CN112426469A - Traditional Chinese medicine composition for treating ehrlich ascites carcinoma - Google Patents
Traditional Chinese medicine composition for treating ehrlich ascites carcinoma Download PDFInfo
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- CN112426469A CN112426469A CN202010821419.9A CN202010821419A CN112426469A CN 112426469 A CN112426469 A CN 112426469A CN 202010821419 A CN202010821419 A CN 202010821419A CN 112426469 A CN112426469 A CN 112426469A
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- ehrlich ascites
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
The invention discloses a traditional Chinese medicine for treating ehrlich ascites carcinoma, which is prepared from the following raw material medicines in parts by weight: 1-2 parts of catechu; 3-6 parts of pubescent angelica root, hop and grassleaf sweelflag rhizome; 6-12 parts of Sichuan jujube, bighead atractylodes rhizome and honeysuckle; 10-20 parts by weight of a day; 15-30 parts of circium japonicum. The invention can enhance the immune function of organisms, kill ehrlich ascites cancer cells, induce the differentiation and apoptosis of the ehrlich ascites cancer cells, prevent the transfer of the ehrlich ascites cancer cells, relieve the pain of patients, improve the living quality of the patients, improve the cure rate of the ehrlich ascites cancer patients, and has the characteristics of obvious treatment effect, no toxic or side effect and the like.
Description
Technical Field
The invention relates to the field of preparation of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating ehrlich ascites carcinoma.
Background
Ehrlich ascites carcinoma easily produces ascites, resulting in an increase in abdominal pressure. The chemotherapy drugs are almost all cytotoxic drugs, and have certain toxic and side effects on normal cells of a human body while killing tumor cells, particularly on cells which are divided, proliferated and relatively fast, such as bone marrow hematopoietic cells, gastrointestinal tract mucosal epithelial cells and the like. Chemotherapy shortens the survival time of patients, and parts of tumors are insensitive to drugs, so that chemotherapy cannot completely kill all ehrlich ascites cancer cells in vivo, and the ehrlich ascites cancer cells can relapse or metastasize in a certain time.
Radiation therapy is often used as an adjuvant or palliative treatment. While tumor destruction is achieved by radiation therapy, normal tissue cells are damaged to some extent, and beyond this limit, irreversible damage to the tissue occurs, and radiation therapy may reduce the immunity of the body. The radiation dose is calculated by theory, which is difficult to conform to the reality, and only the tumor less than 2cm can be completely destroyed at one time.
Disclosure of Invention
The invention aims to improve the defects of the prior art and provide the traditional Chinese medicine composition for treating ehrlich ascites carcinoma, so that the traditional Chinese medicine composition can effectively resist ehrlich ascites carcinoma cells, prevent the ehrlich ascites carcinoma cells from transferring, improve the cure rate of ehrlich ascites carcinoma patients, and has the characteristics of obvious treatment effect, no toxic or side effect and the like.
The invention provides a traditional Chinese medicine composition for treating ehrlich ascites carcinoma, which comprises the following components in part by weight: 1-2 parts of catechu; 3-6 parts of pubescent angelica root, hop and grassleaf sweelflag rhizome; 6-12 parts of Sichuan jujube, bighead atractylodes rhizome and honeysuckle; 10-20 parts by weight of a day; 15-30 parts of circium japonicum.
In a preferred embodiment, the traditional Chinese medicine composition for treating ehrlich ascites carcinoma consists of the following raw material medicines in parts by weight: 2 parts of catechu; 6 parts of pubescent angelica root, hop and grassleaf sweelflag rhizome; 12 parts of Sichuan jujube, largehead atractylodes rhizome and honeysuckle; 20 parts by weight of Tianzhu; and 30 parts of circium japonicum.
Wherein, the catechu: bitter, astringent and slightly cold. It enters lung meridian. Astringe dampness, promote tissue regeneration and heal wound. Catechu has radioprotective, leukocyte increasing and antitumor effects, and can inhibit adhesion between tumor cells and fibrin to prevent tumor cell diffusion. The catechu decoction has a remarkable inhibiting effect on ascites cancer cells, has a strong effect of directly killing ascites cancer cells in vitro, and has no toxic effect on normal cells.
And (3) taking Sichuan jujubes as raw materials: sour, astringent and slightly warm. It enters liver and kidney meridians. Tonify liver and kidney, astringe essence and relieve depletion. In vitro experiment the fructus choerospondiatis decoction can kill all ascites cancer cells.
Herba seu radix Cirsii Japonici: sweet and cool. Cool blood to stop bleeding, dissipate stasis to relieve swelling. In vitro experiment the fructus choerospondiatis decoction can kill all ascites cancer cells.
White atractylodes rhizome: bitter, sweet and warm. It enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. All ehrlich ascites cancer cells can be shed within 24 hours after the atractylodes macrocephala is taken.
Radix angelicae pubescentis: pungent, bitter and slightly warm. It enters kidney and bladder meridians. The pubescent angelica has the function of killing the cancer cells of the ehrlich ascites.
Honeysuckle flower: sweet and cold in flavor. It enters lung, heart and stomach meridians. Clear heat and remove toxicity, cool and disperse wind-heat. The honeysuckle has obvious cytotoxic effect on ehrlich ascites carcinoma.
Grassleaf sweelflag rhizome: pungent, bitter and warm. It enters heart and stomach meridians. Resolve dampness, stimulate appetite, induce resuscitation, eliminate phlegm, refresh mind and promote intelligence. The acorus gramineus can completely kill ascites cancer cells of mice in vitro. The external test shows that the product has inhibitory effect on common carcinogenic dermatophytes.
Day withdrawal: sweet, slightly bitter and cold. It enters lung, stomach and large intestine meridians. Clear heat and remove phlegm, relieve chest stuffiness and dissipate nodulation, moisten dryness and smooth intestines. In vitro experiments, withdrawal of the antibody has lethal effects on ascites cancer cells.
Hop: bitter; is slightly cool in nature. Liver diseases entering; the stomach meridian. Strengthening stomach and promoting digestion; promoting urination and relieving swelling; resisting tuberculosis and diminishing inflammation. The hop can obviously inhibit the proliferation of endothelial cells, has obvious anti-tumor effect and is an effective medicament for inhibiting the angiogenesis diseases of various tumors and the growth and the metastasis of malignant tumors.
The invention is prepared from Chinese traditional herbal medicines, and combines the Chinese traditional medicine which can induce the apoptosis of ehrlich ascites cancer cells and promote the differentiation thereof according to a plurality of principles of Chinese medicine dialectical treatment and modern medicine and the ordered compatibility of natural extracts with certain components and clear effects.
The invention has the effect of chemotherapy, is mild and nontoxic, and can be called 'zero-toxicity chemotherapy'. After the medicine is taken for many years, patients do not have any adverse reaction, blood is tracked to check the blood normally, and the curative effect is not rebounded. In fifty cases of pure traditional Chinese medicine treatment of advanced ehrlich ascites carcinoma, the cure rate is 36%, the survival rate is 60% for more than 5 years, and the effective rate is 100%.
The invention can enable the traditional Chinese medicine components to mutually cooperate and supplement each other while playing the anti-cancer effect, can play a role in mutual promotion, can inhibit the proliferation of ehrlich ascites cancer cells, can kill the ehrlich ascites cancer cells to induce the apoptosis of the ehrlich ascites cancer cells, and plays a role in treating the ehrlich ascites cancer. The invention can promote the recovery of patients, prevent the recurrence and metastasis of postoperative tumors and quickly help the recovery of patients by combining with the operation treatment.
The invention can help the patients with advanced Ehrlich ascites cancer to improve symptoms, relieve pain and improve the quality of life of the patients. For patients who have relapsed or transferred and can not be treated by western medicine operation and radiotherapy and chemotherapy, the traditional Chinese medicine formula is singly taken, so that the immunity function of the organism is enhanced, the differentiation and the apoptosis of ehrlich ascites cancer cells are induced, the effect of prolonging the life of the patients can be achieved, and even the patients can be possibly cured.
The traditional Chinese medicine composition can be used for treating ehrlich ascites carcinoma and has a remarkable curative effect. The treatment cost of the invention is relatively low and is far lower than that of western medicine.
The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.
The invention also provides an oral preparation prepared from the traditional Chinese medicine composition for treating the disease, wherein the oral preparation comprises oral liquid, tablets, capsules, pills and the like, and the preferable dosage forms are oral liquid and capsules, and one dose is taken every day in the morning and at night.
The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.
The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.
Claims (4)
1. The traditional Chinese medicine for treating ehrlich ascites carcinoma is characterized by comprising the following raw material medicines in parts by weight: 1-2 parts of catechu; 3-6 parts of pubescent angelica root, hop and grassleaf sweelflag rhizome; 6-12 parts of Sichuan jujube, bighead atractylodes rhizome and honeysuckle; 10-20 parts by weight of a day; 15-30 parts of circium japonicum.
2. The traditional Chinese medicine for treating ehrlich ascites carcinoma according to claim 1 is characterized by comprising the following raw material medicines in parts by weight: 2 parts of catechu; 6 parts of pubescent angelica root, hop and grassleaf sweelflag rhizome; 12 parts of Sichuan jujube, largehead atractylodes rhizome and honeysuckle; 20 parts by weight of Tianzhu; and 30 parts of circium japonicum.
3. An oral preparation for treating ehrlich ascites carcinoma, which is characterized by being prepared from the traditional Chinese medicine composition of any one of claims 1 or 2.
4. The oral preparation for treating ehrlich ascites carcinoma according to claim 3, wherein the oral preparation comprises oral liquid, tablets, capsules and pills, preferably oral liquid and tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010821419.9A CN112426469A (en) | 2020-08-15 | 2020-08-15 | Traditional Chinese medicine composition for treating ehrlich ascites carcinoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010821419.9A CN112426469A (en) | 2020-08-15 | 2020-08-15 | Traditional Chinese medicine composition for treating ehrlich ascites carcinoma |
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| Publication Number | Publication Date |
|---|---|
| CN112426469A true CN112426469A (en) | 2021-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010821419.9A Withdrawn CN112426469A (en) | 2020-08-15 | 2020-08-15 | Traditional Chinese medicine composition for treating ehrlich ascites carcinoma |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147534A (en) * | 2014-08-26 | 2014-11-19 | 张五星 | Traditional Chinese medicine composition for treating various cancers |
| CN106074689A (en) * | 2016-08-03 | 2016-11-09 | 淮阴工学院 | The herbal composite of suppression cervical cancer cell and preparation method |
-
2020
- 2020-08-15 CN CN202010821419.9A patent/CN112426469A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147534A (en) * | 2014-08-26 | 2014-11-19 | 张五星 | Traditional Chinese medicine composition for treating various cancers |
| CN106074689A (en) * | 2016-08-03 | 2016-11-09 | 淮阴工学院 | The herbal composite of suppression cervical cancer cell and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 云南省药物研究所: "《云南重要天然药物（续一）》", 30 April 2011, 云南科技出版社 * |
| 刘广遐 等: "恶性胸腹水的中医药治疗现状", 《河南中医学院学报》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication | ||
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Application publication date: 20210302 |