CN116390771A - 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 - Google Patents
与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 Download PDFInfo
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- CN116390771A CN116390771A CN202180062762.2A CN202180062762A CN116390771A CN 116390771 A CN116390771 A CN 116390771A CN 202180062762 A CN202180062762 A CN 202180062762A CN 116390771 A CN116390771 A CN 116390771A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- Oncology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
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- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410175152.9A CN118085100A (zh) | 2020-07-13 | 2021-07-12 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063051172P | 2020-07-13 | 2020-07-13 | |
| US63/051,172 | 2020-07-13 | ||
| US202163154531P | 2021-02-26 | 2021-02-26 | |
| US63/154,531 | 2021-02-26 | ||
| PCT/US2021/041304 WO2022015656A1 (en) | 2020-07-13 | 2021-07-12 | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410175152.9A Division CN118085100A (zh) | 2020-07-13 | 2021-07-12 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116390771A true CN116390771A (zh) | 2023-07-04 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| CN202410175152.9A Pending CN118085100A (zh) | 2020-07-13 | 2021-07-12 | 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025103474A1 (zh) * | 2023-11-17 | 2025-05-22 | 成都康弘生物科技有限公司 | 双毒素抗体药物偶联物及其用途 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230097908A1 (en) * | 2020-01-22 | 2023-03-30 | Medimmune Limited | Compounds and conjugates thereof |
| CN115925796B (zh) * | 2020-09-30 | 2024-05-31 | 映恩生物制药(苏州)有限公司 | 一种抗肿瘤化合物及其制备方法和应用 |
| JP2025502147A (ja) * | 2022-01-12 | 2025-01-24 | リジェネロン ファーマシューティカルズ,インク. | タンパク質中のグルタミン残基にコンジュゲートしたカンプトテシンアナログおよびその使用 |
| CN118591524A (zh) * | 2022-01-24 | 2024-09-03 | 北京桦冠生物技术有限公司 | 缀合物及其用途 |
| WO2023172968A1 (en) * | 2022-03-09 | 2023-09-14 | Merck Patent Gmbh | Anti-gd2 antibodies, immunoconjugates and therapeutic uses thereof |
| TW202344252A (zh) * | 2022-05-09 | 2023-11-16 | 大陸商同宜醫藥(蘇州)有限公司 | 一種喜樹鹼衍生物,基於其的抗體-藥物偶聯物和藥物組成物,及其應用 |
| WO2024008102A1 (en) * | 2022-07-05 | 2024-01-11 | Wuxi Xdc (Shanghai) Co., Ltd. | Linker for conjugation |
| KR20250054842A (ko) | 2022-07-29 | 2025-04-23 | 리제너론 파마슈티칼스 인코포레이티드 | 뇌 및 근육으로의 트랜스페린 수용체(tfr)-매개 전달을 위한 조성물 및 방법 |
| IL319866A (en) * | 2022-09-30 | 2025-05-01 | Beigene Switzerland Gmbh | Ligand-drug conjugates of exatacan analogs and their medical use |
| WO2024107765A2 (en) | 2022-11-14 | 2024-05-23 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| AU2023407365A1 (en) * | 2022-12-21 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof |
| CN121001751A (zh) | 2023-02-09 | 2025-11-21 | 里珍纳龙药品有限公司 | 借助逆电子需求狄尔斯-阿尔德反应的抗体-药物缀合物 |
| WO2025014533A1 (en) | 2023-07-10 | 2025-01-16 | Regeneron Pharmaceuticals, Inc. | Anti-human cacng1 antibody-drug conjugates and uses thereof |
| WO2025038752A1 (en) * | 2023-08-14 | 2025-02-20 | Cancer Targeted Technology Llc | Psma binding ligand-linker conjugates and methods for use thereof |
| EP4537854A1 (en) * | 2023-10-04 | 2025-04-16 | Formosa Laboratories, Inc. | Compound for conjugation, conjugate and pharmaceutical composition comprising the same |
| WO2025078841A2 (en) | 2023-10-11 | 2025-04-17 | Antikor Biopharma Limited | Antibodies, conjugates, and uses thereof |
| WO2025199666A1 (en) * | 2024-03-25 | 2025-10-02 | Canwell Biotech Limited | Multivalent linkers for high loading antibody-drug conjugates, and compositions and methods thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104220458A (zh) * | 2012-02-24 | 2014-12-17 | 阿特根公司 | 结合有含半胱氨酸残基的基序的修饰抗体,含该修饰抗体的修饰抗体-药物缀合物以及其制造方法 |
| EP2907824A1 (en) * | 2012-10-11 | 2015-08-19 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
| WO2015155998A1 (en) * | 2014-04-10 | 2015-10-15 | Daiichi Sankyo Company, Limited | Anti-her3 antibody-drug conjugate |
| CN105517577A (zh) * | 2013-06-21 | 2016-04-20 | 先天制药公司 | 多肽的酶促偶联 |
| CN110088138A (zh) * | 2016-09-23 | 2019-08-02 | 瑞泽恩制药公司 | 抗steap2抗体、抗体药物偶联物和结合steap2和cd3的双特异性抗原结合分子以及其用途 |
| WO2019217591A1 (en) * | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| CN110974975A (zh) * | 2019-12-12 | 2020-04-10 | 四川百利药业有限责任公司 | 一种快速释放的抗体药物偶联物 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| CA2008368C (en) | 1989-01-24 | 2003-04-08 | Jeffrey Greve | Soluble molecule related to but distinct from icam-1 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
| EP1572916A4 (en) | 2002-04-05 | 2007-05-30 | Agensys Inc | NUCLEIC ACID AND CORRESPONDING PROTEIN WITH THE NAME 98P4B6, SUITABLE FOR THE TREATMENT AND DETECTION OF CANCER |
| WO2005079490A2 (en) | 2004-02-13 | 2005-09-01 | Nuvelo, Inc. | Methods of therapy and diagnosis using targeting of cells that express steap2 polypeptides |
| TW200539855A (en) | 2004-03-15 | 2005-12-16 | Wyeth Corp | Calicheamicin conjugates |
| CA2567520A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Maytansinoid-antibody conjugates |
| CA2587589A1 (en) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
| JP2010528285A (ja) | 2007-05-23 | 2010-08-19 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 免疫組織化学およびinsituハイブリダーゼーションのためのポリマー担体 |
| CN102083461B (zh) | 2008-04-30 | 2014-09-17 | 伊缪诺金公司 | 有效的偶联物和亲水性连接体 |
| US8969626B2 (en) | 2008-07-21 | 2015-03-03 | Polytherics Limited | Reagents and method for conjugating biological molecules |
| JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| DK2549276T3 (en) | 2009-08-10 | 2015-06-08 | Ucl Business Plc | Reversible, covalent bonding of functional molecules |
| HRP20130953T1 (hr) | 2010-04-15 | 2013-11-22 | Spirogen Sàrl | Pirolobenzodiazepini i njihovi konjugati |
| WO2012005982A2 (en) | 2010-07-06 | 2012-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Reporter for rna polymerase ii termination |
| CA2807282A1 (en) | 2010-08-02 | 2012-02-09 | Regeneron Pharamaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| SG10201605293PA (en) | 2011-05-27 | 2016-08-30 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| BR112014009070B1 (pt) | 2011-10-14 | 2021-11-23 | Medimmune Limited | Método de síntese e intermediários úteis na preparação de pirrolobenzo-diazepinas |
| CN103998450B (zh) | 2011-10-14 | 2017-03-08 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓 |
| CA2850373C (en) | 2011-10-14 | 2019-07-16 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
| CA2857398A1 (en) | 2011-12-05 | 2013-06-13 | Igenica Biotherapeutics, Inc. | Antibody-drug conjugates and related compounds, compositions, and methods |
| SMT202300208T1 (it) | 2012-10-23 | 2023-09-06 | Synaffix Bv | Anticorpo modificato, coniugato di anticorpo e processo per la preparazione degli stessi |
| MX373528B (es) | 2013-08-26 | 2020-04-21 | Regeneron Pharma | Composiciones farmacéuticas que contienen diasterómeros macrólidos, métodos para su síntesis y usos terapéuticos. |
| PH12020552271A1 (en) * | 2014-01-31 | 2022-05-02 | Daiichi Sankyo Co Ltd | Anti-her2 antibody-drug conjugate |
| JP2017114763A (ja) * | 2014-03-26 | 2017-06-29 | 第一三共株式会社 | 抗cd98抗体−薬物コンジュゲート |
| JP6800021B2 (ja) | 2014-06-02 | 2020-12-16 | レゲネロン ファーマシューティカルス,インコーポレーテッド | 抗体−薬物コンジュゲート、それらの製造、及びそれらの治療用途 |
| TWI710573B (zh) * | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| JP6826055B2 (ja) * | 2015-03-13 | 2021-02-03 | サイトメックス セラピューティクス インコーポレイテッド | 抗pdl1抗体、活性化可能抗pdl1抗体、およびその使用方法 |
| KR101757977B1 (ko) | 2015-06-26 | 2017-07-13 | 아주대학교산학협력단 | 바이오 잉크의 제조방법 및 3d 프린터 적용 |
| EA039072B9 (ru) | 2016-01-25 | 2022-02-04 | Регенерон Фармасьютикалз, Инк. | Производные майтанзиноида, их конъюгаты и способы применения |
| WO2017147542A2 (en) | 2016-02-26 | 2017-08-31 | Regeneron Pharmaceuticals, Inc. | Optimized transglutaminase site-specific antibody conjugation |
| MX394528B (es) * | 2016-11-08 | 2025-03-24 | Regeneron Pharma | Esteroides y conjugados de proteinas de los mismos. |
| TWI782930B (zh) * | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
| WO2018182341A1 (ko) | 2017-03-29 | 2018-10-04 | 주식회사 레고켐 바이오사이언스 | 피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물 |
| AU2018269568B2 (en) * | 2017-05-18 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Bis-octahydrophenanthrene carboxamides and protein conjugates thereof |
| CN111065623B9 (zh) | 2017-05-24 | 2024-10-25 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
| AU2018289581C1 (en) * | 2017-06-23 | 2025-01-30 | VelosBio Inc. | ROR1 antibody immunoconjugates |
| MX2020011487A (es) | 2018-04-30 | 2020-12-07 | Regeneron Pharma | Anticuerpos y moleculas biespecificas de union al antigeno que se unen a her2 y/o aplp2, conjugados y usos de estos. |
| US12479926B2 (en) * | 2018-05-18 | 2025-11-25 | Daiichi Sankyo Co., Ltd. | Anti-MUC1 antibody-drug conjugate |
| BR112021009673A2 (pt) * | 2018-11-20 | 2021-12-14 | Regeneron Pharma | Derivados de bis-octa-hidrofenantreno carboxamida e conjugados de proteínas dos mesmos para uso como agonistas de lxr |
| WO2020245229A1 (en) * | 2019-06-03 | 2020-12-10 | Synaffix B.V. | Acetal-based cleavable linkers |
| CA3166619A1 (en) * | 2020-02-28 | 2021-09-02 | Julian Andreev | Bispecific antigen binding molecules that bind her2, and methods of use thereof |
-
2021
- 2021-07-12 BR BR112023000489A patent/BR112023000489A2/pt unknown
- 2021-07-12 CN CN202410175152.9A patent/CN118085100A/zh active Pending
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- 2021-07-12 KR KR1020247008244A patent/KR20240038138A/ko active Pending
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-
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- 2023-01-10 MX MX2024003180A patent/MX2024003180A/es unknown
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- 2023-12-19 JP JP2023214174A patent/JP7776485B2/ja active Active
-
2024
- 2024-02-09 AU AU2024200822A patent/AU2024200822A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104220458A (zh) * | 2012-02-24 | 2014-12-17 | 阿特根公司 | 结合有含半胱氨酸残基的基序的修饰抗体,含该修饰抗体的修饰抗体-药物缀合物以及其制造方法 |
| EP2907824A1 (en) * | 2012-10-11 | 2015-08-19 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
| CN105517577A (zh) * | 2013-06-21 | 2016-04-20 | 先天制药公司 | 多肽的酶促偶联 |
| WO2015155998A1 (en) * | 2014-04-10 | 2015-10-15 | Daiichi Sankyo Company, Limited | Anti-her3 antibody-drug conjugate |
| CN110088138A (zh) * | 2016-09-23 | 2019-08-02 | 瑞泽恩制药公司 | 抗steap2抗体、抗体药物偶联物和结合steap2和cd3的双特异性抗原结合分子以及其用途 |
| WO2019217591A1 (en) * | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| CN110974975A (zh) * | 2019-12-12 | 2020-04-10 | 四川百利药业有限责任公司 | 一种快速释放的抗体药物偶联物 |
Non-Patent Citations (3)
| Title |
|---|
| QI-YING HU等: "Towards the next generation of biomedicines by site-selective conjugation", 《CHEM. SOC. REV.》, vol. 45, 31 December 2016 (2016-12-31), pages 1691 - 1719, XP002772944, DOI: 10.1039/C4CS00388H * |
| YASUAKI ANAMI等: "Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency", 《ORGANIC & BIOMOLECULAR CHEMISTRY》, 26 June 2017 (2017-06-26), pages 1 - 8 * |
| YUSUKE OGITANI等: "Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity", 《CANCER SCIENCE》, vol. 107, no. 7, 31 July 2016 (2016-07-31), pages 1039 - 1046, XP055690751, DOI: 10.1111/cas.12966 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025103474A1 (zh) * | 2023-11-17 | 2025-05-22 | 成都康弘生物科技有限公司 | 双毒素抗体药物偶联物及其用途 |
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