CN115381884B - A topical Chinese medicinal unguent for treating diseases, and its preparation method - Google Patents
A topical Chinese medicinal unguent for treating diseases, and its preparation method Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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Abstract
The application relates to the technical field of traditional Chinese medicine ointment, in particular to traditional Chinese medicine ointment for external application treatment and a preparation method thereof. The traditional Chinese medicine composition disclosed by the application has the advantages of being good in material consumption, having the effects of diminishing inflammation, relieving itching and easing pain, being fast in effect, free of toxic and side effects, and free of recurrence of other skin diseases (eczema, neurodermatitis, urticaria, herpes zoster, femoral psoriasis, folliculitis and rhagadia manus et pedis) except for the recurrence of part of psoriasis patients caused by the diet problem in the later period, and being high in radical cure rate, good news is brought to the patients with skin diseases, and pain and inconvenience brought to the patients due to the skin diseases are solved.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicine paste, in particular to a traditional Chinese medicine paste for external application treatment and a preparation method thereof.
Background
The Chinese medicinal ointment is prepared by mixing the medicaments with a proper amount of excipients, and the effects of the ointment formed by different medicaments are different, so that the Chinese medicinal ointment is prepared by adopting antipruritic and antibacterial Chinese medicaments for patients with skin diseases.
The skin disease is one of common diseases and frequently-occurring diseases which seriously affect the health of people, and the skin disease also comprises psoriasis eczema, neurodermatitis, urticaria, herpes zoster, femoral psoriasis, folliculitis and rhagadia manus et pedis, the traditional Chinese medicine ointment for treating the skin disease has single efficacy and pertinence, has a somewhat insufficient curative effect when being used for most of the skin, has low radical cure rate and is easy to cause recurrence. Therefore, a person skilled in the art provides a traditional Chinese medicine ointment for external application treatment and a preparation method thereof, so as to solve the problems in the background art.
Disclosure of Invention
The application aims to provide a traditional Chinese medicine ointment for external application treatment and a preparation method thereof, which are used for solving the problems in the background technology.
In order to achieve the above purpose, the present application provides the following technical solutions: a traditional Chinese medicine ointment for external application treatment comprises the following components in parts by weight: 1-3 parts of coptis chinensis, 3-7 parts of wild pepper root bark, 3-7 parts of ailanthus altissima root bark, 3-7 parts of fructus kochiae, 1-3 parts of gecko, 1-3 parts of tortoise shell, 1-3 parts of borneol and 15-25 parts of vaseline.
As a further aspect of the present application: the composition also comprises the following components in parts by weight: 2 parts of coptis chinensis, 5 parts of wild pepper root bark, 5 parts of ailanthus altissima root bark, 5 parts of fructus kochiae, 2 parts of gecko, 2 parts of tortoise shell, 2 parts of borneol and 20 parts of Vaseline.
As a further aspect of the present application: a preparation method of a Chinese medicinal ointment for external application treatment comprises the following steps:
step 1: slicing Coptidis rhizoma, radix Zanthoxyli Planispini root bark, and cortex Ailanthi, and grinding to obtain powder A;
step 2: grinding Gekko Swinhonis, carapax et Plastrum Testudinis, and Borneolum Syntheticum to obtain powder B;
step 3: mixing the powder A and the powder B, and sieving with a 100-mesh sieve to obtain mixed powder;
step 4: heating vaseline to obtain vaseline liquid;
step 5: adding the mixed powder into vaseline liquid, heating under stirring, cooling, and bottling to obtain the final product.
As a further aspect of the present application: in the step 5, the heating temperature is controlled at 80 ℃, the heating time is controlled at 15min, and the stirring speed is controlled at 720r/min.
Pharmacological efficacy analysis
Coptis root: has high medicinal value, has effects of clearing heat, eliminating dampness, removing toxic substances, and purging pathogenic fire, and can be used for treating jaundice, damp-heat diarrhea, conjunctival congestion, stomach fire toothache, and eczema;
root bark of wild pricklyash peel: the root bark of the homozygous plant of the pricklyash peel contains skimmin, berberine and castanopsis glauca bark dimethyl ether, is the root of the pricklyash peel of the Rutaceae plant, and has the effects of treating beriberi and eczema;
cortex toonae sinensis Radicis: bitter and astringent taste, cold nature, stomach and large intestine meridian entering, and has the effects of clearing heat and drying dampness, relieving diarrhea with astringents, stopping bleeding, eliminating dampness and relieving itching;
fructus Kochiae: cold, sweet and bitter in taste, has the effects of clearing heat and promoting diuresis, and dispelling wind and relieving itching, and is mainly used for relieving pain of urination, itching of skin and pudendum, rubella, eczema and skin pruritus;
gecko: salty and cold in taste, has effects of dispelling pathogenic wind, arresting convulsion, resolving hard mass, and removing toxic substances, and can be used for treating apoplexy paralysis, wind-damp pain, wind-phlegm convulsion epilepsy, scrofula, and malignant boil;
tortoise shell: salty taste, sweet and slightly cold, and has the effects of nourishing yin, suppressing yang, invigorating kidney, strengthening bone, nourishing blood, and tonifying heart, and is mainly used for treating hectic fever due to yin deficiency, night sweat due to bone steaming, dizziness, internal movement of deficiency wind, flaccidity of tendons and bones, and amnesia due to heart deficiency;
borneol: has pungent and bitter taste and slight cold, has antibacterial and anti-inflammatory effects, can inhibit inflammatory processes such as exudation of liquid and tissue edema, and has inhibiting effects on staphylococcus, streptococcus, pneumococcus, escherichia coli and part of pathogenic dermatophytes;
vaseline: the external skin care lotion has the advantages that the external skin care lotion can be externally used for protecting skin chapping, skin dryness and itching which need to be moistened, has good moisturizing effect and skin moistening effect, and can relieve various conditions of dryness and lack of grease of the skin.
Compared with the prior art, the application has the beneficial effects that: the traditional Chinese medicine composition disclosed by the application has the advantages of being good in material consumption, having the effects of diminishing inflammation, relieving itching and easing pain, being fast in effect, free of toxic and side effects, and free of recurrence of other skin diseases (eczema, neurodermatitis, urticaria, herpes zoster, femoral psoriasis, folliculitis and rhagadia manus et pedis) except for the recurrence of part of psoriasis patients caused by the diet problem in the later period, and being high in radical cure rate, good news is brought to the patients with skin diseases, and pain and inconvenience brought to the patients due to the skin diseases are solved.
Detailed Description
Example 1
The embodiment of the application discloses a traditional Chinese medicine ointment for external application treatment, which comprises the following components in parts by weight: 2 parts of coptis chinensis, 5 parts of wild pepper root bark, 5 parts of ailanthus altissima root bark, 5 parts of fructus kochiae, 2 parts of gecko, 2 parts of tortoise shell, 2 parts of borneol and 20 parts of Vaseline.
Further, a preparation method of the traditional Chinese medicine ointment for external application treatment comprises the following steps:
step 1: slicing Coptidis rhizoma, radix Zanthoxyli Planispini root bark, and cortex Ailanthi, and grinding to obtain powder A;
step 2: grinding Gekko Swinhonis, carapax et Plastrum Testudinis, and Borneolum Syntheticum to obtain powder B;
step 3: mixing the powder A and the powder B, and sieving with a 100-mesh sieve to obtain mixed powder;
step 4: heating vaseline to obtain vaseline liquid;
step 5: adding the mixed powder into vaseline liquid, heating under stirring, cooling, and bottling to obtain the final product.
Further, in the step 5, the heating temperature is controlled at 80 ℃, the heating time is controlled at 15min, and the stirring speed is controlled at 720r/min.
Example 2
The preparation was carried out exactly as in example 1, with the difference from example 1: comprises the following components in parts by weight: 1 part of coptis chinensis, 3 parts of wild pepper root bark, 3 parts of ailanthus altissima root bark, 3 parts of fructus kochiae, 1 part of gecko, 1 part of tortoise shell, 1 part of borneol and 15 parts of Vaseline.
Example 3
The preparation was carried out exactly as in example 1, with the difference from example 1 and example 2: comprises the following components in parts by weight: 3 parts of coptis chinensis, 7 parts of wild pepper root bark, 7 parts of ailanthus altissima root bark, 7 parts of fructus kochiae, 3 parts of gecko, 3 parts of tortoise shell, 3 parts of borneol and 25 parts of Vaseline.
The using method comprises the following steps: the Chinese medicinal ointment is uniformly applied to the affected part at an interval of 8h, and the treatment course is 5-15 days according to the cure condition of the patient.
Test example 1
Test population: 120 patients with clinical symptoms, 57 men and 63 women, with ages of 18-60 years, all suffering from eczema and urticaria.
Test group: examples 1, 2, 3 and reference examples (commercially available urticaria drugs and eczematous ointments with better sales);
test packets: each group was randomly assigned 30 patients;
the test content is as follows: each group of patients smeared with the appointed ointment every day, the treatment effect is recorded every 8 hours, and the recurrence is recorded after 1 year of cure;
test example 2
Test population: 400 patients with neurodermatitis with clinical sign, 187 men and 213 women, and 18-60 years of age are different;
test group: examples 1, 2, 3 and reference examples (commercial neurodermatitis ointment with good sales);
test packets: each group was randomly assigned 100 patients;
the test content is as follows: each group of patients is smeared with the appointed ointment every day, once every 8 hours, the course of treatment is 15 days, and the recurrence is recorded after 1 year of cure;
standard of efficacy:
and (3) curing: the affected part skin has no difference from normal skin, no pain and itching;
the effect is shown: the area of the affected part is reduced, the color is lightened, and the fallen scraps are reduced;
invalidation: the skin damage is still and the area of the affected part is increased;
test results:
| project | Healing | Has obvious effect | Invalidation of | Recurrence after 1 year |
| Example 1 | 92 | 7 | 1 | Without any means for |
| Example 2 | 83 | 13 | 4 | Without any means for |
| Example 3 | 88 | 10 | 2 | Without any means for |
| Reference example | 42 | 37 | 21 | 12 |
Test example 3
Test population: 200 patients with clinical symptoms, 87 men and 113 women, with ages of 18-60, all suffering from psoriasis and tinea cruris;
test group: examples 1, 2, 3 and reference examples (commercially available sphagnum and psoriasis ointment);
test packets: each group was randomly assigned 50 patients;
the test content is as follows: each group of patients is smeared with the appointed ointment every day, once every 8 hours, the course of treatment is 20 days, and the recurrence is recorded after 1 year of cure;
standard of efficacy:
and (3) curing: the mycotic microscopic examination is negative, tinea and pruritus completely disappear, and the skin is not different from normal skin;
the effect is shown: the mycotic microscopic examination is negative, tinea basically disappears, no itching exists, the area of the affected part becomes small, and the skin becomes thin;
invalidation: the mycotic microscopic examination is positive, tinea and pruritus are not relieved, and skin damage is still remained;
test results:
test example 4
Test population: 200 patients with clinical signs, 121 men and 79 women, aged 18-60 years, all suffering from folliculitis and rhagadia manus et pedis;
test group: examples 1, 2, 3 and reference examples (commercially available ointment for folliculitis and rhagadia manus et pedis);
test packets: each group was randomly assigned 50 patients;
the test content is as follows: each group of patients is smeared with the appointed ointment every day, once every 8 hours, the course of treatment is 20 days, and the recurrence is recorded after 1 year of cure;
standard of efficacy:
and (3) curing: skin is not different from normal skin;
the effect is shown: the cysts, the ulcers, the chaps and the itch are obviously improved;
invalidation: skin loss remains;
test results
| Project | Healing | Has obvious effect | Invalidation of | After 1 year, there is no recurrence |
| Example 1 | 42 | 8 | 0 | Without any means for |
| Example 2 | 35 | 13 | 2 | Without any means for |
| Example 3 | 39 | 11 | 0 | Without any means for |
| Reference example | 17 | 23 | 10 | 3 recurrence of |
The above data are combined to show that the treatment effects of the application in the embodiment 1, the embodiment 2 and the embodiment 3 are better than those of similar products in the market, the pertinence is wide, the effect is quick, no toxic or side effect is caused, other skin diseases (eczema, neurodermatitis, urticaria, herpes zoster, stratosphere, folliculitis and rhagadia manus et pedis) patients are not recurrent except that part of psoriasis patients have recurrent caused by the diet problem in the later period after healing, the radical cure rate is high, good news is brought to the majority of skin diseases, and pain and inconvenience brought to the patients due to the skin diseases are solved.
The foregoing description is only a preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art, who is within the scope of the present application, should make equivalent substitutions or modifications according to the technical solution of the present application and the inventive concept thereof, and should be covered by the scope of the present application.
Claims (2)
1. A traditional Chinese medicine ointment for external application treatment with anti-inflammatory, antipruritic and analgesic effects is characterized by comprising the following components in parts by weight: 1-3 parts of coptis chinensis, 3-7 parts of wild pepper root bark, 3-7 parts of ailanthus altissima root bark, 3-7 parts of fructus kochiae, 1-3 parts of gecko, 1-3 parts of tortoise shell, 1-3 parts of borneol and 15-25 parts of vaseline.
2. The traditional Chinese medicine ointment according to claim 1, which is characterized by comprising the following components in parts by weight: 2 parts of coptis chinensis, 5 parts of wild pepper root bark, 5 parts of ailanthus altissima root bark, 5 parts of fructus kochiae, 2 parts of gecko, 2 parts of tortoise shell, 2 parts of borneol and 20 parts of Vaseline.
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| CN1377681A (en) * | 2002-04-19 | 2002-11-06 | 邓幼明 | Wart clearing liquid |
| CN1965959A (en) * | 2005-11-18 | 2007-05-23 | 牛锐 | Method for preparing dampness-removing itching-relieving ointment |
| CN101785836A (en) * | 2009-01-23 | 2010-07-28 | 冷少华 | Traditional Chinese medicine ointment, preparation method and application thereof for skin disease treatment |
| CN102018922A (en) * | 2010-12-21 | 2011-04-20 | 李捍军 | External drug for psoriasis |
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