CN115475205A - Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of swine fever control, in particular to a traditional Chinese medicine composition for controlling swine plague and a preparation method thereof. The composite material comprises the following raw materials in parts by weight: ephedra, mulberry bark, perilla leaf, siberian cocklour herb, white paeony root, cyrtomium rhizome, realgar, swordlike atractylodes rhizome, heartleaf houttuynia herb, indian buead, fineleaf schizonepeta herb, tangerine peel, officinal magnolia bark, golden thread, honeysuckle flower, hawthorn fruit, chinese angelica, chinese pulsatilla root, areca seed and rhubarb. The Chinese medicinal composition has effects of killing bacteria, resisting virus, removing miasma, dispelling plague, protecting liver and kidney, directly phagocytosing bacteria and virus, removing vivotoxin, relieving critical diseases, and preventing and treating disease deterioration. Green, safe, no medicine residue, no drug resistance, high curative effect and no toxic side effect. In the production process, antibiotics and antiviral drugs are replaced to carry out daily health care, and non-antibiotic healthy pork is produced.

Description

Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof

Technical Field

The invention relates to the technical field of prevention and treatment of swine fever, in particular to a traditional Chinese medicine composition for preventing and treating swine plague and a preparation method thereof.

Background

Hog cholera is a highly acute, febrile, contagious disease caused by hog cholera virus (CSFV) and occurring in pigs. The swine fever is wide in prevalence, and the crazy rate and the death rate are high; the main transmission pathways are the digestive and respiratory tracts; after the sow is infected, the fetus is vertically infected through the placenta. The disease is popular all the year round, can cause destructive attack to the pig industry, and is one of the most serious infectious diseases harming the pig industry.

The additive is added to promote health and growth in the pig raising process, so that the antibiotic residue is caused, and the drug resistance to the antibiotic is generated after the antibiotic is utilized by a human body, thereby having adverse effects on the prevention and treatment of diseases of the human body. In order to protect human health and prevent the generation of super drug-resistant bacteria, the use of antibiotic additives for daily health care has been banned in the country. But is still used in large quantities in actual production due to the lack of effective substitute products. An antibiotic-free, green and safe medicament for preventing and treating swine fever is urgently needed.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for preventing and treating swine plague, which can prevent and treat swine plague, does not contain antibiotics, and is green and safe. The invention also provides a preparation method of the traditional Chinese medicine composition, which is simple and easy to obtain.

The invention provides a traditional Chinese medicine composition for preventing and treating swine plague, which comprises the following raw materials in parts by weight: 2.5 to 3.5 parts of ephedra, 2.5 to 3.5 parts of mulberry bark, 2.5 to 3.5 parts of perilla leaf, 2.5 to 3.5 parts of siberian cocklebur, 5.5 to 6.5 parts of white peony root, 5.5 to 6.5 parts of cyrtomium rhizome, 5.5 to 6.5 parts of realgar, 5.5 to 6.5 parts of swordlike atractylodes rhizome, 6 to 7 parts of heartleaf houttuynia herb, 5.5 to 6.5 parts of Indian buead, 5.5 to 6.5 parts of fineleaf schizonepeta herb, 5.5 to 6.5 parts of tangerine peel, 5.5 to 6.5 parts of officinal magnolia bark, 5.5 to 6.5 parts of golden thread, 5.5 to 6.5 parts of honeysuckle, 5.5 to 6.5 parts of hawthorn, 2.5 to 3.5 parts of Chinese angelica, 5.5 to 6.5 parts of Chinese pulsatilla root, 5 to 6.5 parts of areca seed and 0.4 to 0.6 parts of rhubarb.

Preferably, the feed comprises the following raw materials in parts by weight: 3 parts of ephedra, 3 parts of mulberry bark, 3 parts of perilla leaves, 3 parts of siberian cocklour, 6 parts of white paeony root, 6 parts of cyrtomium rhizome, 6 parts of realgar, 6 parts of swordlike atractylodes rhizome, 6.5 parts of heartleaf houttuynia herb, 6 parts of Indian buead, 6 parts of fineleaf schizonepeta herb, 6 parts of tangerine peel, 6 parts of officinal magnolia bark, 6 parts of golden thread, 6 parts of honeysuckle flower, 6 parts of hawthorn, 3 parts of Chinese angelica, 6 parts of Chinese pulsatilla root, 6 parts of betel nut and 0.5 part of rhubarb.

The preparation method of the traditional Chinese medicine composition provided by the invention is to process the raw materials into a finished product preparation.

Preferably, the finished preparation is powder, pill, paste or spray.

Preferably, the finished formulation is a powder.

Preferably, the method comprises the following steps:

(1) Weighing herba Ephedrae, cortex Mori, folium Perillae, herba Xanthii, radix Paeoniae alba, rhizoma Osmundae, realgar, rhizoma Atractylodis, herba Houttuyniae, poria, herba Schizonepetae, pericarpium Citri Tangerinae, cortex Magnolia officinalis, coptidis rhizoma, flos Lonicerae, fructus crataegi, radix Angelicae sinensis, radix Pulsatillae, arecae semen, and radix et rhizoma Rhei, respectively pulverizing and sieving to obtain medicinal powder of each raw material;

(2) Mixing the medicinal powders of the above materials, and sieving to obtain Chinese medicinal powder.

Preferably, the sieving in the step (1) adopts a 24-mesh sieve.

Preferably, a 24-mesh sieve is used for sieving in the step (2).

The treatment mechanism of the traditional Chinese medicine composition for preventing and treating the swine plague provided by the invention is as follows: the adopted cyrtomium rhizome, coptis, honeysuckle, realgar, houttuynia, ephedra, mulberry bark, perilla leaf, xanthium sibiricum, chinese pulsatilla and rhubarb have the functions of clearing heat and detoxifying, resisting virus, bacteria, resisting protozoan and reducing fever; radix Paeoniae alba and radix Angelicae sinensis have effects of benefiting qi and nourishing blood, activating immune organ, relieving immunosuppression, and improving immunity; herba Schizonepetae is pungent and cool, and has effects of dispelling heat, relieving fever, relieving pain, tranquilizing mind, resisting bacteria and virus, and can be used for treating common cold, rhinorrhea, cough, etc. Rhizoma Atractylodis, arecae semen, cortex Magnolia officinalis, pericarpium Citri Tangerinae, and fructus crataegi have effects of invigorating spleen, promoting appetite, activating qi-flowing, and relieving pain; poria cocos inducing diuresis and (4) expelling toxin. The medicines are used for treatment based on syndrome differentiation, conditioning the whole body, treating both principal and secondary aspects and improving the immunity of the organism, thereby achieving the effects of preventing plague and expelling pathogenic factors.

The traditional Chinese medicine composition for preventing and treating the raw swine fever can prevent and eliminate the plague and evil, nourish yin and eliminate dampness, clear heat and detoxify, kill virus and sterilize and enhance the immune function of the organism. The main treatment is as follows: the swine fever, epidemic virus diseases and mixed infection are especially used for hyperpyrexia (40-42 ℃), constipation, yellow urine, anorexia, listlessness and skin erythema caused by swine plague, blue ear disease, circovirus disease, pseudorabies, swine influenza or secondary eperythrozoonosis, toxoplasmosis, asthma, hemorrhagic septicemia and the like; some symptoms are cough and dyspnea, alternate occurrence of later diarrhea and constipation, and finally dehydration, emaciation, exhaustion and death. The Chinese medicinal composition is prepared from pure natural Chinese herbal medicines according to the dialectical treatment principle of homology of medicine and food in traditional Chinese medicine, has the effects of clearing heat and promoting diuresis, relieving diarrhea with astringents, invigorating spleen and removing dampness, protecting gastrointestinal mucosa and regulating endocrine, thereby preventing and treating various stress diarrhea and pathogenic diarrhea of swinery, improving the feed conversion rate and strengthening the body.

In summary, the invention has the following advantages:

(1) The traditional Chinese medicine composition for preventing and treating the swine plague, provided by the invention, has the advantages of integral conditioning, treatment of both symptoms and root causes, practical curative effect and no recurrence, is a special pure traditional Chinese medicine plague preventing and antiviral preparation, and plays a unique role in preventing and treating the livestock plague in recent years.

(2) The traditional Chinese medicine composition for preventing and treating the live swine plague provided by the invention can tonify healthy qi, accelerate blood circulation and metabolism of an animal body, promote digestion, absorption and growth, greatly improve and activate the immunocompetence of each system of the organism, and effectively enhance the immune function of the organism; can effectively increase the number of macrophages, T lymphocytes and B lymphocytes of the organism, greatly improve and activate the immunocompetence of each system of the organism and effectively enhance the immunologic function of the organism.

(3) The traditional Chinese medicine composition for preventing and treating the swine plague provided by the invention can sterilize and resist virus, remove miasma and dispel plague, protect liver and kidney, directly phagocytize bacteria and viruses, remove vivotoxin, relieve critical diseases and prevent and treat disease deterioration.

(4) The traditional Chinese medicine composition for preventing and treating the swine plague provided by the invention can tonify and control kidney qi, and can strengthen thoroughfare and conception vessels, and has good prevention and treatment effects on empty fetus, dead fetus and sterility and estrus caused by the plague virus of sows.

(5) When the traditional Chinese medicine composition for preventing and treating the swine plague is used for preventive medication, the whole group can be integrally and uniformly mixed, the medication cost is reasonable, and the use is convenient.

(6) The traditional Chinese medicine composition for preventing and treating the swine plague is green and safe, has no medicine residue, does not generate medicine resistance, has high curative effect and no toxic or side effect, and can replace antibiotics and antiviral medicines to carry out daily health care in the production process to produce non-antibiotic healthy pork.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular forms also include the plural forms unless the context clearly dictates otherwise, and further, it is understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Examples

A traditional Chinese medicine composition for preventing and treating swine plague comprises the following raw materials in parts by weight: 3 parts of ephedra, 3 parts of mulberry bark, 3 parts of perilla leaf, 3 parts of siberian cocklour herb, 6 parts of white paeony root, 6 parts of cyrtomium rhizome, 6 parts of realgar, 6 parts of swordlike atractylodes rhizome, 6.5 parts of heartleaf houttuynia herb, 6 parts of Indian buead, 6 parts of fineleaf schizonepeta herb, 6 parts of tangerine peel, 6 parts of officinal magnolia bark, 6 parts of golden thread, 6 parts of honeysuckle flower, 6 parts of hawthorn fruit, 3 parts of Chinese angelica, 6 parts of Chinese pulsatilla root, 6 parts of betel nut, 0.5 part of rhubarb and 100 parts of the total.

The traditional Chinese medicine composition is processed into traditional Chinese medicine powder, and the preparation method comprises the following steps:

(1) Weighing herba ephedrae, mulberry bark, perilla leaf, xanthium sibiricum, white paeony root, cyrtomium rhizome, realgar, rhizoma atractylodis, houttuynia cordata, poria cocos, schizonepeta, dried orange peel, mangnolia officinalis, coptis chinensis, honeysuckle, hawthorn, angelica sinensis, chinese pulsatilla root, betel nut and rhubarb, respectively crushing, and then sieving with a 24-mesh sieve to obtain medicinal powder of each raw material;

(2) And (3) fully and uniformly mixing the 20 kinds of medicinal powder according to a proportion, and sieving the mixture by a 24-mesh sieve to obtain the traditional Chinese medicine powder for preventing and treating the swine plague.

The application method of the traditional Chinese medicine powder comprises the following steps: 1. the prevention use at ordinary times: 500 g of the traditional Chinese medicine powder is mixed with 500 kg of pig feed and is used for 5 days per month; epidemic area and epidemic point prevention: it is administered for 5-7 days every half month. 2. The treatment dosage is as follows: the product is orally taken 1 g per kilogram of body weight for 2 times a day, and is continuously taken for 5-7 days.

1. The traditional Chinese medicine powder provided by the embodiment of the invention is subjected to antibacterial and antiviral tests

Experiment I, effect test on the immunoregulation of hog cholera vaccine (provided by institute of animal science and medicine of inner Mongolia university of agriculture)

The influence of the traditional Chinese medicine powder on the immunoregulation effect of the swine fever vaccine is researched by administering the traditional Chinese medicine powder to 20 weaned piglets. The test group was administered with 0.1% of the product in a mixed manner, the control group was not administered with the product, and the titer levels of the IHA antibody were measured at 1 day, 15 days, 45 days, 75 days, and 105 days, respectively. The results of the immunomodulatory test in swine fever vaccine immunization are shown in table 1.

TABLE 1 detection results of swine fever antibody level

The research result shows that the IHA antibody titer level of the swine fever vaccine can be obviously improved by mixed feeding and administration of the product with 0.1 percent of dose in the month of inoculation of the swine fever vaccine, the difference is obvious compared with a control group (P is less than 0.05), and the antibody of an experimental group is generated quickly and lasts for a long time. The Chinese medicinal powder has obvious promotion effect on the generation of swine fever antibodies.

Meanwhile, the traditional Chinese medicine powder can obviously improve the percentage of T lymphocytes in peripheral blood 15 days after the piglets are inoculated with the vaccine (P is less than 0.05), as shown in table 2. The traditional Chinese medicine powder has the functions of promoting T lymphocyte proliferation and strengthening T lymphocyte immunity, thereby improving the cellular immunity level of organisms and enhancing the immunity of the organisms.

TABLE 2T lymphocyte count results

Experiment two, antibacterial action test (provided by college of animal science and medicine of inner Mongolia university)

After culturing the bacteria in vitro for 18 to 24 hours, the product with the concentration of 0.2% in 1 volume is diluted with distilled water to 0.1% (1. The antibacterial results of the traditional Chinese medicine powder are shown in table 3:

table 3 test results of minimum inhibitory concentration of Chinese medicinal powder

The result shows that the traditional Chinese medicine powder has antibacterial effects on escherichia coli, staphylococcus, streptococcus, salmonella and pasteurella, wherein the antibacterial effects on staphylococcus and streptococcus are strongest.

2. Practical application test effect in different pig farms

The traditional Chinese medicine powder prepared in the examples is used in 5 different pig farms, and the specific use process and effect are shown in table 4.

TABLE 4 pig farm test data statistics

The test site No. 1 in the table is the inner Mongolia five-original pig farm, no. 2 is the inner Mongolia Fuchuan pig farm, no. 3 is the Nanjing Danyang pig farm, no. 4 is the Hubei Jingmen pig farm, and No. 5 is the Jiangsu Dafeng pig farm; the ratio of the preventive medicine is the ratio of the feed to the traditional Chinese medicine powder.

The results show that:

(1) Normally, prevention: for the normal immunization pig herd (pigs in No. 1-5 pig farm in the table are all normally immunized), 500 g of the product is regularly used according to 500 kg (0.1%) of the mixed feed every month, and the mixed feed can be used for 5-7 days continuously, so that the pig herd can smoothly live through the epidemic season. Even if a few infections exist, the symptoms are slight, and the patients can be cured by singly feeding the traditional Chinese medicine composition for 3-5 days according to the treatment amount.

(2) The affected area is threatened or the swine herd in the subclinical state (the pig farms No. 1-5 in the table are threatened by epidemic diseases of the peripheral pig farms): 500 kg (0.1%) of 500 g of the product should be mixed with feed for 5-7 days every half month, so that epidemic diseases can be resisted or the health of swinery can be completely recovered.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (8)

1. The traditional Chinese medicine composition for preventing and treating swine plague is characterized by comprising the following raw materials in parts by weight: 2.5 to 3.5 parts of ephedra, 2.5 to 3.5 parts of mulberry bark, 2.5 to 3.5 parts of perilla leaf, 2.5 to 3.5 parts of siberian cocklebur, 5.5 to 6.5 parts of white peony root, 5.5 to 6.5 parts of cyrtomium rhizome, 5.5 to 6.5 parts of realgar, 5.5 to 6.5 parts of swordlike atractylodes rhizome, 6 to 7 parts of heartleaf houttuynia herb, 5.5 to 6.5 parts of Indian buead, 5.5 to 6.5 parts of fineleaf schizonepeta herb, 5.5 to 6.5 parts of tangerine peel, 5.5 to 6.5 parts of officinal magnolia bark, 5.5 to 6.5 parts of golden thread, 5.5 to 6.5 parts of honeysuckle, 5.5 to 6.5 parts of hawthorn, 2.5 to 3.5 parts of Chinese angelica, 5.5 to 6.5 parts of Chinese pulsatilla root, 5 to 6.5 parts of areca seed and 0.4 to 0.6 parts of rhubarb.

2. The traditional Chinese medicine composition for preventing and treating swine plague according to claim 1, is characterized by comprising the following raw materials in parts by weight: 3 parts of ephedra, 3 parts of mulberry bark, 3 parts of perilla leaves, 3 parts of siberian cocklour, 6 parts of white paeony root, 6 parts of cyrtomium rhizome, 6 parts of realgar, 6 parts of swordlike atractylodes rhizome, 6.5 parts of heartleaf houttuynia herb, 6 parts of Indian buead, 6 parts of fineleaf schizonepeta herb, 6 parts of tangerine peel, 6 parts of officinal magnolia bark, 6 parts of golden thread, 6 parts of honeysuckle flower, 6 parts of hawthorn, 3 parts of Chinese angelica, 6 parts of Chinese pulsatilla root, 6 parts of betel nut and 0.5 part of rhubarb.

3. A preparation method of the traditional Chinese medicine composition for preventing and treating swine plague as claimed in claim 1 or 2, characterized in that the raw materials are processed into a finished product preparation.

4. The method of claim 3, wherein the final formulation is a powder, pill, paste or spray.

5. The method of claim 4, wherein the final formulation is a powder.

6. The method of claim 5, comprising the steps of:

(1) Weighing herba Ephedrae, cortex Mori, folium Perillae, herba Xanthii, radix Paeoniae alba, rhizoma Osmundae, realgar, rhizoma Atractylodis, herba Houttuyniae, poria, herba Schizonepetae, pericarpium Citri Tangerinae, cortex Magnolia officinalis, coptidis rhizoma, flos Lonicerae, fructus crataegi, radix Angelicae sinensis, radix Pulsatillae, arecae semen, and radix et rhizoma Rhei, respectively pulverizing and sieving to obtain medicinal powder of each raw material;

(2) Mixing the medicinal powders of the above materials, and sieving to obtain Chinese medicinal powder.

7. The method according to claim 6, wherein the sieving in step (1) is performed with a 24-mesh sieve.

8. The method for preparing the compound of claim 7, wherein the sieving in the step (2) is performed by using a 24-mesh sieve.