CN106074960A - A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy and preparation method thereof - Google Patents
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy and preparation method thereof Download PDFInfo
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- CN106074960A CN106074960A CN201610464761.1A CN201610464761A CN106074960A CN 106074960 A CN106074960 A CN 106074960A CN 201610464761 A CN201610464761 A CN 201610464761A CN 106074960 A CN106074960 A CN 106074960A
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Abstract
The present invention relates to a kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy and preparation method thereof, by Rhizoma Corydalis 10 15 parts, Radix Kansui 28 35 parts, Rhizoma Arisaematis 8 12 parts, Rhizoma Pinelliae 32 38 parts, Bombyx Batryticatus 15 18 parts, Semen Sinapis Albae 18 20 parts, Resina garciniae 18 25 parts, Mirabilitum 20 25 parts, 22 35 parts of Herba Ephedrae, 10 15 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 15 18 parts, Caulis Spatholobi 20 22 parts, Caulis Polygoni Multiflori 25 30 parts, Herba Ecliptae 28 30 parts, Radix Ranunculi Ternati 33 35 parts, Herba Epimedii 25 30 parts composition.The present invention selects above-mentioned ten Six-element medicines to share the function playing QI invigorating blood stasis dispelling, plays the effect of anti-breast cancer transfer；This invention Chinese medicine composition is for the empty stasis of blood state after women with breast cancer chemoradiotherapy, can effectively suppress Metastasis in Breast Cancer and treatment cyclomastopathy based on the medicine prescription that selects of QI invigorating blood stasis dispelling.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy and preparation method thereof, belong to treatment breast
Cancer and the cyclomastopathy field of Chinese medicines.
Background technology
Cancer is the formidable enemy of harm human health.Breast carcinoma is the major malignant tumor of harm WomanHealth, and the whole world is every
Year there are about 1,200,000 women and suffers from breast cancer, and has 500,000 women to die from breast carcinoma.Though China is low area of breast carcinoma, but its
Sick rate rises the most year by year, especially with Shanghai Beijing-Tianjin and coastal area as hotspot, accounts for the 2nd in female malignant., mammary gland
The Therapeutic Method of cancer has operation, chemotherapy, radiotherapy, endocrine therapy, Biotherapeutics, Chinese medicine etc..Operation is first-selected treatment
Method, but substantial amounts of clinical treatment proves, and chemotherapy and radiation has damage to organism normal cell while killing tumor cell
Evil effect.Traditional Chinese Medicine Anti tumor has that mechanism of action uniqueness, lasting medicine, Mutiple Targets, multipath, Antitumor test be wide, toxic and side effects
The advantage such as little, has huge potentiality and irreplaceable advantage for treatment tumor, the most progressively occupies
Leading position.
Summary of the invention
The technical problem to be solved is to provide a kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy, existing
Having the method for excision in technology to add the misery of patient, hinder its vigour, expense is huge, by chemotherapy or the method for radiotherapy,
While killing tumor cell, also injure erythrocyte and leukocyte, cause patient to suffer untold misery, and cure the symptoms, not the disease, be difficult to
Thoroughly remove the defect of the threat of tumor.
The technical scheme is that a kind of Chinese drug-treated group treating breast carcinoma and cyclomastopathy
Compound, by Rhizoma Corydalis 10-15 part, Radix Kansui 28-35 part, Rhizoma Arisaematis 8-12 part, Rhizoma Pinelliae 32-38 part, Bombyx Batryticatus 15-18 part, Semen Sinapis Albae 18-
20 parts, Resina garciniae 18-25 part, Mirabilitum 20-25 part, Herba Ephedrae 22-35 part, Radix Euphorbiae Pekinensis 10-15 part, Rhizoma Cyperi 15-18 part, Caulis Spatholobi 20-22
Part, Caulis Polygoni Multiflori 25-30 part, Herba Ecliptae 28-30 part, Radix Ranunculi Ternati 33-35 part, Herba Epimedii 25-30 part composition.
The invention has the beneficial effects as follows: the present invention selects Rhizoma Corydalis, Radix Kansui, Rhizoma Arisaematis, Rhizoma Pinelliae, Bombyx Batryticatus, Semen Sinapis Albae, Resina garciniae,
Mirabilitum, Herba Ephedrae, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi, Caulis Spatholobi, Caulis Polygoni Multiflori, Herba Ecliptae, Radix Ranunculi Ternati, Herba Epimedii are combined preparing active component.Its
Middle Radix Ginseng, Radix Morindae Officinalis, Rhizoma Polygonati have QI invigorating tonifying YIN effect, and Semen Litchi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris have acupuncture-stimulating blood stasis dispersing, removing toxic substances dissipates
Mass-dissipating efficacy.Above-mentioned ten Six-element medicines share the function playing QI invigorating blood stasis dispelling, play the effect of anti-breast cancer transfer；This invention Chinese drug-treated group
Compound is for the empty stasis of blood state after women with breast cancer chemoradiotherapy, can effectively suppress with the medicine prescription that selects of QI invigorating blood stasis dispelling master
Metastasis in Breast Cancer and treatment cyclomastopathy.
On the basis of technique scheme, the present invention can also do following improvement.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy of the present invention, further, by Rhizoma Corydalis 12 parts,
Radix Kansui 30 parts, Rhizoma Arisaematis 10 parts, Rhizoma Pinelliae 32 parts, Bombyx Batryticatus 15 parts, Semen Sinapis Albae 20 parts, Resina garciniae 20 parts, Mirabilitum 22 parts, 25 parts of Herba Ephedrae,
13 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 18 parts, Caulis Spatholobi 21 parts, Caulis Polygoni Multiflori 26 parts, Herba Ecliptae 28 parts, Radix Ranunculi Ternati 34 parts, Herba Epimedii 28 parts composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy of the present invention, further, by Rhizoma Corydalis 14 parts,
Radix Kansui 30 parts, Rhizoma Arisaematis 11 parts, Rhizoma Pinelliae 35 parts, Bombyx Batryticatus 16 parts, Semen Sinapis Albae 18 parts, Resina garciniae 20 parts, Mirabilitum 23 parts, 30 parts of Herba Ephedrae,
13 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 17 parts, Caulis Spatholobi 21 parts, Caulis Polygoni Multiflori 28 parts, Herba Ecliptae 29 parts, Radix Ranunculi Ternati 34 parts, Herba Epimedii 28 parts composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy of the present invention, further, by Rhizoma Corydalis 15 parts,
Radix Kansui 32 parts, Rhizoma Arisaematis 12 parts, Rhizoma Pinelliae 34 parts, Bombyx Batryticatus 18 parts, Semen Sinapis Albae 18 parts, Resina garciniae 18 parts, Mirabilitum 20 parts, 22 parts of Herba Ephedrae,
15 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 15 parts, Caulis Spatholobi 20 parts, Caulis Polygoni Multiflori 25 parts, Herba Ecliptae 30 parts, Radix Ranunculi Ternati 33 parts, Herba Epimedii 28 parts composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy of the present invention, further, by Rhizoma Corydalis 13 parts,
Radix Kansui 30 parts, Rhizoma Arisaematis 10 parts, Rhizoma Pinelliae 35 parts, Bombyx Batryticatus 16 parts, Semen Sinapis Albae 19 parts, Resina garciniae 23 parts, Mirabilitum 15 parts, 22 parts of Herba Ephedrae,
14 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 16 parts, Caulis Spatholobi 21 parts, Caulis Polygoni Multiflori 28 parts, Herba Ecliptae 28 parts, Radix Ranunculi Ternati 34 parts, Herba Epimedii 28 parts composition.
The preparation method of the above-mentioned a kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy of the present invention, it is also possible to be according to
Above-mentioned weight ratio mixes, and adds 6-10 times amount water soaking 1-2 hour, and decocting extracts 0.5-3 hour, filters, and collects filtrate；Filtering residue adds
5-8 times amount water, decocting extracts 0.5-2 hour, filters, and collects filtrate；Merging filtrate.The evaporation of above-mentioned filtrate is flung to liquid and is prepared as
Dry extract, in baking oven 80 DEG C be baked to be completely dried after be ground into fine powder.Above-mentioned fine powder can also be by adding preparation difference
The various customary adjuvant needed during dosage form, method of Chinese medicinal routinely is prepared as common Chinese medicine preparation formulation.Above-mentioned fine powder
As effective ingredient, add adjuvant and make tablet or capsule.
In the present invention, pharmaceutic adjuvant used, can be selected from binding agent (can be polyvidone, starch slurry, cellulose
Deng), disintegrating agent (can be dried starch, sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, PVP
Deng), lubricant (can be Pulvis Talci, stearic acid, stearic acid calcium and magnesium, calcium stearate etc.), correctives (can be sucrose, A Si
Ba Tian, steviosin, fructose etc.), stabilizer (can be methyl parahydroxybenzoate, propyl p-hydroxybenzoate etc.), diluent
(can be starch, dextrin, Icing Sugar, lactose etc.), wetting agent (can be water or ethanol), fluidizer (can be micropowder silica gel),
Excipient (can be carbohydrate derivative such as lactose, sucrose, glucose, mannitol, sorbitol；Starch based derivant such as Semen Maydis forms sediment
Powder, potato starch, dextrin or carboxymethyl starch；Cellulose derivative such as crystalline fibers, hydroxy propyl cellulose, carboxymethyl cellulose.
The application in preparing antitumor drug of the described anti-tumor Chinese medicine.
Described anti-tumor Chinese medicine is the medicine promoting apoptosis of tumor cells.
Described antitumor drug includes the medicine of adenocarcinoma of lung, the medicine of anti-cervical cancer, the medicine of anti-myeloma.
Effect of raw material used in the present invention is as follows:
Rhizoma Corydalis, warm in nature, acrid in the mouth is bitter, enters the heart, spleen, liver, lung, invigorates blood circulation, regulates the flow of vital energy, pain relieving, be blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain wonderful
Product, are world-famous for effect of pain relieving especially.
Radix Kansui: bitter in the mouth；Cold in nature；Poisonous, spleen channel；Lung meridian；Kidney channel；Bladder warp；Large intestine channel；Small intestine meridian.
Rhizoma Arisaematis: have scattered wind, eliminate the phlegm, relieving convulsion, effect of pain relieving, apoplexy paralysis, carpopedal spasm can be controlled, dizziness of having a headache, frightened
The diseases such as wind-phlegm Sheng.
Rhizoma Pinelliae: pungent, temperature.Poisonous.Return spleen, stomach, lung meridian.
Bombyx Batryticatus: there is expelling wind to relieve convulsion, effect of dissipating phlegm and resolving masses.
Semen Sinapis Albae: " detailed outline ": " pungent, heat, nontoxic." cure mainly and reduce phlegm by drink；Mass dissipating and swelling eliminating；Cough with asthma abundant expectoration；Fullness in the chest and hypochondriac pain；Limb
Body is numb；Arthralgia；Multiple abscess caused by damp-phlegm；Carbuncle of yin nature toxic swelling.Control acute mastitis, breast carcinoma, mammary gland pain, tuberculosis, phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium
Pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain is numb, tinea pedis, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Resina garciniae: Resina garciniae, in be the resin of Garcinia maingayii Resina garciniae Garcinia hanburyi Hook.f..There is detumescence,
Counteracting toxic substances, putrefaction removing sore, hemostasis, effect of parasite killing.It is usually used in swollen ulcer drug, ulcer, eczema, tumor, stubborn dermatitis, treating swelling and pain by traumatic injury, skin ulcer
Hinder hemorrhage and scald.
Mirabilitum: salty, bitter, cold.Return stomach warp；Lung meridian；Spleen channel；Kidney channel；Small intestine meridian；Tri-jiao channel；Large intestine channel.There is heat clearing away solution
Poison, effect of reducing swelling and alleviating pain.
Herba Ephedrae: hardship pungent, micro-, temperature.Return lung, bladder warp；There is diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.
The Radix Euphorbiae Pekinensis: bitter in the mouth, cold in nature, poisonous.Enter lung, spleen, kidney channel.Cure mainly edema distension, phlegm retention accumulation, carbuncle furunculosis, two just
Obstructed.
Rhizoma Cyperi: sweet in the mouth, is slightly cold, nontoxic, enters liver, tri-jiao channel.Regulate the flow of vital energy resolving depression, menstruction regulating and pain relieving.
Caulis Spatholobi: there is blood circulation promoting and enriching, menstruction regulating and pain relieving, effect of relaxing muscles and tendons and activating QI and blood in the collateral.
Caulis Polygoni Multiflori: nature and flavor with return through: sweet, flat.GUIXIN, Liver Channel.There is nourishing blood to tranquillize the mind, effect of dispelling wind and removing obstruction in the collateral.
Herba Ecliptae: sweet, sour, flat, nontoxic.There is effect of convergence, hemostasis, invigorating the liver and kidney.
Radix Ranunculi Ternati: sweet, pungent, tepor.Return liver, lung meridian.There is dissipating phlegm and resolving masses, effect of removing toxic substances and promoting subsidence of swelling.
Herba Epimedii, i.e. Herba Epimedii, nontoxic, acrid, sweet, warm.Return liver, kidney channel.There is kidney-replenishing, bone and muscle strengthening, efficacy of dispelling wind.
Detailed description of the invention
Principle and feature to the present invention are described with the following Examples, and example is served only for explaining the present invention,
It is not intended to limit the scope of the present invention.
Embodiment 1
Chinese medicine composition of the present invention, by Rhizoma Corydalis 12g, Radix Kansui 30g, Rhizoma Arisaematis 10g, Rhizoma Pinelliae 32g, Bombyx Batryticatus 15g, Semen Sinapis Albae
20g, Resina garciniae 20g, Mirabilitum 22g, Herba Ephedrae 25g, Radix Euphorbiae Pekinensis 13g, Rhizoma Cyperi 18g, Caulis Spatholobi 21g, Caulis Polygoni Multiflori 26g, Herba Ecliptae 28g, cat
Pawl grass 34g, Herba Epimedii 28g form.
As a example by ten times of content of starting materials of above-mentioned composition summation, by adding raw material 7 times amount water soaking 1.5 hours, decocting carries
Take 2 hours, filter, collect filtrate；Filtering residue adds 7 times amount water, and decocting extracts 2 hours, filters, and collects filtrate；Merging filtrate.Above-mentioned
Filtrate evaporation is flung to liquid and is prepared as dry extract.This extractum can also in baking oven 80 DEG C be baked to be completely dried after be ground into thin
Powder.
Embodiment 2
Chinese medicine composition of the present invention, by Rhizoma Corydalis 14g, Radix Kansui 30g, Rhizoma Arisaematis 11g, Rhizoma Pinelliae 35g, Bombyx Batryticatus 16g, Semen Sinapis Albae
18g, Resina garciniae 20g, Mirabilitum 23g, Herba Ephedrae 30g, Radix Euphorbiae Pekinensis 13g, Rhizoma Cyperi 17g, Caulis Spatholobi 21g, Caulis Polygoni Multiflori 28g, Herba Ecliptae 29g, cat
Pawl grass 34g, Herba Epimedii 28g form.
As a example by ten times of content of starting materials of above-mentioned composition summation, by adding raw material 10 times amount water soaking 2 hours, decocting extracts
3 hours, filter, collect filtrate；Filtering residue adds 7 times amount water, and decocting extracts 2 hours, filters, and collects filtrate；Merging filtrate, above-mentioned filter
Liquid evaporation is flung to liquid and is prepared as dry extract.This extractum can also in baking oven 80 DEG C be baked to be completely dried after be ground into thin
Powder.
Embodiment 3
Chinese medicine composition of the present invention, by Rhizoma Corydalis 15g, Radix Kansui 32g, Rhizoma Arisaematis 12g, Rhizoma Pinelliae 34g, Bombyx Batryticatus 18g, Semen Sinapis Albae
18g, Resina garciniae 18g, Mirabilitum 20g, Herba Ephedrae 22g, Radix Euphorbiae Pekinensis 15g, Rhizoma Cyperi 15g, Caulis Spatholobi 20g, Caulis Polygoni Multiflori 25g, Herba Ecliptae 30g, cat
Pawl grass 33g, Herba Epimedii 28g form.
As a example by ten times of content of starting materials of above-mentioned composition summation, by adding raw material 10 times amount water soaking 2 hours, decocting extracts
2.5 hours, filter, collect filtrate；Filtering residue adds 6 times amount water, and decocting extracts 1.5 hours, filters, and collects filtrate；Merging filtrate, on
State filtrate evaporation to fling to liquid and be prepared as dry extract.This extractum can also in baking oven 80 DEG C be baked to be completely dried after be ground into
Fine powder.
Embodiment 4
Chinese medicine composition of the present invention, by Rhizoma Corydalis 13g, Radix Kansui 30g, Rhizoma Arisaematis 10g, Rhizoma Pinelliae 35g, Bombyx Batryticatus 16g, Semen Sinapis Albae
19g, Resina garciniae 23g, Mirabilitum 15g, Herba Ephedrae 22g, Radix Euphorbiae Pekinensis 14g, Rhizoma Cyperi 16g, Caulis Spatholobi 21g, Caulis Polygoni Multiflori 28g, Herba Ecliptae 28g, cat
Pawl grass 34g, Herba Epimedii 28g form.
As a example by ten times of content of starting materials of above-mentioned composition summation, by adding raw material 10 times amount water soaking 2 hours, decocting extracts
2.5 hours, filter, collect filtrate；Filtering residue adds 7 times amount water, and decocting extracts 2 hours, filters, and collects filtrate；Merging filtrate, above-mentioned
Filtrate evaporation is flung to liquid and is prepared as dry extract.This extractum can also in baking oven 80 DEG C be baked to be completely dried after be ground into thin
Powder.
Embodiment 5
Chinese medicine composition of the present invention, by Rhizoma Corydalis 10g, Radix Kansui 28g, Rhizoma Arisaematis 8g, Rhizoma Pinelliae 32g, Bombyx Batryticatus 15g, Semen Sinapis Albae
18g, Resina garciniae 18g, Mirabilitum 20-25g, Herba Ephedrae 22g, Radix Euphorbiae Pekinensis 10g, Rhizoma Cyperi 15g, Caulis Spatholobi 20g, Caulis Polygoni Multiflori 25g, Herba Ecliptae 28g,
Radix Ranunculi Ternati 33g, Herba Epimedii 25g form.
As a example by ten times of content of starting materials of above-mentioned composition summation, by adding raw material 6 times amount water soaking 1 hour, decocting extracts
0.5 hour, filter, collect filtrate；Filtering residue adds 5 times amount water, and decocting extracts 0.5 hour, filters, and collects filtrate；Merging filtrate, on
State filtrate evaporation to fling to liquid and be prepared as dry extract.This extractum can also in baking oven 80 DEG C be baked to be completely dried after be ground into
Fine powder.
Embodiment 6
Chinese medicine composition of the present invention, by Rhizoma Corydalis 15g, Radix Kansui 28g, Rhizoma Arisaematis 8g, Rhizoma Pinelliae 38g, Bombyx Batryticatus 15g, Semen Sinapis Albae
20g, Resina garciniae 18g, Mirabilitum 25g, Herba Ephedrae 35g, Radix Euphorbiae Pekinensis 15g, Rhizoma Cyperi 15g, Caulis Spatholobi 20g, Caulis Polygoni Multiflori 25g, Herba Ecliptae 30g, cat
Pawl grass 35g, Herba Epimedii 30g form.
As a example by ten times of content of starting materials of above-mentioned composition summation, by adding raw material 10 times amount water soaking 2 hours, decocting extracts
3 hours, filter, collect filtrate；Filtering residue adds 8 times amount water, and decocting extracts 2 hours, filters, and collects filtrate；Merging filtrate, above-mentioned filter
Liquid evaporation is flung to liquid and is prepared as dry extract.This extractum can also in baking oven 80 DEG C be baked to be completely dried after be ground into thin
Powder.
1, the acute toxinology experiment of embodiment 1 to embodiment 6
Experimental animal: ICR mice 60, body weight 17-22g, male and female half and half.From Medical School of Peking University's laboratory；
Animal is grouped: using the male and female Stochastic Equilibrium method of dividision into groups respectively, be divided into 6 groups, often group 10, one of which is blank
Matched group.
Dosage determines: metering is designed as: fine powder 10g/kg, fine powder 20/kg (Clinical design dosage), fine powder 30/kg,
Fine powder 40/kg, fine powder 50/kg.
It is administered: disposable gastric infusion: fasting 3-5 hour before being administered, fasting 1-2 hour after administration, water is can't help in fasting.Adopt
By administered in portions, negative control group, first of fine powder 10g/kg, fine powder 15g/kg is administered, and determines that set dosage closes after administration
Suitable, then give fine powder 20g/kg, fine powder 30g/kg, fine powder 40g/kg, fine powder 50g/kg.Continuous Observation more than 7 days after administration, with
Rear every day at the upper and lower noon respectively observes once, Continuous Observation 14 days.Itemized record every observation index table 1.
| Group | Fine powder/kg | Quantity | Survival rate % |
| 1 | 10 | 100 | |
| 2 | 10 | 10 | 100 |
| 3 | 20 | 10 | 100 |
| 4 | 30 | 10 | 95 |
| 5 | 40 | 10 | 90 |
| 6 | 50 | 10 | 88 |
Conclusion: tested material time gastric infusion dosage reaches fine powder 50g/kg in this test, occurs death.According to acute
Toxicity grading standard determination, this test medicine can be considered poisonous.
2, long term toxicity test
Rat general 6～9 week old.During on-test, weight differences is not to be exceeded or less than this experimental animal average body
The 20% of weight；
Dosage determines: metering is designed as: fine powder 10g/kg, fine powder 20/kg (Clinical design dosage), fine powder 30/kg,
Fine powder 40/kg, fine powder 50/kg.
Repetitively administered: disposable gastric infusion: fasting 3～5 hours before being administered, fasting 1～2 hours after administration, fasting is not
Prohibit water.Use administered in portions, negative control group, give fine powder 10g/kg, fine powder 20/kg (Clinical design dosage), fine powder
30/kg, fine powder 40/kg, fine powder 50/kg.Successive administration was discontinued medication after 6 months, more than 1 month sky of Continuous Observation.Note in detail
Record every observation index table 2.
Table 2. long_term toxcity result of the test
| Group | Powder/kg | Quantity | Survival rate % |
| 1 | 20 | 100 | |
| 2 | 10 | 20 | 100 |
| 3 | 20 | 20 | 100 |
| 4 | 30 | 20 | 98 |
| 5 | 40 | 20 | 90 |
| 6 | 50 | 20 | 85 |
Conclusion: when tested material gastric infusion dosage in this test reaches with embodiment powder 50g/kg, occur death.
Judging according to acute toxicity grading criteria, this test medicine can be considered poisonous.The present invention is administered orally has certain toxicity, it should abide by
Follow doctor's advice to take.Generally can use in the way of employing is smeared, there is preferable curative effect equally.
Above-described embodiment 1 to embodiment 6 fine powder can add the various customary adjuvant preparing different dosage form, Chinese medicine routinely
Formulation method is prepared as common Chinese medicine preparation formulation, such as tablet, capsule, oral liquid, electuary etc..
The impact that mouse breast cancer tumour is shifted by experimental example 1 Chinese medicine composition of the present invention
Mouse breast cancer model is set up: takes well-grown 4T1 breast carcinoma and passes on solid tumor, prepares tumor with normal saline thin
Born of the same parents' suspension, adjusts cell number 5 × 106Individual cell/ml, is only inoculated under 40 BALB/c mouse mammary fat pad by 0.1ml/, will
Mice is randomly divided into 4 groups, and often group 10, treats by the following method.
Chinese medicine composition dosage group of the present invention includes high dose group (20g/kg), middle dosage group (10g/kg), low dose group
(5g/kg)；Every day gastric infusion once, continuous 14 days；Matched group gives normal saline, puts to death mice next day in drug withdrawal,
Weighing, peel off lungs and Nodules, calculate breast carcinoma Lung metastases suppression ratio, result see table 1.
Mouse breast cancer tumour is shifted metastasis inhibition rate by table 1. Chinese medicine composition
The impact that mouse breast cancer tumour is shifted by embodiment 5 Chinese medicine composition of the present invention
Mouse breast cancer model is set up: takes well-grown 4T1 breast carcinoma and passes on solid tumor, prepares tumor with normal saline thin
Born of the same parents' suspension, adjusts cell number 5 × 106Individual cell/ml, is only inoculated under 40 BALB/c mouse mammary fat pad by 0.1ml/, will
Mice is randomly divided into 4 groups, and often group 10, treats by the following method.
Chinese medicine composition dosage group of the present invention includes high dose group (20g/kg), middle dosage group (10g/kg), low dose group
(5g/kg)；Every day gastric infusion once, continuous 14 days；Matched group gives normal saline, puts to death mice next day in drug withdrawal,
Weighing, peel off lungs and Nodules, calculate breast carcinoma Lung metastases suppression ratio, result see table 2.
Mouse breast cancer tumour is shifted metastasis inhibition rate by table 2. Chinese medicine composition
In embodiment 1 to embodiment 6, the present invention is for treating the using method of breast carcinoma and cyclomastopathy employing mainly
Dry extract is applied on breast, three times a day, each 2g, preferably can be coated with 10-30 minute with preservative film etc..
Model case
Liu, female, 28 years old, worker,
First visit: April 13 in 2000, two breast lump 4 years.Start less, after gradually grow up, menstruation come before distending pain, swollen
Block is hardening, through the softest.Menoxenia, amount polychrome is purple, and is attended by stomachache, rib cylinder the most uncomfortable in chest, infantile anorexia, big dry stool.
Checking, two breast all have about 4X5cm size of luming, obscure boundary, and quality is not answered, and the most smooth thing tuberosity does not glues with surrounding tissue
Even, push away can be movable.The extractum using embodiment 1 is smeared after two months, and distending pain alleviates, and also smooth through row, stool is normal, caking
Deliquescing；Within 3 months, caking still exists, the most not distending pain, but waist the most not distending pain, caking hour, eumenorrhea after 5 months.With
Upper described be only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, institute
Any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (7)
1. the Chinese medicine composition treating breast carcinoma and cyclomastopathy, it is characterised in that have Rhizoma Corydalis 10-15 part, Radix Kansui 28-35
Part, Rhizoma Arisaematis 8-12 part, Rhizoma Pinelliae 32-38 part, Bombyx Batryticatus 15-18 part, Semen Sinapis Albae 18-20 part, Resina garciniae 18-25 part, Mirabilitum 20-25
Part, Herba Ephedrae 22-35 part, Radix Euphorbiae Pekinensis 10-15 part, Rhizoma Cyperi 15-18 part, Caulis Spatholobi 20-22 part, Caulis Polygoni Multiflori 25-30 part, Herba Ecliptae 28-
30 parts, Radix Ranunculi Ternati 33-35 part, Herba Epimedii 25-30 part composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy, it is characterised in that by Rhizoma Corydalis
12 parts, Radix Kansui 30 parts, Rhizoma Arisaematis 10 parts, Rhizoma Pinelliae 32 parts, Bombyx Batryticatus 15 parts, Semen Sinapis Albae 20 parts, Resina garciniae 20 parts, Mirabilitum 22 parts, Herba Ephedrae
25 parts, 13 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 18 parts, Caulis Spatholobi 21 parts, Caulis Polygoni Multiflori 26 parts, Herba Ecliptae 28 parts, Radix Ranunculi Ternati 34 parts, Herba Epimedii 28 parts
Composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy, it is characterised in that by Rhizoma Corydalis
14 parts, Radix Kansui 30 parts, Rhizoma Arisaematis 11 parts, Rhizoma Pinelliae 35 parts, Bombyx Batryticatus 16 parts, Semen Sinapis Albae 18 parts, Resina garciniae 20 parts, Mirabilitum 23 parts, Herba Ephedrae
30 parts, 13 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 17 parts, Caulis Spatholobi 21 parts, Caulis Polygoni Multiflori 28 parts, Herba Ecliptae 29 parts, Radix Ranunculi Ternati 34 parts, Herba Epimedii 28 parts
Composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy, it is characterised in that by Rhizoma Corydalis
15 parts, Radix Kansui 32 parts, Rhizoma Arisaematis 12 parts, Rhizoma Pinelliae 34 parts, Bombyx Batryticatus 18 parts, Semen Sinapis Albae 18 parts, Resina garciniae 18 parts, Mirabilitum 20 parts, Herba Ephedrae
22 parts, 15 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 15 parts, Caulis Spatholobi 20 parts, Caulis Polygoni Multiflori 25 parts, Herba Ecliptae 30 parts, Radix Ranunculi Ternati 33 parts, Herba Epimedii 28 parts
Composition.
A kind of Chinese medicine composition treating breast carcinoma and cyclomastopathy, it is characterised in that by Rhizoma Corydalis
13 parts, Radix Kansui 30 parts, Rhizoma Arisaematis 10 parts, Rhizoma Pinelliae 35 parts, Bombyx Batryticatus 16 parts, Semen Sinapis Albae 19 parts, Resina garciniae 23 parts, Mirabilitum 15 parts, Herba Ephedrae
22 parts, 14 parts, the Radix Euphorbiae Pekinensis, Rhizoma Cyperi 16 parts, Caulis Spatholobi 21 parts, Caulis Polygoni Multiflori 28 parts, Herba Ecliptae 28 parts, Radix Ranunculi Ternati 34 parts, Herba Epimedii 28 parts
Composition.
6. the preparation method of the Chinese medicine composition treating breast carcinoma and cyclomastopathy, it is characterised in that according to claim 1
Weighing the mixing of each raw material to part by weight described in 5 any one, add 6-10 times amount water soaking 1-2 hour, it is little that decocting extracts 0.5-3
Time, filter, collect filtrate；Filtering residue adds 5-8 times amount water, and decocting extracts 0.5-2 hour, filters, and collects filtrate；Merging filtrate.
A kind of preparation method of the Chinese medicine composition treating breast carcinoma and cyclomastopathy, its feature
Being, the evaporation of merging filtrate filtrate is flung to liquid and is prepared as dry extract, in baking oven 80 DEG C be baked to be completely dried after be ground into
Fine powder.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115590914A (en) * | 2022-09-29 | 2023-01-13 | 云南中医药大学（Cn） | Knoxia extract and application thereof in preparation of anti-breast cancer drugs |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444612A (en) * | 2008-12-26 | 2009-06-03 | 高玉民 | Traditional Chinese medicine for treating hyperplasia of mammary glands and breast cancer |
-
2016
- 2016-06-24 CN CN201610464761.1A patent/CN106074960A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444612A (en) * | 2008-12-26 | 2009-06-03 | 高玉民 | Traditional Chinese medicine for treating hyperplasia of mammary glands and breast cancer |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115590914A (en) * | 2022-09-29 | 2023-01-13 | 云南中医药大学（Cn） | Knoxia extract and application thereof in preparation of anti-breast cancer drugs |
| CN115590914B (en) * | 2022-09-29 | 2023-11-24 | 云南中医药大学 | Euphorbia pekinensis extract and application thereof in preparation of breast cancer resisting medicines |
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