CN115154576B - Traditional Chinese medicine composition for treating malignant tumor-associated diarrhea - Google Patents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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Abstract
A traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is prepared from the following raw materials in parts by weight: 6-15 parts of fructus psoraleae, 3-12 parts of shizandra berry, 8-18 parts of dark plum fruit, 10-20 parts of gorgon euryale seed, 10-20 parts of lotus seed, 5-15 parts of baked ginger, 5-15 parts of pericarpium granati and 3-13 parts of radix angelicae. The application of the traditional Chinese medicine composition in preparing medicines for treating malignant tumor-associated diarrhea; the medicine is powder, decoction, granule, pill, tablet, oral liquid, capsule or extract powder of any pharmaceutically acceptable dosage form. The traditional Chinese medicine composition has scientific and reasonable formula compatibility, has the effects of warming kidney and spleen and relieving diarrhea with astringents, can be effectively used for treating the tumor-associated diarrhea, has stable and reliable curative effect and good effect, is a great innovation in medicines for treating the tumor-associated diarrhea, and has huge social and economic benefits.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for treating malignant tumor-related diarrhea.
Background
Tumor-associated diarrhea is a serious and even fatal complication of cancer treatment, the pathogenesis of which is currently unknown. Diarrhea of tumor patients is mostly caused by intestinal bacterial infection caused by intestinal mucosa destruction due to side tumor syndrome, chemotherapy, radiotherapy, surgery, medicines and the like, and the occurrence of diarrhea is different due to different reasons. Wherein the incidence rate of the grade 3-4 diarrhea caused by chemotherapy fluctuates by 5% -47%, and the diarrhea caused by fluorouracil, irinotecan and a combined chemotherapy scheme is the most common. The total prevalence of diarrhea induced by radiation therapy is as high as 35%. When external radiotherapy of patients with cervical cancer, colorectal cancer, prostate cancer, metastatic cancer, etc. is focused on the thoracolumbar spine, the abdominal aortic lymph nodes, abdomen and pelvis, part of the intestinal tract may be exposed to radiation, thereby causing diarrhea. Surgical treatment of cancer patients involves resecting the gastrointestinal tract or an organ having endocrine or digestive functions, etc., and such anatomical changes may limit the gastrointestinal tract's ability to absorb certain nutrients (e.g., fat), thereby causing diarrhea. For oesophagus and gastrectomy, the incidence of diarrhea is about 15%. Endocrine treatment is widely applied to cancer species such as breast cancer, prostate cancer, endometrial cancer and the like, and the aromatase inhibitor causes less gastrointestinal reaction, for example anastrozole, and the diarrhea incidence rate is 4-6%. In addition, other factors should be taken into account, such as food poisoning, infectious gastroenteritis. Most cancer patients have a neutrophil deficiency, low immune function, and a potentially fatal risk for both jettitis, typhus and colitis. Frequent and severe diarrhea, which is an important factor in increasing mortality, with neutropenia and life threatening infection, requires a reduction in chemotherapy doses and even interruption of chemotherapy, and if not actively treated, not only affects the quality of life of the patient, resulting in fear of chemotherapy, but also causes nutritional and metabolic imbalances, delays recovery, increases hospital stays and costs. However, no traditional Chinese medicine specially used for treating tumor-associated diarrhea is disclosed at present.
Disclosure of Invention
Aiming at the situation, the invention aims to overcome the defects of the prior art and provide a traditional Chinese medicine composition for treating malignant tumor-related diarrhea, which can effectively solve the problem that no traditional Chinese medicine for treating tumor-related diarrhea exists at present.
In order to achieve the aim, the technical scheme of the invention is that a traditional Chinese medicine composition for treating malignant tumor-related diarrhea comprises the following raw materials in parts by weight: 6-15 parts of fructus psoraleae, 3-12 parts of shizandra berry, 8-18 parts of dark plum fruit, 10-20 parts of gorgon euryale seed, 10-20 parts of lotus seed, 5-15 parts of baked ginger, 5-15 parts of pericarpium granati and 3-13 parts of radix angelicae.
Application of the traditional Chinese medicine composition in preparing medicines for treating malignant tumor-associated diarrhea
The medicine is powder, decoction, granule, pill, tablet, oral liquid, capsule or extract powder of any pharmaceutically acceptable dosage form.
The traditional Chinese medicine composition has scientific and reasonable formula compatibility, has the effects of warming kidney and spleen and relieving diarrhea with astringents, can be effectively used for treating the tumor-associated diarrhea, has stable and reliable curative effect and good effect, is a great innovation in medicines for treating the tumor-associated diarrhea, and has huge social and economic benefits.
Drawings
FIG. 1 is a histogram of the case age group distribution of the present invention.
Figure 2 is a bar graph of the top three cancer species effectiveness of the present invention.
Detailed Description
The following describes specific embodiments of the present invention in detail with reference to examples and specific cases.
Example 1
A traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is prepared from the following raw materials in parts by weight: 10 parts of fructus psoraleae, 7 parts of schisandra chinensis, 13 parts of dark plum fruit, 15 parts of gorgon euryale seed, 15 parts of lotus seed, 10 parts of baked ginger, 10 parts of pericarpium granati and 8 parts of radix angelicae.
Example 2
A traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is prepared from the following raw materials in parts by weight: 6 parts of fructus psoraleae, 3 parts of schisandra chinensis, 8 parts of dark plum fruit, 10 parts of gorgon euryale seed, 10 parts of lotus seed, 5 parts of baked ginger, 5 parts of pericarpium granati and 3 parts of radix angelicae.
Example 3
A traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is prepared from the following raw materials in parts by weight: 15 parts of fructus psoraleae, 12 parts of shizandra berry, 18 parts of dark plum fruit, 20 parts of gorgon euryale seed, 20 parts of lotus seed, 15 parts of baked ginger, 15 parts of pomegranate rind and 13 parts of radix angelicae.
Example 4
A traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is prepared from the following raw materials in parts by weight: 7 parts of fructus psoraleae, 11 parts of schisandra chinensis, 10 parts of dark plum fruit, 12 parts of gorgon euryale seed, 18 parts of lotus seed, 13 parts of baked ginger, 7 parts of pericarpium granati and 10 parts of radix angelicae.
In the above-mentioned medicine, the medicine,
fructus psoraleae: bitter and warm in nature; enters the spleen of foot taiyin, kidney of foot shaoyin, large intestine meridian of hand yangming. Is mainly used for treating spleen-kidney yang deficiency, diarrhea, impotence, spermatorrhea, enuresis, frequent urination, cold pain of waist and knee, and asthma due to kidney deficiency.
Chinese magnoliavine fruit: sour taste and warm nature; it enters lung, heart and kidney meridians. Mainly treats chronic diarrhea, chronic cough, deficiency asthma, spontaneous perspiration, night sweat, spermatorrhea and seminal emission; thirst due to body fluid consumption and diabetes; palpitations, insomnia, dreaminess. Is the essential herb for promoting the production of body fluid and the astringent.
Dark plum: sour and sweet taste, warm nature; it enters lung, heart and kidney meridians. Is mainly used for treating chronic diarrhea, spermatorrhea, spontaneous perspiration, night sweat, chronic cough, deficiency asthma, thirst due to body fluid consumption, and diabetes; palpitations, insomnia, dreaminess.
Gorgon fruit: sweet and astringent in flavor, neutral in nature, and good in spleen and kidney meridians. Kidney-tonifying, essence-securing, spleen-tonifying, antidiarrheal, dampness-removing and leukorrhagia-stopping, and can be used for treating chronic diarrhea due to spleen deficiency, spermatorrhea, enuresis, frequent urination, turbid urine, leukorrhagia.
Lotus seed: sweet and astringent in flavor, neutral in nature, and good in spleen, kidney and heart meridians. Tonify spleen and stop diarrhea, stop leukorrhagia, tonify kidney and astringe essence, nourish heart and tranquilize mind. Can be used for treating diarrhea due to spleen deficiency, leukorrhagia, spermatorrhea, palpitation, and insomnia.
Baked ginger: pungent and hot, enter spleen, stomach and kidney meridians. Warm meridians to stop bleeding, warm middle energizer to stop pain. Can be used for treating yang deficiency, blood loss, hematemesis, metrorrhagia, spleen and stomach deficiency cold, abdominal pain, emesis and diarrhea.
Pomegranate rind: sour and astringent taste and warm nature. Enter large intestine meridian. Efficacy: astringing intestines to check diarrhea, stopping bleeding, expelling parasites. The main indications are: can be used for treating chronic diarrhea, chronic dysentery, hematochezia, rectocele, metrorrhagia, leukorrhagia, and abdominal pain due to accumulation of parasites.
Radix angelicae: pungent and warm. Enters the lung, spleen and stomach meridians. The main indications are: dispelling wind, eliminating dampness, relieving swelling and pain. For headache, pain of eyebrow and bone, odontalgia, nasosinusitis, cold-dampness, abdominal pain, intestinal wind and fistula, leucorrhea with reddish discharge, carbuncle, ulcer, dry skin, itching, and scabies.
The invention takes fructus psoraleae as a monarch drug, and the shizandra berry and dark plum are mainly used for treating chronic diarrhea and are used as ministerial drugs together; gorgon fruit, lotus seed, pericarpium Granati and radix Angelicae Dahuricae are used as adjuvant drugs and rhizoma Zingiberis recens is used as guiding drug. The medicines monarch, minister, assistant and guide are scientifically and reasonably prepared, mutually supported and matched, and the side effects on the body are reduced while the curative effect of the medicines is exerted. The medicines monarch, minister, assistant and guide are scientifically and reasonably prepared, mutually supported and matched with each other, and the curative effect of the medicines is exerted.
From the above, the traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is mainly used for warming kidney and spleen, astringing intestines and relieving diarrhea, has the advantages of high curative effect and no toxic or side effect, has good curative effect through clinical experiments, and has the following clinical data (prepared into decoction by taking example 1) as follows:
1. and (3) preparation of a water decoction:
a traditional Chinese medicine composition for treating malignant tumor-associated diarrhea is prepared from the following raw materials in parts by weight: the preparation method comprises the steps of mixing 10g of fructus psoraleae, 7g of fructus evodiae, 7g of schisandra chinensis, 13g of dark plum fruit, 15g of semen euryales, 15g of lotus seeds, 10g of baked ginger, 10g of pericarpium granati and 8g of radix angelicae, adding water into the above components, decocting twice, adding water which is 8 times of the total weight of the components for the first time, decocting for 1h, obtaining a first decoction, adding water which is 6 times of the total weight of the components for the second time, decocting for 0.5h, obtaining a second decoction, combining the two decoctions, and filtering to obtain the water decoction (one dose).
2. Case selection:
2.1 case of enrollment:
56 cases of malignant tumor-related diarrhea are clinically observed in a first affiliated hospital of Henan traditional Chinese medicine university and a third affiliated hospital of Henan traditional Chinese medicine university from 12 months 2021 to 30 days 2022, wherein 29 cases of men, 27 cases of women, 4 persons from 30 to 39 years old, 7 persons from 40 to 49 years old, 22 persons from 50 to 59 years old, 14 persons from 60 to 69 years old and 9 persons from 70 to 79 years old are specifically shown in fig. 1, and lung cancer, colon cancer and breast cancer patients are most numerous, and the specific table is shown below.
TABLE 1 distribution of cancerous tumors in patients
Disease seed name | Number of cases | Duty ratio of | Rank order | Disease seed name | Number of cases | Duty ratio of | Rank |
Lung cancer | |||||||
10 | 17.86% | 1 | Ovarian cancer | 2 | 3.57% | 10 | |
|
9 | 16.07% | 2 | Carcinoma of gastric cardia | 2 | 3.57% | 11 |
|
7 | 12.50% | 3 | Malignant tumor of heart | 1 | 1.79% | 12 |
Stomach cancer | 6 | 10.71% | 4 | Adenosarcoma | 1 | 1.79% | 13 |
Renal carcinoma | 4 | 7.14% | 5 | Meningioma | 1 | 1.79% | 14 |
Cervical cancer | 3 | 5.36% | 6 | Osteosarcoma | 1 | 1.79% | 15 |
Liver cancer | 3 | 5.36% | 7 | Multiple myeloma | 1 | 1.79% | 16 |
Pancreatic cancer | 2 | 3.57% | 8 | Bladder cancer | 1 | 1.79% | 17 |
Esophageal cancer | 2 | 3.57% | 9 |
3. Treatment protocol:
the decoction obtained in example 1 was administered 1 dose daily, 2 times a day with 1 course of treatment for 14 days, and the next course of treatment was started 3 days later, and 2-4 courses of treatment were continuously used for statistical treatment.
4. Efficacy assessment:
4.1 evaluation method
The diarrhea, increased stool frequency, debilitation, loose stool, poor sleep, dry mouth, bitter taste and poor appetite of patients are observed.
4.2 therapeutic efficacy criterion
The standard of curative effect is referred to the "guidelines for clinical research of New Chinese medicine" mainly compiled by Zhengyu in 2002, and the curative effect index n= (integral before treatment-integral after treatment)/integral before treatment X100% (calculated by nimodipine method), and the specific syndrome integral is shown in table 2 and 3.
Obvious effect (disappearance): the main symptoms and the physical signs are obviously improved, and the integral of symptoms is reduced by more than 70 percent;
effective (improvement): the main symptoms and the physical signs are obviously improved, and the integral of symptoms is reduced by more than 30 percent;
invalidation: the main symptoms and signs are not obviously improved or even aggravated, and the integral of symptoms is reduced by less than 30 percent.
Effective rate= (number of vanishing cases+number of improving cases)/total number of cases×100%.
Exterior 2 syndrome integration table
Exterior 3 syndrome integration table
5. The treatment effect is as follows:
in the clinical observation cases, the average effective rate of cancer seeds of the first three ranks reaches 84.84% after 2-4 treatment courses are continuously used, wherein the total effective rate of lung cancer reaches up to 88.00%, the total effective rate of colorectal cancer reaches up to 88.89%, the total effective rate of breast cancer reaches up to 85.71%, the effective rate of debilitation symptoms reaches up to 97.22% as shown in figure 2, and the specific table is shown in table 4:
TABLE 4 effective conditions of principal symptoms
From the above results, the effective rate of diarrhea was 80.43%, the symptom effective rate of increased stool frequency was 94.29%, the effective rate of debilitation was 97.22%, the effective rate of loose stool was 86.36%, the effective rate of poor sleep was 88.89%, the effective rate of dry mouth and bitter taste was 85.00%, and the effective rate of anorexia was 88.24%.
Meanwhile, the invention carries out the experiment on the embodiment 1 and also carries out the same clinical experiments on the embodiments 2-4, and the results which are the same as and similar to those of the embodiment 1 are obtained, and the results are not listed one by one, so that the invention has good effect and stable and reliable curative effect.
7. Conclusion(s)
In conclusion, the traditional Chinese medicine composition has the advantages of rich raw materials of the components, scientific and reasonable compatibility, scientific compatibility, low cost, good effect, convenient administration and obvious curative effect of treating the malignant tumor-associated diarrhea, can effectively treat diarrhea, increased stool frequency, debilitation, loose stool, poor sleep, dry mouth, bitter taste and poor appetite, reduces the total integral of traditional Chinese medicine symptoms of the malignant tumor-associated diarrhea, is safe to take, and has no obvious adverse reaction; the monarch, minister, assistant and guide are compatible, the components are mutually supported and mutually matched, the effects of warming the kidney and the spleen and relieving diarrhea with astringents are achieved, the Chinese medicinal composition is effectively used for malignant tumor-related diarrhea, and a satisfactory effect is obtained through clinical tests, so that the Chinese medicinal composition has huge economic and social benefits.
It is to be noted that the technical characteristics and key of the present application are that the compatibility of the traditional Chinese medicine composition is that the decoction is only an embodiment of a dosage form, and all the dosage forms which are made by adopting the equivalent replacement means and are applicable to be taken, such as powder (powder), granules, pills, tablets, oral liquid, capsules, extract powder and the like, are all within the protection scope of the present application.
Claims (7)
1. The traditional Chinese medicine composition for treating the tumor-associated diarrhea is characterized by being prepared from the following raw materials in parts by weight: 6-15 parts of fructus psoraleae, 3-12 parts of shizandra berry, 8-18 parts of dark plum fruit, 10-20 parts of gorgon fruit, 10-20 parts of lotus seed, 5-15 parts of baked ginger, 5-15 parts of pomegranate rind and 3-13 parts of radix angelicae.
2. The traditional Chinese medicine composition for treating tumor-associated diarrhea according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of fructus psoraleae, 7 parts of schisandra chinensis, 13 parts of dark plum fruit, 15 parts of gorgon euryale seed, 15 parts of lotus seed, 10 parts of baked ginger, 10 parts of pericarpium granati and 8 parts of radix angelicae.
3. The traditional Chinese medicine composition for treating tumor-associated diarrhea according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 6 parts of fructus psoraleae, 3 parts of schisandra chinensis, 8 parts of dark plum fruit, 10 parts of gorgon euryale seed, 10 parts of lotus seed, 5 parts of baked ginger, 5 parts of pericarpium granati and 3 parts of radix angelicae.
4. The traditional Chinese medicine composition for treating tumor-associated diarrhea according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 15 parts of fructus psoraleae, 12 parts of shizandra berry, 18 parts of dark plum fruit, 20 parts of gorgon euryale seed, 20 parts of lotus seed, 15 parts of baked ginger, 15 parts of pomegranate rind and 13 parts of radix angelicae.
5. The traditional Chinese medicine composition for treating tumor-associated diarrhea according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 7 parts of fructus psoraleae, 11 parts of schisandra chinensis, 10 parts of dark plum fruit, 12 parts of gorgon euryale seed, 18 parts of lotus seed, 13 parts of baked ginger, 7 parts of pericarpium granati and 10 parts of radix angelicae.
6. Use of the Chinese medicinal composition according to any one of claims 1-5 in the preparation of a medicament for treating tumor-associated diarrhea.
7. The use of the Chinese medicinal composition according to claim 6, wherein the medicament is selected from the group consisting of powders, decoction, granules, pills, tablets, oral liquids and capsules.
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CN105560478A (en) * | 2016-01-28 | 2016-05-11 | 泰山医学院 | Traditional Chinese medicine composition for treating chronic ulcerative colitis |
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CN112546111A (en) * | 2020-12-18 | 2021-03-26 | 江苏省中医药研究院 | Traditional Chinese medicine patch for treating chemotherapy-related diarrhea and preparation method thereof |
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