CN105617007A - Traditional Chinese medicine for treating tumors and preparation method of traditional Chinese medicine - Google Patents

Traditional Chinese medicine for treating tumors and preparation method of traditional Chinese medicine Download PDF

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CN105617007A
CN105617007A CN201610183374.0A CN201610183374A CN105617007A CN 105617007 A CN105617007 A CN 105617007A CN 201610183374 A CN201610183374 A CN 201610183374A CN 105617007 A CN105617007 A CN 105617007A
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chinese medicine
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raw material
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孙维彤
杨春荣
杜娟
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Jiamusi University
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Jiamusi University
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract

The invention relates to traditional Chinese medicine for treating tumors and a preparation method of traditional Chinese medicine. The traditional Chinese medicine comprises plant raw materials and animal raw materials by weight, wherein the plant raw materials are 22 to 35 parts of peach kernel, 12 to 20 parts of acanthopanax senticosus, 15 to 19 parts of cremastra appendiculata, 10 to 15 parts of herba gynostemmatis pentaphylli, 20 to 30 parts of astragalus membranaceus, 32 to 36 parts of semen cuscutae, 12 to 18 parts of radix sophorae flavescentis, 5 to 15 parts of giant knotweed, 8 to 15 parts of juncus effusus, 20 to 30 parts of arenaria brevipetala, 23 to 28 parts of discolorous clinquefoil root, 30 to 34 parts of ginkgo leaves, 20 to 25 parts of aconitum szechnyianum gay, 30 to 36 parts of asparagus cochinchinensis, 28 to 35 parts of starjasmine stem, 8 to 15 parts of fructus polygoni orientalis, 3 to 13 parts of selfheal, 30 to 50 parts of honeysuckle stem, 10 to 18 parts of rhizoma dioscoreae nipponicae, and 8 to 10 parts of uncaria rhynchophylla; theanimal raw materials are 3 to 5 parts of lumbricus, 4 to 8 parts of sea crab shell, and 2 to 5 parts of centipede; the weight ratio of the plant raw materials to the animal raw materials is 1:(0.01 to 0.05). According to the characteristics of drug property compatibility, the traditional Chinese medicine has the advantages that under the condition of inhibiting growth of tumor cells, the organic immunity and resistibility can be improved; the phagocytic function of macrophage can be promoted; the content of white blood cells can be increased; the haematopoietic function of bone marrow is protected; the ill symptoms and signs of patients can be improved.

Description

A kind of Chinese medicine and its preparation method treating tumour
Technical field
The present invention relates to a kind of Chinese medicine and its preparation method for the treatment of tumour, belong to chronic disease therapy field.
Background technology
Tumour (Tumor) is one of main disease of current harm humans health, is a kind of common disease of the histocyte allobiosis hyperplasia causing human body by multiple factor, and lung tumors divides innocent tumour and malignant tumour. Be there is huge demand space by current Global Medicine market in safe and effective antitumor drug. The most basic biological property of tumour is unregulated cell growth, finds the important topic that the antitumour drug that growth of tumour cell has targeted inhibition effect is medicament research and development person.
The means of current treatment tumour mainly comprise chemotherapy, radiotherapy and operative treatment. But a large amount of clinical treatments proves, organism normal cell is had detrimental effect by chemotherapy and radiation while killing tumor cell. Chinese medicine is antitumor has the advantages such as mechanism of action uniqueness, lasting medicine, Mutiple Targets, many approach, Antitumor test is wide, toxic side effect is little, for treatment tumour, there is huge potentiality and irreplaceable advantage, nowadays progressively occupied dominant position clinically.
In the antitumor drug having now found that, what come from plant accounts for 32.25%. Finding antitumor activity component from natural phant is current and the focus of antitumor drug research and development in one period from now on.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine treating tumour, the method of excision in prior art that overcomes adds the misery of patient, hinder its vigour, expense is huge, by the method for chemotherapy or radiotherapy, while killing tumour cell, also red corpuscle and white corpuscle is injured, cause patient to suffer untold misery, and cure the symptoms, not the disease, it is very difficult to thoroughly remove the defect that tumour threatens.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of Chinese medicine treating tumour, is made up of the plant material raw material of following weight part and animal material, and described plant material is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 3-5 part sea crab shell 4-8 part centipede 2-5 part
The part by weight of described plant material and described animal material is 1:0.01-0.05.
The invention has the beneficial effects as follows: select applicable herbal medicine and proportioning according to property of medicine compatible experiments in the present invention; there is benefiting qi and removing blood stasis, clearing heat and detoxicating effect; immunity of organism resistibility can be improved while the growth of inhibition tumor cell; promote the phagocytic function of scavenger cell; increase leucocyte content; protection hemopoietic function of bone marrow; improve patient's ill symptoms and sign; it is mainly used in the treatment of the tumours such as lung tumors, mammary cancer, cancer of the stomach; also can be used for the postoperative adjuvant therapy of above-mentioned cancer; antitumor action is obvious, safe without toxic side effect curative effect.
On the basis of technique scheme, the present invention can also do following improvement.
The present invention is a kind of Chinese medicine treating tumour as mentioned above, and further, described gynostemma pentaphylla is 12-14 part.
The present invention is a kind of Chinese medicine treating tumour as mentioned above, further, and described Japanese Honeysuckle Stem 35-40 part.
The present invention is a kind of Chinese medicine treating tumour as mentioned above, further, and 30 parts, described peach kernel.
The present invention is a kind of Chinese medicine treating tumour as mentioned above, further, is made up of the raw material of following weight part:
Described animal material is made up of following raw material:
Earthworm 3-5 part sea crab shell 4-8 part centipede 2-5 part
The part by weight of described plant material and described animal material is 1:0.02-0.04.
The present invention is a kind of Chinese medicine treating tumour as mentioned above, further, is made up of the raw material of following weight part:
Described animal material is made up of following raw material:
Earthworm 3-5 part sea crab shell 4-8 part centipede 2-5 part
The part by weight of described plant material and described animal material is 1:0.03.
The present invention also provides the preparation method of a kind of Chinese medicine treating tumour, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to ratio boiling 2-3 hour of 1g:20-30ml water, filters; The dregs of a decoction add 3��and 5 times of quality water again decoct and boil 20��40min, filter; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 1.05-1.12;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 60��100 order sieves, again micronizing to particle diameter at 5��50 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes acquisition activeconstituents.
Activeconstituents, as effective ingredient, adds auxiliary material and makes tablet or capsule.
In the present invention, pharmaceutical excipient used, can be selected from tackiness agent (can be polyvidone, starch slurry, Mierocrystalline cellulose etc.), disintegrating agent (can be dry starch, Xylo-Mucine, low-substituted hydroxypropyl cellulose, PVP etc.), lubricant (can be talcum powder, stearic acid, calcium stearate magnesium, calcium stearate etc.), correctives (can be sucrose, A Siba is sweet, Steviosin, fructose etc.), stablizer (can be methyl p-hydroxybenzoate, propylparaben etc.), thinner (can be starch, dextrin, Icing Sugar, lactose etc.), wetting agent (can be water or ethanol), glidant (can be micropowder silica gel), vehicle (can be that carbohydrate derivative is such as lactose, sucrose, glucose, N.F,USP MANNITOL, sorbyl alcohol, starch based derivative is such as W-Gum, potato starch, dextrin or carboxymethyl starch, derivatived cellulose is such as crystalline fibers, hydroxy propyl cellulose, carboxymethyl cellulose.
Described anti-tumor Chinese medicine is in the application prepared in antitumor drug.
Described anti-tumor Chinese medicine is the medicine of short apoptosis of tumor cells.
Described antitumor drug comprises the medicine of adenocarcinoma of lung, the medicine of anti-cervical cancer, the medicine of anti-myeloma.
The pharmaceutical characteristic of each bulk drug of the present invention is as follows:
Above-mentioned all medicine compatibilities, there is positive QI-insufficiency in tumour patient, weakness of the spleen and the stomach, ecchymosis is tied pathogenic characteristic mutually and established;
Peach kernel: peach kernel bitter is sweet and property is put down, and can enter the heart, liver, large intestine, promoting blood circulation to remove blood stasis effect is very wide, available controls the various worn-out disease of stagnation of blood stasis.
Radix Et Caulis Acanthopanacis Senticosi: taste is pungent; Bitter; Micro-sweet; Warm in nature, return Liver Channel; Kidney channel. Function: wind-damp dispelling; Invigorating the liver and kidney; Strengthening the bones and muscles; Invigorate blood circulation arteries and veins; There is vasodilation, improve big cerebral blood volume, blood pressure is had dual regulation. Simultaneously Radix Et Caulis Acanthopanacis Senticosi can also antifatigue, radioprotective, qi-restoratives weak, strengthen hemopoietic function of bone marrow, and there is work of invigorating blood circulation
Pseudobulbus Cremastrae Seu Pleiones: sweet, micro-pungent, cool. Return liver, the spleen channel, clearing heat and detoxicating, the carbuncle that disappears dissipating bind.
Gynostemma pentaphylla, taste is sweet, bitter, cold nature. Gui Jing: return lung channel, the spleen channel, kidney channel. Function: energy benefit gas, calms the nerves, falls blood pressure, clearing heat and detoxicating, cough-relieving apophlegmatic.
The Radix Astragali: the Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation. Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and bursts for a long time and does not hold back, and the deficiency of blood is sallow, and interior heat is quenched one's thirst. " herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving. Qi-restoratives, children's's all kinds of diseases and ailments. " " Japan hanako materia medica " record: " help gas to strengthen muscles and bones, put on flesh and enrich blood. ".
South Dodder Seed Chinese Dodder Seed: South Dodder Seed Chinese Dodder Seed again " Shennong Bencaojing " is listed in top grade return through: smell is pungent, sweet, flat nontoxic. [function with cure mainly]: tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity. The waist knee muscles and bones being applicable to deficiency of the liver and kindey is ached, and legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizzy, blurring of vision, tinnitus are deaf and the disease such as women is with down, habitual abortion. Generally it is listed in top grade can taking for a long time. Take bright order for a long time to make light of one's life by commiting suicide and prolong life.
Kuh-seng: for hot dysentery, have blood in stool, jaundice renal shutdown, leucorrhea with red and white discharge, cloudy swollen pruritus vulvae, eczema, wet sore, skin pruritus, mange leprosy; Control trichomonal vaginitis outward. Matrine has the effect reducing Turnover of Mouse Peritoneal Macrophages suppression P815 tumor cell proliferation in vitro.
Giant knotweed: Rhizoma Polygoni Cuspidati extract has antipyretic effect. Resveratrol glucoside and vetanarcol and urethanum have synergy, can obviously extend mouse sleep time. Scald wound is had convergence, protects from infection and antiinflammation by giant knotweed decoction.
Medulla Junci: micro-cold; Sweet, light; The thoughts of returning home; Lung; Small intestine; Bladder warp. Effect relieving stranguria by diuresis; Clearing heart fire.
Herba arenariae kansuensis: sweet is bitter, cold in nature; Return liver, courage, kidney channel. Nourishing YIN and benefiting blood, invigorating function of kidney and strengthening bone. For dryness of the lung cough, jaundice, hemoptysis, deficiency of blood wandering arthritis, arthralgia and myalgia, dizziness due to the kidney deficiency, essential hypertension.
Herba Potentillae Discoloris: all herbal medicine, can antipyretic, detumescence, only dysentery, hemostasis.
Ginkgo Leaf: nature and flavor: sweet, bitter, puckery is flat. Gui Jing: the thoughts of returning home, lung channel. Have promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, hold back lung and relieving asthma, change turbid effect falling fat. Cure mainly: for obstruction of collaterals by blood stasis, Obstruction of qi in the chest and cardialgia, stroke hemiplegia, the deficiency syndrome of the lung is coughed and breathed heavily, hyperlipidaemia.
Radix aconiti szechenyiani: the total alkali in Radix aconiti szechenyiani extract has significant analgesic activity, its analgesia intensity is 43.7 times of morphine, and its main effectively analgesic composition is napelline, 3-acetylaconitine, deoxidation napelline etc.
Asparagus fern: sweet, bitter, cold. Return lung, kidney channel. Function cures mainly: nourishing YIN to relieve dryness, and clearing lung-heat is promoted the production of body fluid. For dryness of the lung dry cough, pertussis phlegm sticks, and dry throat is thirsty, the dry constipation of intestines.
Stem of confederate-jasmine: have and dispel rheumatism, removes obstruction in channels to relieve pain, clearing heat and cooling blood, and effect of detoxify and promote the subsdence of swelling, cures mainly dispelling wind and removing obstruction in the collateral, and cool blood is subsided a swelling. For beriberoid pyretic arthralgia, muscle arteries and veins contraction, soreness of waist and knee joint, larynx numbness, carbuncle swells, injury from falling down.
Princes-feather Fruit: meridian distribution of property and flavor: salty, micro-cold. 1. " not Lu ": " taste is salty, micro-cold, nontoxic. " 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is cold in nature flat, bitter. " 3. " medicinal material data compilation ": " is pungent, nontoxic. " 4. " medicinal material ": " property is put down, and taste is sweet. " enter liver, stomach, spleen three warp. Having ruffian dissipating bind, clearing away heat to and alleviating pain function. For lump in the abdomen abdominal distension, hepatosplenomegaly, the tuberculosis of cervical lymph nodes, quenches one's thirst, stomachache.
Spica Prunellae, Spica Prunellae is cold in nature, taste hardship sweet, pungent, micro-, there is the effect letting out clearly irascibility, mass dissipating and swelling eliminating, clearing heat and detoxicating, expelling phlegm for arresting cough, cooling blood for hemostasis, under being applicable to lymphoid tuberculosis, thyrocele, acute mastitis, vertigo, facial hemiparalysis, arthralgia and myalgia, pulmonary tuberculosis, metrorrhagia, band, acute infection icterohepatitis and bacillary dysentery etc. Modern pharmacological research shows, Spica Prunellae has the effect reducing blood pressure, and energy vasodilation, contained by it, rutin has anti-inflammatory action, and can reduce vascular permeability, reduces fragility, reduces liver fat and resists the effect of cancer cells.
Japanese Honeysuckle Stem, taste sweetness and bitterness, cold nature, clearing heat and detoxicating, dredge wind and removing obstruction in channels. For warm disease heating, toxic-heat and blood stasis, carbuncle swell sore, beriberoid pyretic arthralgia, and redness and swelling of joints heat is bitterly.
Ningpo Yam Rhizome: medicinal plant, root stock is containing the important source material that diosgenin is synthesizing steroid hormonal medicaments; Property is put down, bitter; Return liver, lung channel; Among the people be used for controlling lumbago and skelalgia, muscles and bones numbness, wound, cough pant.
Yncaria stem with hooks: taste hardship sweet, micro-, cold nature; Return liver, pericardium warp; Matter heavily fortified point is dived and is fallen, and has the flat liver of heat-clearing, and effect of relievng spasm by subduing liver-wind, controls hypertension, has a dizzy spell, nervous headache.
Earthworm: Lumbrukinase has been developed patent medicine, easy administration, safety, can not as streptokinase, and the medicines such as urea kinases easily cause high plasmin mass formed by blood stasis to cause profuse bleeding. Anticancer research proves, the esophageal carcinoma is had restraining effect by earthworm, is used in conjunction the short term effect to lung cancer with chemotherapeutics and is better than simple chemotherapy.
Sea crab shell: taste is salty, cool in nature, relieving dyspepsia, promoting blood circulation and stopping pain, detoxify and promote the subsdence of swelling.
Centipede: pungent, temperature; Poisonous. Returning Liver Channel, breath wind antispastic, dispersing pathogen accumulation, removes obstruction in channels to relieve pain.
In the present invention, mainly through by plant material and animal material combination rational proportion, synergy, has antitumor, auxiliary tumor chemoradiotherapy and has good result for the treatment of.
Embodiment
Being described in conjunction with following principle and feature to the present invention, example, only for explaining the present invention, is not intended to limit the scope of the present invention.
Embodiment 1
A kind of Chinese medicine treating tumour of the present invention, is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 5 parts of sea crab shells, 8 parts of centipedes 5 parts
The part by weight of described plant material and described animal material is 1:0.01.
The preparation method of the Chinese medicine of above-mentioned treatment tumour, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to the ratio boiling 3 hours of 1g:20ml water, filters; The dregs of a decoction add 5 times quality water is again decocted and is boiled 40min, filters; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 1.12;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 60 orders sieves, then micronizing to particle diameter at 50 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes.
Embodiment 2
A kind of Chinese medicine treating tumour of the present invention, is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 3g sea crab shell 4g centipede 2g
The part by weight of described plant material and described animal material is 1:0.05.
The preparation method of the Chinese medicine of above-mentioned treatment tumour, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to the ratio boiling 3 hours of 1g:30ml water, filters; The dregs of a decoction add 3 times quality water is again decocted and is boiled 40min, filters; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 1.05;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 60 orders sieves, then micronizing to particle diameter at 20 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes.
Embodiment 3
A kind of Chinese medicine treating tumour of the present invention, is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 4g sea crab shell 8g centipede 5g
The part by weight of described plant material and described animal material is 1:0.04.
The preparation method of the Chinese medicine of above-mentioned treatment tumour, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to the ratio boiling 3 hours of 1g:30ml water, filters; The dregs of a decoction add 5 times quality water is again decocted and is boiled 40min, filters; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 1.12;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 100 orders sieves, then micronizing to particle diameter at 5 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes.
Embodiment 4
A kind of Chinese medicine treating tumour of the present invention, further, is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 3g sea crab shell 6g centipede 4g
The part by weight of described plant material and described animal material is 1:0.03.
The preparation method of the Chinese medicine of above-mentioned treatment tumour, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to the ratio boiling 3 hours of 1g:30ml water, filters; The dregs of a decoction add 5 times quality water is again decocted and is boiled 40min, filters; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 1.12;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 100 orders sieves, then micronizing to particle diameter at 50 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes.
Embodiment 5
A kind of Chinese medicine treating tumour of the present invention, is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 4 parts of sea crab shells, 6 parts of centipedes 3 parts
The part by weight of described plant material and described animal material is 1:0.03.
The preparation method of the Chinese medicine of above-mentioned treatment tumour, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to the ratio boiling 3 hours of 1g:30ml water, filters; The dregs of a decoction add 3 times quality water is again decocted and is boiled 40min, filters; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 11.12;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 60 orders sieves, then micronizing to particle diameter at 30 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes.
The present invention can also concentrate and add routine and make capsule edible auxiliary materials and make capsule or granule.
1, acute toxinology experiment
Experimental animal: ICR mouse 70, body weight 17-22g, male and female half and half. From medical college of Peking University laboratory;
1.1, animal grouping: adopting male and female Stochastic Equilibrium method of grouping respectively, be divided into 7 groups, often organize 10, wherein a group is blank group.
1.2, dosage is determined: metering is designed to: quite former medicine 100g/kg, quite former medicine 200/kg (clinical design dosage), quite former medicine 300/kg, quite former medicine 400/kg, quite former medicine 500/kg.
1.3, administration: disposable gastric infusion: fasting 3-5 hour before administration, fasting 1-2 hour after administration, water is can't help in fasting. Adopt administration in batches, negative control group, quite former medicine 100g/kg, the first of quite former medicine 150g/kg sells medicine wholesale, determine after administration that set dosage is suitable, then give quite former medicine 200g/kg, quite former medicine 300g/kg, quite former medicine 400g/kg, quite former medicine 500g/kg. Observing more than 7 days continuously after administration, every day, the upper and lower noon respectively observed once subsequently, observed 14 days continuously. Record every observation index table 1 in detail.
Table 1. administration amount and survival condition
Group In former medicine/kg Quantity Survival rate %
1 10 100
2 100 10 100
3 200 10 100
4 300 10 100
5 400 10 100
6 500 10 100
Conclusion: when tested material gastric infusion dosage in this test reaches in former medicine 500g/kg, death does not occur. Judging according to acute toxicity grading criteria, this test medicine can be considered nontoxic.
2, long term toxicity test
General 6��9 week age of rat. When test starts, weight differences should not exceed or lower than the 20% of this experimental animal mean body weight;
Test grouping: generally establish three dosage groups and a control group. Dosage is determined: metering is designed to: quite former medicine 100g/kg, quite former medicine 200g/kg (clinical design dosage), quite former medicine 300g/kg, quite former medicine 400g/kg, quite former medicine 500g/kg.
Repetitively administered: disposable gastric infusion: fasting 3��5 hours before administration, fasting 1��2 hour after administration, water is can't help in fasting. Adopt administration in batches, negative control group, quite former medicine 100g/kg, the first of quite former medicine 150g/kg sells medicine wholesale, determine after administration that set dosage is suitable, then give quite former medicine 200g/kg, quite former medicine 300g/kg, quite former medicine 400g/kg, quite former medicine 500g/kg. Successive administration stops medication after 6 months, observe more than 1 month sky continuously. Record every observation index table 2 in detail.
Table 2. long_term toxcity test-results
Group In former medicine/kg Quantity Survival rate %
1 20 100
2 100 20 100
3 200 20 100
4 300 20 100
5 400 20 100
6 500 20 100
3, to the embodiment of the present invention 3 antineoplastic evaluating drug effect of Chinese medicine composition
3.1, animal grouping and modeling
50 ICR mouse, female, 18-22g, is divided into 5 groups at random after weighing, and often organizes 10. It is respectively: blank group, positive controls, the high, medium and low dosage group of Chinese medicine composition of the present invention. Select the S180 sarcoma knurl kind of 7��10 days of well-grown, it is inoculated in right side of mice armpit subcutaneous, about 4.5��5 �� 106Cell/only;
3.2, test medicine
Tumor inoculation is after 24 hours, and except model group and blank group, all the other group mouse give corresponding medicine, as follows:
Positive controls: select ZhenQi capsule to be positive control drug.
The Chinese medicine high dosage for the treatment of tumour: quite former medicine 500g/kg;
Dosage in the Chinese medicine for the treatment of tumour: quite former medicine 300g/kg;
The Chinese medicine low dosage for the treatment of tumour: quite former medicine 100g/kg;
3.3, Testing index
During administration, every day measures body weight, within the 8th day, puts to death animal, claims knurl weight, calculate each group of average knurl weight, press formula and obtain tumor control rate and carry out X2Inspection.
3.4, result
Chinese medicine composition of the present invention is little on the body weight impact of S180 sarcoma mouse, but S180 sarcoma is had obvious restraining effect. Tumour inhibiting rate is 43.7-64.52%; The results are shown in Table 3. Result shows this Chinese medicine inventive composition, and tumor inhibition effect is obvious, compares with model group and has significant differences P < 0.01.
Table 3. present composition is to the tumor-inhibiting action result of S180 mouse
��Represent and compare P < 0.01 with model group
The foregoing is only the better embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment of doing, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the Chinese medicine of tumour for one kind, it is characterised in that, it is made up of the plant material of following weight part and animal material; Described plant material is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 3-5 part sea crab shell 4-8 part centipede 2-5 part.
2. a kind of Chinese medicine treating tumour according to claim 1, it is characterised in that, the part by weight of described plant material and described animal material is 1:0.01-0.05.
3. a kind of Chinese medicine treating tumour according to claim 1, it is characterised in that, described gynostemma pentaphylla is 12-14 part.
4. a kind of Chinese medicine treating tumour according to claim 3, it is characterised in that, described Japanese Honeysuckle Stem 35-40 part.
5. a kind of Chinese medicine treating tumour according to claim 3, it is characterised in that, 30 parts, described peach kernel.
6. a kind of Chinese medicine treating tumour according to claim 1, it is characterised in that, it is made up of the raw material of following weight part, described plant material is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 3-5 part sea crab shell 4-8 part centipede 2-5 part.
7. a kind of Chinese medicine treating tumour according to claim 6, it is characterised in that, the part by weight of described plant material and described animal material is 1:0.02-0.04.
8. a kind of Chinese medicine treating tumour according to claim 1, it is characterised in that, it is made up of the raw material of following weight part, described plant material is made up of following raw material:
Described animal material is made up of following raw material:
Earthworm 3-5 part sea crab shell 4-8 part centipede 2-5 part.
9. a kind of Chinese medicine treating tumour according to claim 8, it is characterised in that, the part by weight of described plant material and described animal material is 1:0.03.
10. the preparation method of the Chinese medicine of the described treatment tumour of the arbitrary item of claim 1 to 9, it is characterized in that, step 1) take plant material according to described part by weight and animal material mixes respectively, the blends of plant materials obtained, according to ratio boiling 2-3 hour of 1g:20-30ml water, filters; The dregs of a decoction add 3��and 5 times of quality water again decoct and boil 20��40min, filter; Merge twice fried liquid, fluid is concentrated to relative density be the medicinal extract of 1.05-1.12;
Step 2) described part by weight takes animal material, the animal material mixture obtained is elementary pulverized 60��100 orders sieves, then micronizing to particle diameter at 5��50 �� m, according to part by weight and step 1 after sterilizing) medicinal extract mixes.
CN201610183374.0A 2016-03-28 2016-03-28 Traditional Chinese medicine for treating tumors and preparation method of traditional Chinese medicine Pending CN105617007A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106491827A (en) * 2016-12-09 2017-03-15 河池市技术开发中心 A kind of Chinese medicine composition for treating colt diarrhoeal diseasess and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN101972454A (en) * 2010-11-03 2011-02-16 何玉伟 Medicament for treating lymphoma
CN104825817A (en) * 2015-05-15 2015-08-12 黑龙江中医药大学 Traditional Chinese medicine preparation with antitumor effect

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101972454A (en) * 2010-11-03 2011-02-16 何玉伟 Medicament for treating lymphoma
CN104825817A (en) * 2015-05-15 2015-08-12 黑龙江中医药大学 Traditional Chinese medicine preparation with antitumor effect

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106491827A (en) * 2016-12-09 2017-03-15 河池市技术开发中心 A kind of Chinese medicine composition for treating colt diarrhoeal diseasess and preparation method thereof

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