CN115475205B - Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof - Google Patents

Abstract

The application relates to the technical field of swine fever prevention and treatment, in particular to a traditional Chinese medicine composition for preventing and treating swine plague and a preparation method thereof. The material comprises the following raw materials in parts by weight: herba Ephedrae, cortex Mori, folium Perillae, herba Xanthii, radix Paeoniae alba, rhizoma Osmundae, realgar, rhizoma Atractylodis, herba Houttuyniae, poria, herba Schizonepetae, pericarpium Citri Tangerinae, cortex Magnolia officinalis, coptidis rhizoma, flos Lonicerae, fructus crataegi, radix Angelicae sinensis, radix Pulsatillae, arecae semen, and radix et rhizoma Rhei. The Chinese medicinal composition has effects of sterilizing, resisting toxic substances, removing cataract, dispelling pestilence, protecting liver and kidney, directly phagocytizing bacteria and viruses, eliminating in vivo toxins, relieving critical diseases, and preventing and treating exacerbation of disease. Green, safe, no drug residue, no drug resistance, high curative effect and no toxic or side effect. The pork without resistance is produced by daily health care instead of antibiotics and antiviral drugs in the production process.

Description

Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof

Technical Field

The application relates to the technical field of swine fever prevention and treatment, in particular to a traditional Chinese medicine composition for preventing and treating swine plague and a preparation method thereof.

Background

Swine fever is a highly acute, febrile, contagious disease caused by the swine fever virus (CSFV) that occurs in pigs. The hog cholera is widely prevalent, and the crazy rate and the death rate are high; the main transmission paths are the digestive tract and the respiratory tract; after infection of the sow, the fetus is infected vertically through the placenta. The disease is popular all the year round, can cause destructive attack to the pig industry, and is one of the most serious infectious diseases endangering the pig industry.

In the pig raising process, the antibiotic additive is added for health care and growth promotion, so that antibiotic residues are caused, and after the antibiotic residues are utilized by human bodies, the antibiotic residues have drug resistance to the antibiotic, so that adverse effects on disease control of the human bodies are generated. To protect human health and prevent the production of super resistant bacteria, the use of antibiotic additives for daily health care has been banned by the country. But are still in substantial use in actual production due to the lack of effective replacement products. There is an urgent need for an antibiotic-free, green and safe drug for preventing and treating swine fever.

Disclosure of Invention

The first aim of the application is to provide a traditional Chinese medicine composition for preventing and treating swine plague, which can prevent and treat swine fever, is free from antibiotics and is green and safe. The application also provides a preparation method of the traditional Chinese medicine composition, which is simple and easy to obtain.

The application provides a traditional Chinese medicine composition for preventing and treating swine plague, which comprises the following raw materials in parts by weight: 2.5 to 3.5 parts of ephedra herb, 2.5 to 3.5 parts of mulberry bark, 2.5 to 3.5 parts of perilla leaf, 2.5 to 3.5 parts of cocklebur fruit, 5.5 to 6.5 parts of white paeony root, 5.5 to 6.5 parts of cyrtomium rhizome, 5.5 to 6.5 parts of realgar, 5.5 to 6.5 parts of rhizoma atractylodis, 6 to 7 parts of cordate houttuynia, 5.5 to 6.5 parts of tuckahoe, 5.5 to 6.5 parts of schizonepeta herb, 5.5 to 6.5 parts of dried orange peel, 5.5 to 6.5 parts of magnolia bark, 5.5 to 6.5 parts of coptis root, 5.5 to 6.5 parts of honeysuckle flower, 5.5 to 6.5 parts of hawthorn fruit, 2.5 to 3.5 parts of angelica, 5.5 to 6.5 parts of Chinese pulsatilla root, 5.5 to 6.5 parts of betel nut and 0.4 to 0.6 part of rhubarb.

Preferably, the material comprises the following raw materials in parts by weight: 3 parts of ephedra herb, 3 parts of mulberry bark, 3 parts of perilla leaf, 3 parts of siberian cocklour fruit, 6 parts of white paeony root, 6 parts of cyrtomium rhizome, 6 parts of realgar, 6 parts of rhizoma atractylodis, 6.5 parts of heartleaf houttuynia herb, 6 parts of Indian buead, 6 parts of fineleaf schizonepeta herb, 6 parts of tangerine peel, 6 parts of officinal magnolia bark, 6 parts of golden thread, 6 parts of honeysuckle, 6 parts of hawthorn fruit, 3 parts of Chinese angelica, 6 parts of Chinese pulsatilla root, 6 parts of betel nut and 0.5 part of rhubarb.

The preparation method of the traditional Chinese medicine composition provided by the application processes the raw materials into a finished product preparation.

Preferably, the finished formulation is a powder, a pill, a paste or a spray.

Preferably, the finished formulation is a powder.

Preferably, the method comprises the following steps:

(1) Weighing herba Ephedrae, cortex Mori, folium Perillae, herba Xanthii, radix Paeoniae alba, rhizoma Osmundae, realgar, rhizoma Atractylodis, herba Houttuyniae, poria, herba Schizonepetae, pericarpium Citri Tangerinae, cortex Magnolia officinalis, coptidis rhizoma, flos Lonicerae, fructus crataegi, radix Angelicae sinensis, radix Pulsatillae, arecae semen, and radix et rhizoma Rhei, pulverizing respectively, and sieving to obtain medicinal powder of each raw material;

(2) Mixing the above medicinal powders, and sieving to obtain Chinese medicinal powder.

Preferably, the screening in the step (1) adopts a 24-mesh screen.

Preferably, the screening in the step (2) adopts a 24-mesh screen.

The treatment mechanism of the traditional Chinese medicine composition for preventing and treating the swine plague provided by the application is as follows: the adopted cyrtomium rhizome, coptis chinensis, honeysuckle, realgar, cordate houttuynia, ephedra herb, mulberry bark, perilla leaf, cocklebur and Chinese pulsatilla root have the effects of clearing heat and removing toxicity, resisting virus and bacteria, resisting protozoa and reducing fever; white peony root and Chinese angelica root can tonify qi and nourish blood, activate immune organs, relieve immunosuppression and improve immunity; herba Schizonepetae is pungent and cool to disperse, and has effects of relieving fever, relieving pain, tranquilizing, resisting bacteria and virus, and can be used for treating common cold, nasal discharge, cough, etc. Rhizoma Atractylodis, arecae semen, cortex Magnolia officinalis, pericarpium Citri Tangerinae, fructus crataegi, with effects of invigorating spleen, promoting appetite, activating qi-flowing and relieving pain; poria is used for inducing diuresis and expelling toxin. The medicines are treated by differentiation of symptoms and signs, and are integrally conditioned, and the principal and subordinate symptoms are taken into consideration, so that the immunity of the organism is improved, and the effects of preventing plague and eliminating evil are achieved.

The traditional Chinese medicine composition for preventing and treating swine fever provided by the application can prevent and eliminate the fever, nourish yin and dispel dampness, clear heat and detoxify, kill viruses and sterilize, and enhance the immune function of organisms. The main indications are: the preparation is used for treating swine fever, epidemic viral diseases and mixed infection, especially swine fever, blue ear disease, circovirus disease, pseudorabies, swine influenza or secondary erythrozoonosis, toxoplasmosis, asthma, hemorrhagic septicemia and other high fever (40-42 ℃), constipation, yellow urine, anorexia, listlessness and skin erythema; cough and dyspnea, alternate occurrence of late diarrhea and constipation, and finally dehydration, emaciation, failure and death. The application adopts purely natural Chinese herbal medicines, is prepared according to the dialectical treatment principle of homology of Chinese medicine and food, has the effects of clearing heat, promoting diuresis, astringing intestines, relieving diarrhea, strengthening spleen, removing dampness, protecting gastrointestinal mucosa, regulating endocrine, thereby preventing and treating various stress diarrhea and pathogenic diarrhea of swinery, improving the feed conversion rate and strengthening body.

In summary, the application has the following advantages:

(1) The traditional Chinese medicine composition for preventing and treating the pestilence of the live pigs provided by the application has the advantages of overall conditioning, treatment of both symptoms and root causes, practical curative effect and no recurrence, is a special pure traditional Chinese medicine pestilence prevention and virus resistance preparation, and plays a peculiar role in preventing and treating the pestilence of the livestock in recent years.

(2) The traditional Chinese medicine composition for preventing and treating the swine plague provided by the application can tonify healthy qi, accelerate blood circulation and metabolism of livestock, promote digestion, absorption and growth, greatly improve and activate the immune activity of each system of the organism, and effectively enhance the immune function of the organism; can effectively increase the quantity of macrophages, T lymphocytes and B lymphocytes of the organism, greatly improve and activate the immunocompetence of various systems of the organism, and effectively strengthen the immune function of the organism.

(3) The traditional Chinese medicine composition for preventing and treating the swine plague provided by the application can sterilize, resist toxin, remove the cataract, expel the plague, protect the liver and the kidney, directly engulf bacteria and viruses, remove toxins in the body, relieve critical symptoms and prevent and treat exacerbation of the illness.

(4) The traditional Chinese medicine composition for preventing and treating the pestilence of the live pigs can tonify and take care of kidney qi, and can also strengthen thoroughfare and conception vessels, and has good preventing and treating effects on empty fetuses, dead fetuses, infertility and aphrodisiac of sows caused by pestilence and toxicity diseases.

(5) When the traditional Chinese medicine composition for preventing and treating the swine plague is used for preventing and treating the swine plague, the whole group can be uniformly mixed with the materials, and the traditional Chinese medicine composition is reasonable in administration cost and convenient to use.

(6) The traditional Chinese medicine composition for preventing and treating the swine plague is green, safe, free of medicine residues, free of drug resistance, high in curative effect and free of toxic and side effects, and can replace antibiotics and antiviral drugs for daily health care in the production process to produce the pork without resistance to health.

Detailed Description

It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular forms also include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The technical solutions of the present application will be clearly and completely described in connection with the embodiments, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

Examples

A traditional Chinese medicine composition for preventing and treating swine plague is prepared from the following raw materials in parts by weight: 3 parts of ephedra herb, 3 parts of mulberry bark, 3 parts of perilla leaf, 3 parts of siberian cocklour fruit, 6 parts of white paeony root, 6 parts of cyrtomium rhizome, 6 parts of realgar, 6 parts of rhizoma atractylodis, 6.5 parts of heartleaf houttuynia herb, 6 parts of Indian buead, 6 parts of fineleaf schizonepeta herb, 6 parts of tangerine peel, 6 parts of officinal magnolia bark, 6 parts of golden thread, 6 parts of honeysuckle, 6 parts of hawthorn fruit, 3 parts of Chinese angelica, 6 parts of Chinese pulsatilla root, 6 parts of betel nut, 0.5 part of rhubarb and 100 parts in total.

The traditional Chinese medicine composition is processed into traditional Chinese medicine powder, and the preparation method comprises the following steps:

(1) Weighing herba Ephedrae, cortex Mori, folium Perillae, herba Xanthii, radix Paeoniae alba, rhizoma Osmundae, realgar, rhizoma Atractylodis, herba Houttuyniae, poria, herba Schizonepetae, pericarpium Citri Tangerinae, cortex Magnolia officinalis, coptidis rhizoma, flos Lonicerae, fructus crataegi, radix Angelicae sinensis, radix Pulsatillae, arecae semen, and radix et rhizoma Rhei, pulverizing respectively, and sieving with 24 mesh sieve to obtain medicinal powder of each raw material;

(2) The 20 medicinal powders are fully and uniformly mixed according to a proportion and then are sieved by a 24-mesh sieve, so that the traditional Chinese medicine powder for preventing and treating the swine plague is obtained.

The use method of the traditional Chinese medicine powder comprises the following steps: 1. the prevention and use at ordinary times: 500 g of the traditional Chinese medicine powder is mixed with 500 kg of pig feed, and the traditional Chinese medicine powder is used for 5 days per month; epidemic areas and epidemic spots are prevented: it is administered for 5-7 days every half month. 2. The treatment dosage is as follows: the product is taken 1 g per kg body weight for 2 times daily for 5-7 days.

1. The traditional Chinese medicine powder provided by the embodiment of the application is subjected to an antibacterial and antiviral test

Experiment one, an influence test on the immunoregulatory effect of classical swine fever vaccine (provided by the university of inner Mongolia animal science and medical college)

The influence of the traditional Chinese medicine powder on the immunoregulation effect of the swine fever vaccine is studied by taking the traditional Chinese medicine powder for 20 weaned pigs. The test group was dosed at 0.1% of the dose, and the control group was not dosed, and IHA antibody titer levels at 1 day, 15 days, 45 days, 75 days, and 105 days of dosing were measured, respectively. The results of the immunomodulation test in swine fever vaccine immunization are shown in Table 1.

TABLE 1 Swine fever antibody level assay results

The research result shows that the IHA antibody titer level of the swine fever vaccine can be obviously improved by mixed feeding with the product at the dosage of 0.1% in the current month of swine fever vaccine inoculation, the difference is obvious compared with a control group (P < 0.05), and the antibody of an experimental group is produced quickly and has long duration. The Chinese medicinal powder has obvious promotion effect on the production of swine fever antibodies.

Meanwhile, the traditional Chinese medicine powder can obviously improve the percentage of T lymphocytes in peripheral blood (P is less than 0.05) compared with a control group 15 days after vaccination of piglets, as shown in Table 2. The traditional Chinese medicine powder has the effects of promoting T lymphocyte proliferation and enhancing T lymphocyte immune function, thereby improving the cellular immune level of organisms and enhancing the immunity of organisms.

TABLE 2T lymphocyte count results

Experiment two, antibacterial action test (provided by the university of inner Mongolia animal science and medical college)

After bacteria are cultured in vitro for 18 to 24 hours by adopting a double dilution method, 1 volume of the product with the concentration of 0.2 percent is diluted into 0.1 percent (1:2), 0.05 percent (1:4), 0.025 percent (1:8) and 0.0125 percent (1:16) by distilled water in sequence, and the minimum antibacterial concentration of the product is measured. The antibacterial results of the traditional Chinese medicine powder are shown in table 3:

TABLE 3 results of minimum inhibitory concentration test of Chinese medicinal powders

The results show that the traditional Chinese medicine powder has antibacterial effects on escherichia coli, staphylococcus, streptococcus, salmonella and pasteurella, wherein the antibacterial effects on staphylococcus and streptococcus are strongest.

2. Practical application test effect in different pig farms

5 different pig farms are selected, all the traditional Chinese medicine powder prepared by the embodiment is used, and the specific use process and effect are shown in table 4.

Table 4 pig farm test data statistics

The test site in the table is the inner Mongolian penta pig farm, the inner Mongolian Fuchun pig farm, the Nanjing pellet Yang Zhuchang, the Hubei Jinmen pig farm, and the Jiangsu Dafeng pig farm; the ratio of the preventive medicine is the ratio of the feed to the traditional Chinese medicine powder.

The results show that:

(1) Prevention at ordinary times: the pig group with normal immunization (pigs in pig farms 1-5 in the table are all immunized normally), and the pig group can be used regularly for 5-7 days according to 500 g of the feed mixture (0.1%) per month, so that the pig group can be smoothly transited in epidemic disease season. Even if there are few infections, the symptoms are mild, and the patients can be cured after taking the medicine for 3-5 days according to the treatment amount.

(2) Pigs in epidemic areas threatened or in sub-clinical state (pigs 1-5 in the table are all threatened by epidemic diseases in surrounding pig farms): 500 g of the feed should be mixed according to 500 kg (0.1%) of the feed, and the feed can resist epidemic diseases or completely restore the health of pigs after being used for 5-7 days every half month.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the application has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the application.

Claims (7)

1. The traditional Chinese medicine composition for preventing and treating the swine plague is characterized by comprising the following raw materials in parts by weight: 3 parts of ephedra herb, 3 parts of mulberry bark, 3 parts of perilla leaf, 3 parts of siberian cocklour fruit, 6 parts of white paeony root, 6 parts of cyrtomium rhizome, 6 parts of realgar, 6 parts of rhizoma atractylodis, 6.5 parts of heartleaf houttuynia herb, 6 parts of Indian buead, 6 parts of fineleaf schizonepeta herb, 6 parts of tangerine peel, 6 parts of officinal magnolia bark, 6 parts of golden thread, 6 parts of honeysuckle, 6 parts of hawthorn fruit, 3 parts of Chinese angelica, 6 parts of Chinese pulsatilla root, 6 parts of betel nut and 0.5 part of rhubarb.

2. A method for preparing a Chinese medicinal composition for preventing and treating swine plague according to claim 1, wherein the raw materials are processed into a finished preparation.

3. The method of claim 2, wherein the finished formulation is a powder, a pill, a paste, or a spray.

4. A method of preparation according to claim 3, wherein the finished formulation is a powder.

5. The method of manufacturing according to claim 4, comprising the steps of:

(1) Weighing herba Ephedrae, cortex Mori, folium Perillae, herba Xanthii, radix Paeoniae alba, rhizoma Osmundae, realgar, rhizoma Atractylodis, herba Houttuyniae, poria, herba Schizonepetae, pericarpium Citri Tangerinae, cortex Magnolia officinalis, coptidis rhizoma, flos Lonicerae, fructus crataegi, radix Angelicae sinensis, radix Pulsatillae, arecae semen, and radix et rhizoma Rhei, pulverizing respectively, and sieving to obtain medicinal powder of each raw material;

(2) Mixing the above medicinal powders, and sieving to obtain Chinese medicinal powder.

6. The method according to claim 5, wherein the sieving in the step (1) is performed by a 24-mesh sieve.

7. The method according to claim 6, wherein the sieving in the step (2) is performed by a 24-mesh sieve.