CN112546111A - Traditional Chinese medicine patch for treating chemotherapy-related diarrhea and preparation method thereof - Google Patents
Traditional Chinese medicine patch for treating chemotherapy-related diarrhea and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
The invention relates to a traditional Chinese medicine patch for treating chemotherapy-related diarrhea and a preparation method thereof, belonging to the technical field of medicinal preparations. Aiming at the problems in the prior art, the medicinal patch is used for treating chemotherapy-related diarrhea, has the characteristics of quick response, obvious curative effect and high safety, and is superior to other similar preparations in the prior art. The traditional Chinese medicine patch for treating chemotherapy-related diarrhea disclosed by the invention is composed of the following raw medicinal materials in parts by weight: 1-3 parts of fructus evodiae and 2-6 parts of gallnut. The formula of the invention accords with the traditional Chinese medicine pathogenesis of treating chemotherapy-related diarrhea, and is scientific. Wu Zhu Yu is pungent and hot in property, warms middle energizer to alleviate pain, regulates qi and relieves stagnation, and is good at ascending, encouraging stomach qi and warming lower energizer. Therefore, Wu Zhu Yu is the key herb for diarrhea in the morning due to spleen-kidney yang deficiency because it can warm spleen, strengthen yang and check diarrhea. The medicinal materials, the auxiliary materials and the packaging materials in the invention have low cost, can reduce the economic burden of the treatment of patients, and have high clinical application and popularization values.
Description
Technical Field
The invention relates to a traditional Chinese medicine patch for treating chemotherapy-related diarrhea and a preparation method thereof, belonging to the technical field of medicinal preparations.
Background
Malignant tumor is a common disease, the incidence rate of which is increasing, and the disease greatly threatens the life and health of people. Chemotherapy is a therapeutic method that uses chemical drugs to kill tumor cells of a patient and inhibit the growth, reproduction and differentiation of tumor cells in the body of the patient. Chemotherapy is one of the important means for treating malignant tumors, and because of poor selectivity of chemotherapeutic drugs, the chemotherapy drugs also have inevitable toxic and side effects on normal tissues of organisms during treatment, and chemotherapy-related diarrhea is one of the common adverse reactions. The medicines which are easy to cause chemotherapy-related diarrhea clinically comprise irinotecan, 5-fluorouracil, oxaliplatin, capecitabine, adriamycin, methotrexate, cytarabine and the like. Irinotecan alone had a 31% incidence of clinically severe grade iii to iv chemotherapy-associated diarrhea; when the 5-fluorouracil and irinotecan are jointly used, 50-80% of patients have chemotherapy-related diarrhea, and more than 30% of patients have severe grade III-V acute diarrhea; capecitabine is used in combination with oxaliplatin, and the incidence of clinically severe grade III to IV chemotherapy-associated diarrhea is 10%. Chemotherapy-related diarrhea can cause dehydration, electrolyte disturbance, renin and blood volume reduction, shock and even death. Severe chemotherapy-associated diarrhea requires lowering the dose of the chemotherapeutic agent, changing the chemotherapeutic agent, or terminating the chemotherapy, thereby affecting the treatment of the malignancy. In the aspect of treating chemotherapy-related diarrhea, loperamide, octreotide and the like are mainly used clinically for symptomatic treatment at present. Loperamide is used for treating light diarrhea, but has limited effect in diarrhea above grade III, 9-30% of patients have no response to loperamide, and in addition, loperamide can cause adverse reactions such as gastrointestinal spasm, delayed anaphylaxis, dysuria and the like. The curative effect of octreotide on chemotherapy-related diarrhea is not ideal, and the incidence rate of paralytic ileus increases with the increase of the dosage, so that certain risks exist.
Chemotherapy-related diarrhea belongs to the category of diarrhea in traditional Chinese medicine. Chemotherapy-related diarrhea differs from medical common diarrhea in etiology and pathogenesis in traditional Chinese medicine. The common diarrhea in the department of medicine is responsible for both the internal injury and the external infection. Six exogenous pathogens affecting the large intestine and spleen dysfunction can cause diarrhea, mainly damp pathogen, accompanied by cold, heat and summer-heat, which is equivalent to acute or chronic enteritis. Internal injuries include food and drink injuries, emotional disorders, weakness of the spleen and stomach, and kidney-yang weakness. Injury due to diet: diarrhea is caused by food fullness, food retention, food addiction, cold food, improper food intake, impairment of the spleen and stomach, and abnormal transportation and transformation. Emotional disorder: the spleen-stomach deficiency may cause the diarrhea due to the depression, anger, anxiety, liver depression, liver qi transverse reversal, spleen qi involvement, spleen and stomach restriction, dysfunction of transportation and transformation. Weakness of the spleen and the stomach: spleen governing transportation and transformation, stomach governing reception, improper diet, fatigue and internal injury, lingering long-term illness all can lead to deficiency of spleen and stomach, failure to receive food and essence, food stagnation, clear and turbid nature, mixed and descending, and diarrhea. Deficiency of kidney yang: chronic diseases affecting the kidney, or old and weak, or kidney yang failing to function, decline of fire from the gate of life, yang-qi deficiency, spleen failing to warm up, failing to rot food, and food grains failing to transform into diarrhea.
Chemotherapy-associated diarrhea is different from common diarrhea. Most chemotherapy drugs are bitter and cold, and have the effect of destroying the stomach, spleen and large intestine, which causes the dysfunction of the spleen and stomach, the dysfunction of transportation and transformation, the deficiency of spleen and kidney fire, and the failure of digestion to cause diarrhea. It is considered as internal injury diarrhea and acute cold diarrhea, so it is clinically manifested as watery stool, thin water stool, more frequent, less frequent 5-6 times/day, and more frequent 10-20 times/day. Clinically, it is usually indicated for acute diarrhea due to cold or excess, and it is also indicated for the elderly and infirm with diarrhea due to deficiency and cold. .
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the traditional Chinese medicine patch for treating the chemotherapy-related diarrhea and the preparation method thereof.
In order to achieve the purpose of the invention, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine patch for treating chemotherapy-related diarrhea comprises the following raw medicinal materials in parts by weight: 1-3 parts of fructus evodiae and 2-6 parts of gallnut.
The traditional Chinese medicine patch for treating chemotherapy-related diarrhea is specifically composed of the following raw medicinal materials in parts by weight: 1.25-2.75 parts of fructus evodiae and 2.5-5.5 parts of gallnut.
The traditional Chinese medicine patch for treating chemotherapy-related diarrhea is specifically composed of the following raw medicinal materials in parts by weight: 1.5-2.5 parts of fructus evodiae and 3-5 parts of gallnut.
The traditional Chinese medicine patch for treating chemotherapy-related diarrhea is specifically composed of the following raw medicinal materials in parts by weight: 2 parts of fructus evodiae and 4 parts of gallnut.
The raw material medicinal materials in the invention are as follows:
the fructus evodiae is Rutaceae plant fructus evodiaeEuodia rutaecarpa(Juss.) Benth, stone tigerEuodia rutaecarpa ( Juss. ) Benth. var.officinalis(Dode) Huang or RutaceaeEuodia rutaecarpa(Juss. ) Benth. var. bodinieri(Dode) Huang's dried near-ripe fruit.
Galla chinensis is Rhus chinensis Mill of AnacardiaceaeRhus chinensisMilk, green bran poplarRhus potaniniiMaxim, or cottonwoodRhus punjabensis Stew.var.sinicaGall on leaves of (Diels) Rehd. et wils. the main species of aphid gallnut aphidMelaphis chinensis(Bell) Baker parasitic.
Another object of the present invention is to provide a method for preparing the patch of the present invention. The preparation method comprises the following steps:
(1) oven drying fructus evodiae and Galla chinensis at 40-60 deg.C for 4-6 hr;
(2) respectively pulverizing dried fructus evodiae and Galla chinensis, sieving, weighing fructus evodiae and Galla chinensis powder according to the above weight ratio, and mixing;
(3) adding pharmaceutically acceptable adjuvants into the mixed powder of fructus evodiae and Galla chinensis, making into cake-like, paste-like or pasty mixture containing medicine, and filling onto impermeable plaster cloth containing pressure sensitive adhesive to obtain traditional Chinese medicine patch for treating chemotherapy-related diarrhea.
(4) In the step (2), the evodia rutaecarpa and the gallnut are ground and sieved by a sieve of 80-500 meshes.
(5) In the step (3), the pharmaceutically acceptable auxiliary materials are as follows: mixing white vaseline, lanolin and azone with fructus evodiae and Galla chinensis powder, making into cake, and filling into impermeable plaster cloth containing pressure sensitive adhesive to obtain Chinese medicinal patch for treating chemotherapy-related diarrhea.
The raw medicinal materials of the invention consist of evodia and gallnut. The evodia rutaecarpa is pungent, bitter and hot, and has the effects of dispelling cold, relieving pain, calming the adverse-rising energy, arresting vomiting, supporting yang and stopping diarrhea. Galla chinensis, sour, astringent and cold. Has the effects of astringing lung to reduce pathogenic fire, astringing intestine to stop diarrhea, astringing dampness and healing sore, and can be used for treating chronic diarrhea and chronic sore. Has the effects of warming spleen, supporting yang, astringing intestine and relieving diarrhea.
Due to the adoption of the technical scheme, the invention has the following beneficial effects;
(1) the medicine formula of the invention accords with the traditional Chinese medicine pathogenesis of treating chemotherapy-related diarrhea, and is scientific. Wu Zhu Yu is pungent and hot in property, warms middle energizer to alleviate pain, regulates qi and relieves stagnation, and is good at ascending, encouraging stomach qi and warming lower energizer. Therefore, Wu Zhu Yu is the key herb for diarrhea in the morning due to spleen-kidney yang deficiency because it can warm spleen, strengthen yang and check diarrhea. Modern pharmacological studies show that the fructus evodiae has an inhibiting effect on intestinal activities and can reduce diarrhea times of a diarrhea mouse model. For example, evodiae fructus has inhibitory effect on the activity of nicotine, physostigmine, reserpine, phentolamine, etc. The evodia rutaecarpa decoction is orally taken by mice, so that the frequency of diarrhea caused by castor oil can be reduced, and the diarrhea effect caused by senna leaves can be resisted. The fructus evodiae is used as a main drug in the formula of the invention. Galla chinensis is sour and astringent, and can astringe intestine to check diarrhea, so it is good at treating diarrhea and dysentery. Modern pharmacological research shows that the gallnut has an astringent effect, and tannin in the gallnut can coagulate ulcer mucosa, inhibit secretion generation and protect ulcer surfaces. In addition, the gallnut has an antibacterial effect, and has an obvious inhibiting or killing effect on staphylococcus aureus, streptococcus, pneumococcus, typhoid bacillus and other bacteria in vitro tests. The Chinese gall is an adjuvant drug in the composition of the medicine. The evodia rutaecarpa and the gallnut are used together, and the main one and the auxiliary one supplement each other to achieve the effects of warming spleen and tonifying yang, and astringing intestines to stop diarrhea.
(2) Clinical observation and research prove that the raw material medicinal material composition and the preparation thereof in weight ratio have the cure rate of 86.7 percent and the effective rate of 98.92 percent on chemotherapy-related diarrhea. The medicinal material composition and the preparation thereof can effectively treat chemotherapy-related diarrhea, and the effect of patients is achieved in 0.5 day on average after treatment, and the diarrhea can be stopped in 1.5 days; can obviously improve the diarrhea properties of patients such as loose stools, watery stools, sticky stool and the like; can remarkably improve the general dehydration symptom of the patient; no adverse reaction occurs after the patient uses the medicine. Therefore, the traditional Chinese medicine raw material medicinal composition and the preparation thereof are used for treating chemotherapy-related diarrhea, have the characteristics of quick response, obvious curative effect and high safety, and are superior to other similar preparations in the prior art.
(3) The administration form of the raw medicinal materials for treating the chemotherapy-related diarrhea is the traditional Chinese medicine patch, and the traditional Chinese medicine patch is used for umbilical administration. The patch is convenient for patients to use and carry. The patch is suitable for treating chemotherapy-related diarrhea caused by therapeutic drugs such as irinotecan, 5-fluorouracil, oxaliplatin, capecitabine, adriamycin, methotrexate, cytarabine and the like, and is suitable for wide crowds.
(4) The medicinal materials, the auxiliary materials and the packaging materials in the patch for treating chemotherapy-related diarrhea have low cost, can reduce the economic burden of treatment of patients, and has high clinical application and popularization values.
Detailed Description
The following are specific examples of the present disclosure for illustrating technical solutions to technical problems to be solved in the present disclosure, and for helping those skilled in the art to understand the present disclosure, but the embodiments of the present disclosure are not limited thereto according to the prior art known in the art, and therefore, all equivalent substitutions in the art made according to the present disclosure are within the scope of the present disclosure.
Example 1
And respectively taking fructus evodiae and gallnut, and drying in a 40 ℃ oven for 6 hours. Pulverizing dried fructus evodiae and Galla chinensis respectively, sieving with 80 mesh sieve, mixing 1 part of fructus evodiae powder and 6 parts of Galla chinensis powder. Adding appropriate amount of vaseline into the mixed powder, making into paste, and filling onto impermeable plaster cloth containing pressure sensitive adhesive to obtain the Chinese medicinal patch for treating chemotherapy-related diarrhea.
Example 2
And respectively taking fructus evodiae and gallnut, and drying in a 60 ℃ oven for 4 hours. Pulverizing dried fructus evodiae and Galla chinensis respectively, sieving with 200 mesh sieve, mixing with 3 parts of fructus evodiae powder and 2 parts of Galla chinensis powder. Adding appropriate amount of vaseline and lanoline into the mixed powder, making into paste, and filling onto impermeable plaster cloth containing pressure sensitive adhesive to obtain the Chinese medicinal patch for treating chemotherapy-related diarrhea.
Example 3
And respectively taking fructus evodiae and gallnut, and drying in a 50 ℃ oven for 5 hours. Pulverizing dried fructus evodiae and Galla chinensis respectively, sieving with 500 mesh sieve, mixing 2 parts of fructus evodiae powder and 4 parts of Galla chinensis powder. Adding appropriate amount of vaseline, lanoline, and azone into the mixed powder, making into cake, and filling onto impermeable plaster cloth containing pressure sensitive adhesive to obtain the Chinese medicinal patch for treating chemotherapy-related diarrhea.
To further verify the efficacy of the final preparation of the present invention, we performed corresponding clinical trials on the final patch preparation prepared in example 3 above, and the results are reported below.
1. General data
Case selection: all 30 cases were hospitalized in the oncology department of our hospital, with 20 men, 10 women, and an average age of 67.5 years.
Diagnostic criteria:
(1) diarrhea caused by chemotherapeutic drugs on the day of chemotherapy or after chemotherapy; (2) diarrhea is painless or accompanied by mild abdominal pain; (3) the diarrhea is mainly watery and is in a spray shape; (4) the diarrhea is treated several times or tens of times for several days, even for 2-3 months.
2. Method of treatment
Treatment groups: cleaning navel, applying to navel part, one patch each time, and replacing once in 24 hr for 3 days;
3. evaluation of therapeutic Effect
The treatment is divided into cure, improvement and non-cure according to whether symptoms of chemotherapy-related diarrhea diseases disappear or not. The results are shown in Table 1.
TABLE 1 statistics of post-treatment clinical efficacy of chemotherapy-related diarrhea
| Group of | n | Cure of disease | Improvement of life | Not cured | Total effective rate (%) |
| Treatment group | 30 | 26 | 3 | 1 | 96.7 |
Clinical results show that: the traditional Chinese medicine patch provided by the invention has a remarkable effect of treating chemotherapy-related diarrhea, after application treatment, the cure rate reaches 86.7%, the average cure time is 1.5 days, and the total effective rate is 96.7%. The medicinal plaster has remarkable advantages in treating chemotherapy-related diarrhea in terms of cure rate and total effective rate.
The associated typical cases:
case 1: chengwei, male, 49 years old, hospitalization number 240645, liver metastasis after rectal cancer surgery, chemotherapy with irinotecan, diarrhea appeared 10 days after chemotherapy, and the disease appeared as watery stool with dull pain in lower abdomen 10 times a day. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, the diarrhea frequency in one day after the application is 1, and the diarrhea frequency in the next day is 0.
Case 2: yaoyaolong, male, age 68, hospitalization number 275563, liver metastasis after rectal cancer operation, adopting erbitux + XELOX scheme for chemotherapy, and generating diarrhea on day 2 of chemotherapy, wherein the diarrhea degree is 20 times per day and is watery. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, and the diarrhea frequency is 0 time after the application in one day.
Case 3: luzhong, male, age 63, hospitalization No. 216987, esophagus cancer, and chemotherapy with the regimen of Ipomonen and 5-fluorouracil, wherein diarrhea appears on day 3 of chemotherapy, and 8 times a day, and the disease is watery. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, the diarrhea frequency in one day after the application is 1, and the diarrhea frequency in the next day is 0.
Case 4: zhao somewhat loyal, male, age 70, hospitalization number 262033, rectal cancer lung metastasis, chemotherapy with oxaliplatin + capecitabine regimen, diarrhea on day 13 of chemotherapy, 17 times a day, watery stool with vomiting, nausea, and abdominal pain. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, the diarrhea frequency in one day is 6 times, and the diarrhea frequency in the next day is 0.
Case 5: pan one phoenix, female, 70 years old, hospitalization number 235479, liver and lung metastasis after colon cancer, chemotherapy with irinotecan + bevacizumab scheme, and chemotherapy for 2 days, diarrhea appeared, 5 times a day, watery stool with abdominal distension and abdominal pain. The traditional Chinese medicine patch of the embodiment 3 of the invention is applied to the umbilical region, and the diarrhea frequency of the patch after the patch is applied is 4 times in one day, 4 times in the next day and 0 time in the third day.
Case 6: songzheng, male, age 54, hospitalization number 216982, gastric cancer liver-lung metastasis, chemotherapy with fluorouracil + docetaxel + cisplatin regimen, and chemotherapy for 10 days with diarrhea, 5 times daily, watery stool with acid regurgitation. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, the diarrhea frequency in one day is 4 times, and the diarrhea frequency in the next day is 0 time.
Case 7: xuan Chao, male, 60 years old, hospitalization number 252510, left lung cancer pleura-brain metastasis, chemotherapy with Tarceva program, diarrhea on 10 days of chemotherapy, 6 times a day, and watery stool. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, and the diarrhea frequency of the patch after the patch is applied is 2 times in one day, 2 times in the next day and 0 time in the third day.
Case 8: qiaozhi, male, age 68, hospitalization number 251438, postoperative peritoneal metastasis of gastric carcinoma, chemotherapy with paclitaxel + herceptin regimen, diarrhea on day 4 of chemotherapy, 5 times daily, watery stool. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, and the diarrhea frequency is 0 time after the application in one day.
Case 9: ganzhi method, male age 65, hospitalization number 271316, gastric cancer, chemotherapy with the regimen of purifluracil, docetaxel and cisplatin, diarrhea appeared on day 5 of chemotherapy, 4 times a day, and watery stool appeared. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, and the diarrhea frequency is 0 time after the application in one day.
Case 10: rana dybowskii, female, age 65, hospital number 271316, and after uterine cancer operation, adopts the mechanocin scheme for chemotherapy, diarrhea appears on the 10 th day of chemotherapy, and the diarrhea appears 6 times a day and is watery. The Chinese medicinal patch of the embodiment 3 of the invention is applied to the umbilical region, the diarrhea frequency in one day is 3 times, and the diarrhea frequency in the next day is 0 time.
The traditional Chinese medicine preparation is a reasonable formula under the guidance of the theory of traditional Chinese medicine, and accords with the theory of treating diarrhea by traditional Chinese medicine; the preparation process of the traditional Chinese medicine patch for treating chemotherapy-related diarrhea is scientific and reasonable, and the effectiveness of the finally prepared traditional Chinese medicine preparation is ensured; clinical tests prove that the medicinal plaster has remarkable curative effect on treating chemotherapy-related diarrhea and has no adverse reaction. Therefore, the traditional Chinese medicine preparation is a medicine for treating chemotherapy-related diarrhea with reliable curative effect, safety and effectiveness, and is worthy of further popularization.
Claims (8)
1. A traditional Chinese medicine patch for treating chemotherapy-related diarrhea is characterized by comprising the following raw medicinal materials in parts by weight: 1-3 parts of fructus evodiae and 2-6 parts of gallnut.
2. The traditional Chinese medicine patch for treating chemotherapy-related diarrhea according to claim 1, is characterized by comprising the following raw medicinal materials in parts by weight: 1.25-2.75 parts of fructus evodiae and 2.5-5.5 parts of gallnut.
3. The traditional Chinese medicine patch for treating chemotherapy-related diarrhea according to claim 1, is characterized by comprising the following raw medicinal materials in parts by weight: 1.5-2.5 parts of fructus evodiae and 3-5 parts of gallnut.
4. The traditional Chinese medicine patch for treating chemotherapy-related diarrhea according to claim 1, is characterized by comprising the following raw medicinal materials in parts by weight: 2 parts of fructus evodiae and 4 parts of gallnut.
5. The traditional Chinese medicine patch for treating chemotherapy-related diarrhea according to any one of claims 1 to 4, characterized in that the preparation method thereof comprises the following steps:
(1) oven drying fructus evodiae and Galla chinensis at 40-60 deg.C for 4-6 hr;
(2) respectively pulverizing dried fructus evodiae and Galla chinensis, sieving, weighing fructus evodiae and Galla chinensis powder according to the above weight ratio, and mixing;
(3) adding pharmaceutically acceptable adjuvants into the mixed powder of fructus evodiae and Galla chinensis, making into cake-like, paste-like or pasty mixture containing medicine, and filling onto impermeable plaster cloth containing pressure sensitive adhesive to obtain traditional Chinese medicine patch for treating chemotherapy-related diarrhea.
6. The preparation method of the traditional Chinese medicine patch for treating chemotherapy-related diarrhea according to claim 5, wherein in the step (2), the evodia rutaecarpa and the gallnut are crushed and sieved by a sieve of 80-500 meshes.
7. The preparation method of the traditional Chinese medicine patch for treating chemotherapy-related diarrhea according to claim 5, wherein in the step (3), the pharmaceutically acceptable auxiliary materials are: mixing white vaseline, lanolin and azone with fructus evodiae and Galla chinensis powder, making into cake, and filling into impermeable plaster cloth containing pressure sensitive adhesive to obtain Chinese medicinal patch for treating chemotherapy-related diarrhea.
8. The patch according to any one of claims 1 to 5, wherein the patch is applied to the navel.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113384638A (en) * | 2021-07-09 | 2021-09-14 | 上海交通大学医学院附属上海儿童医学中心 | Traditional Chinese medicine composition for allergic rhinitis, patch and preparation method of patch |
| CN115154576A (en) * | 2022-07-19 | 2022-10-11 | 河南中医药大学 | Traditional Chinese medicine composition for treating malignant tumor-related diarrhea |
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| CN102049029A (en) * | 2010-11-21 | 2011-05-11 | 王玉青 | Chinese medical preparation for treating infantile diarrhea |
| CN103977114A (en) * | 2014-05-30 | 2014-08-13 | 周冠旻 | Traditional Chinese medicine patch for treating infantile diarrhea |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113384638A (en) * | 2021-07-09 | 2021-09-14 | 上海交通大学医学院附属上海儿童医学中心 | Traditional Chinese medicine composition for allergic rhinitis, patch and preparation method of patch |
| CN115154576A (en) * | 2022-07-19 | 2022-10-11 | 河南中医药大学 | Traditional Chinese medicine composition for treating malignant tumor-related diarrhea |
| CN115154576B (en) * | 2022-07-19 | 2023-04-25 | 河南中医药大学 | Traditional Chinese medicine composition for treating malignant tumor-associated diarrhea |
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