it can be seen that the reed extract, the corn silk extract, the rice extract, the aloe vera leaf extract and the mallow flower leaf and stem extract in the skin conditioner a have optimal anti-inflammatory and repairing effects when the five raw materials are matched in a specific proportion, and the lack of any one component can affect the anti-inflammatory and repairing effects of the mask; replacing SPHINGOMONAS (SPHINGOMONAS) fermentation product extract in the skin conditioner b with a component wild soybean (GLYCINE SOJA) seed extract commonly used in the prior art, wherein the TNF-alpha inhibition rate and the hyaluronidase inhibition rate are reduced; the hydroxypropyl tetrahydropyran triol in the skin conditioner c is replaced by ergothioneine which is a common component in the prior art, so that the inhibition rate of TNF-alpha and the inhibition rate of hyaluronidase are reduced; the oligopeptide-1, tremella (TREMELLA FUCIFORMIS) fruiting body extract and glyceroglycosides in the skin conditioner d are matched in a specific proportion for interaction, and any one component is absent, so that the TNF-alpha inhibition rate and the hyaluronidase inhibition rate are reduced; the extracts of radix Stephaniae Tetrandrae (STEPHANIA TETRANDRA) and radix Gentianae (GENTIANA SCABRA) in skin conditioner e are matched with each other, and if any one of the components is absent, the TNF-alpha inhibition rate and the hyaluronidase inhibition rate are reduced.
Comparative examples 1-5 illustrate that skin conditioner a, skin conditioner b, skin conditioner c, skin conditioner d and skin conditioner e in the mask work together to exert the effects of anti-inflammatory and soothing and repairing the skin, and if any one of the skin conditioners is absent, the TNF-alpha inhibition rate and the hyaluronidase inhibition rate of the mask are reduced, and the anti-inflammatory and repairing effects of the mask are affected.
Test example 3
Test population: the temperature of the test environment is 20-22 ℃, the humidity is 40-60%, and real-time dynamic monitoring is carried out. The subjects were 18-55 years old, 30 subjects total, and the lyophilized mask prepared in example 1 was used after cleansing every night for 8 weeks, and no product (cosmetic or topical medicine) could be used 1 day before testing the test site. Prior to testing, the subjects were required to uniformly clean the face and wipe it clean with dry facial tissues. After cleaning, measurement area markings were made on the face of the subject. Before formal test, the test bed should sit still for 30min in a room meeting the standard, can not drink water, and is placed in a test state to be kept relaxed.
The skin conditions of subjects using the freeze-dried mask of the present invention were detected, respectively, and then the skin conditions of 30 subjects at weeks 4 and 8 of the use of the freeze-dried mask, respectively, were detected.
Test instrument: VISIA 7.
The subject's anterior facial inflammation using the lyophilized mask is shown in figure 1; the subject used the lyophilized mask for 4 weeks facial inflammation conditions as shown in figure 2; the facial inflammatory conditions of the subjects using the lyophilized mask for 8 weeks are shown in figure 3.
Compared with the freeze-dried mask, the freeze-dried mask provided by the invention has the advantages that the total reduction amplitude of the red area of the face of a subject is about 25% in 4 weeks and about 45% in 8 weeks, and the freeze-dried mask provided by the invention has better effects of relieving sensitivity and repairing skin injury.
The applicant states that the process of the invention is illustrated by the above examples, but the invention is not limited to, i.e. does not mean that the invention must be carried out in dependence on the above process steps. It should be apparent to those skilled in the art that any modification of the present invention, equivalent substitution of selected raw materials, addition of auxiliary components, selection of specific modes, etc. fall within the scope of the present invention and the scope of disclosure.
Claims (9)
1. The freeze-dried mask for moisturizing and repairing is characterized in that the preparation raw materials of the freeze-dried mask comprise a humectant, a skin conditioner a, a skin conditioner b, a skin conditioner c, a skin conditioner d and a skin conditioner e;
the skin conditioner a comprises reed extract, corn silk extract, rice extract, aloe vera leaf extract and mallow flower leaf and stem extract;
the skin conditioner b comprises a sphingomonas fermentation product extract;
the skin conditioning agent c comprises hydroxypropyl tetrahydropyran triol;
the skin conditioner d comprises oligopeptide-1, tremella fruit body extract and glyceroglycosides;
the skin conditioner e comprises radix stephaniae tetrandrae extract and radix gentianae extract.
2. The lyophilized facial mask according to claim 1, wherein the mass ratio of reed extract, corn silk extract, rice extract, aloe vera leaf extract and mallow flower leaf and stem extract in the skin conditioner a is (8-10): 5-7): 1.
3. The lyophilized mask according to claim 1, wherein the mass percentage of the sphingomonas fermentation product extract in the skin conditioner b is 4-6%.
4. The lyophilized facial mask according to claim 1, wherein the content of hydroxypropyl tetrahydropyran triol in the skin conditioner c is 20-40% by mass.
5. The lyophilized facial mask according to claim 1, wherein the mass ratio of oligopeptide-1, tremella fruit body extract and glyceroglycosides in the skin conditioner d is 1 (0.5-1.5) (10-15).
6. The lyophilized facial mask according to claim 1, wherein the mass ratio of radix Stephaniae Tetrandrae extract to radix Gentianae extract in the skin conditioner e is (1.5-2): 1.
7. The lyophilized facial mask according to claim 1, wherein the mass ratio of the raw materials for preparing the lyophilized facial mask, skin conditioner a, skin conditioner b, skin conditioner c, skin conditioner d and skin conditioner e, is (3.5-4.5): 1.5-2.5): 2-2.5:1.
8. The lyophilized facial mask of claim 1, wherein the humectant comprises trehalose, glycerol, sodium hyaluronate, sodium polyglutamate, beta-glucan, hydrolyzed sodium hyaluronate, tetrahydropyrimidine carboxylic acid, 1, 2-hexanediol, butylene glycol, 1, 2-pentanediol, and propylene glycol.
9. A method of preparing a lyophilized mask as defined in any one of claims 1-8, comprising:
(1) Adding humectant and water into a batching pot, stirring, homogenizing, cooling, adding skin conditioner a, skin conditioner b, skin conditioner c, skin conditioner d and skin conditioner e, continuously stirring, homogenizing, and filtering to obtain facial mask liquid;
(2) Soaking the mask cloth in the mask liquid, and freeze-drying the completely soaked mask cloth to obtain the freeze-dried mask.
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1699390A (en) * | 2004-04-23 | 2005-11-23 | 莱雅公司 | New C-glycoside derivation and its titivating use |
| WO2018101517A1 (en) * | 2016-12-01 | 2018-06-07 | 주식회사 진켐 | Anti-inflammatory composition |
| CN109234180A (en) * | 2017-07-10 | 2019-01-18 | 伽蓝（集团）股份有限公司 | Sphingol single-cell, its extracellular products and its preparation method and application |
| KR101950382B1 (en) * | 2017-10-11 | 2019-02-20 | 주식회사 코리아나화장품 | Cosmetic Composition for Whitening of the Skin Comprising Fermented Extracts of Cassia tora, Phragmites communis, Sasa quelpaertensis, Anemarrhena asphodeloides and Gardenia jasminoides Ellis |
| CN111743836A (en) * | 2020-07-08 | 2020-10-09 | 广州暨创医美生物科技有限公司 | Soothing and repairing mask liquid, preparation method thereof and freeze-dried mask containing soothing and repairing mask liquid |
| CN112675122A (en) * | 2021-01-19 | 2021-04-20 | 优颜皮肤科学研究(广州)有限公司 | Soothing and repairing essence and preparation method thereof |
| JP2022031140A (en) * | 2020-08-07 | 2022-02-18 | 共栄化学工業株式会社 | External preparation for skin |
| CN114272150A (en) * | 2021-12-24 | 2022-04-05 | 诺斯贝尔化妆品股份有限公司 | Cutin stripping composition for cutin layer tissue and cutin stripping product |
| WO2022129549A1 (en) * | 2020-12-18 | 2022-06-23 | L'oreal | Extract of bacteria of the genus sphingomonas |
| CN115154379A (en) * | 2022-05-27 | 2022-10-11 | 广州市红十字会医院（暨南大学医学院附属广州红十字会医院） | Skin repair composition |
| KR20220138649A (en) * | 2021-04-06 | 2022-10-13 | 주식회사 단정바이오 | Composition for protecting skin comprising extract of Oryza Sativa(Rice), Phragmites Communis, Zea Mays(Corn) Silk, Malva Sylvestris(Mallow) and Aloe Barbadensis as active ingredient |
| CN116036000A (en) * | 2023-03-07 | 2023-05-02 | 浙江犀望生物科技有限公司 | Anti-allergy essence and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023076578A1 (en) * | 2021-10-31 | 2023-05-04 | L'oreal | Cosmetic compositions comprising high amounts of hydroxypropyl tetrahydropyrantriol |
-
2023
- 2023-06-12 CN CN202310690467.2A patent/CN116473901B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1699390A (en) * | 2004-04-23 | 2005-11-23 | 莱雅公司 | New C-glycoside derivation and its titivating use |
| WO2018101517A1 (en) * | 2016-12-01 | 2018-06-07 | 주식회사 진켐 | Anti-inflammatory composition |
| CN109234180A (en) * | 2017-07-10 | 2019-01-18 | 伽蓝（集团）股份有限公司 | Sphingol single-cell, its extracellular products and its preparation method and application |
| KR101950382B1 (en) * | 2017-10-11 | 2019-02-20 | 주식회사 코리아나화장품 | Cosmetic Composition for Whitening of the Skin Comprising Fermented Extracts of Cassia tora, Phragmites communis, Sasa quelpaertensis, Anemarrhena asphodeloides and Gardenia jasminoides Ellis |
| CN111743836A (en) * | 2020-07-08 | 2020-10-09 | 广州暨创医美生物科技有限公司 | Soothing and repairing mask liquid, preparation method thereof and freeze-dried mask containing soothing and repairing mask liquid |
| JP2022031140A (en) * | 2020-08-07 | 2022-02-18 | 共栄化学工業株式会社 | External preparation for skin |
| WO2022129549A1 (en) * | 2020-12-18 | 2022-06-23 | L'oreal | Extract of bacteria of the genus sphingomonas |
| CN112675122A (en) * | 2021-01-19 | 2021-04-20 | 优颜皮肤科学研究(广州)有限公司 | Soothing and repairing essence and preparation method thereof |
| KR20220138649A (en) * | 2021-04-06 | 2022-10-13 | 주식회사 단정바이오 | Composition for protecting skin comprising extract of Oryza Sativa(Rice), Phragmites Communis, Zea Mays(Corn) Silk, Malva Sylvestris(Mallow) and Aloe Barbadensis as active ingredient |
| CN115192501A (en) * | 2021-04-06 | 2022-10-18 | 有限公司丹鼎生物 | Cosmetic composition for skin protection comprising extracts of rice, reed, corn silk, malva sylvestris and aloe vera |
| CN114272150A (en) * | 2021-12-24 | 2022-04-05 | 诺斯贝尔化妆品股份有限公司 | Cutin stripping composition for cutin layer tissue and cutin stripping product |
| CN115154379A (en) * | 2022-05-27 | 2022-10-11 | 广州市红十字会医院（暨南大学医学院附属广州红十字会医院） | Skin repair composition |
| CN116036000A (en) * | 2023-03-07 | 2023-05-02 | 浙江犀望生物科技有限公司 | Anti-allergy essence and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| "Self-Adhesive and Antioxidant Poly(vinylpyrrolidone)/Alginate- Based Bilayer Films Loaded with Malva sylvestris Extracts as Potential Skin Dressings";Marco Contardi等;《Appl. Bio Mater.》;第5卷;第2880−2893页 * |
| "鞘氨醇单胞菌的特性及应用研究进展";张颖 等;《化学与生物工程》;第38卷(第3期);第6-13页 * |
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