CN115368975A - 一种碱性清洗液及其制备方法 - Google Patents
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- 238000004140 cleaning Methods 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 239000012530 fluid Substances 0.000 title description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229910052751 metal Inorganic materials 0.000 claims abstract description 14
- 239000002184 metal Substances 0.000 claims abstract description 14
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 13
- 239000002738 chelating agent Substances 0.000 claims abstract description 13
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 12
- 239000006172 buffering agent Substances 0.000 claims abstract description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 25
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 18
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 18
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 239000004115 Sodium Silicate Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 11
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 11
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims description 10
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical group CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims description 10
- 235000019795 sodium metasilicate Nutrition 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 6
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- QLBHNVFOQLIYTH-UHFFFAOYSA-L dipotassium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QLBHNVFOQLIYTH-UHFFFAOYSA-L 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- RHPXYIKALIRNFA-UHFFFAOYSA-L disodium;2-[carboxylatomethyl(carboxymethyl)amino]acetate Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CC([O-])=O RHPXYIKALIRNFA-UHFFFAOYSA-L 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 8
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- 238000012423 maintenance Methods 0.000 abstract description 3
- 239000006260 foam Substances 0.000 abstract description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 230000003670 easy-to-clean Effects 0.000 abstract 1
- 238000005303 weighing Methods 0.000 description 15
- CEGPKOIWQYWDNX-UHFFFAOYSA-N 2-[bis(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CC(O)=O CEGPKOIWQYWDNX-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
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- 230000000052 comparative effect Effects 0.000 description 4
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- 239000003513 alkali Substances 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007785 strong electrolyte Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229910052910 alkali metal silicate Inorganic materials 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- -1 compound ions Chemical class 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
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- 239000006185 dispersion Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000001935 peptisation Methods 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/008—Polymeric surface-active agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/044—Hydroxides or bases
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/08—Silicates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/10—Carbonates ; Bicarbonates
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
- C11D2111/14—Hard surfaces
- C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Detergent Compositions (AREA)
Abstract
本发明涉及一种碱性清洗液,按照质量百分比计,包括非离子表面活性剂0.1~2.5%,碱金属氢氧化物0.1~3.5%,金属螯合剂0.1~3%,缓冲剂0.1~4%,余量为水。本发明还涉及碱性清洗液的制备方法。本发明涉及的碱性清洗液清洗效果优异,能够对反应杯管壁上残留的蛋白质、有机离子和脂类等起到良好的清洁作用,可有效降低蛋白质、有机离子和脂类以及金属离子残留所产生的影响,且泡沫量低,易清洗,试剂稳定性好,对仪器可以起到一定的防锈保养作用。本发明的碱性清洗液配制方法简单,试剂成本低,其价格比市场同等生化分析仪用碱性清洗液的价格低,有利于降低医疗成本,完全能够替代现有的进口碱性清洗液。
Description
技术领域
本发明涉及体外诊断领域,具体涉及一种自动化生化分析仪在分析样本及日常维护时使用的碱性清洗液。
背景技术
全自动生化分析仪由于其高准确性和精密度以及操作简便,结果可靠和性能稳定成为临床实验室必不可少的仪器设备。碱性清洗液是自动生化分析仪器每日运行的必需品,在使用生化分析仪进行检测时,为减少反应杯之间差异、减少样本或试剂间的携带污染率,以及对反应杯、样本针、管道进行清洗,每日需要消耗大量的碱性清洗液,目前临床实验室使用的碱性清洗液大多是进口碱性清洗液,但进口试剂成本高昂无法广泛应用,还有一部分使用国产碱性清洗液,但国产清洗液清洗效果不佳,对脂类等有机物质和无机成分清洗不彻底,导致这些残留物质附着在反应杯上和废液管壁上,极易降低检测结果的精密度和准确性。
发明内容
本发明克服了现有技术中的不足,在于提供一种清洗效果好的碱性清洗液及其制备方法,该碱性清洗液能够对反应杯管壁上残留的蛋白质、有机离子和脂类等起到良好的清洁作用。
本发明的具体技术方案如下:
一种碱性清洗液,按照质量百分比计,包括非离子表面活性剂0.1~2.5%,碱金属氢氧化物0.1~3.5%,金属螯合剂0.1~3%,缓冲剂0.1~4%,余量为水。
优选的,所述非离子表面活性剂为壬基酚聚氧乙烯醚、辛基酚聚氧乙烯醚或脂肪醇聚氧乙烯醚。非离子表面活性剂具有很高的表面活性,良好的增溶、抗静电、钙皂分散等性能,刺激性小,在水中和有机溶剂中都有较好的溶解性,在溶液中稳定性高,不易受强电解质无机盐、酸、碱的影响,有良好的耐硬水能力和低起泡性的特点,还有优异的润湿和洗涤功能,能够对反应杯管壁上残留的蛋白质、有机离子和脂类起到良好的清洁作用。
优选的,所述碱金属氢氧化物为氢氧化钠或氢氧化钾,碱金属氢氧化物可以溶解蛋白质和脂类物质,有效增强碱性清洗液的清洁能力。
优选的,所述金属螯合剂为乙二胺四乙酸二钠、次氨基三乙酸二钠或乙二胺四乙酸二钾,金属螯合剂可以与溶于水中的Ca2+、Mg2+、Fe3+等金属离子有络合作用,生成可溶性络合物,防止金属离子生成难溶的金属氢氧化物沉淀附着于反应杯和管壁上。
优选的,所述缓冲剂为无水偏硅酸钠、碳酸钠或硅酸钠,缓冲剂去污力能力强,缓冲能力大,易溶于水,具有良好的分散性和乳化性,可使脂肪和油类乳化,对无机物有反絮凝作用,对金属有防腐蚀作用,可以对仪器起到防锈和保养效果。
本发明还涉及碱性清洗液的制备方法,包括如下步骤:
(1)将碱金属氢氧化物加入水中,缓慢搅拌至完全溶解;
(2)将缓冲剂加入水中,缓慢搅拌至完全溶解;
(3)将金属螯合剂加入水中,缓慢搅拌至完全溶解;
(4)将非离子表面活性剂加入水中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
制备碱性清洗液时先将碱金属氢氧化物加入水中,为整个体系提供碱性环境,因为后续加入的物质在碱性环境下更容易溶解,为防止碱金属氢氧化物放热反应危险需缓慢搅拌至溶解;之后的步骤(2)、步骤(3)、步骤(4)没有先后顺序,为使溶质分布均匀且防止溶质沉于底部结块也需缓慢搅拌至完全溶解再加入其他物质。
本发明涉及的碱性清洗液中,其中碱金属氢氧化物与油脂会发生皂化反应,与蛋白质发生水解反应;金属螯合剂中螯合剂分子与金属离子发生强结合作用,将金属离子包含到螯合剂内部,将不易溶解的多价金属离子络合起来,形成可溶解的复合离子;缓冲剂可以稳定pH值,从而起到缓冲作用,且具有很好的悬浮力和稳定性,可增加洗涤溶剂的乳化力,另外偏硅酸钠在金属表面会形成碱金属硅酸盐及SiO2凝胶薄膜,使金属免受外界酸、碱等的腐蚀;非离子表面活性剂在溶液中不是以离子状态存在,所以它的稳定性高,不易受强电解质存在的影响,也不易受酸、碱的影响,相容性好,在各种溶剂中均有良好的溶解性,在固体表面上不发生强烈吸附,且泡沫量低,易清洗,使试剂稳定性更好。
本发明涉及的碱性清洗液清洗效果优异,能够对反应杯管壁上残留的蛋白质、有机离子和脂类等起到良好的清洁作用,可有效降低蛋白质、有机离子和脂类以及金属离子残留所产生的影响。本发明的碱性清洗液配制方法简单,试剂成本低,其价格比市场同等生化分析仪用碱性清洗液的价格低,有利于降低医疗成本,完全能够替代现有的进口碱性清洗液,具有良好的推广应用价值。
具体实施方式
下面对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种碱性清洗液的制备方法,包括如下步骤:
(1)用量筒称取1000ml纯化水倒入烧杯中;
(2)用天平称取氢氧化钠1.5g倒入烧杯中,缓慢搅拌至完全溶解;
(3)用天平称取碳酸钠1.2g倒入烧杯中,缓慢搅拌至完全溶解;
(4)用天平称取乙二胺四乙酸二钠1.05g倒入烧杯中,缓慢搅拌至完全溶解;
(5)用天平称取壬基酚聚氧乙烯醚1.1g倒入烧杯中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
实施例2
一种碱性清洗液的制备方法,包括如下步骤:
(1)用量筒称取1000ml纯化水倒入烧杯中;
(2)用天平称取氢氧化钾8g倒入烧杯中,缓慢搅拌至完全溶解;
(3)用天平称取碳酸钠12g倒入烧杯中,缓慢搅拌至完全溶解;
(4)用天平称取乙二胺四乙酸二钾8g倒入烧杯中,缓慢搅拌至完全溶解;
(5)用天平称取辛基酚聚氧乙烯醚5g倒入烧杯中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
实施例3
一种碱性清洗液的制备方法,包括如下步骤:
(1)用量筒称取1000ml纯化水倒入烧杯中;
(2)用天平称取氢氧化钠10g倒入烧杯中,缓慢搅拌至完全溶解;
(3)用天平称取无水偏硅酸钠15g倒入烧杯中,缓慢搅拌至完全溶解;
(4)用天平称取次氨基三乙酸二钠10g倒入烧杯中,缓慢搅拌至完全溶解;
(5)用天平称取壬基酚聚氧乙烯醚6g倒入烧杯中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
实施例4
一种碱性清洗液的制备方法,包括如下步骤:
(1)用量筒称取1000ml纯化水倒入烧杯中;
(2)用天平称取氢氧化钠38g倒入烧杯中,缓慢搅拌至完全溶解;
(3)用天平称取无水偏硅酸钠45g倒入烧杯中,缓慢搅拌至完全溶解;
(4)用天平称取次氨基三乙酸二钠34g倒入烧杯中,缓慢搅拌至完全溶解;
(5)用天平称取脂肪醇聚氧乙烯醚27g倒入烧杯中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
对比例1
一种碱性清洗液的制备方法,包括如下步骤:
(1)用量筒称取1000ml纯化水倒入烧杯中;
(2)用天平称取氢氧化钠10g倒入烧杯中,缓慢搅拌至完全溶解;
(3)用天平称取次氨基三乙酸二钠10g倒入烧杯中,缓慢搅拌至完全溶解;
(4)用天平称取壬基酚聚氧乙烯醚6g倒入烧杯中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
对比例2
一种碱性清洗液的制备方法,包括如下步骤:
(1)用量筒称取1000ml纯化水倒入烧杯中;
(2)用天平称取氢氧化钠10g倒入烧杯中,缓慢搅拌至完全溶解;
(3)用天平称取无水偏硅酸钠15g倒入烧杯中,缓慢搅拌至完全溶解;
(4)用天平称取十二烷基三甲基氯化铵5g倒入烧杯中,缓慢搅拌至完全溶解;
(5)用天平称取次氨基三乙酸二钠10g倒入烧杯中,缓慢搅拌至完全溶解;
(6)用天平称取壬基酚聚氧乙烯醚6g倒入烧杯中,缓慢搅拌至完全溶解;过滤得到碱性清洗液。
用日立7100自动生化分析仪分别测试上述四种碱性清洗液,执行清洗程序后,取混合血清标本,重复测定总蛋白(TP)、铁(Fe)、甘油三酯(TG)、肌酐(CRE-E)、葡萄糖(GLU-OX)、胆固醇(TCH)、磷(P)各20次,并在30天内对三批次碱性清洗液采用同一批标本做批间重复性,检测项目相同,同时采用贝克曼库尔特和森蓝厂家的碱性清洗液做为对照,测试结果如表1~表4所示。
表1实施例1与对照试剂批内、批间重复性
表2.实施例2与对照试剂批内、批间重复性
表3.实施例3与对照试剂以及对比例试剂批内、批间重复性
表4.实施例4与对照试剂批内、批间重复性
使用本发明的碱性清洗液进行清洗后,自动生化分析仪检测结果重复性良好,七个项目测试20次批内重复性平均值≤3.57%,三批次试剂批间重复性平均值≤3.13%,均小于进口试剂与国产试剂测值,且与对比例相比测值也更小,无交叉污染,测试前后340nm波长下杯空白无显著差异,具有低物质残留,清洗效果佳。
Claims (6)
1.一种碱性清洗液,其特征在于,按照质量百分比计,包括非离子表面活性剂0.1~2.5%,碱金属氢氧化物0.1~3.5%,金属螯合剂0.1~3%,缓冲剂0.1~4%,余量为水。
2.根据权利要求1所述的碱性清洗液,其特征在于,所述非离子表面活性剂为壬基酚聚氧乙烯醚、辛基酚聚氧乙烯醚或脂肪醇聚氧乙烯醚。
3.根据权利要求1所述的碱性清洗液,其特征在于,所述碱金属氢氧化物为氢氧化钠或氢氧化钾。
4.根据权利要求1所述的碱性清洗液,其特征在于,所述金属螯合剂为乙二胺四乙酸二钠、次氨基三乙酸二钠或乙二胺四乙酸二钾。
5.根据权利要求1所述的碱性清洗液,其特征在于,所述缓冲剂为无水偏硅酸钠、碳酸钠或硅酸钠。
6.权利要求1至5任一项所述的碱性清洗液的制备方法,其特征在于包括如下步骤:
(1)将碱金属氢氧化物加入水中,缓慢搅拌至完全溶解;
(2)将缓冲剂加入水中,缓慢搅拌至完全溶解;
(3)将金属螯合剂加入水中,缓慢搅拌至完全溶解;
(4)将非离子表面活性剂加入水中,缓慢搅拌至完全溶解;过滤得到碱性清洗液;
步骤(2)、步骤(3)、步骤(4)没有先后顺序。
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101470123A (zh) * | 2007-12-26 | 2009-07-01 | 深圳迈瑞生物医疗电子股份有限公司 | 一种用于自动生化分析仪的清洗液 |
CN102102051A (zh) * | 2010-12-01 | 2011-06-22 | 宁波美康盛德生物科技有限公司 | 用于自动生化分析仪的碱性清洗液 |
CN102304439A (zh) * | 2011-08-08 | 2012-01-04 | 宁波美康盛德生物科技有限公司 | 用于全自动生化分析仪的抗菌清洗液 |
JP2014102084A (ja) * | 2012-11-16 | 2014-06-05 | Toyobo Co Ltd | 液体試料分析のための多層試験片、およびそれを用いた測定方法 |
CN103897909A (zh) * | 2012-12-28 | 2014-07-02 | 上海复星医药(集团)股份有限公司 | 一种用于自动生化分析仪的清洗液 |
CN107557180A (zh) * | 2017-09-26 | 2018-01-09 | 重庆赞龙生物科技有限公司 | 一种清洗液 |
CN108004038A (zh) * | 2017-11-23 | 2018-05-08 | 中山市创艺生化工程有限公司 | 一种碱性清洗液及其制备方法 |
-
2022
- 2022-08-03 CN CN202210924993.6A patent/CN115368975A/zh active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101470123A (zh) * | 2007-12-26 | 2009-07-01 | 深圳迈瑞生物医疗电子股份有限公司 | 一种用于自动生化分析仪的清洗液 |
CN102102051A (zh) * | 2010-12-01 | 2011-06-22 | 宁波美康盛德生物科技有限公司 | 用于自动生化分析仪的碱性清洗液 |
CN102304439A (zh) * | 2011-08-08 | 2012-01-04 | 宁波美康盛德生物科技有限公司 | 用于全自动生化分析仪的抗菌清洗液 |
JP2014102084A (ja) * | 2012-11-16 | 2014-06-05 | Toyobo Co Ltd | 液体試料分析のための多層試験片、およびそれを用いた測定方法 |
CN103897909A (zh) * | 2012-12-28 | 2014-07-02 | 上海复星医药(集团)股份有限公司 | 一种用于自动生化分析仪的清洗液 |
CN107557180A (zh) * | 2017-09-26 | 2018-01-09 | 重庆赞龙生物科技有限公司 | 一种清洗液 |
CN108004038A (zh) * | 2017-11-23 | 2018-05-08 | 中山市创艺生化工程有限公司 | 一种碱性清洗液及其制备方法 |
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