CN115701986A - 包含地夸磷索的眼用组合物 - Google Patents

包含地夸磷索的眼用组合物 Download PDF

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Publication number
CN115701986A
CN115701986A CN202180045168.2A CN202180045168A CN115701986A CN 115701986 A CN115701986 A CN 115701986A CN 202180045168 A CN202180045168 A CN 202180045168A CN 115701986 A CN115701986 A CN 115701986A
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CN
China
Prior art keywords
composition
diquafosol
amount
ophthalmic composition
present
Prior art date
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Pending
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CN202180045168.2A
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English (en)
Chinese (zh)
Inventor
李俊晔
柳尚录
韩秉贤
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Taejoon Pharm Co Ltd
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Taejoon Pharm Co Ltd
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Filing date
Publication date
Application filed by Taejoon Pharm Co Ltd filed Critical Taejoon Pharm Co Ltd
Publication of CN115701986A publication Critical patent/CN115701986A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202180045168.2A 2020-06-23 2021-06-23 包含地夸磷索的眼用组合物 Pending CN115701986A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2020-0076573 2020-06-23
KR20200076573 2020-06-23
PCT/KR2021/007923 WO2021261931A1 (ko) 2020-06-23 2021-06-23 디쿠아포솔을 포함하는 점안 조성물

Publications (1)

Publication Number Publication Date
CN115701986A true CN115701986A (zh) 2023-02-14

Family

ID=79178835

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180045168.2A Pending CN115701986A (zh) 2020-06-23 2021-06-23 包含地夸磷索的眼用组合物

Country Status (4)

Country Link
JP (1) JP2023531725A (https=)
KR (3) KR102365008B1 (https=)
CN (1) CN115701986A (https=)
WO (2) WO2021261931A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
KR102689517B1 (ko) 2023-10-26 2024-07-29 강현희 반려동물용 인공눈물의 조성물
KR20260048121A (ko) * 2024-10-02 2026-04-09 주식회사 대웅테라퓨틱스 개선된 안정성 및 투약 편의성을 갖는 레바미피드를 포함하는 조성물

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1489480A (zh) * 2001-01-09 2004-04-14 ·��˹��Լ�����ߺ��ɶ� 治疗和/或护理眼睛的方法和组合物
CN104983786A (zh) * 2015-07-14 2015-10-21 天津青松华药医药有限公司 一种聚乙烯醇组合物
CN106692048A (zh) * 2017-01-19 2017-05-24 蚌埠丰原医药科技发展有限公司 一种含有聚乙烯醇的单剂量滴眼液及其制备方法
CN109260146A (zh) * 2018-10-12 2019-01-25 广州大光制药有限公司 地夸磷索钠眼用即用型凝胶滴眼液及制备方法
WO2019168023A1 (ja) * 2018-02-28 2019-09-06 参天製薬株式会社 ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物
WO2020061249A2 (en) * 2018-09-21 2020-03-26 Ps Therapies Ltd. Artificial tear, contact lens and drug vehicle compositions and methods of use thereof

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
CN100484528C (zh) * 2003-11-07 2009-05-06 千寿制药株式会社 含有前列腺素的药物组合物
US7939511B2 (en) * 2004-09-28 2011-05-10 Senju Pharmaceutical Co., Ltd. Ophthalmic composition containing xanthan gum and amino acid
CN101405009B (zh) * 2006-03-23 2011-04-13 千寿制药株式会社 包含黄原胶和葡萄糖的眼科组合物
AU2013222801B2 (en) * 2012-02-24 2015-09-17 Bausch & Lomb Incorporated Ophthalmic compositions with alkoxylated natural waxes
JP6768653B2 (ja) * 2014-11-25 2020-10-14 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 安定したオメガ−３眼科用組成物
KR102330736B1 (ko) * 2014-12-25 2021-11-23 산텐 세이야꾸 가부시키가이샤 수성 점안액
CN107635565A (zh) * 2015-06-05 2018-01-26 参天制药株式会社 以向佩戴有软性隐形眼镜的干眼症患者的眼中滴入的方式使用为特征的干眼症治疗剂

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1489480A (zh) * 2001-01-09 2004-04-14 ·��˹��Լ�����ߺ��ɶ� 治疗和/或护理眼睛的方法和组合物
CN104983786A (zh) * 2015-07-14 2015-10-21 天津青松华药医药有限公司 一种聚乙烯醇组合物
CN106692048A (zh) * 2017-01-19 2017-05-24 蚌埠丰原医药科技发展有限公司 一种含有聚乙烯醇的单剂量滴眼液及其制备方法
WO2019168023A1 (ja) * 2018-02-28 2019-09-06 参天製薬株式会社 ジクアホソルおよびカチオン性ポリマーを含有する眼科用組成物
US20210000844A1 (en) * 2018-02-28 2021-01-07 Santen Pharmaceutical Co., Ltd. Ophthalmic composition comprising diquafosol and cationic polymer
WO2020061249A2 (en) * 2018-09-21 2020-03-26 Ps Therapies Ltd. Artificial tear, contact lens and drug vehicle compositions and methods of use thereof
CN109260146A (zh) * 2018-10-12 2019-01-25 广州大光制药有限公司 地夸磷索钠眼用即用型凝胶滴眼液及制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
罗旭升, 曾庆华, 于晓林: "干眼局部用药研究进展", 中国中医眼科杂志, no. 02, 11 May 1999 (1999-05-11), pages 121 - 124 *

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Publication number Publication date
KR102365008B1 (ko) 2022-02-23
KR20220025775A (ko) 2022-03-03
WO2021261927A1 (ko) 2021-12-30
JP2023531725A (ja) 2023-07-25
KR20210158355A (ko) 2021-12-30
WO2021261931A1 (ko) 2021-12-30
KR20210158310A (ko) 2021-12-30

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