CN116018335B - 用于制备1,3-苯并二氧杂环戊烯衍生物的方法 - Google Patents
用于制备1,3-苯并二氧杂环戊烯衍生物的方法Info
- Publication number
- CN116018335B CN116018335B CN202180046125.6A CN202180046125A CN116018335B CN 116018335 B CN116018335 B CN 116018335B CN 202180046125 A CN202180046125 A CN 202180046125A CN 116018335 B CN116018335 B CN 116018335B
- Authority
- CN
- China
- Prior art keywords
- mixture
- added
- formula
- compound represented
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Light Receiving Elements (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020117639 | 2020-07-08 | ||
| JP2020-117639 | 2020-07-08 | ||
| PCT/JP2021/025537 WO2022009911A1 (ja) | 2020-07-08 | 2021-07-07 | １，３－ベンゾジオキソール誘導体の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116018335A CN116018335A (zh) | 2023-04-25 |
| CN116018335B true CN116018335B (zh) | 2025-10-10 |
Family
ID=79553255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180046125.6A Active CN116018335B (zh) | 2020-07-08 | 2021-07-07 | 用于制备1,3-苯并二氧杂环戊烯衍生物的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230257368A1 (https=) |
| EP (1) | EP4180426A4 (https=) |
| JP (1) | JP7720846B2 (https=) |
| KR (1) | KR20230037488A (https=) |
| CN (1) | CN116018335B (https=) |
| BR (1) | BR112022026641A2 (https=) |
| IL (1) | IL299730A (https=) |
| TW (1) | TW202216654A (https=) |
| WO (1) | WO2022009911A1 (https=) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106132954A (zh) * | 2014-03-17 | 2016-11-16 | 第三共株式会社 | 1，3‑苯并二氧杂环戊烯衍生物 |
| WO2019204490A1 (en) * | 2018-04-18 | 2019-10-24 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP2020045306A (ja) * | 2018-09-18 | 2020-03-26 | 第一三共株式会社 | ヘテロシクロアルキル環を含むアミド誘導体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7208630B2 (en) * | 2004-10-27 | 2007-04-24 | University Of Kansas | Heat shock protein 90 inhibitors |
| JP2007161674A (ja) * | 2005-12-16 | 2007-06-28 | Tanabe Seiyaku Co Ltd | ピペリジン化合物およびその製法 |
| WO2008071646A1 (en) * | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
| BR112018001688B1 (pt) * | 2015-07-30 | 2023-05-02 | Daiichi Sankyo Company, Limited | Uso de um composto |
| CN106883125A (zh) * | 2017-03-07 | 2017-06-23 | 怀化金鑫新材料有限公司 | 感光材料稳定剂4‑十六烷氧羰基氧基‑3，5‑二氯苯甲酸乙酯的合成方法 |
| EP3797108B1 (en) * | 2018-05-21 | 2022-07-20 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
-
2021
- 2021-07-07 CN CN202180046125.6A patent/CN116018335B/zh active Active
- 2021-07-07 US US18/012,090 patent/US20230257368A1/en active Pending
- 2021-07-07 TW TW110124923A patent/TW202216654A/zh unknown
- 2021-07-07 WO PCT/JP2021/025537 patent/WO2022009911A1/ja not_active Ceased
- 2021-07-07 KR KR1020227040350A patent/KR20230037488A/ko active Pending
- 2021-07-07 EP EP21836791.0A patent/EP4180426A4/en active Pending
- 2021-07-07 BR BR112022026641A patent/BR112022026641A2/pt unknown
- 2021-07-07 JP JP2022535364A patent/JP7720846B2/ja active Active
- 2021-07-07 IL IL299730A patent/IL299730A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106132954A (zh) * | 2014-03-17 | 2016-11-16 | 第三共株式会社 | 1，3‑苯并二氧杂环戊烯衍生物 |
| WO2019204490A1 (en) * | 2018-04-18 | 2019-10-24 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP2020045306A (ja) * | 2018-09-18 | 2020-03-26 | 第一三共株式会社 | ヘテロシクロアルキル環を含むアミド誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7720846B2 (ja) | 2025-08-08 |
| EP4180426A1 (en) | 2023-05-17 |
| TW202216654A (zh) | 2022-05-01 |
| KR20230037488A (ko) | 2023-03-16 |
| BR112022026641A2 (pt) | 2023-02-07 |
| IL299730A (en) | 2023-03-01 |
| CA3185274A1 (en) | 2022-01-13 |
| EP4180426A4 (en) | 2024-08-07 |
| US20230257368A1 (en) | 2023-08-17 |
| WO2022009911A1 (ja) | 2022-01-13 |
| CN116018335A (zh) | 2023-04-25 |
| JPWO2022009911A1 (https=) | 2022-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7685551B2 (ja) | Ｏ－置換セリン誘導体の製造方法 | |
| EP2665728B1 (en) | Preparation method of intermediate of sitagliptin | |
| EP3828170A1 (en) | Method for safely preparing pimavanserin and tartrate salt thereof using triphosgene | |
| KR102295388B1 (ko) | 광학 활성 다이아민 유도체 및 티아졸 유도체의 생산을 위한 새로운 합성경로 | |
| US20230227459A1 (en) | Method for producing 3,6-disubstituted-imidazo[1,2-b]pyridazine derivative | |
| KR20180101610A (ko) | 오시머티닙(azd9291) 또는 이의 염, 및 ＂azd9291 아닐린＂ 또는 이의 염의 개선된 제조 방법 | |
| WO2019036441A1 (en) | PROCESSES FOR PREPARING NIRAPARIB AND INTERMEDIATES THEREOF | |
| JP6862354B2 (ja) | ナイトロジェンマスタード誘導体の調製方法 | |
| CN116018335B (zh) | 用于制备1,3-苯并二氧杂环戊烯衍生物的方法 | |
| ES3028540T3 (en) | Process for the preparation of sphingosine-1-phosphate receptor agonist | |
| KR20190044652A (ko) | 인돌 카르복스아미드 화합물을 제조하는 방법 | |
| WO2011156355A1 (en) | Production method of phenyl guanidine salts and their intermediates | |
| US20190345163A1 (en) | Processes for the Preparation of Ribociclib and Intermediates Thereof | |
| CA3185274C (en) | Method for producing 1,3-benzodioxole derivative | |
| CN111233866B (zh) | 托法替尼或其盐的制备方法 | |
| HU208838B (en) | Method for producing peptones containing aza aminoacides by means of solid-phase synthesis | |
| HK40094193A (en) | Method for producing 1,3-benzodioxole derivative | |
| CN114057751B (zh) | 一种dpp-iv抑制剂及其关键中间体的制备方法 | |
| CA2819381A1 (en) | Method of making azaindazole derivatives | |
| CN113583003A (zh) | 一种伐地那非类似物及其合成方法和应用 | |
| CN114057668B (zh) | 一种氨基保护基手性2-氨基-3-(4-吗啉基苯基)丙酸的合成方法 | |
| KR102137340B1 (ko) | Eob-dtpa의 신규 제조방법 | |
| CA3225147A1 (en) | Synthesis of a bis-mesylate salt of 4-amino-n-(1 -((3-chloro-2- fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2- d]pyrimidine-7-carboxamide and intermediates thereto | |
| KR20240163708A (ko) | 4-[5-[비스(2-클로로에틸)아미노]-1-메틸-1H-벤조[d]이미다졸-2-일]부티르산알킬 에스테르 및 포르밀화 유도체의 제조 방법 | |
| JPH08253497A (ja) | ペプチド型化合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |