CN115260310B - 抗补体因子c1q的fab片段及其应用 - Google Patents

抗补体因子c1q的fab片段及其应用 Download PDF

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CN115260310B
CN115260310B CN202210711282.0A CN202210711282A CN115260310B CN 115260310 B CN115260310 B CN 115260310B CN 202210711282 A CN202210711282 A CN 202210711282A CN 115260310 B CN115260310 B CN 115260310B
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disease
fab fragment
antibody fab
antibody
complement
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CN115260310A (zh
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T·耶德诺克
S·桑卡拉纳拉亚南
A·罗森塔尔
M·莱维坦
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Annexon Inc
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Annexon Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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CN202210711282.0A 2015-11-24 2016-11-23 抗补体因子c1q的fab片段及其应用 Active CN115260310B (zh)

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Application Number Priority Date Filing Date Title
US201562259227P 2015-11-24 2015-11-24
US62/259,227 2015-11-24
CN201680079670.4A CN108779171B (zh) 2015-11-24 2016-11-23 抗补体因子c1q的fab片段及其应用
PCT/US2016/063587 WO2017091719A1 (en) 2015-11-24 2016-11-23 Anti-complement factor c1q fab fragments and uses thereof

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CN115260310B true CN115260310B (zh) 2025-02-25

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WO2014030750A1 (ja) 2012-08-24 2014-02-27 中外製薬株式会社 マウスFcγRII特異的Fc抗体
SG11201508170TA (en) 2013-04-02 2015-11-27 Chugai Pharmaceutical Co Ltd Fc REGION VARIANT
KR102321320B1 (ko) 2013-07-09 2021-11-03 애넥슨, 인코포레이티드 항-보체 인자 ｃ１ｑ 항체 및 이의 용도
US10316081B2 (en) 2014-11-05 2019-06-11 Annexon, Inc. Humanized anti-complement factor C1Q antibodies
BR112018010360A2 (en) 2015-11-24 2018-12-04 Annexon, Inc. anti-c1q complement factor fab fragments and uses thereof
EP4640703A2 (en) 2017-11-14 2025-10-29 Chugai Seiyaku Kabushiki Kaisha Anti-c1s antibodies and methods of use
MX2020010528A (es) * 2018-04-13 2020-11-06 Chugai Pharmaceutical Co Ltd Anticuerpos anti-componente de complemento y metodos de uso.
FI3893924T3 (fi) 2018-12-13 2024-10-04 argenx BV Ihmisen komplementtitekijän C2B vasta-aineita sekä niiden käyttötapoja
BR112021021689A2 (pt) 2019-05-15 2022-03-22 Chugai Pharmaceutical Co Ltd Molécula de ligação a antígeno, composição farmacêutica, e método
GB2584105B (en) * 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
WO2021076991A1 (en) * 2019-10-17 2021-04-22 Annexon, Inc. Compositions and methods for treating blood disorders
CN110716038B (zh) * 2019-10-23 2022-08-30 俞梦越 一种急性冠脉综合征补体检测试剂盒及其使用方法
CA3177879A1 (en) * 2020-05-05 2021-12-02 Jeanne T. PAZ Compositions and methods for treating epilepsy
CN112194719A (zh) * 2020-09-01 2021-01-08 中日友好医院(中日友好临床医学研究所) Crt抗原和mage-a1抗原的制备及其应用
CN112837822B (zh) * 2020-09-24 2023-05-02 广州市疾病预防控制中心(广州市卫生检验中心、广州市食品安全风险监测与评估中心、广州医科大学公共卫生研究院) 预测covid-19患者发生轻至重度进展的标志物及试剂盒和建立方法
AU2021361067A1 (en) * 2020-10-16 2023-06-01 Annexon, Inc. Compositions and methods for treating blood disorders
CA3200976A1 (en) * 2020-12-04 2022-06-09 Anita GROVER Compositions and methods for treating ocular diseases
US12486322B2 (en) * 2021-12-13 2025-12-02 Annexon, Inc. Anti-complement factor C1q antibodies with single binding arms and uses thereof
WO2023130001A1 (en) * 2021-12-30 2023-07-06 Annexon, Inc. Compositions and methods for treating huntington's disease
EP4518896A1 (en) * 2022-04-29 2025-03-12 Annexon, Inc. Compositions and methods for treating ocular diseases
CA3253133A1 (en) * 2022-05-13 2023-11-16 Annexon Inc COMPOSITIONS AND METHODS OF TREATMENT OF LUPUS NEPHRITIS
CN119371528B (zh) * 2024-10-30 2025-06-24 泰州市人民医院 一种C1q抗体及其应用、一种抑制补体经典途径活化的药剂及其应用

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