CN111228402A - Chinese herbal medicine composition for preventing and controlling African swine fever, preparation method and pig feed - Google Patents

Chinese herbal medicine composition for preventing and controlling African swine fever, preparation method and pig feed Download PDF

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Publication number
CN111228402A
CN111228402A CN202010255580.4A CN202010255580A CN111228402A CN 111228402 A CN111228402 A CN 111228402A CN 202010255580 A CN202010255580 A CN 202010255580A CN 111228402 A CN111228402 A CN 111228402A
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China
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parts
swine fever
root
african swine
herbal medicine
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CN202010255580.4A
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Chinese (zh)
Inventor
宾艳芳
舒会友
朱建火
苏毅
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Guangzhou Guanglilai Biotechnology Co ltd
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Guangzhou Guanglilai Biotechnology Co ltd
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Priority to CN202010255580.4A priority Critical patent/CN111228402A/en
Publication of CN111228402A publication Critical patent/CN111228402A/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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Abstract

The invention provides a Chinese herbal medicine composition for preventing and controlling African swine fever, a preparation method thereof and a pig feed. The Chinese herbal medicine composition for preventing and controlling African swine fever provided by the invention comprises, by weight, 1-3 parts of scutellaria baicalensis, 1-3 parts of golden cypress, 1-3 parts of coptis chinensis, 0.5-3 parts of isatis root, 1-5 parts of honeysuckle, 1-4 parts of rheum officinale, 1-8 parts of sweet wormwood herb, 1-5 parts of codonopsis pilosula, 3-7 parts of astragalus membranaceus, 1-5 parts of ginseng, 2-4 parts of rhizoma polygonati, 0.5-3 parts of radix polygonati officinalis, 0.5-3 parts of hawthorn, 0.2-2 parts of endothelium corneum gigeriae galli, 0.5-4 parts of liquorice, 1-5 parts of poria cocos, 0.2-2 parts of bighead atractylodes rhizome, 1-5 parts of angelica sinensis, 1-5 parts of medlar, 1-3 parts of pseudo-ginseng, 1-5 parts of. The Chinese herbal medicine composition for preventing and controlling African swine fever, the preparation method thereof and the pig feed provided by the invention can reduce the death rate of pigs and improve the infection threshold of a swinery on African swine fever viruses, thereby reducing the infection chance.

Description

Chinese herbal medicine composition for preventing and controlling African swine fever, preparation method and pig feed
Technical Field
The invention belongs to the technical field of pig feed, and particularly relates to a Chinese herbal medicine composition for preventing and controlling African swine fever, a preparation method and pig feed.
Background
African swine fever, a virulent infectious disease that was first discovered in Africa and endangers the swine industry, first appeared in Kenya in 1921 until the mid-20 th century invades Europe and spreads to the south America and Caribbean. Since 2007, it has spread and prevailed in many countries around the world, particularly russia and surrounding areas. African Swine Fever (ASF) is an acute, febrile, highly contagious disease of swine caused by African Swine Fever (ASFV), with 100% morbidity and mortality. The African swine fever virus is a very unique virus, has a large and complex genome, has a plurality of protective layers, has super-strong in vitro viability, is cold-resistant, dirty-resistant, salty-resistant and particularly low-temperature-resistant, can survive for several years in a freezing environment, has a very wide tolerance range on a pH value, and can survive in a pH environment of 3.9-11.5. The world animal health Organization (OIE) classifies the animal epidemic disease as a legal report animal epidemic disease, and China classifies the animal epidemic disease as a type of animal epidemic disease.
China is a big country for pig raising and pork consumption, live pigs are in stock, stock and pork consumption are all in the top of the world, the Ministry of agriculture publishes that 2017 years old China can breed 3424 thousands of sows, the pork yield is 5451 ten thousand tons, live pigs are in stock 70202 ten thousand, stock 44158 thousands, and the pork consumption is 5568 ten thousand tons. Since the epidemic situation of the African swine fever in China is first developed in 8 months in 2018, the epidemic disease is spread to China in short time of one year, no province exists, the number of the direct and indirect economic losses is trillions, part of group enterprises are affected by the fact that the national banked sows are reduced by more than 40%, and the majority of pig farms bear huge debts, so that heavy attacks are brought to the domestic pig breeding industry and the national economy, and serious influences are brought to near-hundred million practitioners at the upper and lower reaches of the pig raising industry.
The natural spreading speed of the African swine fever is slow, the African swine fever is spread in a high contact way, and epidemic diseases can be spread by direct contact, ingestion, tick bite, injection and the like. The digestive (oral) and respiratory (nasal) tract are the major infection pathways of the african swine fever virus; the susceptible animals are domestic pigs and wild pigs; the incubation period is 3-19 days; the African swine fever virus has three types of strains with strong toxicity, moderate toxicity, low toxicity and the like. Clinically, it can be classified into the most acute type, subacute type and chronic type. The most acute type of symptoms are: the temperature of the sick pig reaches 41-42 ℃, and the sick pig shows symptoms of anorexia, inappetence, mental depression, skin congestion and the like and dies within 1-4 days. There were also asymptomatic dead pigs. The morbidity and the mortality can reach 100 percent; acute symptoms: the body temperature of the sick pig reaches 40-42 ℃, and the sick pig has anorexia, unwilling activity, red skin, vomit, nasal hemorrhage, bloody stool, constipation and the like. The pregnant sow is aborted. The fatality rate can reach 90-100%; symptoms of the subacute type: similar to the acute type. The sick pigs have moderate fever and reduced appetite. Skin hemorrhage and edema, death 7-20 days after infection, disease death rate of 30% -70%; chronic type of symptoms: the sick pigs have the disadvantages of weight loss and poor growth, intermittent heat, necrosis or ulcer of the skin at the ear, abdomen and inner side of thigh, arthrocele and respiratory symptoms of infected pigs.
Since the discovery of African swine fever, scientists in various countries never stop the development of vaccines, but because of the complex infection mechanism of African swine fever viruses, no vaccine for effectively preventing the African swine fever is available all the time in the world, and no specific medicine for treating the African swine fever is available. Therefore, the control of the transmission path is very key to well perform biological safety control of the pig farm and reduce the virus carrying capacity of the environmental viruses of the pig farm; however, enhancing the immunity of the swine herd of the susceptible animals and increasing the infection threshold of the susceptible animals to the African swine fever virus are among the major factors for preventing and controlling the African swine fever.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a Chinese herbal medicine composition for preventing and controlling African swine fever, a preparation method thereof and a pig feed.
The invention provides a Chinese herbal medicine composition for preventing and controlling African swine fever, which comprises, by weight, 1-3 parts of scutellaria baicalensis, 1-3 parts of golden cypress, 1-3 parts of coptis chinensis, 0.5-3 parts of isatis root, 1-5 parts of honeysuckle, 1-4 parts of rheum officinale, 1-8 parts of sweet wormwood, 1-5 parts of codonopsis pilosula, 3-7 parts of astragalus membranaceus, 1-5 parts of ginseng, 2-4 parts of rhizoma polygonati, 0.5-3 parts of radix polygonati officinalis, 0.5-3 parts of hawthorn, 0.2-2 parts of endothelium corneum gigeriae galli, 0.5-4 parts of liquorice, 1-5 parts of poria cocos, 0.2-2 parts of bighead atractylodes rhizome, 1-5 parts of angelica sinensis, 1-5 parts of medlar, 1-3 parts of pseudo-ginseng, 1-5 parts of white.
Preferably, 1.5-2 parts of scutellaria baicalensis, 1.5-2 parts of phellodendron, 1.5-2 parts of coptis chinensis, 1.0-2 parts of isatis root, 2-3 parts of honeysuckle, 1.5-2 parts of rheum officinale, 3-5 parts of sweet wormwood herb, 2-3 parts of codonopsis pilosula, 3.5-5.5 parts of astragalus membranaceus, 2-3 parts of ginseng, 2.3-3.5 parts of rhizoma polygonati, 0.5-1.5 parts of radix polygonati officinalis, 0.5-1.5 parts of hawthorn, 0.2-1 part of endothelium corneum gigeriae galli, 1-2 parts of liquorice, 2-3 parts of poria cocos, 0.2-1 part of bighead atractylodes rhizome, 2-3 parts of angelica sinensis, 2-3 parts of medlar, 1.5-2.5 parts of pseudo-ginseng, 2-3 parts of radix paeoniae alba and 3-.
Preferably, the Chinese herbal medicine composition for preventing and controlling African swine fever further comprises 1-3 parts of rhizoma atractylodis, 0.3-2 parts of radix sileris, 0.5-2 parts of lithospermum, 0.5-2 parts of pulsatilla chinensis, 0.3-2 parts of Japanese ampelopsis root, 1-5 parts of red paeony root, 1-5 parts of ligusticum wallichii, 1-5 parts of cortex moutan, 1-5 parts of earthworm, 1-5 parts of radix bupleuri, 1-5 parts of achyranthes bidentata, 1-5 parts of fleece-flower root, 1-3 parts of leech, 2-6 parts of salvia miltiorrhiza, 1-4 parts of gecko and 1-5 parts of tribulus terrestris.
Preferably, the traditional Chinese medicine composition comprises 1.3-2 parts of rhizoma atractylodis, 0.3-1 part of radix sileris, 0.5-1 part of lithospermum, 0.6-1.2 parts of Chinese pulsatilla root, 0.3-1 part of Japanese ampelopsis root, 2-3 parts of red paeony root, 2-3 parts of ligusticum wallichii, 2-3 parts of cortex moutan, 2-3 parts of earthworm, 2-3 parts of radix bupleuri, 2.5-3.5 parts of achyranthes root, 2-3 parts of fleece-flower root, 1-1.5 parts of leech, 3.5-4.5 parts of salvia miltiorrhiza, 1.5-2.5 parts of gecko, 2.3-3.5 parts of tribulus terrestris and 20-80 parts of corn flour.
Preferably, the traditional Chinese medicine composition is prepared from 1.5-2 parts of scutellaria baicalensis, 1.5-2 parts of phellodendron bark, 1.5-2 parts of coptis chinensis, 1.0-2 parts of isatis root, 1.3-2 parts of rhizoma atractylodis, 0.3-1 part of divaricate saposhnikovia root, 3-5 parts of sweet wormwood herb, 1-2 parts of liquorice, 0.5-1 part of lithospermum, 0.6-1.2 parts of Chinese pulsatilla root, 0.3-1 part of Japanese ampelopsis root, 2.3-3.5 parts of rhizoma polygonati, 3.5-5 parts of astragalus mongholicus, 2-3 parts of white paeony root, 2-3 parts of red paeony root, 2-3 parts of ligusticum wallichii, 2-3 parts of medlar, 0.5-1.5 part of radix polygonati officinalis, 2-3 parts of cortex moutan, 2-3 parts of earthworm, 2-3 parts of radix bupleuri, 2-3 parts of angelica, 2.5-3.5 parts of achyranthes bidentata, 2-3 parts of fleece-3 parts of leech, 1.5-4., 1.5 to 2.5 portions of pseudo-ginseng, 1.5 to 2.5 portions of gecko, 2 to 3 portions of tuckahoe, 2.3 to 3.5 portions of tribulus terrestris, 1.5 to 2 portions of rhubarb, 0.2 to 1 portion of gizzard lining, 2 to 3 portions of ginseng, 2 to 3 portions of honeysuckle, 2 to 3 portions of radix codonopsitis, 0.2 to 1 portion of largehead atractylodes rhizome and 20 to 80 portions of corn flour.
Preferably, the average particle size of the Chinese herbal medicine composition for preventing and controlling African swine fever is 50-100 meshes.
Preferably, the Chinese herbal medicine composition for preventing and controlling African swine fever contains 0.5-5% of baicalin, 0.5-8% of alkaloid, 0.5-5% of flavone, 0.5-5% of polysaccharide, 0.5-7% of saponin and 1-10% of polyphenol.
The invention also provides a preparation method of the Chinese herbal medicine composition for preventing and controlling African swine fever, which comprises the following steps:
(1) drying the raw materials until the water content is less than 10% by mass;
(2) crushing the raw materials into particles with the particle size of 50-100 meshes;
(3) mixing the pulverized raw materials in proportion.
The invention also provides a pig feed, which comprises a main pig feed material and the Chinese herbal medicine composition for preventing and controlling the African swine fever, wherein the weight ratio of the main pig feed material to the Chinese herbal medicine composition for preventing and controlling the African swine fever is 1000: 2 to 20.
Preferably, the weight ratio of the pig feed main material to the Chinese herbal medicine composition for preventing and controlling African swine fever is 1000: 5 to 10.
The Chinese herbal medicine composition for preventing and controlling African swine fever, the preparation method thereof and the pig feed provided by the invention can well reduce the death rate of pigs.
Detailed Description
The technical solutions of the present invention are further described in detail with reference to specific examples so that those skilled in the art can better understand the present invention and can implement the present invention, but the examples are not intended to limit the present invention.
The embodiment of the invention provides a Chinese herbal medicine composition for preventing and controlling African swine fever, which comprises, by weight, 1-3 parts of scutellaria baicalensis, 1-3 parts of golden cypress, 1-3 parts of coptis chinensis, 0.5-3 parts of isatis root, 1-5 parts of honeysuckle, 1-4 parts of rheum officinale, 1-8 parts of sweet wormwood herb, 1-5 parts of codonopsis pilosula, 3-7 parts of astragalus membranaceus, 1-5 parts of ginseng, 2-4 parts of rhizoma polygonati, 0.5-3 parts of polygonatum odoratum, 0.5-3 parts of hawthorn, 0.2-2 parts of endothelium corneum gigeriae galli, 0.5-4 parts of liquorice, 1-5 parts of poria cocos, 0.2-2 parts of bighead atractylodes rhizome, 1-5 parts of angelica sinensis, 1-5 parts of medlar, 1-3 parts of pseudo-ginseng, 1-5 parts.
The Chinese herbal medicine composition for preventing and controlling African swine fever has the function of clearing lung heat. Clearing away lung heat: the colloquial language: "the lung is nourished first, the lung is good for all diseases, the lung is the most frequent and important organ contacting with the outside in the respiratory system, the lung is also the most delicate one; the swinery is affected by various factors such as dust, ammonia gas, feed, stress and the like, so that lung qi and body fluids are continuously lost, and the lung is not nourished to form lung heat; lung qi has the functions of regulating respiration and qi, blood and water of the whole body, and once damaged, it affects the operation and repair functions of the whole body and affects the whole body.
The Chinese herbal medicine composition for preventing and controlling African swine fever has medicinal materials such as scutellaria baicalensis, phellodendron amurense, coptis chinensis, isatis roots, honeysuckle, rheum officinale and sweet wormwood herbs, and has the effects of clearing lung heat, strengthening lungs, harmonizing five internal organs and clearing lung heat by regulating the metabolic pathway of arachidonic acid in a pig group, inhibiting the activity of cell factors and increasing the perfusion of blood in the lungs through various alkaloid flavone active substances such as baicalin and berberine contained in the medicinal materials.
The Chinese herbal medicine composition for preventing and controlling African swine fever has the function of strengthening the spleen and stomach. Strengthening the spleen and stomach: the spleen is the largest immune organ of an animal body and also is an important lymph organ, contains a large amount of macrophages and lymphocytes, can also generate the lymphocytes, is the center of humoral immunity and cellular immunity of the body, and has the functions of participating in bone marrow hematopoiesis, storing blood, filtering toxins and foreign matters in the blood, clearing old blood cells, participating in human immunity and the like. The traditional Chinese medicine considers that the spleen is the acquired root, the source of qi and blood generation, and the spleen is healthy and can nourish the whole body to maintain the normal needs of various organs and tissues.
The Chinese herbal medicine composition for preventing and controlling African swine fever has the medicinal materials of codonopsis pilosula, astragalus membranaceus, ginseng, rhizoma polygonati, radix polygonati officinalis, hawthorn, endothelium corneum gigeriae galli, liquorice, poria cocos, bighead atractylodes rhizome and the like, the secretion of gastric mucus is promoted through polysaccharides and saponins contained in the medicinal materials, the gastric mucus-bicarbonate barrier effect is enhanced, the content of endogenous prostaglandin with a protection effect on the gastric mucosa is increased, and meanwhile, the spleen and stomach functions are regulated and strengthened through the modes of promoting bone marrow hematopoiesis, spleen erythropoiesis, promoting macrophage proliferation, cell volume increase, pseudopodia increase and the like.
The Chinese herbal medicine composition for preventing and controlling African swine fever has the function of improving the immunity of the swine herd. Improving the immunity of the organism: the immunity refers to the defense mechanism of animals, is the physiological reaction for recognizing and eliminating the abnormal self, and is the ability for resisting invasion and maintaining the stability of the environment in the organism; from the new coronavirus pneumonia epidemic situation in 2020, people with strong immunity have lower chance of suffering from the disease, and even if the people suffer from the disease, most of the people are mild diseases and can be quickly cured, while severe patients are mostly old people, have more basic diseases and low immunity; for African swine fever without vaccine and specific medicine, the immunity of the organism is the specific medicine as the novel coronary pneumonia.
The Chinese herbal medicine composition for preventing and controlling African swine fever has the traditional Chinese medicines of astragalus, angelica, codonopsis pilosula, medlar, ginseng, pseudo-ginseng, rhizoma polygonati, radix paeoniae alba, radix rehmanniae preparata and the like, and can promote the development of immune organs such as thymus, spleen and the like and the hematopoiesis of bone marrow through the polysaccharide and the polyphenol substances contained in the medicinal materials; can promote phagocytosis of macrophage, promote proliferation of T and B lymphocytes, and improve immunocyte function; regulating immune cell to secrete interferon, interleukin, antibody and other immune factors; meanwhile, the antioxidant enzyme activity of the organism is activated and the antioxidant enzyme is directly combined with oxygen free radicals, so that the oxygen free radical resistance of the organism is improved, the tissue and organ efficacy is recovered, and the inflammatory factor storm is prevented, so that the immunity of the swinery is improved.
The Chinese herbal medicine composition for preventing and controlling the African swine fever provided by the embodiment of the invention can be used for preventing the African swine fever.
The Chinese herbal medicine composition for preventing and controlling the African swine fever in the embodiment of the invention realizes that the obtained Chinese herbal medicine composition for preventing and controlling the African swine fever can better improve the immunity of a swinery and reduce the infection threshold of a pig to the African swine fever virus, thereby reducing the infection chance and the death rate of the pig.
In a preferred embodiment, 1.5-2 parts of scutellaria baicalensis, 1.5-2 parts of phellodendron amurense, 1.5-2 parts of coptis chinensis, 1.0-2 parts of isatis roots, 2-3 parts of honeysuckle, 1.5-2 parts of rheum officinale, 3-5 parts of sweet wormwood herbs, 2-3 parts of codonopsis pilosula, 3.5-5.5 parts of astragalus membranaceus, 2-3 parts of ginseng, 2.3-3.5 parts of polygonatum sibiricum, 0.5-1.5 parts of polygonatum odoratum, 0.5-1.5 parts of hawthorn, 0.2-1 part of endothelium corneum gigeriae galli, 1-2 parts of liquorice, 2-3 parts of poria cocos, 0.2-1 part of bighead atractylodes rhizome, 2-3 parts of angelica sinensis, 2-3 parts of lycium barbarum, 1.5-2.5 parts of panax notoginseng, 2-.
In a preferred embodiment, the Chinese herbal medicine composition for preventing and controlling African swine fever further comprises 1-3 parts of rhizoma atractylodis, 0.3-2 parts of divaricate saposhnikovia root, 0.5-2 parts of lithospermum, 0.5-2 parts of Chinese pulsatilla root, 0.3-2 parts of Japanese ampelopsis root, 1-5 parts of red paeony root, 1-5 parts of Szechuan lovage rhizome, 1-5 parts of cortex moutan, 1-5 parts of earthworm, 1-5 parts of Chinese thorowax root, 1-5 parts of twotooth achyranthes root, 1-5 parts of tuber fleeceflower root, 1-3 parts of leech, 2-6 parts of red-rooted salvia root, 1-4 parts.
In a preferred embodiment, 1.3-2 parts of rhizoma atractylodis, 0.3-1 part of radix sileris, 0.5-1 part of lithospermum, 0.6-1.2 parts of Chinese pulsatilla root, 0.3-1 part of Japanese ampelopsis root, 2-3 parts of red paeony root, 2-3 parts of ligusticum wallichii, 2-3 parts of cortex moutan, 2-3 parts of earthworm, 2-3 parts of radix bupleuri, 2.5-3.5 parts of achyranthes root, 2-3 parts of fleece-flower root, 1-1.5 parts of leech, 3.5-4.5 parts of salvia miltiorrhiza, 1.5-2.5 parts of gecko, 2.3-3.5 parts of tribulus terrestris and 20-80 parts of corn flour.
In the preferred embodiment, the traditional Chinese medicine composition is prepared from 1.5-2 parts of scutellaria baicalensis, 1.5-2 parts of phellodendron bark, 1.5-2 parts of coptis chinensis, 1.0-2 parts of isatis root, 1.3-2 parts of rhizoma atractylodis, 0.3-1 part of divaricate saposhnikovia root, 3-5 parts of sweet wormwood herb, 1-2 parts of liquorice, 0.5-1 part of lithospermum, 0.6-1.2 parts of Chinese pulsatilla root, 0.3-1 part of Japanese ampelopsis root, 2.3-3.5 parts of rhizoma polygonati, 3.5-5 parts of astragalus mongholicus, 2-3 parts of white paeony root, 2-3 parts of red paeony root, 2-3 parts of ligusticum wallichii, 2-3 parts of medlar, 0.5-1.5 parts of radix polygonati officinalis, 2-3 parts of cortex moutan, 2-3 parts of earthworm, 2-3 parts of radix bupleuri, 2-3 parts of angelica sinensis, 2.5-3.5 parts of achyranthes bidentata, 2-3 parts of polygonum multiflorum, 1-1.5 parts, 1.5 to 2.5 portions of pseudo-ginseng, 1.5 to 2.5 portions of gecko, 2 to 3 portions of tuckahoe, 2.3 to 3.5 portions of tribulus terrestris, 1.5 to 2 portions of rhubarb, 0.2 to 1 portion of gizzard lining, 2 to 3 portions of ginseng, 2 to 3 portions of honeysuckle, 2 to 3 portions of radix codonopsitis, 0.2 to 1 portion of largehead atractylodes rhizome and 20 to 80 portions of corn flour.
In a preferred embodiment, scutellaria baicalensis is 1.5-1.7 parts, such as 1.5 parts, 1.6 parts, or 1.7 parts; or 1.8-2 parts of scutellaria baicalensis, such as 1.8 parts, 1.9 parts or 2.0 parts.
In a preferred embodiment, 1.5-1.7 parts, such as 1.5 parts, 1.6 parts, or 1.7 parts, of phellodendron bark; or 1.8-2 parts of phellodendron bark, such as 1.8 parts, 1.9 parts or 2.0 parts.
In a preferred embodiment, coptis chinensis is 1.5-1.7 parts, such as 1.5 parts, 1.6 parts, or 1.7 parts; or 1.8-2 parts of coptis root, such as 1.8 parts, 1.9 parts or 2.0 parts.
In a preferred embodiment, 1.0-1.5 parts of isatis root, such as 1.0 part, 1.2 parts or 1.4 parts; or 1.6-2 parts of isatis root, such as 1.6 parts, 1.8 parts or 2.0 parts.
In a preferred embodiment, 1.3-1.6 parts, such as 1.3 parts, 1.4 parts, 1.5 parts or 1.6 parts, of atractylodes lancea; or 1.7-2 parts of rhizoma atractylodis, such as 1.7 parts, 1.8 parts, 1.9 parts or 2.0 parts.
In preferred embodiments, ledebouriella root 0.3-0.7 parts, such as 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, or 0.7 parts; or 0.8 parts, 0.9 parts, or 1.0 parts.
In preferred embodiments, the sweet wormwood is 3.5-4.5 parts, such as 3.5 parts, 4.0 parts or 4.5 parts.
In a preferred embodiment, 1-1.5 parts, such as 1.0 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, or 1.5 parts, of licorice; or 1.6-2.0 parts of licorice, such as 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts or 2.0 parts.
In a preferred embodiment, 0.7-0.9 parts, such as 0.7 parts, 0.8 parts, or 0.9 parts, of comfrey.
In a preferred embodiment, the pulsatillae radix is 0.7-1.0 parts, such as 0.7 parts, 0.8 parts, 0.9 parts or 1.0 parts.
In a preferred embodiment, 0.5-0.8 parts, such as 0.5 parts, 0.6 parts, 0.7 parts or 0.8 parts, of ampelopsis japonica.
In a preferred embodiment, polygonatum is 2.5-3 parts, such as 2.5 parts, 2.7 parts, 2.9 parts or 3.0 parts.
In a preferred embodiment, the astragalus membranaceus is 4.0-5.0 parts, such as 4.0 parts, 4.5 parts, or 5.0 parts.
In preferred embodiments, white peony root is 2.2-2.8 parts, e.g., 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, or 2.8 parts.
In a preferred embodiment, the red peony root is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, the ligusticum wallichii is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, the wolfberry is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, or 2.8 parts.
In a preferred embodiment, polygonatum odoratum is 0.8-1.2 parts, e.g., 0.8 parts, 0.9 parts, 1.0 parts, 1.1 parts or 1.2 parts.
In a preferred embodiment, the cortex moutan is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, or 2.8 parts.
In a preferred embodiment, the earthworm is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, the bupleurum root is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, angelica sinensis is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, achyranthes bidentata 2.8-3.2 parts, such as 2.8 parts, 2.9 parts, 3.0 parts, 3.1 parts, or 3.2 parts.
In a preferred embodiment, 2.2-2.8 parts of fleece-flower root, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, the leech is 1.1-1.4 parts, such as 1.1 parts, 1.2 parts, 1.3 parts or 1.4 parts.
In a preferred embodiment, 3.8-4.2 parts of salvia miltiorrhiza, such as 3.8 parts, 3.9 parts, 4.0 parts, 4.1 parts or 4.2 parts.
In a preferred embodiment, the prepared rhizome of rehmannia is 3.2-3.8 parts, e.g., 3.2 parts, 3.3 parts, 3.4 parts, 3.5 parts, 3.6 parts, 3.7 parts, or 3.8 parts.
In a preferred embodiment, 0.8-1.2 parts, e.g., 0.8 parts, 0.9 parts, 1.0 parts, 1.1 parts, or 1.2 parts, of hawthorn is used.
In a preferred embodiment, 1.8-2.2 parts, such as 1.8 parts, 1.9 parts, 2.0 parts, 2.1 parts or 2.2 parts, of notoginseng are used.
In preferred embodiments, gecko is 1.8-2.2 parts, such as 1.8 parts, 1.9 parts, 2.0 parts, 2.1 parts, or 2.2 parts.
In a preferred embodiment, poria cocos wolf is 2.2-2.8 parts, such as 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In a preferred embodiment, tribulus terrestris 2.5-3.2 parts, e.g., 2.5 parts, 2.6 parts, 2.7 parts, 2.8 parts, 2.9 parts, 3.0 parts, 3.1 parts, or 3.2 parts.
In preferred embodiments, rhubarb is 1.6 to 1.8 parts, e.g., 1.6 parts, 1.7 parts, or 1.8 parts.
In preferred embodiments, the endothelium corneum is 0.4-0.8 parts, such as 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, or 0.8 parts.
In preferred embodiments, the ginseng is 2.2-2.8 parts, e.g., 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, or 2.8 parts.
In a preferred embodiment, the honeysuckle is 2.2-2.8 parts, e.g., 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts, or 2.8 parts.
In a preferred embodiment, the dangshen is 2.2 to 2.8 parts, such as, 2.2 parts, 2.3 parts, 2.4 parts, 2.5 parts, 2.6 parts, 2.7 parts or 2.8 parts.
In preferred embodiments, 0.4-0.8 parts, e.g., 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, or 0.8 parts, of Atractylodis rhizoma.
In a preferred embodiment, the Chinese herbal medicine composition for preventing and controlling African swine fever comprises 100 parts of total, 1.5 parts of Scutellaria baicalensis, 1.5 parts of phellodendron amurense, 1.5 parts of coptis chinensis, 1.0 part of isatis root, 1.3 parts of rhizoma atractylodis, 0.3 part of radix sileris, 3 parts of sweet wormwood herb, 1 part of liquorice, 0.5 part of lithospermum, 0.6 part of Chinese pulsatilla root, 0.3 part of Japanese ampelopsis root, 2.3 parts of rhizoma polygonati, 3.5 parts of astragalus membranaceus, 2 parts of white peony root, 2 parts of red peony root, 2 parts of Ligusticum wallichii, 2 parts of medlar, 0.5 part of rhizoma polygonati officinalis, 2 parts of cortex moutan, 2 parts of earthworm, 2 parts of radix bupleuri, 2 parts of angelica sinensis, 2.5 parts of achyranthes bidentata, 2 parts of Polygonum multiflorum, 1 part of leech, 3.5 parts of Salvia miltiorrhiza, 3 parts of prepared rhizome of rehmannia, 0.5 part of hawthorn, 1.5 part of pseudo-ginseng, 1.5 part of Gekko Swinhonis.
In a preferred embodiment, the Chinese herbal medicine composition for preventing and controlling African swine fever comprises, by weight, 100 parts of Baikal skullcap root 1.75 parts, phellodendron bark 1.75 parts, coptis root 1.75 parts, isatis root 1.5 parts, atractylodes rhizome 1.65 parts, ledebouriella root 0.65 parts, sweet wormwood 4 parts, licorice root 1.5 parts, alkanna tinctoria 0.75 parts, Chinese pulsatilla root 0.9 parts, Japanese ampelopsis root 0.65 parts, Siberian solomonseal rhizome 2.9 parts, astragalus root 4.5 parts, root of herbaceous peony 2.5 parts, red peony root 2.5 parts, Ligusticum wallichii 2.5 parts, matrimony vine 2.5 parts, fragrant solomonseal rhizome 2.5 parts, root bark of tree peony 2.5 parts, earthworm 2.5 parts, honeysuckle flower 2.5 parts, Chinese angelica root 2.5 parts, achyranthes bidentata 3 parts, fleece-flower root 2.5 parts, leech 1.25 parts, root 4 parts, prepared rhizome of red-rooted saliva 3.5 parts, haw 1 part, notoginseng 2 parts, Bupleurum 2.5 parts, poria cocos 2.9 parts, rhubarb horsetails, corn flour 1.75 parts.
In a preferred embodiment, the Chinese herbal medicine composition for preventing and controlling African swine fever comprises 100 parts of Baikal skullcap root 2 parts, phellodendron bark 2 parts, coptis root 2 parts, isatis root 2 parts, atractylodes rhizome 2 parts, ledebouriella root 1 part, sweet wormwood 5 parts, licorice root 2 parts, alkanna tinctoria 1 part, pulsatilla root 1.2 parts, Japanese ampelopsis root 1 part, Siberian solomonseal rhizome 3.5 parts, astragalus root 5.5 parts, root of herbaceous peony 3 parts, red peony root 3 parts, Ligusticum wallichii 3 parts, matrimony vine 3 parts, fragrant solomonseal rhizome 1.5 parts, root bark 3 parts, earthworm 3 parts, Bupleurum root 3 parts, Chinese angelica root 3.5 parts, achyranthes and cyathula root 3.5 parts, fleece-flower root 3 parts, leech 1.5 parts, root of red rooted saliva 4.5 parts, prepared rhizome of rehmannia, haw 1.5 parts, notoginseng 2.5 parts, Gekko Swinhonis 2.5 parts, poria cocos 3 parts, Tribulus terrestris 3.
In a preferred embodiment, the average particle size of the Chinese herbal medicine composition for preventing and controlling African swine fever is 50-100 meshes.
In the preferred embodiment, the Chinese herbal medicine composition for preventing and controlling African swine fever contains baicalin 0.5-5%, alkaloid 0.5-8%, flavone 0.5-5%, polysaccharide 0.5-5%, saponin 0.5-7% and polyphenol 1-10%.
Baicalin: baicalin (baicailin) is a flavonoid compound extracted from dried root of Scutellaria baicalensis Georgi (Scutellaria baicalensis Georgi) belonging to family Labiatae, and is light yellow powder at room temperature and bitter in taste. Is insoluble in methanol, ethanol, acetone, chloroform and nitrobenzene, is almost insoluble in water, and is soluble in hot acetic acid. When the ferric trichloride is in contact with the ferric trichloride, the ferric trichloride shows green, and when the ferric trichloride is in contact with the lead acetate, orange precipitate is generated. The yellow color of the solution dissolved in alkali and ammonia water is changed into black brown color after a while.
The baicalin in this example is derived from scutellaria baicalensis, and the method for testing baicalin in this example is a method for measuring the content of baicalin recorded in pharmacopoeia of the people's republic of china.
Alkaloid: alkaloids are nitrogen-containing basic organic compounds existing in nature, and have alkali-like properties, so the alkaloids are also called pseudo-alkalis in the past. Most of the Chinese herbal medicines have complex ring structures, nitrogen is mostly contained in the ring, and the Chinese herbal medicines have remarkable biological activity and are one of important effective components in the Chinese herbal medicines. Has optical activity. Some nitrogen-containing organic compounds which are derived from plants without alkalinity have obvious biological activity and are included in the range of alkaloids. Some nitrogen-containing organic compounds derived from natural sources, such as certain vitamins, amino acids and peptides, are not traditionally "alkaloids".
In the present example, the content test of alkaloid is obtained by using high performance liquid chromatography.
And (3) flavone: it refers to a series of compounds formed by connecting two benzene rings (A-and B-rings) with phenolic hydroxyl groups through a central three-carbon atom, and the basic parent nucleus of the compounds is 2-phenyl chromone.
The flavone content test in the embodiment is obtained by a high performance liquid chromatography method.
Polysaccharide: is a polymeric carbohydrate composed of glycosidically bonded sugar chains, at least more than 10 monosaccharides, and can be represented by the general formula (C)6H10O5)nAnd (4) showing. Polysaccharides composed of the same monosaccharides are called homopolysaccharides, such as starch, cellulose, and glycogen; polysaccharides composed of different monosaccharides are called heteropolysaccharides, and gum arabic is composed of pentose, galactose, and the like. Polysaccharides are not purely chemical substances but are mixtures of substances which polymerize to a different extent. Polysaccharides are generally insoluble in water, have no sweet taste, cannot form crystals, and have no reducibility and no racemization. Polysaccharides are also glycosides and therefore can be hydrolyzed, often producing a series of intermediates during the hydrolysis process, ultimately leading to complete hydrolysis to monosaccharides.
The polysaccharide content test in the example was performed by high performance liquid chromatography.
Saponin: saponin (saponin) is also known as: an alkaline soap body; saponin; saponins (zao dai); a saponin; or saponin. The term "Saponin" is intended to be interpreted by the english name sapon, which is derived from the lapin Sapo and means soap. Saponins (Saponin) are glycosides whose aglycones are triterpenes or spirostanols, and are mainly distributed in plants such as terrestrial plateau and are also present in marine organisms such as starfish and sea cucumber in small quantities.
The saponin content test in this example was performed by high performance liquid chromatography.
Polyphenol: polyphenols are compounds found in plant foods with potential health promoting effects, and are present in some common plant foods. The main active component is polyphenol, and the polyphenol compound is a general name of plant components with a plurality of phenolic hydroxyl groups in the molecular structure.
The polyphenol content test in this example was performed by high performance liquid chromatography.
The invention also provides a preparation method of the Chinese herbal medicine composition for preventing and controlling African swine fever, which comprises the following steps:
(1) drying the Chinese herbal medicine raw materials until the water content is less than 10 percent by mass; for example, the Chinese herbal medicine materials can be respectively dried.
(2) Crushing the dried Chinese herbal medicine raw materials into particles with the particle size of 50-100 meshes;
(3) the crushed raw material particles are mixed according to the formula proportion of the Chinese herbal medicine composition for preventing and controlling African swine fever in any embodiment.
The invention also provides a pig feed, which comprises a main pig feed material and the Chinese herbal medicine composition for preventing and controlling the African swine fever of any one embodiment, wherein the weight ratio of the main pig feed material to the Chinese herbal medicine composition for preventing and controlling the African swine fever is 1000: 2 to 20. The main material of the pig feed in this embodiment is a feed for feeding pigs, and may be a self-made main material of the pig feed or a purchased main material of the pig feed for feeding.
In a preferred embodiment, the weight ratio of the main pig feed material to the Chinese herbal medicine composition for preventing and controlling African swine fever is 1000: 5 to 10.
The foregoing disclosure is further illustrated by the following specific examples in order to provide further understanding and appreciation of the invention and to highlight its progressive effects.
Example 1
(1) Preparing raw materials: radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, radix Isatidis, rhizoma Atractylodis, radix Saposhnikoviae, herba Artemisiae Annuae, radix Glycyrrhizae, radix Arnebiae, radix Pulsatillae, radix Ampelopsis, rhizoma Polygonati, radix astragali, radix Paeoniae alba, radix Paeoniae Rubra, rhizoma Chuanxiong, fructus Lycii, rhizoma Polygonati Odorati, cortex moutan, Pheretima, radix bupleuri, radix Angelicae sinensis, radix Achyranthis bidentatae, radix Polygoni Multiflori, Hirudo, radix Salviae Miltiorrhizae, radix rehmanniae Preparata, fructus crataegi, radix Notoginseng, Gekko Swinhonis, Poria, fructus Tribuli, radix Et rhizoma Rhei, endothelium corneum Gigeriae Galli, radix Ginseng, flos
(2) Drying the Chinese herbal medicine raw materials respectively until the water content is below 10 percent;
(3) crushing the Chinese herbal medicine raw materials to particles with the particle size of 50-100 meshes by a crusher;
(4) weighing the corresponding parts of the crushed raw materials according to the following proportion, and then uniformly mixing.
The Chinese herbal medicine composition for preventing and controlling African swine fever comprises, by weight, 100 parts of total 100 parts of Baikal skullcap root, 1.5 parts of phellodendron bark, 1.5 parts of coptis root, 1.0 part of isatis root, 1.3 parts of rhizoma atractylodis, 0.3 part of divaricate saposhnikovia root, 3 parts of sweet wormwood herb, 1 part of liquorice, 0.5 part of lithospermum, 0.6 part of Chinese pulsatilla root, 0.3 part of Japanese ampelopsis root, 2.3 parts of rhizoma polygonati, 3.5 parts of astragalus root, 2 parts of white peony root, 2 parts of red peony root, 2 parts of Szechuan lovage rhizome, 2 parts of Chinese wolfberry, 0.5 part of fragrant solomonseal rhizome, 2 parts of cortex moutan, 2 parts of earthworm, 2 parts of Chinese thorowax root, 2 parts of Chinese angelica, 2.5 parts of twotooth achyranthes root, 2 parts of multiflower knotweed root, 1 part of leech, 3.5 parts of red sage root, 3 parts of prepared rhizome of rehmannia, 0.5 part of hawthorn, 1.5 part of pseudo-ginseng, 1..
Example 2
(1) Preparing raw materials: radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, radix Isatidis, rhizoma Atractylodis, radix Saposhnikoviae, herba Artemisiae Annuae, radix Glycyrrhizae, radix Arnebiae, radix Pulsatillae, radix Ampelopsis, rhizoma Polygonati, radix astragali, radix Paeoniae alba, radix Paeoniae Rubra, rhizoma Chuanxiong, fructus Lycii, rhizoma Polygonati Odorati, cortex moutan, Pheretima, radix bupleuri, radix Angelicae sinensis, radix Achyranthis bidentatae, radix Polygoni Multiflori, Hirudo, radix Salviae Miltiorrhizae, radix rehmanniae Preparata, fructus crataegi, radix Notoginseng, Gekko Swinhonis, Poria, fructus Tribuli, radix Et rhizoma Rhei, endothelium corneum Gigeriae Galli, radix Ginseng, flos
(2) Drying the Chinese herbal medicine raw materials respectively until the water content is below 10 percent;
(3) crushing the Chinese herbal medicine raw materials to particles with the particle size of 50-100 meshes by a crusher;
(4) weighing the corresponding parts of the crushed raw materials according to the following proportion, and then uniformly mixing.
The total amount of the Chinese herbal medicine composition for preventing and controlling African swine fever is 100 parts, 1.75 parts of radix scutellariae, 1.75 parts of phellodendron bark, 1.75 parts of coptis chinensis, 1.5 parts of isatis root, 1.65 parts of rhizoma atractylodis, 0.65 part of radix sileris, 4 parts of sweet wormwood herb, 1.5 parts of liquorice, 0.75 part of lithospermum, 0.9 part of Chinese pulsatilla root, 0.65 part of Japanese ampelopsis root, 2.9 parts of rhizoma polygonati, 4.5 parts of astragalus root, 2.5 parts of white peony root, 2.5 parts of red peony root, 2.5 parts of rhizoma ligustici wallichii, 2.5 parts of medlar, 2 parts of radix polygonati officinalis, 2.5 parts of cortex moutan, 2.5 parts of earthworm, 2.5 parts of radix bupleuri, 2.5 parts of angelica, 3 parts of achyranthes root, 2.5 parts of fleece-flower root, 1.25 parts of leech, 4 parts of radix salviae miltiorrhizae, 3.5 parts of prepared rhizome of rehmannia, 1 part of hawthorn, 2 parts of pseudo-ginseng, 2 parts of gecko, 2.5 parts of poria cocos, 2.9 parts of.
Example 3
(1) Preparing raw materials: radix Scutellariae, cortex Phellodendri, rhizoma Coptidis, radix Isatidis, rhizoma Atractylodis, radix Saposhnikoviae, herba Artemisiae Annuae, radix Glycyrrhizae, radix Arnebiae, radix Pulsatillae, radix Ampelopsis, rhizoma Polygonati, radix astragali, radix Paeoniae alba, radix Paeoniae Rubra, rhizoma Chuanxiong, fructus Lycii, rhizoma Polygonati Odorati, cortex moutan, Pheretima, radix bupleuri, radix Angelicae sinensis, radix Achyranthis bidentatae, radix Polygoni Multiflori, Hirudo, radix Salviae Miltiorrhizae, radix rehmanniae Preparata, fructus crataegi, radix Notoginseng, Gekko Swinhonis, Poria, fructus Tribuli, radix Et rhizoma Rhei, endothelium corneum Gigeriae Galli, radix Ginseng, flos
(2) Drying the Chinese herbal medicine raw materials respectively until the water content is below 10 percent;
(3) crushing the Chinese herbal medicine raw materials to particles with the particle size of 50-100 meshes by a crusher;
(4) weighing the corresponding parts of the crushed raw materials according to the following proportion, and then uniformly mixing.
The Chinese herbal medicine composition for preventing and controlling African swine fever comprises, by weight, 100 parts of Baikal skullcap root 2 parts, phellodendron bark 2 parts, coptis root 2 parts, isatis root 2 parts, atractylodes rhizome 2 parts, ledebouriella root 1 part, sweet wormwood 5 parts, licorice root 2 parts, alkanna tinctoria 1 part, Chinese pulsatilla root 1.2 parts, ampelopsis root 1 part, Siberian solomonseal rhizome 3.5 parts, astragalus root 5.5 parts, root of herbaceous peony 3 parts, red peony root 3 parts, Ligusticum wallichii 3 parts, matrimony vine 3 parts, fragrant solomonseal rhizome 1.5 parts, root bark of tree peony 3 parts, earthworm 3 parts, Bupleurum root 3 parts, Chinese angelica 3 parts, achyranthes and cyathula root 3 parts, fleece-flower root 3 parts, leech 1.5 parts, root of red rooted saliva 4.5 parts, prepared rhizome of rehmannia, haw 1.5 parts, notoginseng 2.5 parts, Gekko Swinhonis 2.5 parts, poria cocos 3 parts, tribulus terrestris 3.
Effects of the embodiment
Test site: new Focus pig farm of Pingjiang of Hunan province.
Test objectives: 200 nursery piglets were selected and randomly divided into 4 groups of 50 piglets each.
Test time: 7/8 th to 9/8 th in 2019.
The first group is a control group, and is fed with common piglet feed;
feeding a second group of pig feed obtained by mixing the Chinese herbal medicine composition for preventing and controlling the African swine fever in the example 1 and the common piglet feed which is a main pig feed material, wherein the weight ratio of the common piglet feed to the Chinese herbal medicine composition for preventing and controlling the African swine fever in the example 1 is 1000: 5.
the third group is fed with the pig feed obtained by mixing the Chinese herbal medicine composition for preventing and controlling the African swine fever in the example 2 and the common piglet feed which is a main pig feed material, wherein the weight ratio of the common piglet feed to the Chinese herbal medicine composition for preventing and controlling the African swine fever in the example 2 is 1000: 7.5.
the fourth group is fed with the pig feed obtained by mixing the Chinese herbal medicine composition for preventing and controlling the African swine fever in the example 3 and the common piglet feed which is a main pig feed material, wherein the weight ratio of the common piglet feed to the Chinese herbal medicine composition for preventing and controlling the African swine fever in the example 3 is 1000: 10.
after four groups of different pig feeds are fed to piglets for one month, the data of total protein, albumin, globulin, IgA, IgM, IgG, SOD, GSH-PX, death head number and hemoglobin of the piglets are counted, and the specific data are shown in Table 1.
TABLE 1
Figure BDA0002437188140000141
As can be seen from the data in Table 1, the total protein, albumin and globulin contents of the pigs bred in the group to which the herbal composition for controlling African swine fever of examples 1-3 was added were increased by 15.73%, 22.33% and 17.23%, respectively, as compared with the control group. Total protein, albumin and globulin in serum can reflect the digestion and absorption degree of the animal to the protein, maintain the colloid osmotic pressure of the organism, increase the content of the protein, correspondingly improve the immunity of the organism, enhance the nutritional level of the organism and improve the capability of the organism for resisting the external adverse environment influence. The piglet serum globulin is derived from the secretion of plasma cells, and the globulin mainly comprises antibody molecules and complement components, so the increase of the serum globulin quantity reflects the increase of the antibody level of an organism to a certain extent.
Compared with the control group, the contents of the immunoglobulin IgA, IgM and IgG of the group added with the Chinese herbal medicine composition for preventing and controlling African swine fever of the embodiment 1-3 are respectively improved by 28.56%, 32.35% and 42.74%. IgG has the functions of antibiosis and antivirus, can neutralize virus to make the virus lose toxicity, condition, agglomerate and precipitate antigen, and plays an important role in humoral immunity; IgM is an antibody which is firstly generated when an organism is firstly contacted with an antigen substance, also has the functions of resisting bacteria, resisting viruses and neutralizing toxins, and is combined with complement to dissolve pathogens after the organism is infected by the pathogens; IgA has antibacterial, antiviral and antitoxin effects, plays a very important role in local mucosal immunity of respiratory tracts, digestive tracts and the like of organisms, and particularly has an anti-infection effect on pathogenic microorganisms infected by certain mucous membranes. It is demonstrated that the herbal composition for prevention and control of African swine fever of the present examples 1-3 can provide the piglets with better immunity after being added.
Compared with the control group, the contents of two antioxidant enzymes SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase) in the piglet group added with the Chinese herbal medicine composition for preventing and controlling African swine fever of the examples 1-3 are respectively increased by 33.06 percent and 10.78 percent. The free radical refers to any atom or atomic group which can exist independently and contains one or more unpaired electrons, a large amount of free radicals are generated in vivo due to animal metabolism, stress or diseases, the free radicals generated by the organism and the rate of clearing the free radicals are in a dynamic balance state under a normal physiological state, but the generated amount of the free radicals in the organism can damage proteins, lipids and DNA of the organism to cause tissue organ necrosis, and SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase) are two most important antioxidases for clearing the free radicals in the organism, and the contents of the antioxidases can be directly the antioxidant capacity of the organism. The contents of the antioxidant enzymes SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase) can be increased after the Chinese herbal medicine composition for preventing and controlling African swine fever in the embodiments 1-3 is added, so that the generation of large amount of free radicals and unbalance in the organism can be avoided.
The hemoglobin content of the piglets of the group to which the Chinese herbal medicine composition for preventing and controlling African swine fever of examples 1-3 was added was increased by 18.5% compared to the control group. Hemoglobin is a protein responsible for oxygen transport (abbreviated as HB or HGB) that makes blood red in higher organisms; the red blood cells contain a large amount of hemoglobin (Hb), the function of the red blood cells is mainly completed by the hemoglobin, the hemoglobin can be used as a blood buffer substance to play a role, and can also be used as a transportation team of an animal body to transport oxygen from the lung to the tissue through arterial blood, and can also carry carbon dioxide generated by the metabolism of the tissue to the lung through venous blood and then is discharged out of the body; the degree of animal anemia can be better reflected through hemoglobin counting, and hemoglobin is often used as an important index for judging whether anemia exists clinically. The Chinese herbal medicine composition for preventing and controlling African swine fever in the embodiments 1-3 is added to make the piglets have higher hemoglobin content, so as to better avoid the anemia of the piglets.
After the Chinese herbal medicine composition for preventing and controlling African swine fever in the embodiment 1-3 is added for feeding, the survival rate of the piglets is higher and is 100%, and the survival rate of the control composition is 98%.
In conclusion, the formula of the invention is reasonable, and the obtained Chinese herbal medicine composition for preventing and controlling the African swine fever can obviously improve the contents of total protein, albumin, globulin, IgA, IgM, IgG, SOD (superoxide dismutase), GSH-PX (glutathione peroxidase) and hemoglobin of piglets after being blended with the main pig feed material for feeding, and improve the infection threshold of the piglets on the African swine fever virus, thereby reducing the infection chance.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims (10)

1. A Chinese herbal medicine composition for preventing and controlling African swine fever is characterized by comprising, by weight, 1-3 parts of scutellaria baicalensis, 1-3 parts of golden cypress, 1-3 parts of coptis chinensis, 0.5-3 parts of isatis root, 1-5 parts of honeysuckle, 1-4 parts of rheum officinale, 1-8 parts of sweet wormwood herb, 1-5 parts of codonopsis pilosula, 3-7 parts of astragalus membranaceus, 1-5 parts of ginseng, 2-4 parts of rhizoma polygonati, 0.5-3 parts of radix polygonati officinalis, 0.5-3 parts of hawthorn, 0.2-2 parts of endothelium corneum gigeriae galli, 0.5-4 parts of liquorice, 1-5 parts of poria cocos, 0.2-2 parts of bighead atractylodes rhizome, 1-5 parts of angelica sinensis, 1-5 parts of medlar, 1-3 parts of pseudo-ginseng, 1-5 parts of white paeony.
2. The Chinese herbal medicine composition for preventing and controlling African swine fever according to claim 1, wherein the Scutellaria baicalensis is 1.5-2 parts, the phellodendron bark is 1.5-2 parts, the coptis chinensis is 1.5-2 parts, the isatis root is 1.0-2 parts, the honeysuckle is 2-3 parts, the rhubarb is 1.5-2 parts, the sweet wormwood is 3-5 parts, the codonopsis pilosula is 2-3 parts, the astragalus membranaceus is 3.5-5.5 parts, the ginseng is 2-3 parts, the sealwort is 2.3-3.5 parts, the polygonatum odoratum is 0.5-1.5 parts, the hawthorn is 0.5-1.5 parts, the endothelium corneum gigeriae galli is 0.2-1 part, the liquorice is 1-2 parts, the poria cocos is 2-3 parts, the bighead atractylodes rhizome is 0.2-1 part, the angelica sinensis is 2-3 parts, the medlar is 1.5-2.5 parts.
3. The Chinese herbal medicine composition for preventing and controlling African swine fever according to claim 1, further comprising 1-3 parts of rhizoma atractylodis, 0.3-2 parts of radix sileris, 0.5-2 parts of lithospermum, 0.5-2 parts of pulsatilla, 0.3-2 parts of Japanese ampelopsis, 1-5 parts of red peony root, 1-5 parts of Ligusticum wallichii, 1-5 parts of cortex moutan, 1-5 parts of earthworm, 1-5 parts of radix bupleuri, 1-5 parts of achyranthes bidentata, 1-5 parts of fleece-flower root, 1-3 parts of leech, 2-6 parts of Salvia miltiorrhiza, 1-4 parts of Gekko Swinhonis, 1-5 parts of Tribulus terrestris and 20-80 parts of corn flour.
4. The Chinese herbal medicine composition for preventing and controlling African swine fever according to claim 3, wherein the Chinese herbal medicine composition comprises 1.3-2 parts of rhizoma atractylodis, 0.3-1 part of radix sileris, 0.5-1 part of lithospermum, 0.6-1.2 parts of Chinese pulsatilla root, 0.3-1 part of Japanese ampelopsis root, 2-3 parts of red peony root, 2-3 parts of Ligusticum wallichii, 2-3 parts of cortex moutan, 2-3 parts of earthworm, 2-3 parts of radix bupleuri, 2.5-3.5 parts of achyranthes bidentata, 2-3 parts of fleece-flower root, 1-1.5 parts of leech, 3.5-4.5 parts of Salvia miltiorrhiza, 1.5-2.5 parts of Gekko Swinhonis, 2.3-3.5 parts of Tribulus terrestris and 20-.
5. The Chinese herbal medicine composition for preventing and controlling African swine fever according to claim 1, which is prepared from 1.5-2 parts of Scutellaria baicalensis, 1.5-2 parts of phellodendron amurense, 1.5-2 parts of Coptis chinensis, 1.0-2 parts of isatis root, 1.3-2 parts of Atractylodes lancea, 0.3-1 part of Saposhnikovia divaricata, 3-5 parts of Artemisia apiacea, 1-2 parts of licorice, 0.5-1 part of lithospermum, 0.6-1.2 parts of pulsatilla chinensis, 0.3-1 part of Ampelopsis japonica, 2.3-3.5 parts of Polygonatum sibiricum Red, 3.5-5.5 parts of Astragalus membranaceus, 2-3 parts of radix Paeoniae alba, 2-3 parts of radix Paeoniae Rubra, 2-3 parts of Ligusticum wallichii, 2-3 parts of Lycium Chinense, 0.5-1.5 parts of Polygonatum, 2-3 parts of cortex moutan, 2-3 parts of Pheretima, 2-3 parts of Bupleur, 3.5 to 4.5 portions of salvia miltiorrhiza, 3 to 4 portions of prepared rhizome of rehmannia, 0.5 to 1.5 portions of hawthorn, 1.5 to 2.5 portions of panax notoginseng, 1.5 to 2.5 portions of gecko, 2 to 3 portions of tuckahoe, 2.3 to 3.5 portions of tribulus terrestris, 1.5 to 2 portions of rhubarb, 0.2 to 1 portion of gizzard pepsin, 2 to 3 portions of ginseng, 2 to 3 portions of honeysuckle, 2 to 3 portions of codonopsis pilosula, 0.2 to 1 portion of atractylodes macrocephala and 20 to 80 portions of corn flour.
6. The herbal composition for preventing and controlling African swine fever according to claim 1, wherein the average particle size of the herbal composition for preventing and controlling African swine fever is 50-100 mesh.
7. The herbal composition of claim 1, wherein the herbal composition comprises baicalin 0.5-5%, alkaloids 0.5-8%, flavones 0.5-5%, polysaccharides 0.5-5%, saponins 0.5-7% and polyphenols 1-10%.
8. The method for preparing a herbal composition for prevention and control of African swine fever according to any one of claims 1-7, comprising the steps of:
(1) drying the raw materials until the water content is less than 10% by mass;
(2) crushing the raw materials into particles with the particle size of 50-100 meshes;
(3) mixing the pulverized raw materials in proportion.
9. A pig feed, which is characterized by comprising a pig feed main material and the Chinese herbal medicine composition as claimed in any one of claims 1 to 7, wherein the weight ratio of the pig feed main material to the Chinese herbal medicine composition is 1000: 2 to 20.
10. The pig feed according to claim 9, wherein the weight ratio of the pig feed main material to the Chinese herbal medicine composition is 1000: 5 to 10.
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CN114404505A (en) * 2022-02-25 2022-04-29 广东温氏大华农生物科技有限公司 South-medicine-based traditional Chinese medicine preparation for preventing and controlling African swine fever and preparation method thereof
CN115475205A (en) * 2022-10-09 2022-12-16 包头市草原立新绿色养殖园有限公司 Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof
CN116019866A (en) * 2023-02-16 2023-04-28 潍坊中创生物科技有限公司 Traditional Chinese medicine composition for preventing and controlling African swine fever as well as preparation method and application thereof
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CN110559363A (en) * 2019-10-15 2019-12-13 郑州赛科药业科技有限公司 Traditional Chinese medicine compound fermented oral liquid for preventing and treating African swine fever and preparation process thereof
CN110624094A (en) * 2019-11-02 2019-12-31 卢鹏 Traditional Chinese medicine composition for treating and preventing African swine fever
CN110898126A (en) * 2019-11-26 2020-03-24 陈俢龙 Traditional Chinese medicine composition, preparation method and application thereof

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CN112062716A (en) * 2020-08-03 2020-12-11 河南佰景生物科技有限公司 Hyperforin derivatives, use thereof and antiviral preparations containing the same
CN116406738A (en) * 2021-12-31 2023-07-11 天津傲绿神农科技有限公司 Composition for livestock and preparation method and application thereof
CN114404505A (en) * 2022-02-25 2022-04-29 广东温氏大华农生物科技有限公司 South-medicine-based traditional Chinese medicine preparation for preventing and controlling African swine fever and preparation method thereof
CN115475205A (en) * 2022-10-09 2022-12-16 包头市草原立新绿色养殖园有限公司 Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof
CN115475205B (en) * 2022-10-09 2023-09-01 包头市草原立新绿色养殖园有限公司 Traditional Chinese medicine composition for preventing and treating swine plague and preparation method thereof
CN116019866A (en) * 2023-02-16 2023-04-28 潍坊中创生物科技有限公司 Traditional Chinese medicine composition for preventing and controlling African swine fever as well as preparation method and application thereof

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