CN112426487A

CN112426487A - Traditional Chinese medicine composition for treating lung cancer

Info

Publication number: CN112426487A
Application number: CN202010821413.1A
Authority: CN
Inventors: 仲崇允
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-08-15
Filing date: 2020-08-15
Publication date: 2021-03-02
Also published as: CN113304226A

Abstract

The invention discloses a traditional Chinese medicine for treating lung cancer, which is prepared from the following raw material medicines in parts by weight: 3-6 g of pimento and hop; rosemary and cinnamon 5-10 g; 6-12 g of Stephania delavayi Diels and dendrobium nobile Lindl; 9-18 g of Fenghuangbai grass, herba fibraureae recisae and mistletoe; 20-40 g of unlocking lock. The traditional Chinese medicine composition can enhance the immune function of organisms, kill lung cancer cells, induce the differentiation and apoptosis of the lung cancer cells, prevent the transfer of the lung cancer cells, relieve the pain of patients, improve the living quality of the patients, improve the cure rate of the lung cancer patients, and has the characteristics of obvious treatment effect, no toxic or side effect and the like.

Description

Traditional Chinese medicine composition for treating lung cancer

Technical Field

The invention relates to the field of preparation of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating lung cancer.

Background

Lung cancer is one of the most rapidly growing malignancies that threaten human health and life. In many countries, the incidence and mortality of lung cancer have been reported to be significantly increased in recent 50 years, with lung cancer incidence and mortality in men accounting for the first of all malignancies and incidence and mortality in women accounting for the second.

The traditional treatment method has various defects, the tumor can be removed by surgical treatment, however, the surgical risk is high, the wound of the operation on the human body is large, the immunity of a patient is reduced, the resistance to diseases is reduced, the operation is a local treatment means, and the traditional treatment method is only suitable for the patient with early stage and body condition tolerance; surgical resection can not remove roots and can directly cause lung cancer cell diffusion.

The chemotherapy drugs are almost all cytotoxic drugs, and have certain toxic and side effects on normal cells of a human body while killing tumor cells, particularly on cells which are divided, proliferated and relatively fast, such as bone marrow hematopoietic cells, gastrointestinal tract mucosal epithelial cells and the like. Chemotherapy shortens the survival time of patients and makes part of tumors insensitive to drugs, so that chemotherapy cannot completely kill all lung cancer cells in vivo, and lung cancer cells can relapse or metastasize within a certain time.

Radiation therapy is often used as an adjuvant or palliative treatment. While tumor destruction is achieved by radiation therapy, normal tissue cells are damaged to some extent, and beyond this limit, irreversible damage to the tissue occurs, and radiation therapy may reduce the immunity of the body. The radiation dose is calculated by theory, which is difficult to conform to the reality, and only the tumor less than 2cm can be completely destroyed at one time.

Disclosure of Invention

The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating lung cancer, so that the traditional Chinese medicine composition can effectively resist lung cancer cells, prevent the lung cancer cells from transferring, improve the cure rate of lung cancer patients, and has the characteristics of obvious treatment effect, no toxic or side effect and the like.

The invention provides a traditional Chinese medicine composition for treating lung cancer, which comprises the following components: 3-6 g of pimento and hop; rosemary and cinnamon 5-10 g; 6-12 g of Stephania delavayi Diels and dendrobium nobile Lindl; 9-18 g of Fenghuangbai grass, herba fibraureae recisae and mistletoe; 20-40 g of unlocking lock.

In a preferred embodiment, the traditional Chinese medicine composition for treating lung cancer comprises the following raw material medicines in parts by weight: 6 g of pimento and hop; rosemary and cinnamon 10 g; 12g of Qianliang and dendrobium stem; 18 g of phoenix-tail fern, herba fibraureae recisae and mistletoe; 20-40 g of unlocking lock.

The invention also provides an oral preparation for treating lung cancer, which is prepared from the traditional Chinese medicine composition.

Wherein, the gold lock is opened: slightly pungent, astringent and cool. It enters lung meridian. Clear heat and remove toxicity, expel pus and remove stasis. The radix Cynanchi Oldhamii can obviously inhibit nucleic acid metabolism in cancer cells, and has a lung cancer killing rate of 92.1%.

Qianlianjin: pungent, sweet and warm. It enters liver and kidney meridians. Tonify kidney yang, strengthen tendons and bones, dispel wind-damp. The ardisia japonica can enhance the killing activity of immune cells and has better anti-cancer activity, and the ardisia japonica can block the lung cancer A549 cells in the S phase and has obvious apoptosis promoting effect. The Qiandijin can also reduce the mRNA and protein expression level of related genes bcl-2 and c-myc while inducing the apoptosis of tumor cells. The ardisia japonica can also obviously inhibit the activity of telomerase of lung cancer cells, and the activity reduction of the telomerase is in negative correlation with the expression rate of a cell surface granulocyte differentiation antigen CD11 b. The effect is stronger along with the increase of the concentration of the medicine and the prolonging of the action time.

Fragrant pepper: pungent taste; warming; it enters stomach meridian due to small toxicity. Warming middle energizer to relieve pain; kill parasites and relieve itching. The pimento volatile oil can inhibit proliferation of non-small cell lung cancer and induce apoptosis.

Cassia bark: pungent taste; sweet; and (4) temperature. Invigorating spleen; the stomach; liver; kidneys. Warming the spleen and stomach; warming liver and kidney; dispelling cold and relieving pain; dispel stasis and relieve swelling. Inducing the differentiation of the lung cancer cells, and is a natural differentiation agent with the function of the differentiation of the lung cancer cells.

And (3) fibraurea stems: bitter and pungent in flavor, slightly warm in nature, entering liver, spleen and large intestine meridians. Dispel wind, activate blood, resolve swelling and alleviate pain. The fibraurea recisa pierre total terpenoid has obvious cytotoxicity on non-small cell lung cancer, breast cancer, colon cancer, nasopharyngeal carcinoma, glioma and prostatic cancer, and is an effective and safe multidrug resistance reversal agent.

Rosemary 4.5-9 g: pungent taste; and (4) temperature. Sweating; invigorating spleen; tranquilization; can be used for relieving pain. After the rosemary extract acts for 48 hours, the inhibition rate of the rosemary extract on human lung cancer cell strains is (93.06 +/-1.56)%.

Phoenix-tail grass: bitter; pungent taste; cool, enter liver; the large intestine channel. Clearing heat and promoting diuresis; cooling blood to stop bleeding; detoxify and detumescence. Decoct 9-15 g. The Fenghuangfeng can strongly inhibit the synthesis of DNA and RNA of epithelial cells of leukemia and lung adenocarcinoma, obviously inhibit the proliferation of lung cancer cells, and particularly obviously block the synthesis of protein in the G2/M stage.

Dendrobium nobile: sweet and slightly cold. It enters stomach and kidney meridians. The dendrobium nobile lindl has strong anti-tumor activity and obvious cytotoxicity effect on human lung cancer cells, human ovarian adenocarcinoma cells and human promyelocytic leukemia. Especially has killing effect and great inhibition effect on lung cancer cells, and the inhibition rate is as high as 74.7-97.2%. Can obviously improve the symptoms of patients with lung cancer, and particularly has good symptomatic adjuvant therapy effect on patients with radiotherapy and chemotherapy accompanied by yin deficiency symptoms. And improve the immunologic function of the patient, improve the life quality and prolong the life time.

Mistletoe: bitter, sweet and neutral. It enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, dispel wind-damp, and prevent abortion. Mistletoe can inhibit lung cancer, ascites carcinoma, sarcoma ascites reticuloma obviously, leukemia and liver cancer inhibiting rate up to 73.8%, esophagus cancer inhibiting rate of 39.8-67%, stomach cancer inhibiting rate of 33.6-719%, and lung cancer metastasis obviously.

Hop: bitter; is slightly cool in nature. Liver diseases entering; the stomach meridian. Strengthening stomach and promoting digestion; promoting urination and relieving swelling; resisting tuberculosis and diminishing inflammation. The hop can obviously inhibit the proliferation of endothelial cells, has obvious anti-tumor effect and is an effective medicament for inhibiting the angiogenesis diseases of various tumors and the growth and the metastasis of malignant tumors.

The invention is prepared from Chinese traditional herbal medicines, and combines the traditional Chinese medicine for inducing the apoptosis of lung cancer cells and promoting the differentiation of the lung cancer cells by orderly matching certain natural extracts with definite components and clear effects according to a plurality of principles of traditional Chinese medicine treatment based on syndrome differentiation and modern medicine.

The invention has the effect of chemotherapy, is mild and nontoxic, and can be called 'zero-toxicity chemotherapy'. After the medicine is taken for many years, patients do not have any adverse reaction, blood is tracked to check the blood normally, and the curative effect is not rebounded. The cure rate is 20%, the survival rate is 75% for more than 5 years, and the effective rate is 100%.

The invention can enable the traditional Chinese medicine components to mutually cooperate and supplement each other while playing the anticancer role, can play a role in mutual promotion, can inhibit the proliferation of lung cancer cells, can kill the lung cancer cells to induce the apoptosis of the lung cancer cells, and plays a role in treating the lung cancer. The invention can promote the recovery of patients, prevent the recurrence and metastasis of postoperative tumors and quickly help the recovery of patients by combining with the operation treatment.

The traditional Chinese medicine composition can help patients with advanced lung cancer to improve symptoms, relieve pain and improve the life quality of the patients. For patients who have relapsed or metastasized and can not be treated by western medicine operations and chemoradiotherapy, the traditional Chinese medicine formula is taken alone to enhance the immune function of the organism and induce the differentiation and apoptosis of lung cancer cells, so that the effect of prolonging the life of the patients can be achieved, and even the patients can live with tumors.

The traditional Chinese medicine composition can be used for treating lung cancer and has a remarkable curative effect. The treatment cost of the invention is relatively low and is far lower than that of western medicine.

The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.

The invention also provides an oral preparation prepared from the traditional Chinese medicine composition for treating the disease, wherein the oral preparation comprises oral liquid, tablets, capsules, pills and the like, and the preferable dosage forms are oral liquid and capsules, and one dose is taken every day in the morning and at night.

The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.

The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.

Claims

1. The traditional Chinese medicine for treating lung cancer is characterized by comprising the following raw material medicines in parts by weight: 3-6 g of pimento and hop; rosemary and cinnamon 5-10 g; 6-12 g of Stephania delavayi Diels and dendrobium nobile Lindl; 9-18 g of Fenghuangbai grass, herba fibraureae recisae and mistletoe; 20-40 g of unlocking lock.

2. The traditional Chinese medicine for treating lung cancer according to claim 1 is characterized by comprising the following raw material medicines in parts by weight: 6 g of pimento and hop; rosemary and cinnamon 10 g; 12g of Qianliang and dendrobium stem; 18 g of phoenix-tail fern, herba fibraureae recisae and mistletoe; the gold lock is opened by 40 grams.

3. An oral preparation for treating lung cancer, which is prepared from the traditional Chinese medicine composition of any one of claims 1 or 2.

4. The oral preparation for treating lung cancer according to claim 3, wherein the oral preparation comprises oral liquid, tablets, capsules and pills, and preferably oral liquid and tablets.