CN115475112A - A facial mask containing low molecular sodium hyaluronate and silk fibroin and its preparation method - Google Patents

Abstract

The invention provides a beauty mask containing low molecular sodium hyaluronate and silk fibroin and a preparation method thereof, the beauty mask is divided into four components A, B, C and D, the mask can permeate into a dermis layer, increase the absorption of nutrient substances, inhibit the formation of free radicals and keep the skin smooth by compounding the low molecular sodium hyaluronate with different proportions; the natural silk fibroin has good comfort, good water absorption and water resistance, good glossiness and good ultraviolet resistance effect, can promote the synthesis of collagen, enhance the tension and elasticity of skin, promote the decomposition of pigment and homogenize the skin color; the honey extract mainly plays a long-acting moisturizing role in the horny layer of the skin, is rich in oligosaccharide, organic acid and various mineral substances, can rapidly soften the dry and hardened horny layer, recovers softness and elasticity, has a good beautifying effect, and has the function of superposing various effective components, so that the mask has the functions of diminishing inflammation, inhibiting bacteria, resisting oxidation and replenishing water. Multiple effects of whitening skin, etc.

Description

A facial mask containing low molecular sodium hyaluronate and silk fibroin and its preparation method

Technical Field

The invention relates to the field of cosmetics, and in particular relates to a beauty mask containing low-molecular sodium hyaluronate and silk fibroin and a preparation method thereof.

Background

The facial mask can be used as a carrier of a beauty product, can be divided into various types according to different forms, and has the functions of moisturizing, whitening, resisting aging, balancing grease and the like when being applied to the face. And has the advantages of quick effect, high cost performance and the like when being applied to the face, and the cosmetic becomes a more and more sought-after cosmetic in recent years. The principle is that the skin is wrapped by the mask for a short time to temporarily isolate external air and pollution, so that the stratum corneum of the skin is supplemented with moisture, humectant, nutritional agents and the like contained in the mask. Generally, moisturizers such as polyhydric alcohols including glycerin, propylene glycol, sorbitol, 1, 3-butylene glycol, and the like are added to cosmetics, and a natural moisturizing factor sodium hyaluronate having a unique water-retaining and lubricating function is also added to high-grade cosmetics. However, the commonly used sodium hyaluronate is sodium hyaluronate with relatively high molecular weight, and the molecular weight of the commonly used sodium hyaluronate is more than 100-300 ten thousand Da. Although a layer of breathable film is formed on the surface layer of the skin, the breathable film helps to lock moisture and prevent moisture from evaporating and preserving moisture for a long time. But have poor penetration and are not absorbed by the skin. The effect of lasting moisture retention desired by consumers is difficult to achieve by adding common sodium hyaluronate. And the low-molecular sodium hyaluronate within 100 ten thousand Da can easily permeate into the dermis layer of the skin, can nourish cells, lock water for a long time and delay the evaporation of water on the surface of the skin.

The silk fibroin is natural polymer fibrin extracted from silk, the content of the natural polymer fibrin accounts for about 70-80% of the silk, the silk fibroin contains 18 amino acids, and glycine (Gly), alanine (Ala) and serine (Ser) account for more than 80% of the total composition and are most similar to the protein contained in a human body. The silk fibroin used as the raw material of the skin care product has the unique characteristics that: such as good comfort, good water absorption, good water resistance, good glossiness and good ultraviolet resistance. The silk fibroin is slowly degraded, and is very beneficial to cell repair. And the degradation of the silk fibroin has controllability, so that the loss of materials is reduced while the cell growth space is ensured. The silk fibroin can also be partially degraded, and the degradation product can obviously promote the healing of skin tissues, so that the silk fibroin is commonly used in the fields of medical science, beauty and biological tissue repair.

Disclosure of Invention

The invention aims to provide a beauty mask containing low-molecular sodium hyaluronate and silk fibroin.

Yet another object of the present invention is to: provides a preparation method of a beauty mask containing low molecular sodium hyaluronate and silk fibroin.

The purpose of the invention is realized by the following scheme: a beauty mask containing low molecular sodium hyaluronate and silk fibroin is characterized by being prepared from the following four components A, B, C and D, wherein the components are as follows by weight percent:

component A

(1) Deionized water: 50% -80%;

(2) Glycerol: 1% -10%;

(3) Allantoin: 0.01% -1%;

(4) D-panthenol: 0.05% -2%;

(5) Betaine: 0.1% -5%;

(6) Beta-glucan: 0.05% -2%;

(7) Dipotassium glycyrrhizinate: 0.005% -0.5%;

(8) Carbomer: 0.005% -2%;

(9) Low molecular sodium hyaluronate: 0.001% -2%;

(10) Pyrollidinone carboxylic acids: 0.001% -2%;

and the component B comprises:

(11) Xanthan gum: 1% -20%;

(12) And (3) honey extract: 1% -20%;

(13) Silk fibroin: 0.01% -1%;

and C, component C:

(14) Alkali liquor: 0.05 to 15 percent;

and (D) component:

(15) 1, 3-butanediol: 1% -10%;

(16) Essence: 0.00% -0.50%;

(17) Preservative: 0.00% -0.50%.

The invention provides a beauty mask containing low-molecular sodium hyaluronate and silk fibroin, which is prepared from the following four components A, B, C and D, wherein the component contents are as follows by weight percent:

component A

(1) Deionized water: 60% -75%;

(2) Glycerol: 2% -8%;

(3) Allantoin: 0.05% -0.5%;

(4) D-panthenol: 0.1% -1%;

(5) Betaine: 0.5% -2%;

(6) Beta-glucan: 0.1% -1%;

(7) Dipotassium glycyrrhizinate: 0.01 to 0.1 percent

(8) Carbomer: 0.01% -1%

(9) Low molecular sodium hyaluronate: 0.01 to 1 percent

(10) Pyrollidinone carboxylic acid: 0.01 to 1 percent

And the component B comprises:

(11) Xanthan gum: 5% -15%;

(12) And (3) honey extract: 5% -15%;

(13) Silk fibroin: 0.5 to 5 percent

And C, component C:

(14) Alkali liquor: 0.1% -10%;

and (D) component:

(15) 1, 3-butanediol: 2% -8%;

(16) Essence: 0.00% -0.3%;

(17) Preservative: 0.00% -0.3%.

The invention provides a beauty mask containing low-molecular sodium hyaluronate and silk fibroin, which is characterized by being prepared from the following four components A, B, C and D in percentage by weight:

component A

(1) Deionized water: 63.5 percent;

(2) Glycerol: 5 percent;

(3) Allantoin: 0.1 percent;

(4) D-panthenol: 0.6 percent;

(5) Betaine: 1 percent;

(6) Beta-glucan: 0.5 percent;

(7) Dipotassium glycyrrhizinate: 0.1 percent of

(8) Carbomer: 0.5 percent

(9) Low molecular sodium hyaluronate: 0.5 percent

(10) Pyrollidinone carboxylic acids: 0.5 percent

And B component:

(11) Xanthan gum: 10 percent;

(12) And (3) honey extract: 10 percent;

(13) Silk fibroin: 0.5 percent

And (C) component:

(14) Alkali liquor: 2 percent

And (D) component:

(15) 1, 3-butanediol: 5 percent

(16) Essence: 0.1 percent of

(17) Preservative: 0.1 percent.

The low molecular sodium hyaluronate is sodium hyaluronate with molecular weight below 100 ten thousand Da.

The alkali solution is one of 4.5% KOH solution or 5% NaOH solution.

The silk fibroin is one or a mixture of silk powder 144, silk powder 400, silk peptide 500, silk peptide 1000 and silk amino acid 90.

The invention provides a preparation method of a beauty mask containing low-molecular sodium hyaluronate and silk fibroin, which comprises the following steps:

(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen, mixing and stirring at 50 r/min-80 r/min, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;

(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;

(3) Adding the raw material of the component C in the step (2), and uniformly stirring;

(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, detecting to be qualified, and discharging.

Has the advantages that:

1. the low molecular sodium hyaluronate with the permeability of less than 100 ten thousand Da is added, and the low molecular sodium hyaluronate with the good permeability is deeply penetrated into a corium layer, so that the low molecular sodium hyaluronate can slightly expand capillary vessels, increase blood circulation, enhance nutrient absorption, inhibit the formation of free radicals, reduce the evaporation of skin moisture and keep the skin smooth.

2. The added silk fibroin, also called fibroin, is a structural protein extracted from natural high molecular material silk. The main components of the skin-care cream comprise various amino acids such as the ethionine, the alanine, the serine, the proline, the tyrosine and the like, and the skin-care cream has obvious efficacy, is safe and has no side effect, and also has strong advantages and development space in the fields of beauty treatment and skin care. The silk fibroin used as the raw material of the skin care product has the unique characteristics that: good comfort, good water absorption and water resistance, good glossiness and good ultraviolet resistance. The composite gel of silk fibroin and sodium hyaluronate can promote the gelation of hyaluronic acid macromolecules, slow down the degradation rate of hyaluronic acid macromolecules, optimize the filling effect and prolong the effective time. Compared with the traditional gel with hyaluronic acid simply crosslinked, the silk fibroin particles effectively slow down the degradation speed of the composite gel, prolong the action time of the composite gel in tissue repair and filling, and improve the effectiveness of the material.

3. The added honey extract mainly plays a long-acting moisturizing role in the skin cuticle, is rich in oligosaccharide, organic acid and various mineral substances, can rapidly soften the dry and hardened cuticle and recover softness and elasticity, and has a good beautifying effect.

Detailed Description

The present invention is described in detail by the following specific examples, but the scope of the present invention is not limited to these examples.

The first embodiment is as follows:

a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by the following four groups of components A, B, C and D, and is prepared by the following steps:

the component A comprises: deionized water: 63.5 percent; glycerin: 5 percent; allantoin: 0.1 percent; d-panthenol: 0.6 percent;

betaine: 1 percent; beta-glucan: 0.5 percent; dipotassium glycyrrhizinate: 0.1 percent; carbomer: 0.5 percent; low molecular sodium hyaluronate: 0.5 percent; pyrollidinone carboxylic acid: 0.5 percent;

and the component B comprises: xanthan gum: 10 percent; and (3) honey extract: 10 percent; silk fibroin: 0.5 percent;

and C, component C: 4.5% KOH solution: 2 percent;

and (D) component: 1, 3-butanediol: 5 percent; essence: 0.1 percent; preservative: 0.1 percent;

the preparation method of the facial mask comprises the following steps:

(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen, mixing and stirring at 50r/min, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;

(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;

(3) Adding the raw material of the component C in the step (2), and uniformly stirring;

(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, and discharging after the detection is qualified.

Example two:

a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by four groups of components A, B, C and D, wherein the component contents are as follows by weight percent:

the component A comprises: deionized water: 66.48 percent; glycerol: 5 percent; allantoin: 0.05 percent; d-panthenol: 0.1 percent;

betaine: 0.5 percent; beta-glucan: 0.05 percent; dipotassium glycyrrhizinate: 0.01 percent; carbomer: 1 percent; low molecular sodium hyaluronate: 0.5 percent; pyrollidinone carboxylic acids: 0.01 percent;

and B component: xanthan gum: 7 percent; and (3) honey extract: 2.5 percent; silk fibroin: 1.5 percent;

and (C) component: 5% NaOH solution: 7 percent;

and (D) component: 1, 3-butanediol: 8 percent; essence: 0.2 percent; preservative: 0.1 percent;

the preparation method of the facial mask comprises the following steps:

(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen, mixing and stirring at the speed of 80r/min, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;

(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;

(3) Adding the raw material of the component C in the step (2), and uniformly stirring;

(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, and discharging after the detection is qualified.

Example three:

a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by four groups of components A, B, C and D, wherein the contents of the components are as follows by weight percent:

and (2) component A: deionized water: 79.26 percent; glycerol: 3 percent; allantoin: 0.01 percent; d-panthenol: 0.1 percent;

betaine: 0.1 percent; beta-glucan: 0.05 percent; dipotassium glycyrrhizinate: 0.01 percent; carbomer: 0.2 percent; low molecular sodium hyaluronate: 2 percent; pyrollidinone carboxylic acids: 0.01 percent;

and the component B comprises: xanthan gum: 3 percent; and (3) honey extract: 2 percent; silk fibroin: 0.2 percent;

and C, component C: 5% NaOH solution: 5 percent;

and (D) component: 1, 3-butanediol: 5 percent; essence: 0.05 percent; preservative: 0, 01%;

the preparation method of the mask is the same as the first embodiment.

Example four:

a beauty mask containing low molecular sodium hyaluronate and silk fibroin is prepared by four groups of components A, B, C and D, wherein the component contents are as follows by weight percent:

the component A comprises: deionized water: 55.89 percent; glycerol: 5 percent; allantoin: 0.5 percent; d-panthenol: 2 percent;

betaine: 2 percent; beta-glucan: 0.5 percent; dipotassium glycyrrhizinate: 0.1 percent; carbomer: 0.8 percent; low molecular sodium hyaluronate: 0.1 percent; pyrollidinone carboxylic acid: 1 percent;

and B component: xanthan gum: 5 percent; and (3) honey extract: 10 percent; silk fibroin: 5 percent;

and C, component C: 4.5% KOH solution: 10 percent;

and (D) component: 1, 3-butanediol: 2 percent; essence: 0.1 percent; preservative: 0.01 percent;

the preparation method of the mask is the same as the second embodiment.

Example five:

and (3) testing the using effect: randomly selecting 30 healthy adults (average age of 35 years) as objects, wiping the products prepared in the first embodiment and the third embodiment on the face for 30min each time and 14 days continuously, and having good moisturizing and whitening effects, wherein the feedback of the testers is shown in tables 1 and 2:

。

Claims (7)

1. a beauty mask containing low molecular sodium hyaluronate and silk fibroin is characterized by being prepared from the following four components A, B, C and D, wherein the components are as follows by weight percent:

the component A comprises: 50% to 80% deionized water, 1% to 10% glycerin, 0.01% to 1% allantoin, 0.05% to 2% of D-panthenol, 0.1% to 5% betaine, 0.05% to 2% beta-glucan, 0.005% to 0.5% dipotassium glycyrrhizinate: 0.005% -2% of carbomer, 0.001% -2% of low molecular weight sodium hyaluronate and 0.001% -2% of pyrollidone carboxylic acid;

the component B comprises: 1% -20% of xanthan gum, 1% -20% of honey extract and 0.01% -1% of silk fibroin;

a component C comprising: alkali liquor: 0.05 to 15 percent;

a component D comprising: 1 to 10 percent of 1, 3-butanediol, 0.00 to 0.50 percent of essence and 0.00 to 0.50 percent of preservative.

2. The beauty mask containing the low-molecular-weight sodium hyaluronate and the silk fibroin according to claim 1 is characterized by being prepared from the following four components A, B, C and D, wherein the components are as follows in percentage by weight:

component A

(1) Deionized water: 60% -75%;

(2) Glycerol: 2% -8%;

(3) Allantoin: 0.05% -0.5%;

(4) D-panthenol: 0.1% -1%;

(5) Betaine: 0.5% -2%;

(6) Beta-glucan: 0.1% -1%;

(7) Dipotassium glycyrrhizinate: 0.01 to 0.1 percent

(8) Carbomer: 0.01 to 1 percent

(9) Low molecular sodium hyaluronate: 0.01 to 1 percent

(10) Pyrollidinone carboxylic acids: 0.01 to 1 percent

And B component:

(11) Xanthan gum: 5% -15%;

(12) And (3) honey extract: 5% -15%;

(13) Silk fibroin: 0.5% -5%;

and C, component C:

(14) Alkali liquor: 0.1% -10%;

and (D) component:

(15) 1, 3-butanediol: 2% -8%;

(16) Essence: 0.00% -0.3%;

(17) Preservative: 0.00% -0.3%.

3. The beauty mask containing the low-molecular sodium hyaluronate and the silk fibroin as claimed in claim 1 is characterized by being prepared from the following four components A, B, C and D, wherein the component contents are as follows by weight percent:

component A

(1) Deionized water: 63.5 percent;

(2) Glycerol: 5 percent;

(3) Allantoin: 0.1 percent;

(4) D-panthenol: 0.6 percent;

(5) Betaine: 1 percent;

(6) Beta-glucan: 0.5 percent;

(7) Dipotassium glycyrrhizinate: 0.1 percent of

(8) Carbomer: 0.5 percent

(9) Low molecular sodium hyaluronate: 0.5 percent

(10) Pyrollidinone carboxylic acids: 0.5 percent

And the component B comprises:

(11) Xanthan gum: 10 percent;

(12) And (3) honey extract: 10 percent;

(13) Silk fibroin: 0.5 percent

And C, component C:

(14) Alkali liquor: 2 percent of

And (D) component:

(15) 1, 3-butanediol: 5 percent of

(16) Essence: 0.1 percent of

(17) Preservative: 0.1 percent.

4. A cosmetic mask as claimed in any one of claims 1 to 3 comprising low molecular weight sodium hyaluronate and silk fibroin, wherein the low molecular weight sodium hyaluronate is sodium hyaluronate with a molecular weight of less than 100 kiloda.

5. A cosmetic mask as claimed in any one of claims 1-3 containing low molecular sodium hyaluronate and silk fibroin, wherein said lye is one of 4.5% koh solution or 5% naoh solution.

6. The facial mask according to any one of claims 1 to 3, comprising low molecular sodium hyaluronate and silk fibroin, wherein the silk fibroin is one or more selected from silk powder 144, silk powder 400, silk peptide 500, silk peptide 1000 and silk amino acid 90.

7. A method for preparing a facial mask containing low molecular sodium hyaluronate and silk fibroin according to any one of claims 1-6. The method is characterized by comprising the following steps:

(1) Respectively adding the raw materials in the component A into a reaction kettle, introducing sterile nitrogen at the speed of 50-80 r/min, mixing and stirring, slowly heating to 70 ℃, controlling heating, continuously stirring until the raw materials are completely dissolved, and cooling to 50 ℃ for later use;

(2) Adding the raw material of the component B in the step (1), introducing sterile nitrogen, continuously stirring uniformly, and cooling to below 45 ℃ for later use;

(3) Adding the raw material of the component C in the step (2), and uniformly stirring;

(4) And (4) uniformly stirring the material of the component D, adding the material into the reaction kettle obtained in the step (3), stirring for 5min, cooling to 30 ℃, and discharging after the detection is qualified.