CN115531607A - 一种混合可降解材料微球以及复合物制剂的制备方法 - Google Patents
一种混合可降解材料微球以及复合物制剂的制备方法 Download PDFInfo
- Publication number
- CN115531607A CN115531607A CN202211294349.1A CN202211294349A CN115531607A CN 115531607 A CN115531607 A CN 115531607A CN 202211294349 A CN202211294349 A CN 202211294349A CN 115531607 A CN115531607 A CN 115531607A
- Authority
- CN
- China
- Prior art keywords
- microspheres
- preparation
- collagen
- mass
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004005 microsphere Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 239000000463 material Substances 0.000 title claims abstract description 29
- 239000002131 composite material Substances 0.000 title claims abstract description 12
- 239000000499 gel Substances 0.000 claims abstract description 31
- 102000008186 Collagen Human genes 0.000 claims abstract description 16
- 108010035532 Collagen Proteins 0.000 claims abstract description 16
- 229920001436 collagen Polymers 0.000 claims abstract description 16
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims abstract description 13
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 12
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 12
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 12
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 229920001432 poly(L-lactide) Polymers 0.000 claims abstract description 11
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 10
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 10
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920001661 Chitosan Polymers 0.000 claims abstract description 8
- 239000000661 sodium alginate Substances 0.000 claims abstract description 8
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 8
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 5
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 21
- 239000000243 solution Substances 0.000 claims description 16
- 239000003960 organic solvent Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000008346 aqueous phase Substances 0.000 claims description 9
- 238000010008 shearing Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 230000003204 osmotic effect Effects 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- 229930182555 Penicillin Natural products 0.000 claims description 7
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 229940049954 penicillin Drugs 0.000 claims description 7
- 239000012071 phase Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 238000012216 screening Methods 0.000 claims description 7
- 230000008961 swelling Effects 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000001804 emulsifying effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000007634 remodeling Methods 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 2
- 230000002500 effect on skin Effects 0.000 description 12
- 239000000945 filler Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- 238000001125 extrusion Methods 0.000 description 11
- 238000012360 testing method Methods 0.000 description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 5
- 238000004945 emulsification Methods 0.000 description 5
- 229920002674 hyaluronan Polymers 0.000 description 5
- 229960003160 hyaluronic acid Drugs 0.000 description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 239000008215 water for injection Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000000635 electron micrograph Methods 0.000 description 3
- 238000001000 micrograph Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 239000003589 local anesthetic agent Substances 0.000 description 2
- 229960005015 local anesthetics Drugs 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229920006022 Poly(L-lactide-co-glycolide)-b-poly(ethylene glycol) Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
编号 | PLLA比例 | PLGA比例 | PCL比例 |
实施例1 | 50% | 50% | 0 |
实施例2 | 80% | 20% | 0 |
实施例3 | 80% | 0 | 20% |
实施例4 | 0 | 60% | 40% |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211294349.1A CN115531607B (zh) | 2022-10-21 | 2022-10-21 | 一种混合可降解材料微球以及复合物制剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211294349.1A CN115531607B (zh) | 2022-10-21 | 2022-10-21 | 一种混合可降解材料微球以及复合物制剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115531607A true CN115531607A (zh) | 2022-12-30 |
CN115531607B CN115531607B (zh) | 2023-08-22 |
Family
ID=84735536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202211294349.1A Active CN115531607B (zh) | 2022-10-21 | 2022-10-21 | 一种混合可降解材料微球以及复合物制剂的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115531607B (zh) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103462902A (zh) * | 2013-08-21 | 2013-12-25 | 华南理工大学 | 具有分层结构和海岛型形貌plga/pcl复合微球的制备方法 |
CN105126166A (zh) * | 2015-09-17 | 2015-12-09 | 北京爱美客生物科技有限公司 | 注射用含两亲性微球的透明质酸混合凝胶及其制备方法 |
CN109998997A (zh) * | 2019-04-04 | 2019-07-12 | 山东谷雨春生物科技有限公司 | 一种利用膜乳化法制备聚酯类有机高分子微球的方法 |
CN110327488A (zh) * | 2019-07-18 | 2019-10-15 | 王月玲 | 一种注射填充微球制剂及其制备方法 |
CN114028610A (zh) * | 2021-10-26 | 2022-02-11 | 北京诺康达医药科技股份有限公司 | 一种亲水性注射型皮肤填充组合物及其制备方法与应用 |
CN114099771A (zh) * | 2020-08-27 | 2022-03-01 | 杭州协合医疗用品有限公司 | 一种含混合聚合物微球的梯度注射剂 |
CN114177352A (zh) * | 2021-12-22 | 2022-03-15 | 西安德诺海思医疗科技有限公司 | 一种梯度降解皮肤填充剂及其制备方法 |
LU501136B1 (en) * | 2021-12-31 | 2022-06-30 | Hangzhou Techderm Biological Products Co Ltd | Method for preparing medical modified sodium hyaluronate and polycaprolactone gel |
-
2022
- 2022-10-21 CN CN202211294349.1A patent/CN115531607B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103462902A (zh) * | 2013-08-21 | 2013-12-25 | 华南理工大学 | 具有分层结构和海岛型形貌plga/pcl复合微球的制备方法 |
CN105126166A (zh) * | 2015-09-17 | 2015-12-09 | 北京爱美客生物科技有限公司 | 注射用含两亲性微球的透明质酸混合凝胶及其制备方法 |
CN109998997A (zh) * | 2019-04-04 | 2019-07-12 | 山东谷雨春生物科技有限公司 | 一种利用膜乳化法制备聚酯类有机高分子微球的方法 |
CN110327488A (zh) * | 2019-07-18 | 2019-10-15 | 王月玲 | 一种注射填充微球制剂及其制备方法 |
CN114099771A (zh) * | 2020-08-27 | 2022-03-01 | 杭州协合医疗用品有限公司 | 一种含混合聚合物微球的梯度注射剂 |
CN114028610A (zh) * | 2021-10-26 | 2022-02-11 | 北京诺康达医药科技股份有限公司 | 一种亲水性注射型皮肤填充组合物及其制备方法与应用 |
CN114177352A (zh) * | 2021-12-22 | 2022-03-15 | 西安德诺海思医疗科技有限公司 | 一种梯度降解皮肤填充剂及其制备方法 |
LU501136B1 (en) * | 2021-12-31 | 2022-06-30 | Hangzhou Techderm Biological Products Co Ltd | Method for preparing medical modified sodium hyaluronate and polycaprolactone gel |
Also Published As
Publication number | Publication date |
---|---|
CN115531607B (zh) | 2023-08-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105126166B (zh) | 注射用含两亲性微球的透明质酸混合凝胶及其制备方法 | |
CN102458496B (zh) | 用于制造组织工程用支架的组合物及其生产方法 | |
CN113730652B (zh) | 一种注射用混合凝胶及其制备方法和应用 | |
CN109010910B (zh) | 一种可注射左旋聚乳酸微球的制备方法 | |
CN111184909B (zh) | 一种透明质酸缓释填充物及制备方法 | |
CN103834053A (zh) | 一种可注射的交联透明质酸凝胶及其制备方法 | |
KR102181033B1 (ko) | 생분해성 고분자 미립자, 이를 포함하는 고분자 필러 및 이의 제조방법 | |
KR101854540B1 (ko) | 지속성이 우수한 안면성형용 plla 필러의 제조방법 | |
KR102173939B1 (ko) | 생분해성 고분자 미세입자의 혼합물로 구성된 성형용 필러 조성물의 제조방법 | |
US9744260B2 (en) | Timing controlled in-situ cross-linking of halyuronic acid during injection | |
EP3556797A1 (en) | Porous microparticles of biodegradable polymer, and polymer filler comprising same | |
EP3660078A1 (en) | Method for preparing biodegradable polymer microparticles, and biodegradable polymer microparticles prepared thereby | |
CN114904049A (zh) | 含透明质酸和胶原蛋白的聚己内酯微球凝胶及其制备方法 | |
CN110327488B (zh) | 一种注射填充微球制剂及其制备方法 | |
CN115245597A (zh) | 交联透明质酸凝胶与脱细胞基质微粒组合物 | |
CN115414528A (zh) | 一种复合透明质酸钠微球凝胶及其制备方法和应用 | |
CN114450040A (zh) | 组织再生用水凝胶组合物以及利用其制备的支撑体 | |
Seok et al. | Bio-plotted hydrogel scaffold with core and sheath strand-enhancing mechanical and biological properties for tissue regeneration | |
Wang et al. | 3D printed chondrogenic functionalized PGS bioactive scaffold for cartilage regeneration | |
CN115531607A (zh) | 一种混合可降解材料微球以及复合物制剂的制备方法 | |
CN115317665B (zh) | 一种聚酯粒子复合温敏即型凝胶皮下植入剂 | |
CN111249525A (zh) | 一种注射型美容整形用面部填充剂组合物凝胶及制备方法 | |
CN115260545A (zh) | 一种小粒径琼脂糖凝胶、其制备方法及应用 | |
CN116672498A (zh) | 一种注射用复合材料及其用途 | |
CN114668890A (zh) | 注射用含碳酸钙微球的混合凝胶及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 100176 Building 22, Yard 1, Jinghai 5th Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee after: Angel Biomed Co.,Ltd. Address before: 100176 Building 22, Yard 1, Jinghai 5th Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: Beijing Anqi Biomedical Technology Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20231130 Address after: 100176 2F, building 22, yard 1, Jinghai fifth road, Tongzhou District, Beijing Patentee after: BEIJING ABACE BIOTECHNOLOGY Co.,Ltd. Patentee after: Angel Biomed Co.,Ltd. Address before: 100176 Building 22, Yard 1, Jinghai 5th Road, Beijing Economic and Technological Development Zone, Daxing District, Beijing Patentee before: Angel Biomed Co.,Ltd. |