CN104800094B - A kind of anti-striae of pregnancy peritonaeum - Google Patents
A kind of anti-striae of pregnancy peritonaeum Download PDFInfo
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- CN104800094B CN104800094B CN201410039948.8A CN201410039948A CN104800094B CN 104800094 B CN104800094 B CN 104800094B CN 201410039948 A CN201410039948 A CN 201410039948A CN 104800094 B CN104800094 B CN 104800094B
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- pregnancy
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- peritonaeum
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Abstract
The present invention relates to cosmetic technical field, and in particular to a kind of anti-striae of pregnancy peritonaeum.The invention discloses a kind of anti-striae of pregnancy peritonaeum, it is characterised in that it mainly contains 1% 10% fermentation collagen protein extracts of the collagen of 1% 25% superpurity small molecules of gross weight and gross weight.Anti- striae of pregnancy peritonaeum of the present invention contains the collagen of superpurity small molecule prepared by the method for the invention, it is easier to penetrate into skin, fibroblastic growth can be promoted, synthesis and secretion collagenous fibres, elastomer, reticular fibre, increase elastomer and collagen structure content in skin, can effectively prevent striae of pregnancy or improve striae of pregnancy symptom；Chemicals is not used in the preparation process of the anti-striae of pregnancy peritonaeum, it is green safe, reduce allergic risk.
Description
Technical field
The present invention relates to cosmetic technical field, and in particular to a kind of anti-striae of pregnancy peritonaeum.
Background technology
Striae of pregnancy（Stretch marks）Formation be mainly that gestational period load-bearing your twilight is rung, the bulge of belly makes skin
Elastic fibers and collagenous fibres attenuated because external force pulls by different degrees of damage or fracture, thinning of skin, stomach wall skin
The wavy decorative pattern of the pink that some width are different, different in size or aubergine occurs in skin.Fibroblast in skin
Attempt to synthesize new fiber and go to plug the gap, but these Fresh fats are lower than old quality.After the several months, old striae of pregnancy becomes
Pearl white is simultaneously shinny.The related striae of pregnancy of pregnancy occurs especially in the preceding surface of belly, but they also betide chest, thigh and stern
Portion.
At present, striae of pregnancy is impossible to be completely eliminated, but there is a possibility that damage mitigates or improved.The processing method for the treatment of
The substantially local compound using all-trans vitamin A acid or tartaric acid, or use peeling（peeling）Or laser, but imitate
Fruit is bad.
Pathological Physiology based on striae of pregnancy, prevention and reduction need to use to pregnant related striae of pregnancy and target skin
Fibroblastic product, it can be bred by active cell and stimulate metabolism, particularly elasticity is fine in increase skin
Peacekeeping collagen structure content plays a role.People are come frequently with skin using collagen or its hydrolysate, it is intended to
Directly increase collagen content in skin, but because collagen or its hydrolysate are not easy to pass through keratoderma, and can not play
It is acted on.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of anti-striae of pregnancy peritonaeum and preparation method thereof, are mitigated with improving
Or improve striae of pregnancy symptom.
For the above-mentioned technical problem of solution, the invention discloses a kind of anti-striae of pregnancy peritonaeum, its feature its mainly contain weight
The fermentation collagen protein extract that the collagen and weight ratio for the superpurity small molecule that amount ratio is 1%-25% are 1%-10%.
The collagen of the superpurity small molecule is prepared by the following steps：
A, the preparation of collagen powder：Fish-skin or fish scale material after pulverizer crushes and obtains collagen raw material,
Water：The raw material is with 30：70 ratio is well mixed and adjusts pH value to be added to 7.5 by the 0.4% of collagen weight
Bacillus licheniformis, kept for 4 hours at 60 DEG C.Then the above-mentioned collagen solution pH value after processing is adjusted
To after 6.5, then by weight 0.2% addition Bacillus amyloliquefaciens fermented two hours at 45 DEG C, pass through survey
The viscosity of collagen, molecular weight are heated rapidly to 85 DEG C 1000 or so, and terminate enzyme activity；Centrifugation, foreign matter is removed, with filter
After paper filtering, concentration, sterilizing；
B, the 2nd hydrolysis of collagen powder, it comprises the following steps：
The concentrate of collagen after 1st hydrolysis, using the volume ratio with water as 60：40 ratio mixing,
Enzymolysis：The 1.0% of pepsin addition collagen weight, 5 DEG C, 6-12 hours;
Pyrohydrolysis：70 DEG C, 1 hour, stirring；
Super-pressure hydrolyzes：40-1000MPa, 1-24 hour；
It is freeze-dried 24-36 hours, sealing.
The fermentation collagen protein extract is prepared by the following steps：
Lactobacillus inoculum is trained into the fermentation culture of the collagen containing above-mentioned superpurity small molecule at 40-50 DEG C
Support 24 hours and filter, add lactic acid bacteria, at 40-50 DEG C, be further cultured for 24 hours；Fermentation-derived product, concentrate, sterilizing.
In certain embodiments, the lactic acid bacteria is lactobacillus bulgaricus（Lactobacillus bulgaricus）.
In certain embodiments, the anti-striae of pregnancy peritonaeum also contains antioxidant, and weight ratio is 1%-3%, the antioxygen
Agent is vitamin C, L-Ascorbic Acid L-O-Phosphate, vitamin C alkyl phosphate, VCE, AA2G, dimension
One of raw plain E acetates, tocopherol or combinations thereof, preferably vitamin C, AA2G, Vitwas E
And tocopherol.
In certain embodiments, the anti-striae of pregnancy peritonaeum also contains niacinamide；
In certain embodiments, the anti-striae of pregnancy peritonaeum also contains dipotassium glycyrrhizinate；
In certain embodiments, the anti-striae of pregnancy peritonaeum by following weight ratio material composition：
In certain embodiments, the anti-striae of pregnancy peritonaeum also contains skin penetration enhancer, and the Transdermal absorption promotes
Agent is one of terpene, essential oil, lactone or pyrrolidinone compounds or combinations thereof, preferably volatile clove oil, peppermint oil, eucalyptus
The thio good fortune quinoline of oil, borneol, azone, 4- lauryl alcohols, N- dodecanes-α-adjoin and cough up quinoline ketone, N- dodecane -2- piperidines
Ketone, to one of 5 FU 5 fluorouracil or N- acetyl proline amylalcohol esters or combinations thereof, most preferably weight is than 1: 1: 1
Volatile clove oil, peppermint oil and azone combination.
Anti- striae of pregnancy peritonaeum of the present invention contains the micromolecular collagen that molecular weight is less than 1000 dalton, makes small point
Sub- collagen is easier to penetrate into skin, can promote fibroblastic growth, synthesis and secretion collagenous fibres, elastomer, net
Shape fiber, increase elastomer and collagen structure content in skin, effectively prevent striae of pregnancy or improve striae of pregnancy symptom；It is described
Chemicals is not used in the preparation process of anti-striae of pregnancy peritonaeum, it is green safe, reduce allergic risk.
Brief description of the drawings
Fig. 1, collagen powder liquid mass spectrometry analyze total ion figure；
Fig. 2, the collagen liquid mass spectrometry of superpurity small molecule analyze total ion figure；
Embodiment
Below in conjunction with specific embodiment, the present invention is expanded on further.These embodiments are merely to illustrate the present invention and not had to
In limitation the scope of the present invention.The experimental method of unreceipted actual conditions in the following example, generally according to normal condition or press
According to the condition proposed by manufacturer.Unless otherwise defined, all specialties used in text are ripe with this area with scientific words
It is identical to practice meaning known to personnel.In addition, any method similar or impartial to described content and material all can be applied to
In the inventive method.Preferable implementation described in text only presents a demonstration with material to be used.
Embodiment 1, the collagen of superpurity small molecule are prepared by the following steps：
1st, the preparation of collagen powder：
Dry walleye pollack skin is after pulverizer crushes and obtains collagen raw material, water：The raw material is with 30：70 ratio
Example is well mixed and adjusts pH value Bacillus licheniformis to be added by the 0.4% of collagen weight, at 60 DEG C to 7.5
It is lower to be kept for 4 hours.Then after the above-mentioned collagen solution pH value after processing being adjusted into 6.5, then 0.2% addition by weight
Bacillus amyloliquefaciens ferment two hours at 45 DEG C, and by surveying the viscosity of collagen, molecular weight exists
1000 or so, temperature makes its rapid increase under conditions of 85 DEG C, and terminate unnecessary enzyme（Ferment）Priming reaction.At ferment
Collagen extract centrifugation after reason, removes foreign matter, after being filtered with filter paper, is concentrated with 40% concentration.Collagen egg after concentration
Quality is examined after spray drying after 121 DEG C, lasting sterilizing in 0.8 second with UHT TYPE sterilizers in vain, is the 1st after sterilization packaging
Secondary Hydrolyzed Collagen.；
2nd, the 2nd hydrolysis of collagen powder：
Collagen after 1st hydrolysis, using the ratio with water as 60：40 ratio mixing,
Enzymolysis：The 1.0% of pepsin addition collagen weight, 5 DEG C, 6-12h;
Pyrohydrolysis：70 DEG C, 1h, stirring；
Super-pressure hydrolyzes：40-1000MPa, 1-24h；
The collagen freezing processing of 2nd hydrolysis;
- 75 DEG C of the temperature in freeze drier (Freeze Dryer, Ilshinbiobase), pressure 5mbar freeze-dryings
24-36 hours, sealing.
Microorganism preventing agent 1,2-Hexanediol, Pentylene can be added after enzymolysis processing in collagen
Glycol。
Collagen powder and the collagen of superpurity small molecule carry out Mass Spectrometer Method respectively, find non-highly pressured hydrolysis
2000m/z macromolecules collagen (Fig.1) in collagen (base peak698.33m/z) be present, but pass through water under high pressure
More than 2000m/z macromolecule collagen protein ratio significantly reduces in collagen (base peak663.42m/z) z of solution
(Fig.2).This shows that collagen highly pressured hydrolysis can reduce molecular weight, makes the increase of micromolecular collagen content, macromolecular
Collagen content reduces.
It is prepared by the fermentation collagen protein extract of embodiment 2
In the collagen aqueous solution of 10% 2nd hydrolysis inoculating strain (Lactobacillus bulgaricus,
KCTC3635 at 40-50 DEG C of incubation temperature, culture is filtered after 24 hours, adds 1.0% by) 1.0%, the KCTC3635 of inoculation
After bacterial strain, as 1 fermentation procedure, at 40-50 DEG C, cultivate 24 hours.After 2 fermentations, filtering, concentrated with rotary pressing
Machine, pressurize spin concentration after, sterilizing filling.
The preparation of the anti-striae of pregnancy peritonaeum of embodiment 3
According to 1000g gross weights, each formula composition is as follows, and surplus is total to 1000g by water polishing
| Collagen | Extract | Antioxidant | Niacinamide | Dipotassium glycyrrhizinate | Emulsifying agent | Preservative | Gelatin | Transdermal agent | |
| Formula 1 | 250 | 50 | 20.102 | 0.2 | 0.3 | 3 | 1.11 | 1 | - |
| Formula 2 | 100 | 10 | 30 | 0.1 | 0.2 | 2 | 1 | 2 | - |
| Formula 3 | 10 | 100 | 10 | 0.05 | 0.1 | 1 | 1.5 | 1 | - |
| Formula 4 | 250 | 50 | 20.102 | 0.2 | 0.3 | 3 | 1.11 | 1 | 5 |
The collagen is the collagen of the superpurity small molecule prepared by embodiment 1；The extract is implementation
Fermentation collagen protein extract prepared by example 2；
The antioxidant is vitamin C, L-Ascorbic Acid L-O-Phosphate, vitamin C alkyl phosphate, vitamin C ethyl
One of ether, AA2G, Vitwas E, tocopherol or combinations thereof, preferably AA2G, dimension life
Plain E acetates and tocopherol.
The emulsifying agent is Bis-PEG-18Methyl Ether Dimethyl silane0.2%, PEG-
60Hydrogenated Castor Oil0.1%；The preservative is Methylparaben0.1%,
Propylparaben0.01%, Phenoxyethanol~0.015% (are included in extract)；
The transdermal agent refers to skin penetration enhancer, and the skin penetration enhancer is terpene, essential oil, lactone or pyrroles
One of alkanone class or combinations thereof, preferably volatile clove oil, peppermint oil, eucalyptus oil, borneol, azone, 4- lauryl alcohols
Thio good fortune quinoline, N- dodecanes-α-adjoin and cough up quinoline ketone, N- dodecane -2- piperidones, to 5 FU 5 fluorouracil or N- acetyl
One of proline amylalcohol ester or combinations thereof, most preferably volatile clove oil of the weight than 1: 1: 1, peppermint oil and bay nitrogen
Ketone combines.
Said components, in addition to emulsifying agent, it is well mixed, adding qs pH adjuster makes pH of mixed to 6.5-7.5, then adds
Enter emulsifying agent to be well mixed, filter, plastic film mulch shaping.
Embodiment 4, striae of pregnancy of dispelling experiment
After person on probation cleans skin of abdomen sooner or later daily, anti-striae of pregnancy peritonaeum prepared by embodiment 1 is covered at belly,
10-15 minutes, after trying out 60-70 days, assessment result, evaluation criteria：Striae of pregnancy disappears or partial disappearance is effective；Do not disappear and be
It is invalid.
As a result：
| Type | Test total number of persons | Efficiently individual quantity | Invalid number | It is efficient |
| Striae of pregnancy | 200 | 190 | 10 | 95% |
The scope of the present invention is not limited by the specific embodiments described, and the embodiment is only used as illustrating the present invention respectively
The single example of individual aspect, the method and component of functional equivalent are also included in the scope of the invention.In fact, except as described herein
Outside content, those skilled in the art can easily grasp a variety of improvement to the present invention with reference to described above and accompanying drawing.Institute
Improvement is stated to also fall within the scope of the appended claims.Every bibliography mentioned above is all included in conduct herein in full
With reference to.
Claims (10)
1. a kind of anti-striae of pregnancy peritonaeum, it is characterised in that it mainly contains the glue of the 1%-25% of gross weight superpurity small molecule
Former albumen and the 1%-10% of gross weight fermentation collagen protein extracts, the collagen egg of at least a portion superpurity small molecule
It is made in vain using highly pressured hydrolysis method.
2. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the anti-striae of pregnancy peritonaeum is also containing gross weight
1%-3% antioxidants, the antioxidant are vitamin C, L-Ascorbic Acid L-O-Phosphate, vitamin C alkyl phosphate, dimension life
One of plain C ethylethers, AA2G, Vitwas E, tocopherol or combinations thereof.
3. anti-striae of pregnancy peritonaeum as claimed in claim 2, it is characterised in that the antioxidant is vitamin C, vitamin C sugar
Glycosides, Vitwas E and tocopherol.
4. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the anti-striae of pregnancy peritonaeum contains gross weight
0.02% niacinamide.
5. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the anti-striae of pregnancy peritonaeum also contains gross weight
0.03% dipotassium glycyrrhizinate.
6. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the anti-striae of pregnancy peritonaeum contains gross weight 0.5%
Skin penetration enhancer, the skin penetration enhancer be one of terpene, essential oil, lactone or pyrrolidinone compounds or they
Combination.
7. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the anti-striae of pregnancy peritonaeum is by following weight ratio
Material composition：
8. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the collagen of the superpurity small molecule be by
The following steps are prepared：
A, the preparation of collagen powder：Fish-skin or fish scale material are after pulverizer crushes and obtains collagen raw material, water：
The raw material is with 30：70 ratio is well mixed and adjusts pH value to add Bacillus by the 0.4% of collagen weight to 7.5
Licheniformis, kept at 60 DEG C 4 hours, after the above-mentioned collagen solution pH value after processing then is adjusted into 6.5,
0.2% addition Bacillus amyloliquefaciens by weight ferment two hours at 45 DEG C again, then rapid heating
To 85 DEG C, terminate enzyme activity；Centrifugation, foreign matter is removed, after being filtered with filter paper, concentration, sterilizing；
B, the 2nd hydrolysis of collagen powder, it comprises the following steps：
The concentrate of collagen after 1st hydrolysis, using the volume ratio with water as 60：40 ratio mixing, enzymolysis：Pepsin adds
Add the 1.0% of collagen weight, 5 DEG C, 6-12 hours；
Pyrohydrolysis：70 DEG C, 1 hour, stirring；
Super-pressure hydrolyzes：40-1000MPa, 1-24 hour；
It is freeze-dried 24-36 hours, sealing.
9. anti-striae of pregnancy peritonaeum as claimed in claim 1, it is characterised in that the fermentation collagen protein extract is by following
Step is prepared：
A) lactobacillus inoculum is cultivated into the fermentation culture of the collagen containing above-mentioned superpurity small molecule at 40-50 DEG C
Filter within 24 hours, add lactic acid bacteria, at 40-50 DEG C, be further cultured for 24 hours；
B) fermentation-derived product；
C) concentrate, sterilizing.
10. anti-striae of pregnancy peritonaeum as claimed in claim 9, it is characterised in that the lactic acid bacteria is lactobacillus bulgaricus.
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| CN201410039948.8A CN104800094B (en) | 2014-01-27 | 2014-01-27 | A kind of anti-striae of pregnancy peritonaeum |
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| CN106265310A (en) * | 2016-08-31 | 2017-01-04 | 天津天狮生物发展有限公司 | Prevention striae gravidarum compositions and striae gravidarum frost and preparation method thereof |
| CN106890098A (en) * | 2017-03-24 | 2017-06-27 | 贾广袖 | Tripe film and the belly beauty method using tripe film |
| CN107496345A (en) * | 2017-09-01 | 2017-12-22 | 安庆徽云博冠化妆品科技有限公司 | A kind of protein chelates mildy wash and preparation method thereof |
| CN107519036A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of striae of pregnancy spray containing polypeptide and preparation method thereof |
| CN110478295A (en) * | 2019-09-17 | 2019-11-22 | 马志银 | A kind of film plaster formula and preparation method for repairing striae of pregnancy |
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| CN101886106A (en) * | 2010-07-02 | 2010-11-17 | 湖北远成药业有限公司 | Method for extracting collagen peptide from fish scales |
| CN102318843B (en) * | 2011-07-01 | 2013-08-21 | 中国科学院海洋研究所 | Scale collagen polypeptide and preparation method thereof |
| BR112014011481B1 (en) * | 2011-11-29 | 2019-02-05 | Gelita Ag | use of collagen hydrolyzate in the production of a product for the treatment and / or prevention of cellulite and / or stretch marks |
| CN103479565A (en) * | 2013-09-02 | 2014-01-01 | 吉安市御美丽健康产业有限公司 | Skin cream for removing striae gravidarum |
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