CN115768763A - 一种cdk4/6抑制剂的制备方法 - Google Patents

一种cdk4/6抑制剂的制备方法 Download PDF

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Publication number
CN115768763A
CN115768763A CN202180041423.6A CN202180041423A CN115768763A CN 115768763 A CN115768763 A CN 115768763A CN 202180041423 A CN202180041423 A CN 202180041423A CN 115768763 A CN115768763 A CN 115768763A
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CN
China
Prior art keywords
compound
sma
bis
palladium dichloride
solvent
Prior art date
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Pending
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CN202180041423.6A
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English (en)
Inventor
刘国峰
王勇
郭猛
张喜全
宋开镇
刘金虎
落俊山
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of CN115768763A publication Critical patent/CN115768763A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

涉及一种CDK4/6抑制剂的制备方法，具体涉及式(I)化合物：5‑氟‑4‑(3‑异丙基‑2‑甲基‑2H‑吲唑‑5‑基)‑氮‑(5‑(哌嗪‑1‑基)吡唑‑2‑基)嘧啶‑2‑胺的制备方法。提供的制备方法起始原料和试剂均廉价易得，总反应步骤也大大缩短，反应时间缩短，总收率提高，关键中间体和终产物的纯度均较高，非常适用于工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (11)

  1. PCT国内申请，权利要求书已公开。
CN202180041423.6A 2020-06-22 2021-06-21 一种cdk4/6抑制剂的制备方法 Pending CN115768763A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020105713937 2020-06-22
CN202010571393 2020-06-22
PCT/CN2021/101246 WO2021259203A1 (zh) 2020-06-22 2021-06-21 一种cdk4/6抑制剂的制备方法

Publications (1)

Publication Number Publication Date
CN115768763A true CN115768763A (zh) 2023-03-07

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ID=79281957

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180041423.6A Pending CN115768763A (zh) 2020-06-22 2021-06-21 一种cdk4/6抑制剂的制备方法

Country Status (4)

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US (1) US20230331699A1 (zh)
EP (1) EP4159728A1 (zh)
CN (1) CN115768763A (zh)
WO (1) WO2021259203A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023237055A1 (zh) * 2022-06-09 2023-12-14 正大天晴药业集团股份有限公司 一种cdk4/6抑制剂治疗去分化脂肪肉瘤的用途
CN115057845B (zh) * 2022-06-14 2024-05-03 山东罗欣药业集团恒欣药业有限公司 一种阿贝西利的制备方法
WO2024032751A1 (zh) * 2022-08-12 2024-02-15 正大天晴药业集团股份有限公司 一种取代的2-氢-吡唑衍生物的晶型及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8852901A1 (es) * 2008-12-22 2010-07-27 Lilly Co Eli Inhibidores de proteina cinasa
US9502766B2 (en) 2014-07-25 2016-11-22 Raytheon Company Electronically reconfigurable, piecewise-linear, scalable analog monopulse network
US9969719B2 (en) 2015-03-11 2018-05-15 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug
JP7100625B2 (ja) 2016-09-09 2022-07-13 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド 置換２－ｈ－ピラゾール誘導体の結晶形、塩型及びその製造方法

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Publication number Publication date
US20230331699A1 (en) 2023-10-19
EP4159728A1 (en) 2023-04-05
WO2021259203A1 (zh) 2021-12-30

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