CN115518017A

CN115518017A - Skin care product with soothing and repairing effects and preparation method thereof

Info

Publication number: CN115518017A
Application number: CN202211333522.4A
Authority: CN
Inventors: 黄浩寒; 赖汉春
Original assignee: Guangzhou Tingcai Cosmetics Co ltd
Current assignee: Guangzhou Tingcai Cosmetics Co ltd
Priority date: 2022-10-28
Filing date: 2022-10-28
Publication date: 2022-12-27

Abstract

The invention discloses a skin care product with a soothing and repairing effect and a preparation method thereof. The skin care product comprises, by mass, 1-12 parts of a composite plant extract, 0.5-2 parts of a de-reddening factor, 0.5-4 parts of 4D hyaluronic acid, 0.5-5 parts of tetrahydromethylpyrimidine carboxylic acid, 0.5-5 parts of panthenol, 0.1-2 parts of beta-glucan, 0.2-1 part of carboxymethyl chitosan, 1-4 parts of erythritol, 3-5 parts of 1,2-pentanediol, 0.5-1 part of 1,2-hexanediol, 5-8 parts of butanediol and 100 parts of deionized water. The invention solves the skin problem induced by various factors such as environment, region, staying up night, pressure, season change and the like through the interaction of various components and multi-channel effect.

Description

Skin care product with soothing and repairing effects and preparation method thereof

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to a skin care product with a soothing and repairing effect.

Background

The human skin contains abundant sensory nerve fibers, which allow the central nervous system to detect the condition of the skin at any time and respond to various stimuli such as physical factor stimuli (climate change, air pollution, ultraviolet irradiation), chemical factor stimuli (use of bad cosmetics, excessive acid brushing), internal factor stimuli (stress, emotion, endocrine dyscrasia) and the like. Sensitive skin is in a sub-healthy state, the natural barrier of the skin is damaged due to various physical factors, chemical factors and internal psychological and physiological factors, once the skin is damaged, the horny layer of the damaged skin becomes thinner, the horny layer of the skin cannot better lock water, the skin is lack of water and dry, and the like, the self-repairing ability and the immunity of the skin are seriously reduced and even lost, so that the skin is sensitive. The self defense ability is reduced, so that the afferent of sensory nerve signals of the skin is enhanced, the tolerance threshold is reduced, the weak stimulation reaction to the outside is excessive, the immune response of the skin is activated, and the subjective symptoms such as vessel expansion, inflammatory factor release, burning sensation, stabbing pain, pruritus and tightness of the skin are caused, and objective signs such as erythema, scale and telangiectasia are accompanied or not accompanied.

Consumers desire soothing repair products that provide immediate skin relief and long-term skin barrier repair, with a wide market demand.

The existing relieving and repairing products in the market have the following defects:

1. the safety is not high, the formula system is too thick or sticky, the oily skin is not friendly enough, and the problems of barrier damage, dryness and peeling, susceptibility to sensitivity, dark skin color and the like of the skin cannot be fundamentally improved;

2. aiming at that the anti-allergy usually only has a single solution, the symptoms of red, swelling, heat, pain and itching are difficult to be solved simultaneously, and the comfort and repair effects are difficult to be considered;

3. the instant relieving component for skin problems such as allergy is mainly a corticoid drug which relieves anaphylactic reaction by inhibiting the immune reaction of a human body, but the corticoid drug is used for inhibiting not only the abnormal immune reaction causing anaphylaxis but also the normal immune reaction and reducing the resistance of skin cells so as to induce adverse reactions such as non-allergic dermatitis, skin tumor, melanin deposition, abnormal skin growth and the like, if the skin problems such as allergy and the like are not relieved after long-term use, drug dependence can be generated, and the cosmetic is not allowed to be added with the component;

4. some rely on simple ingredients, antiseptic to reduce means and cause the formulation to use for a long time, the antiseptic system can not guarantee the product life-span, or repair the cycle longer, or keep improper, easy to be infected by the microorganism, get adverse effects instead.

Disclosure of Invention

The invention mainly solves the technical problem of providing a skin care product with a soothing and repairing effect and a preparation method thereof, and the skin care product has the effects of relieving skin redness, pruritus, stabbing pain, removing free radicals, resisting inflammation, improving skin tolerance, repairing skin barriers and the like by the interaction of all components and multi-channel effect, solving the skin problem induced by various factors such as environment, region, night-out, pressure, season change and the like, and has the effects of relieving skin redness, pruritus, stabbing pain, removing free radicals, resisting inflammation, improving skin tolerance and the like; the skin care product can be better absorbed by skin, the skin burden is relieved, the nutrition of loss and secretion reduction of the skin is supplemented, the effects of relieving stimulation, enhancing the skin resistance and repairing the skin barrier are achieved, the skin is repaired and eased, the skin care product is applied to cosmetics, the skin care product has better smearing sense, absorption degree, moisture retention and stability maintenance, multiple components are in accurate cooperation, the skin sensitivity, the sticky sense and the dryness and ease degree are solved and avoided, and the skin care product can be used for daily care of crowds with various skin types, particularly for barrier repair of damaged skin. .

In order to solve the technical problems, the invention adopts a technical scheme that: the skin care product with the soothing and repairing effects comprises, by mass, 1-12 parts of a composite plant extract, 0.5-2 parts of a red removing factor, 0.5-4 parts of 4D hyaluronic acid, 0.5-5 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.5-5 parts of panthenol, 0.1-2 parts of beta-glucan, 0.2-1 part of carboxymethyl chitosan, 1-4 parts of erythritol, 3-5 parts of 1,2-pentanediol, 0.5-1 part of 1,2-hexanediol, 5-8 parts of butanediol and 100 parts of deionized water.

The composite plant extract comprises water, butanediol, glycerol, a golden chamomile extract, a field mint leaf extract, a purslane extract, a pelargonium graveolens extract, an aloe barbadensis extract, a kuh-seng root extract, 1,2-hexanediol and p-hydroxyacetophenone; the quality is respectively as follows: 29%, 20%, 12%, 10%, 9%, 8%, 7%, 3%, 1%, 0.5%, and has immediate relieving, itching relieving, red fading, and antiinflammatory effects.

Removing red factors: dextran sodium sulfate is obtained by performing biological fermentation on specially selected leuconostoc, so that polysaccharide with smaller molecular weight is obtained, the penetration is more excellent, active ingredients are enriched, the biological activity of active molecules is improved, and the dextran sodium sulfate has more remarkable and efficient anti-inflammatory and red-removing effects. The action mechanism is as follows: the expression of COX-2 is inhibited, and the expression of PGE2 is effectively inhibited; the erythema caused by ultraviolet rays is obviously reduced; the gene expression of TP63 protein is facilitated, and the structural integrity of the skin is maintained; is helpful for the gene expression of the GADD45a protein and the repair of damaged DNA.

4D hyaluronic acid: the skin care product contains 4 sodium hyaluronate cross-linked polymers with different molecular weights, sodium hyaluronate, acetylated sodium hyaluronate and hydrolyzed sodium hyaluronate, and after the sodium hyaluronate is acted on skin, the sodium hyaluronate with different molecular weights can accurately position the surface layer, the cuticle layer, the epidermal layer and the dermis layer of the skin, can instantly play a three-dimensional moisturizing effect, and can moisturize the inner layer, lock water on the outer layer and present four-fold and multi-level tender skin. The skin feel is soft and smooth and has elasticity, a long-acting biological protective film can be formed on the surface of the skin, the skin barrier function is enhanced, and the skin care cream has multiple functions of water locking, water storage, isolation, protection and the like.

Tetrahydro-methyl-pyrimidine-carboxylic acid: the osmotic pressure compensating solute exists in halotolerant bacteria, plays a chemical transmitter-like role in cells, has a protective effect on the stability of the cells in adverse environment, can also stabilize the structure of enzyme protein in organisms, has the functions of activating skin and resisting aging, can also protect neutrophil, and has an anti-inflammatory effect.

Panthenol: the vitamin B5 derivative has small molecular weight, can effectively permeate into the cuticle and infiltrate into the cuticle on the surface of the skin, has a strong moisturizing effect, effectively improves the roughness of the skin, enables the skin to be soft and not to be sticky, and also has the effects of stimulating the growth of epithelial cells, accelerating wound healing and repairing tissue wounds.

Carboxymethyl chitosan: the marine natural polysaccharide is sourced, and can quickly relieve itching, inhibit inflammation and repair skin barriers.

Beta-glucan: a barrier is formed on the surface layer of the skin, the barrier function of the skin is repaired, and the moisturizing effect is very good.

Further, the composite plant extract comprises water, butanediol, glycerol, a chamomile extract, a peppermint leaf extract, a purslane extract, a geranium extract, an aloe vera extract and a sophora flavescens root extract, 1,2-hexanediol, and p-hydroxyacetophenone.

Further, the 4D hyaluronic acid comprises water, 1,2-pentanediol, acetylated sodium hyaluronate, a sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate, and ethylhexylglycerin.

The skin care product comprises, by mass, 12 parts of a composite plant extract, 1 part of erythrofactor, 3 parts of 4D hyaluronic acid, 3 parts of tetrahydro-methyl pyrimidine carboxylic acid, 4 parts of panthenol, 0.5 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

A preparation method of a skin care product with a soothing and repairing effect comprises the following steps:

the method comprises the following steps:

(1) Passing the compound plant extract through an ultramicro precision filter;

(2) Stirring deionized water, erythritol and butanediol, heating to 80-90 deg.C, maintaining the temperature for 20-40 min, sterilizing, cooling to 45-55 deg.C, adding red removing factor, carboxymethyl chitosan and beta-dextran, and stirring;

(3) Cooling to 40-50 ℃, adding the composite plant extract prepared in the step (1), uniformly stirring, adding 4D hyaluronic acid, tetrahydromethylpyrimidine carboxylic acid, panthenol, 1,2-pentanediol, 1,2-hexanediol, and stirring to obtain the skin care product.

And (2) stirring deionized water, erythritol and butanediol, heating to 85 ℃, keeping the temperature for 30 minutes, sterilizing, cooling to 50 ℃, adding a de-reddening factor, carboxymethyl chitosan and beta-glucan, and stirring.

And (3) cooling to 45 ℃, adding the composite plant extract prepared in the step (1), uniformly stirring, adding 4D hyaluronic acid, tetrahydromethylpyrimidine carboxylic acid, panthenol, 1,2-pentanediol, 1,2-hexanediol, and uniformly stirring to obtain the skin care product.

In the step (1), the conditions of the ultramicro precision filter and the ultrafiltration membrane are 20 ℃, the pressure is 1.0MPa, and the transmittance is 80-90%.

Further, in the steps (2) and (3), the stirring speed is 200-300rpm/min, and the stirring time is 15-20min.

Further, in the steps (2) and (3), the stirring speed is 250rpm/min, and the stirring time is 18min.

The invention has the following beneficial effects:

1. sensitive skin is easy to produce skin inflammation, epidermis releases inflammation media and is in an inflammation state, the symptoms of redness and fever are caused by vasodilatation, the skin is thicker than usual due to excessive cell proliferation, and the external state of the skin is changed due to the disorder of the internal tissue structure of the skin, so that the invention has good effects on the aspects of improving the water loss of the skin, reducing the heme, improving the redness and sensitivity and the like;

2. the skin care cream is natural and safe, can effectively relieve sensitive symptoms, is tender and stable, is gentle and maintenance, aims at the problems of skin damage and sensitivity, maintains the barrier function of the skin, and repairs the damaged cuticle;

3. the skin care product can relieve itching, red swelling and fever skin states in allergy, relieve irritation, has a certain skin repair effect, enhances the resistance of skin to an allergen, is safe, only contains components allowed to be used in cosmetics, and achieves the functions of improving skin allergy, enhancing skin barrier and moisturizing.

Detailed Description

The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention, and to clearly and unequivocally define the scope of the present invention.

The components in the examples and comparative examples are all commercially available. The composite plant extract comprises water, butanediol, glycerol, a golden chamomile extract, a field mint leaf extract, a purslane extract, a pelargonium graveolens extract, an aloe barbadensis extract, a picrasma kurarianum root extract, 1,2-hexanediol and p-hydroxyacetophenone, and the mass of the composite plant extract is respectively as follows: 29%, 20%, 12%, 10%, 9%, 8%, 7%, 3%, 1%, 0.5%. The manufacturer is as follows: nckemica Biotechnology s.l. The 4D hyaluronic acid comprises water, 1,2-pentanediol, acetylated sodium hyaluronate, a sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and ethylhexylglycerin, and the manufacturers are as follows: hua Xi Biotechnology GmbH.

Unless otherwise specified, the examples and comparative examples are parallel tests with identical components, component contents, preparation steps, preparation parameters.

Example 1

The application provides a composition, which comprises the following components in parts by mass:

12 parts of composite plant extract, 1 part of erythrofactor, 3 parts of 4D hyaluronic acid, 3 parts of tetrahydromethyl pyrimidinecarboxylic acid, 4 parts of panthenol, 0.5 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

Example 2

10 parts of composite plant extract, 1 part of de-reddening factor, 2 parts of 4D hyaluronic acid, 2 parts of tetrahydro-methyl pyrimidine carboxylic acid, 4 parts of panthenol, 1 part of beta-glucan, 1 part of carboxymethyl chitosan, 2 parts of erythritol, 4 parts of 1,2-pentanediol, 0.8 part of 1,2-hexanediol, 6 parts of butanediol and 100 parts of deionized water.

Example 3

8 parts of composite plant extract, 2 parts of de-reddening factor, 4 parts of 4D hyaluronic acid, 3 parts of tetrahydro-methyl pyrimidine carboxylic acid, 3 parts of panthenol, 1 part of beta-glucan, 1 part of carboxymethyl chitosan, 4 parts of erythritol, 3.5 parts of 1,2-pentanediol, 0.8 part of 1,2-hexanediol, 5 parts of butanediol and 100 parts of deionized water.

Example 4

8 parts of composite plant extract, 2 parts of de-reddening factor, 4 parts of 4D hyaluronic acid, 2 parts of tetrahydromethyl pyrimidine carboxylic acid, 3 parts of panthenol, 1 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 0.5 part of 1,2-hexanediol, 5 parts of butanediol and 100 parts of deionized water.

Example 5

6 parts of composite plant extract, 2 parts of de-reddening factor, 4 parts of 4D hyaluronic acid, 3 parts of tetrahydro-methyl pyrimidine carboxylic acid, 2 parts of panthenol, 1 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 3.5 parts of 1,2-pentanediol, 0.5 part of 1,2-hexanediol, 6 parts of butanediol and 100 parts of deionized water.

Comparative example 1

The composition provided by the comparative example comprises the following components in parts by mass:

12 parts of composite plant extract, 3 parts of 4D hyaluronic acid, 3 parts of tetrahydro-methyl pyrimidine carboxylic acid, 4 parts of panthenol, 0.5 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

Comparative example 2

12 parts of composite plant extract, 1 part of erythrosin, 3 parts of 4D hyaluronic acid, 3 parts of tetrahydro-methyl pyrimidine carboxylic acid, 4 parts of panthenol, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

Comparative example 3

The comparative example provides a composition comprising the following mass numbers of components:

12 parts of composite plant extract, 1 part of erythrofactor, 3 parts of 4D hyaluronic acid, 3 parts of tetrahydromethyl pyrimidinecarboxylic acid, 4 parts of panthenol, 0.5 part of beta-glucan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

Comparative example 4

12 parts of composite plant extract, 1 part of erythrosin, 3 parts of 4D hyaluronic acid, 4 parts of panthenol, 0.5 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

The above examples were prepared according to the following procedure:

(1) Passing the compound plant extract through an ultramicro precision filter;

an ultramicro precision filter, wherein the filtering condition of an ultrafiltration membrane is 20 ℃, the pressure is 1.0MPa, and the transmittance is 85 percent;

(2) Stirring deionized water, erythritol and butanediol, heating to 85 deg.C, maintaining the temperature for 30min, sterilizing, cooling to 50 deg.C, adding red removing factor, carboxymethyl chitosan and beta-dextran, and stirring;

(3) Cooling to 45 ℃, adding the composite plant extract prepared in the step (1), uniformly stirring, adding 4D hyaluronic acid, tetrahydromethylpyrimidine carboxylic acid, panthenol, 1,2-pentanediol and 1,2-hexanediol, and uniformly stirring to obtain the skin care product with stable activity.

In the steps (2) and (3), the stirring speed is 250rpm/min, and the stirring time is 18min.

Comparative example was prepared with reference to the above procedure.

In order to better illustrate the advantages of the technical solutions provided by the present application, the skin care products of examples 1 to 5 and comparative examples 1 to 4 of the present application are respectively taken to perform efficacy tests, and specific test results are shown in the following experimental examples.

Detecting the content:

evaluation test of human body efficacy

The detection method comprises the following steps:

selecting a Chinese healthy male/female subject 31 which is considered to be sensitive muscle by self, has a lactic acid sting score of more than or equal to 3 points, has dry and rough face, lacks moisture and has barrier function which is more complicated with certain redness than the face, and the age range is 18-50 years old. By adopting a front-back comparison method, the moisture content of the stratum corneum of the tested part of the tested person and the skin percutaneous moisture loss value are respectively tested and the whole face picture of the tested person is taken before and after the product is continuously used for 28 days, and the evaluation results before and after the product is used are compared by a statistical test method so as to judge whether the statistical difference exists.

Detection of the site:

1. lactic acid sting test-bilateral sides of the nose (screening)

2. Skin cuticle moisture content-cheek (left/right)

3. Skin percutaneous water loss value-cheek (left/right)

4. Visia red area ratio of whole face

5. Statistical method

6. The statistical analysis software was SPSS. If the numerical value is normal distribution, performing statistical analysis by adopting a t test method; if the numerical value is in non-normal distribution, performing statistical analysis by adopting a rank sum test method;

7. the statistical methods all adopt a two-tail test, and the test level is alpha =0.05.

8. The calculation formula is as follows:

9. delta (difference) = D28-D0 for 28 days using product

10. Rate of change for 28 days using product = [ Mean D28-Mean (D0) ]/Mean (D0) × 100%

11. In the formula, D0 is the basic value of the skin parameter before the product is used in the tested area.

12. D28 — test area for 28 days of product application, skin parameter value.

13. N-number of subjects.

Experiment 1

Lactic acid sting value score:

after a test subject cleans the face, the test subject sits statically for 30min in a constant temperature and humidity environment, a 10% lactic acid water solution is smeared on any side part of a nasolabial sulcus for 30s, 3min and 5min respectively, and the discomfort degree of the test part is evaluated by the test subject. Scoring was done on a 4 point scale (no sensation at 0 points, mild at 1 point, moderate at 2 points, and severe at 3 points). The lactic acid stabbing pain is positive when the stabbing pain feeling is accumulated to be more than or equal to 3 within 30s, 3min and 5 min.

TABLE 1 lactic acid test results statistics

Skin reactions	30s	3min	5min
				Has no feeling	5	3	2
Mild degree of	3	2	1
				Of moderate degree	6	2	1
Severe degree of gravity	14	10	8

Experiment 2

Skin stratum corneum moisture content detection

Testing an instrument: corneometer for skin moisture tester

Test samples: the skin care products of examples 1-5 and comparative examples 1-4.

The testing principle is as follows: the probe of the skin moisture tester is based on the principle of capacitance to measure. Water has a dielectric constant of 81, other substances generally have a dielectric constant of less than 7, and water is the substance with the highest dielectric constant on the skin. When the moisture content changes, the capacitance of the skin also changes, so the moisture content on the skin surface can be analyzed by measuring the capacitance of the skin. The measured value is a relative value. Units are expressed in% (Corneometeterinits).

Subject: selecting 31 subjects, selecting subjects with 15-40% of forearm cuticle water content;

testing parts: inner measuring of forearm, drawing 6 lines 3cm ² The area of (a);

the product dosage is as follows: 0.25mg/cm ² (ii) a Each tester used 5 samples plus one control area at random.

Testing frequency: d0 and D28.

Environmental conditions: the test results were observed under a constant environment at a temperature of 21. + -. 1 ℃ and a relative humidity of 50. + -. 10% RH.

The specific test results are shown in table 2 below:

TABLE 2 skin stratum corneum moisture content

Sample (I)	D0	D28	Rate of change of moisture content%
				Example 1	19.71	36.52	85.29
Example 2	20.13	36.85	83.06
				Example 3	19.23	35.04	82.22
Example 4	21.23	38.35	80.64
				Example 5	20.46	37.06	81.14
Comparative example 1	20.68	36.35	75.77
				Comparative example2	21.31	38.18	79.16
Comparative example 3	22.68	39.27	73.15
				Comparative example 4	18.65	33.45	79.36

Interpretation of the results: after the soothing repairing skin care product disclosed by the invention is used for 28 days, the moisture content change rate of the skin is more than 73.15%. According to the moisturizing effects of examples 1 to 5 and comparative examples 1 to 4, the moisture content of the stratum corneum of the skin of the test area in examples 1 to 5 was significantly increased compared to comparative examples 1 to 4.

Experiment 3

Skin transdermal water loss value detection

Testing an instrument: a skin water loss tester, tewameter;

test samples: skin care products of examples 1-5 and comparative examples 1-4;

the test principle is as follows: a test probe of a skin water loss tester forms a relatively stable test small environment on the surface of skin by using a specially designed cylindrical cavity vehicle probe with two open ends, measures the water vapor pressure gradient at two different points formed by the water loss of the cuticle near the epidermis (within about 1 cm) through two groups of temperature and humidity sensors, and directly measures the water content evaporated by the epidermis so as to measure the water loss condition on the surface of the skin. The unit is g/cm ² . In particular, the less moisture loss, the better the skin barrier function.

Subject: selecting a subject, selecting a subject with dry forearm skin, and enabling the inclusion moisture value to be less than 45;

testing parts: inner measurement of forearm;

the product dosage is as follows: 2mL/cm ² ；

The test results are shown in table 3:

TABLE 3 skin transdermal Water loss values

Sample (I)	D0	D28	Rate of change of water loss%
				Example 1	25.68	16.27	-36.64
Example 2	25.41	16.20	-36.24
				Example 3	25.65	16.34	-36.3
Example 4	24.85	16.45	-33.80
				Example 5	25.61	16.76	-34.56
Comparative example 1	26.54	19.62	-26.07
				Comparative example 2	26.71	17.85	-29.65
Comparative example 3	24.48	17.35	-29.13
				Comparative example 4	25.31	18.15	-28.29

Interpretation of the results: the skin transdermal water loss of the test areas of examples 1-5 was significantly reduced compared to comparative examples 1-4 by the subjects using the product soothing repair product for 28 consecutive days.

Experiment 4

Visia red zone area ratio detection

Testing an instrument: facial image analyzer Visia

The test principle is as follows: the Visia skin detector is an instrument capable of quantitatively analyzing pathological characteristics of skin. And (4) using an ultra-high-definition camera to shoot the damaged area and then processing the shot area to read the red area value.

The test results are shown in table 4:

TABLE 4 Red zone area

Sample(s)	D0	D28	Red zone index Change Rate%
				Example 1	35.37	31.88	-15.52
Example 2	35.74	30.56	-14.49
				Example 3	36.24	32.05	-11.56
Example 4	36.24	32.05	-11.56
				Example 5	36.35	32.25	-11.28
Comparative example 1	34.56	31.24	-9.61
				Comparative example 2	35.78	32.45	-9.31
Comparative example 3	35.45	32.62	-7.98
				Comparative example 4	35.21	33.35	-5.28

Interpretation of the results: the area ratio of the skin Visia red zone in the tested area of examples 1-5 was significantly reduced compared to comparative examples 1-4 when the subjects continued to use the product soothing and rejuvenating product for 28 days.

According to the test result, the moisture content of the stratum corneum of the skin in the tested area is obviously different before and after the product is used after the skin care product is continuously used for 28 days, which shows that the product has the moisturizing effect. Before and after the product is used, the skin percutaneous water loss value of a tested area and the area of a Visia red area are reduced, and the obvious difference is shown, so that the product has a promotion effect on the recovery of the transepidermal water loss of the skin with damaged barriers, can effectively relieve the skin, and has the effects of repairing and relieving.

Accessories

Attachment 1: safety evaluation results

After the subjects used the products of examples 1-5 and comparative examples 1-4 as required, the subjects were asked, examined, and recorded for the presence of skin reactions or systemic adverse reactions, including the appearance, time of occurrence, treatment and outcome of adverse events, and judged for the relationship between adverse events and the samples used, as detailed in the following table:

the results describe: referring to the classification standard of adverse skin reactions of human trial tests specified in 2015 edition of technical Specification for cosmetic safety, 31 subjects do not have any adverse skin reactions when carrying out human trial test research.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structural changes made by using the contents of the present specification, or any other related technical fields directly or indirectly, are included in the scope of the present invention.

Claims

1. A skin care product with a soothing and repairing effect is characterized in that: the skin care product comprises, by mass, 1-12 parts of a composite plant extract, 0.5-2 parts of a de-reddening factor, 0.5-4 parts of 4D hyaluronic acid, 0.5-5 parts of tetrahydromethylpyrimidine carboxylic acid, 0.5-5 parts of panthenol, 0.1-2 parts of beta-glucan, 0.2-1 part of carboxymethyl chitosan, 1-4 parts of erythritol, 3-5 parts of 1,2-pentanediol, 0.5-1 part of 1,2-hexanediol, 5-8 parts of butanediol and 100 parts of deionized water.

2. A skin care product having soothing and rejuvenating effects according to claim 1, wherein:

the compound plant extract comprises water, butanediol, glycerol, a chamomile extract, a peppermint leaf extract, a purslane extract, a geranium extract, an aloe vera extract, a radix sophorae flavescentis extract, 1,2-hexanediol and p-hydroxyacetophenone.

3. A skin care product having soothing and rejuvenating effects according to claim 1 or 2, characterized in that:

the 4D hyaluronic acid comprises water, 1,2-pentanediol, acetylated sodium hyaluronate, a sodium hyaluronate cross-linked polymer, hydrolyzed sodium hyaluronate and ethylhexylglycerin.

4. A soothing and rejuvenating skin care product as claimed in any one of claims 1 to 3 wherein:

the skin care product comprises, by mass, 12 parts of a composite plant extract, 1 part of erythrofactor, 3 parts of 4D hyaluronic acid, 3 parts of tetrahydromethylpyrimidine carboxylic acid, 4 parts of panthenol, 0.5 part of beta-glucan, 1 part of carboxymethyl chitosan, 3 parts of erythritol, 4 parts of 1,2-pentanediol, 1 part of 1,2-hexanediol, 8 parts of butanediol and 100 parts of deionized water.

5. A method of preparing a soothing and rejuvenating skin care product according to any one of claims 1 to 4, characterized in that: the method comprises the following steps:

(1) Passing the compound plant extract through an ultramicro precision filter;

6. The method of preparing a soothing and rejuvenating skin care product according to claim 5, wherein: (2) Stirring deionized water, erythritol and butanediol, heating to 85 deg.C, maintaining the temperature for 30min, sterilizing, cooling to 50 deg.C, adding de-reddening factor, carboxymethyl chitosan and beta-glucan, and stirring.

7. A method of preparing a skin care product with soothing and rejuvenating effects according to claim 5 or 6, characterized in that: (3) Cooling to 45 ℃, adding the composite plant extract prepared in the step (1), uniformly stirring, adding 4D hyaluronic acid, tetrahydromethylpyrimidine carboxylic acid, panthenol, 1,2-pentanediol and 1,2-hexanediol, and uniformly stirring to obtain the skin care product.

8. A method of preparing a soothing and rejuvenating skin care product according to any one of claims 5 to 7, characterized in that: in the step (1), the conditions of the ultramicro precision filter and the ultrafiltration membrane are 20 ℃, the pressure is 1.0MPa, and the transmittance is 80-90%.

9. A method of preparing a soothing and rejuvenating skin care product according to any one of claims 5 to 8, characterized in that: in the steps (2) and (3), the stirring speed is 200-300rpm/min, and the stirring time is 15-20min.

10. A method of preparing a soothing and rejuvenating skin care product according to any one of claims 5 to 9, characterized in that: in the steps (2) and (3), the stirring speed is 250rpm/min, and the stirring time is 18min.